Disease-related and genetic correlates of psychotic symptoms in Parkinson's disease
Identifieur interne : 000244 ( Pmc/Curation ); précédent : 000243; suivant : 000245Disease-related and genetic correlates of psychotic symptoms in Parkinson's disease
Auteurs : Stewart A. Factor [États-Unis] ; N. Kyle Steenland [États-Unis] ; Donald S. Higgins [États-Unis] ; Eric S. Molho [États-Unis] ; Denise M. Kay [États-Unis] ; Jennifer Montimurro [États-Unis] ; Ami R. Rosen [États-Unis] ; Cyrus P. Zabetian [États-Unis] ; Haydeh Payami [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2011.
Abstract
To examine disease-related and genetic correlates of the development of psychotic symptoms in a large Parkinson's Disease (PD) population.
We studied 500 PD subjects from the NeuroGenetics Research Consortium using logistic regression models. Predictors were demographic, clinical (motor/ non-motor features) and genetic measured as continuous or dichotomous variables. Continuous measures were divided into population based tertiles.
Results are given as odds ratios (95% confidence intervals) for dichotomous variables and by ascending tertile for continuous variables. Psychotic symptoms were associated with increasing age; 4.86 (1.62-14.30), and 6.25 (2.09-18.74) (test for trend p=.01); and duration of disease 3.81 (1.23-11.76), and 5.33 (1.68-16.89) (test for trend p=.03). For non-motor features we demonstrated positive trends with depression, 1.31 (0.47-3.61), and 5.01 (2.04-12.33) (test for trend p<.0001) and cognitive dysfunction, 0.69 (0.26-1.84) and 2.51 (1.00-6.29) (test for trend p=.03), and an excess for those with sleep disorders, 2.00 (1.03-3.89) (p=.04). Psychotic symptoms were not associated with tremor or postural instability scores but there was an association with freezing of gait, 3.83 (1.67-8.75) (p<.002). Psychotic symptoms were not associated with the presence of any examined polymorphisms in the apolipoprotein, alpha-synuclein, or
This is the largest study to examine correlates of psychotic symptoms in PD. We discovered a novel association with freezing of gait. We demonstrated an association with depression and duration of disease, both of which were inconsistently related in prior studies, and confirmed the association with age, cognitive dysfunction and sleep disorders.
Url:
DOI: 10.1002/mds.23806
PubMed: 21714002
PubMed Central: 4216677
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Kyle Steenland</name><affiliation wicri:level="1"><nlm:aff id="A1">Emory University, Atlanta, GA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Emory University, Atlanta, GA</wicri:regionArea></affiliation></author><author><name sortKey="Higgins, Donald S" sort="Higgins, Donald S" uniqKey="Higgins D" first="Donald S." last="Higgins">Donald S. Higgins</name><affiliation wicri:level="2"><nlm:aff id="A2">Samuel Stratton VA Medical Center Albany, NY USA</nlm:aff><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Samuel Stratton VA Medical Center Albany</wicri:cityArea></affiliation></author><author><name sortKey="Molho, Eric S" sort="Molho, Eric S" uniqKey="Molho E" first="Eric S." last="Molho">Eric S. 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Factor</name><affiliation wicri:level="1"><nlm:aff id="A1">Emory University, Atlanta, GA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Emory University, Atlanta, GA</wicri:regionArea></affiliation></author><author><name sortKey="Steenland, N Kyle" sort="Steenland, N Kyle" uniqKey="Steenland N" first="N. Kyle" last="Steenland">N. Kyle Steenland</name><affiliation wicri:level="1"><nlm:aff id="A1">Emory University, Atlanta, GA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Emory University, Atlanta, GA</wicri:regionArea></affiliation></author><author><name sortKey="Higgins, Donald S" sort="Higgins, Donald S" uniqKey="Higgins D" first="Donald S." last="Higgins">Donald S. Higgins</name><affiliation wicri:level="2"><nlm:aff id="A2">Samuel Stratton VA Medical Center Albany, NY USA</nlm:aff><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Samuel Stratton VA Medical Center Albany</wicri:cityArea></affiliation></author><author><name sortKey="Molho, Eric S" sort="Molho, Eric S" uniqKey="Molho E" first="Eric S." last="Molho">Eric S. Molho</name><affiliation wicri:level="1"><nlm:aff id="A3">Albany Medical Center, Albany, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Albany Medical Center, Albany, NY</wicri:regionArea></affiliation></author><author><name sortKey="Kay, Denise M" sort="Kay, Denise M" uniqKey="Kay D" first="Denise M." last="Kay">Denise M. Kay</name><affiliation wicri:level="1"><nlm:aff id="A4">New York State Department of Health, Albany, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>New York State Department of Health, Albany, NY</wicri:regionArea></affiliation></author><author><name sortKey="Montimurro, Jennifer" sort="Montimurro, Jennifer" uniqKey="Montimurro J" first="Jennifer" last="Montimurro">Jennifer Montimurro</name><affiliation wicri:level="1"><nlm:aff id="A4">New York State Department of Health, Albany, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>New York State Department of Health, Albany, NY</wicri:regionArea></affiliation></author><author><name sortKey="Rosen, Ami R" sort="Rosen, Ami R" uniqKey="Rosen A" first="Ami R." last="Rosen">Ami R. Rosen</name><affiliation wicri:level="1"><nlm:aff id="A1">Emory University, Atlanta, GA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Emory University, Atlanta, GA</wicri:regionArea></affiliation></author><author><name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P." last="Zabetian">Cyrus P. Zabetian</name><affiliation wicri:level="1"><nlm:aff id="A5">VA Puget Sound Health Care System and University of Washington, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>VA Puget Sound Health Care System and University of Washington, Seattle, WA</wicri:regionArea></affiliation></author><author><name sortKey="Payami, Haydeh" sort="Payami, Haydeh" uniqKey="Payami H" first="Haydeh" last="Payami">Haydeh Payami</name><affiliation wicri:level="1"><nlm:aff id="A4">New York State Department of Health, Albany, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>New York State Department of Health, Albany, NY</wicri:regionArea></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P1">To examine disease-related and genetic correlates of the development of psychotic symptoms in a large Parkinson's Disease (PD) population.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We studied 500 PD subjects from the NeuroGenetics Research Consortium using logistic regression models. Predictors were demographic, clinical (motor/ non-motor features) and genetic measured as continuous or dichotomous variables. Continuous measures were divided into population based tertiles.</p></sec><sec id="S3"><title>Results</title><p id="P3">Results are given as odds ratios (95% confidence intervals) for dichotomous variables and by ascending tertile for continuous variables. Psychotic symptoms were associated with increasing age; 4.86 (1.62-14.30), and 6.25 (2.09-18.74) (test for trend p=.01); and duration of disease 3.81 (1.23-11.76), and 5.33 (1.68-16.89) (test for trend p=.03). For non-motor features we demonstrated positive trends with depression, 1.31 (0.47-3.61), and 5.01 (2.04-12.33) (test for trend p<.0001) and cognitive dysfunction, 0.69 (0.26-1.84) and 2.51 (1.00-6.29) (test for trend p=.03), and an excess for those with sleep disorders, 2.00 (1.03-3.89) (p=.04). Psychotic symptoms were not associated with tremor or postural instability scores but there was an association with freezing of gait, 3.83 (1.67-8.75) (p<.002). Psychotic symptoms were not associated with the presence of any examined polymorphisms in the apolipoprotein, alpha-synuclein, or <italic>MAPT</italic> genes.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">This is the largest study to examine correlates of psychotic symptoms in PD. We discovered a novel association with freezing of gait. We demonstrated an association with depression and duration of disease, both of which were inconsistently related in prior studies, and confirmed the association with age, cognitive dysfunction and sleep disorders.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id><journal-id journal-id-type="pubmed-jr-id">5937</journal-id><journal-id journal-id-type="nlm-ta">Mov Disord</journal-id><journal-id journal-id-type="iso-abbrev">Mov. Disord.</journal-id><journal-title-group><journal-title>Movement disorders : official journal of the Movement Disorder Society</journal-title></journal-title-group><issn pub-type="ppub">0885-3185</issn><issn pub-type="epub">1531-8257</issn></journal-meta><article-meta><article-id pub-id-type="pmid">21714002</article-id><article-id pub-id-type="pmc">4216677</article-id><article-id pub-id-type="doi">10.1002/mds.23806</article-id><article-id pub-id-type="manuscript">NIHMS482898</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Disease-related and genetic correlates of psychotic symptoms in Parkinson's disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Factor</surname><given-names>Stewart A.</given-names></name><degrees>DO</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Steenland</surname><given-names>N. Kyle</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Higgins</surname><given-names>Donald S.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Molho</surname><given-names>Eric S.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Kay</surname><given-names>Denise M.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Montimurro</surname><given-names>Jennifer</given-names></name><degrees>MS</degrees><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Rosen</surname><given-names>Ami R.</given-names></name><degrees>MS, CGC</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Zabetian</surname><given-names>Cyrus P.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Payami</surname><given-names>Haydeh</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A4">4</xref></contrib></contrib-group><aff id="A1"><label>1</label>Emory University, Atlanta, GA, USA</aff><aff id="A2"><label>2</label>Samuel Stratton VA Medical Center Albany, NY USA</aff><aff id="A3"><label>3</label>Albany Medical Center, Albany, NY, USA</aff><aff id="A4"><label>4</label>New York State Department of Health, Albany, NY, USA</aff><aff id="A5"><label>5</label>VA Puget Sound Health Care System and University of Washington, Seattle, WA, USA</aff><author-notes><corresp id="FN1">Address Correspondence to: Stewart A. Factor, DO, Emory University School of Medicine, Department of Neurology, 1841 Clifton Road NE, Atlanta, GA 30329 USA, Phone: 404-728-6415, Fax: 404-728-6685, <email>sfactor@emory.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>24</day><month>10</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>28</day><month>6</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>10</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>02</day><month>11</month><year>2014</year></pub-date><volume>26</volume><issue>12</issue><fpage>2190</fpage><lpage>2195</lpage><pmc-comment>elocation-id from pubmed: 10.1002/mds.23806</pmc-comment>
<abstract><sec id="S1"><title>Objective</title><p id="P1">To examine disease-related and genetic correlates of the development of psychotic symptoms in a large Parkinson's Disease (PD) population.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We studied 500 PD subjects from the NeuroGenetics Research Consortium using logistic regression models. Predictors were demographic, clinical (motor/ non-motor features) and genetic measured as continuous or dichotomous variables. Continuous measures were divided into population based tertiles.</p></sec><sec id="S3"><title>Results</title><p id="P3">Results are given as odds ratios (95% confidence intervals) for dichotomous variables and by ascending tertile for continuous variables. Psychotic symptoms were associated with increasing age; 4.86 (1.62-14.30), and 6.25 (2.09-18.74) (test for trend p=.01); and duration of disease 3.81 (1.23-11.76), and 5.33 (1.68-16.89) (test for trend p=.03). For non-motor features we demonstrated positive trends with depression, 1.31 (0.47-3.61), and 5.01 (2.04-12.33) (test for trend p<.0001) and cognitive dysfunction, 0.69 (0.26-1.84) and 2.51 (1.00-6.29) (test for trend p=.03), and an excess for those with sleep disorders, 2.00 (1.03-3.89) (p=.04). Psychotic symptoms were not associated with tremor or postural instability scores but there was an association with freezing of gait, 3.83 (1.67-8.75) (p<.002). Psychotic symptoms were not associated with the presence of any examined polymorphisms in the apolipoprotein, alpha-synuclein, or <italic>MAPT</italic> genes.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">This is the largest study to examine correlates of psychotic symptoms in PD. We discovered a novel association with freezing of gait. We demonstrated an association with depression and duration of disease, both of which were inconsistently related in prior studies, and confirmed the association with age, cognitive dysfunction and sleep disorders.</p></sec></abstract><kwd-group><kwd>Parkinson's disease</kwd><kwd>psychosis</kwd><kwd>depression</kwd><kwd>sleep</kwd><kwd>freezing of gait</kwd><kwd>genetics</kwd><kwd>risk factors</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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