Disease-Related and Genetic Correlates of Psychotic Symptoms in Parkinson's Disease
Identifieur interne : 001C18 ( Main/Merge ); précédent : 001C17; suivant : 001C19Disease-Related and Genetic Correlates of Psychotic Symptoms in Parkinson's Disease
Auteurs : Stewart A. Factor [États-Unis] ; N. Kyle Steenland [États-Unis] ; Donald S. Higgins [États-Unis] ; Eric S. Molho [États-Unis] ; Denise M. Kay [États-Unis] ; Jennifer Montimurro [États-Unis] ; Ami R. Rosen [États-Unis] ; Cyrus P. Zabetian [États-Unis] ; Haydeh Payami [États-Unis]Source :
- Movement disorders [ 0885-3185 ] ; 2011.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Congélation.
English descriptors
- KwdEn :
Abstract
Our aim was to examine disease-related and genetic correlates of the development of psychotic symptoms in a large population of patients with Parkinson's disease. We studied 500 patients with Parkinson's disease from the NeuroGenetics Research Consortium using logistic regression models. Predictors were demographic, clinical (motor/nonmotor features), and genetic, measured as continuous or dichotomous variables. Continuous measures were divided into population-based tertiles. Results are given as odds ratios (95% confidence intervals) for dichotomous variables and by ascending tertile for continuous variables. Psychotic symptoms were associated with increasing age: 4.86 (1.62-14.30) and 6.25 (2.09-18.74) (test for trend: P = 0.01); and duration of disease: 3.81 (1.23-11.76) and 5.33 (1.68-16.89) (test for trend: P = 0.03). For nonmotor features, we demonstrated positive trends with depression: 1.31 (0.47-3.61) and 5.01 (2.04-12.33) (test for trend: P < 0.0001); cognitive dysfunction: 0.69 (0.26-1.84) and 2.51 (1.00-6.29) (test for trend: P = 0.03); and an excess for those with sleep disorders: 2.00 (1.03-3.89) (P = 0.04). Psychotic symptoms were not associated with tremor or postural instability scores, but there was an association with freezing of gait: 3.83 (1.67-8.75) (P < 0.002). Psychotic symptoms were not associated with the presence of any examined polymorphisms in the apolipoprotein, alpha-synuclein, or micro-tubule associated protein tau genes. This is the largest study to examine correlates of psychotic symptoms in Parkinson's disease. We discovered a novel association with freezing of gait. We demonstrated an association with depression and duration of disease, both of which were inconsistently related in previous studies, and confirmed the association with age, cognitive dysfunction, and sleep disorders.
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Factor</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Emory University</s1><s2>Atlanta, Georgia</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Kyle Steenland, N" sort="Kyle Steenland, N" uniqKey="Kyle Steenland N" first="N." last="Kyle Steenland">N. Kyle Steenland</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Emory University</s1><s2>Atlanta, Georgia</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Higgins, Donald S" sort="Higgins, Donald S" uniqKey="Higgins D" first="Donald S." last="Higgins">Donald S. Higgins</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Samuel Stratton Veterans Affairs Medical Center</s1><s2>Albany, New York</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Molho, Eric S" sort="Molho, Eric S" uniqKey="Molho E" first="Eric S." last="Molho">Eric S. Molho</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Albany Medical Center</s1><s2>Albany, New York</s2><s3>USA</s3><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Kay, Denise M" sort="Kay, Denise M" uniqKey="Kay D" first="Denise M." last="Kay">Denise M. Kay</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>New York State Department of Health</s1><s2>Albany, New York</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Montimurro, Jennifer" sort="Montimurro, Jennifer" uniqKey="Montimurro J" first="Jennifer" last="Montimurro">Jennifer Montimurro</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>New York State Department of Health</s1><s2>Albany, New York</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Rosen, Ami R" sort="Rosen, Ami R" uniqKey="Rosen A" first="Ami R." last="Rosen">Ami R. Rosen</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Emory University</s1><s2>Atlanta, Georgia</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P." last="Zabetian">Cyrus P. Zabetian</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Veterans Affairs Puget Sound Health Care System and University of Washington</s1><s2>Seattle, Washington</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Payami, Haydeh" sort="Payami, Haydeh" uniqKey="Payami H" first="Haydeh" last="Payami">Haydeh Payami</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>New York State Department of Health</s1><s2>Albany, New York</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Depression</term><term>Freezing</term><term>Genetic disease</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Psychosis</term><term>Risk factor</term><term>Sleep</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Psychose</term><term>Maladie de Parkinson</term><term>Etat dépressif</term><term>Pathologie du système nerveux</term><term>Maladie héréditaire</term><term>Sommeil</term><term>Congélation</term><term>Facteur risque</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Congélation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Our aim was to examine disease-related and genetic correlates of the development of psychotic symptoms in a large population of patients with Parkinson's disease. We studied 500 patients with Parkinson's disease from the NeuroGenetics Research Consortium using logistic regression models. Predictors were demographic, clinical (motor/nonmotor features), and genetic, measured as continuous or dichotomous variables. Continuous measures were divided into population-based tertiles. Results are given as odds ratios (95% confidence intervals) for dichotomous variables and by ascending tertile for continuous variables. Psychotic symptoms were associated with increasing age: 4.86 (1.62-14.30) and 6.25 (2.09-18.74) (test for trend: P = 0.01); and duration of disease: 3.81 (1.23-11.76) and 5.33 (1.68-16.89) (test for trend: P = 0.03). For nonmotor features, we demonstrated positive trends with depression: 1.31 (0.47-3.61) and 5.01 (2.04-12.33) (test for trend: P < 0.0001); cognitive dysfunction: 0.69 (0.26-1.84) and 2.51 (1.00-6.29) (test for trend: P = 0.03); and an excess for those with sleep disorders: 2.00 (1.03-3.89) (P = 0.04). Psychotic symptoms were not associated with tremor or postural instability scores, but there was an association with freezing of gait: 3.83 (1.67-8.75) (P < 0.002). Psychotic symptoms were not associated with the presence of any examined polymorphisms in the apolipoprotein, alpha-synuclein, or micro-tubule associated protein tau genes. This is the largest study to examine correlates of psychotic symptoms in Parkinson's disease. We discovered a novel association with freezing of gait. We demonstrated an association with depression and duration of disease, both of which were inconsistently related in previous studies, and confirmed the association with age, cognitive dysfunction, and sleep disorders.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li><li>Washington (État)</li><li>État de New York</li></region><settlement><li>Seattle</li></settlement><orgName><li>Université de Washington</li></orgName></list><tree><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Factor, Stewart A" sort="Factor, Stewart A" uniqKey="Factor S" first="Stewart A." last="Factor">Stewart A. Factor</name></region><name sortKey="Higgins, Donald S" sort="Higgins, Donald S" uniqKey="Higgins D" first="Donald S." last="Higgins">Donald S. Higgins</name><name sortKey="Kay, Denise M" sort="Kay, Denise M" uniqKey="Kay D" first="Denise M." last="Kay">Denise M. Kay</name><name sortKey="Kyle Steenland, N" sort="Kyle Steenland, N" uniqKey="Kyle Steenland N" first="N." last="Kyle Steenland">N. Kyle Steenland</name><name sortKey="Molho, Eric S" sort="Molho, Eric S" uniqKey="Molho E" first="Eric S." last="Molho">Eric S. Molho</name><name sortKey="Montimurro, Jennifer" sort="Montimurro, Jennifer" uniqKey="Montimurro J" first="Jennifer" last="Montimurro">Jennifer Montimurro</name><name sortKey="Payami, Haydeh" sort="Payami, Haydeh" uniqKey="Payami H" first="Haydeh" last="Payami">Haydeh Payami</name><name sortKey="Rosen, Ami R" sort="Rosen, Ami R" uniqKey="Rosen A" first="Ami R." last="Rosen">Ami R. Rosen</name><name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P." last="Zabetian">Cyrus P. Zabetian</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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