Disease‐related and genetic correlates of psychotic symptoms in Parkinson's disease
Identifieur interne : 001697 ( Main/Exploration ); précédent : 001696; suivant : 001698Disease‐related and genetic correlates of psychotic symptoms in Parkinson's disease
Auteurs : Stewart A. Factor [États-Unis] ; N. Kyle Steenland [États-Unis] ; Donald S. Higgins [États-Unis] ; Eric S. Molho [États-Unis] ; Denise M. Kay [États-Unis] ; Jennifer Montimurro [États-Unis] ; Ami R. Rosen [États-Unis] ; Cyrus P. Zabetian [États-Unis] ; Haydeh Payami [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-10.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Congélation.
English descriptors
- KwdEn :
- Age Factors, Aged, Apolipoproteins E (genetics), Cognition Disorders (etiology), Community Health Planning, Depression, Female, Freezing, Genetic disease, Humans, Logistic Models, Male, Middle Aged, Nervous system diseases, Parkinson Disease (complications), Parkinson Disease (genetics), Parkinson disease, Parkinson's disease, Polymorphism, Single Nucleotide (genetics), Psychosis, Psychotic Disorders (etiology), Psychotic Disorders (genetics), Risk Factors, Risk factor, Severity of Illness Index, Sleep, alpha-Synuclein (genetics), depression, freezing of gait, genetics, psychosis, risk factors, sleep, tau Proteins (genetics).
- MESH :
- chemical , genetics : Apolipoproteins E, alpha-Synuclein, tau Proteins.
- complications : Parkinson Disease.
- etiology : Cognition Disorders, Psychotic Disorders.
- genetics : Parkinson Disease, Polymorphism, Single Nucleotide, Psychotic Disorders.
- Age Factors, Aged, Community Health Planning, Female, Humans, Logistic Models, Male, Middle Aged, Risk Factors, Severity of Illness Index.
Abstract
Our aim was to examine disease‐related and genetic correlates of the development of psychotic symptoms in a large population of patients with Parkinson's disease. We studied 500 patients with Parkinson's disease from the NeuroGenetics Research Consortium using logistic regression models. Predictors were demographic, clinical (motor/nonmotor features), and genetic, measured as continuous or dichotomous variables. Continuous measures were divided into population‐based tertiles. Results are given as odds ratios (95% confidence intervals) for dichotomous variables and by ascending tertile for continuous variables. Psychotic symptoms were associated with increasing age: 4.86 (1.62–14.30) and 6.25 (2.09–18.74) (test for trend: P = 0.01); and duration of disease: 3.81 (1.23–11.76) and 5.33 (1.68–16.89) (test for trend: P = 0.03). For nonmotor features, we demonstrated positive trends with depression: 1.31 (0.47–3.61) and 5.01 (2.04–12.33) (test for trend: P < 0.0001); cognitive dysfunction: 0.69 (0.26–1.84) and 2.51 (1.00–6.29) (test for trend: P = 0.03); and an excess for those with sleep disorders: 2.00 (1.03–3.89) (P = 0.04). Psychotic symptoms were not associated with tremor or postural instability scores, but there was an association with freezing of gait: 3.83 (1.67–8.75) (P < 0.002). Psychotic symptoms were not associated with the presence of any examined polymorphisms in the apolipoprotein, alpha‐synuclein, or microtubule associated protein tau genes. This is the largest study to examine correlates of psychotic symptoms in Parkinson's disease. We discovered a novel association with freezing of gait. We demonstrated an association with depression and duration of disease, both of which were inconsistently related in previous studies, and confirmed the association with age, cognitive dysfunction, and sleep disorders. © 2011 Movement Disorder Society
Url:
- https://api.istex.fr/document/7097244E458A7DAA287CE66C58166160D188172E/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216677
DOI: 10.1002/mds.23806
Affiliations:
- États-Unis
- Géorgie (États-Unis), Washington (État), État de New York
- Seattle
- Université de Washington
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Le document en format XML
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<term>Community Health Planning</term>
<term>Depression</term>
<term>Female</term>
<term>Freezing</term>
<term>Genetic disease</term>
<term>Humans</term>
<term>Logistic Models</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nervous system diseases</term>
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<front><div type="abstract" xml:lang="en">Our aim was to examine disease‐related and genetic correlates of the development of psychotic symptoms in a large population of patients with Parkinson's disease. We studied 500 patients with Parkinson's disease from the NeuroGenetics Research Consortium using logistic regression models. Predictors were demographic, clinical (motor/nonmotor features), and genetic, measured as continuous or dichotomous variables. Continuous measures were divided into population‐based tertiles. Results are given as odds ratios (95% confidence intervals) for dichotomous variables and by ascending tertile for continuous variables. Psychotic symptoms were associated with increasing age: 4.86 (1.62–14.30) and 6.25 (2.09–18.74) (test for trend: P = 0.01); and duration of disease: 3.81 (1.23–11.76) and 5.33 (1.68–16.89) (test for trend: P = 0.03). For nonmotor features, we demonstrated positive trends with depression: 1.31 (0.47–3.61) and 5.01 (2.04–12.33) (test for trend: P < 0.0001); cognitive dysfunction: 0.69 (0.26–1.84) and 2.51 (1.00–6.29) (test for trend: P = 0.03); and an excess for those with sleep disorders: 2.00 (1.03–3.89) (P = 0.04). Psychotic symptoms were not associated with tremor or postural instability scores, but there was an association with freezing of gait: 3.83 (1.67–8.75) (P < 0.002). Psychotic symptoms were not associated with the presence of any examined polymorphisms in the apolipoprotein, alpha‐synuclein, or microtubule associated protein tau genes. This is the largest study to examine correlates of psychotic symptoms in Parkinson's disease. We discovered a novel association with freezing of gait. We demonstrated an association with depression and duration of disease, both of which were inconsistently related in previous studies, and confirmed the association with age, cognitive dysfunction, and sleep disorders. © 2011 Movement Disorder Society</div>
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<name sortKey="Higgins, Donald S" sort="Higgins, Donald S" uniqKey="Higgins D" first="Donald S." last="Higgins">Donald S. Higgins</name>
<name sortKey="Kay, Denise M" sort="Kay, Denise M" uniqKey="Kay D" first="Denise M." last="Kay">Denise M. Kay</name>
<name sortKey="Molho, Eric S" sort="Molho, Eric S" uniqKey="Molho E" first="Eric S." last="Molho">Eric S. Molho</name>
<name sortKey="Montimurro, Jennifer" sort="Montimurro, Jennifer" uniqKey="Montimurro J" first="Jennifer" last="Montimurro">Jennifer Montimurro</name>
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<name sortKey="Steenland, N Kyle" sort="Steenland, N Kyle" uniqKey="Steenland N" first="N. Kyle" last="Steenland">N. Kyle Steenland</name>
<name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P." last="Zabetian">Cyrus P. Zabetian</name>
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