Progressive supranuclear palsy syndrome presenting as progressive nonfluent aphasia: A neuropsychological and neuroimaging analysis
Identifieur interne : 001A84 ( Main/Exploration ); précédent : 001A83; suivant : 001A85Progressive supranuclear palsy syndrome presenting as progressive nonfluent aphasia: A neuropsychological and neuroimaging analysis
Auteurs : Jonathan D. Rohrer [Royaume-Uni] ; Dominic Paviour [Royaume-Uni] ; Adolfo M. Bronstein [Royaume-Uni] ; Sean S. O'Sullivan [Royaume-Uni] ; Andrew Lees (neurologue) [Royaume-Uni] ; Jason D. Warren [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-01-30.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Aphasia, Apraxia, Atrophy, Brain (pathology), Cognition, Extrapyramidal Tracts (physiopathology), Female, Humans, Magnetic Resonance Imaging, Male, Memory, Mesencephalon (pathology), Nervous system diseases, Neuropsychological Tests, Oculomotor Muscles (physiopathology), Prefrontal Cortex (pathology), Primary Progressive Nonfluent Aphasia (etiology), Primary Progressive Nonfluent Aphasia (physiopathology), Primary Progressive Nonfluent Aphasia (psychology), Prospective Studies, Speech, Supranuclear Palsy, Progressive (complications), Supranuclear Palsy, Progressive (etiology), Supranuclear Palsy, Progressive (pathology), Supranuclear Palsy, Progressive (physiopathology), Supranuclear ophthalmoplegia, Syndrome, Verbal Behavior, apraxia of speech, primary progressive aphasia, progressive supranuclear palsy.
- MESH :
- complications : Supranuclear Palsy, Progressive.
- etiology : Primary Progressive Nonfluent Aphasia, Supranuclear Palsy, Progressive.
- pathology : Brain, Mesencephalon, Prefrontal Cortex, Supranuclear Palsy, Progressive.
- physiopathology : Extrapyramidal Tracts, Oculomotor Muscles, Primary Progressive Nonfluent Aphasia, Supranuclear Palsy, Progressive.
- psychology : Primary Progressive Nonfluent Aphasia.
- Aged, Aged, 80 and over, Atrophy, Cognition, Female, Humans, Magnetic Resonance Imaging, Male, Memory, Neuropsychological Tests, Prospective Studies, Syndrome, Verbal Behavior.
Abstract
There is currently considerable interest in the clinical spectrum of progressive nonfluent aphasia (PNFA) and progressive supranuclear palsy (PSP) and the intersection of these two entities. Here, we undertook a detailed prospective clinical, neuropsychological, and neuroimaging analysis of 14 consecutive patients presenting with PNFA to identify cases meeting clinical criteria for PSP. These patients had further detailed assessment of extrapyramidal and oculomotor functions. All patients had high‐resolution MR brain volumetry and a cortical thickness analysis was undertaken on the brain images. Four patients presenting with PNFA subsequently developed features of a PSP syndrome, including a typical oculomotor palsy. The neuropsychological profile in these cases was similar to other patients with PNFA, however, with more marked reduction in propositional speech, fewer speech errors, less marked impairment of literacy skills but more severe associated deficits of episodic memory and praxis. These PSP‐PNFA cases had less prominent midbrain atrophy but more marked prefrontal atrophy than a comparison group of five patients with pathologically confirmed PSP without PNFA and more prominent midbrain atrophy but less marked perisylvian atrophy than other PNFA cases. In summary, although the PSP‐PNFA syndrome overlaps with PNFA without PSP, certain neuropsychological and neuroanatomical differences may help predict the development of a PSP syndrome. © 2010 Movement Disorder Society
Url:
- https://api.istex.fr/document/C22DF4BFEC2A19DF330AA7E1933A9B4F1D064D52/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608044
DOI: 10.1002/mds.22946
Affiliations:
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Rohrer</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Paviour, Dominic" sort="Paviour, Dominic" uniqKey="Paviour D" first="Dominic" last="Paviour">Dominic Paviour</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Reta Lila Weston Institute, UCL Institute of Neurology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Bronstein, Adolfo M" sort="Bronstein, Adolfo M" uniqKey="Bronstein A" first="Adolfo M." last="Bronstein">Adolfo M. Bronstein</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Neuroscience, Charing Cross Hospital, Imperial College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="O Sullivan, Sean S" sort="O Sullivan, Sean S" uniqKey="O Sullivan S" first="Sean S." last="O'Sullivan">Sean S. 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Here, we undertook a detailed prospective clinical, neuropsychological, and neuroimaging analysis of 14 consecutive patients presenting with PNFA to identify cases meeting clinical criteria for PSP. These patients had further detailed assessment of extrapyramidal and oculomotor functions. All patients had high‐resolution MR brain volumetry and a cortical thickness analysis was undertaken on the brain images. Four patients presenting with PNFA subsequently developed features of a PSP syndrome, including a typical oculomotor palsy. The neuropsychological profile in these cases was similar to other patients with PNFA, however, with more marked reduction in propositional speech, fewer speech errors, less marked impairment of literacy skills but more severe associated deficits of episodic memory and praxis. These PSP‐PNFA cases had less prominent midbrain atrophy but more marked prefrontal atrophy than a comparison group of five patients with pathologically confirmed PSP without PNFA and more prominent midbrain atrophy but less marked perisylvian atrophy than other PNFA cases. In summary, although the PSP‐PNFA syndrome overlaps with PNFA without PSP, certain neuropsychological and neuroanatomical differences may help predict the development of a PSP syndrome. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement><orgName><li>National Hospital for Neurology and Neurosurgery</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Rohrer, Jonathan D" sort="Rohrer, Jonathan D" uniqKey="Rohrer J" first="Jonathan D." last="Rohrer">Jonathan D. Rohrer</name></region><name sortKey="Bronstein, Adolfo M" sort="Bronstein, Adolfo M" uniqKey="Bronstein A" first="Adolfo M." last="Bronstein">Adolfo M. Bronstein</name><name sortKey="Lees, Andrew" sort="Lees, Andrew" uniqKey="Lees A" first="Andrew" last="Lees">Andrew Lees (neurologue)</name><name sortKey="O Sullivan, Sean S" sort="O Sullivan, Sean S" uniqKey="O Sullivan S" first="Sean S." last="O'Sullivan">Sean S. O'Sullivan</name><name sortKey="Paviour, Dominic" sort="Paviour, Dominic" uniqKey="Paviour D" first="Dominic" last="Paviour">Dominic Paviour</name><name sortKey="Paviour, Dominic" sort="Paviour, Dominic" uniqKey="Paviour D" first="Dominic" last="Paviour">Dominic Paviour</name><name sortKey="Warren, Jason D" sort="Warren, Jason D" uniqKey="Warren J" first="Jason D." last="Warren">Jason D. Warren</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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