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Progressive Supranuclear Palsy Syndrome Presenting as Progressive Nonfluent Aphasia: A Neuropsychological and Neuroimaging Analysis

Identifieur interne : 002473 ( Main/Merge ); précédent : 002472; suivant : 002474

Progressive Supranuclear Palsy Syndrome Presenting as Progressive Nonfluent Aphasia: A Neuropsychological and Neuroimaging Analysis

Auteurs : Jonathan D. Rohrer [Royaume-Uni] ; Dominic Paviour [Royaume-Uni] ; Adolfo M. Bronstein [Royaume-Uni] ; Sean S. O'Sullivan [Royaume-Uni] ; Andrew Lees (neurologue) [Royaume-Uni] ; Jason D. Warren [Royaume-Uni]

Source :

Movement disorders [ 0885-3185 ] ; 2010.

RBID : Pascal:10-0303306

Descripteurs français

Pascal (Inist)
- Aphasie, Apraxie, Pathologie du système nerveux, Ophtalmoplégie supranucléaire, Parole.

English descriptors

KwdEn :
- Aphasia, Apraxia, Nervous system diseases, Speech, Supranuclear ophthalmoplegia.

Abstract

There is currently considerable interest in the clinical spectrum of progressive nonfluent aphasia (PNFA) and progressive supranuclear palsy (PSP) and the intersection of these two entities. Here, we undertook a detailed prospective clinical, neuropsychological, and neuroimaging analysis of 14 consecutive patients presenting with PNFA to identify cases meeting clinical criteria for PSP. These patients had further detailed assessment of extrapyramidal and oculomotor functions. All patients had high-resolution MR brain volumetry and a cortical thickness analysis was undertaken on the brain images. Four patients presenting with PNFA subsequently developed features of a PSP syndrome, including a typical oculomotor palsy. The neuropsychological profile in these cases was similar to other patients with PNFA, however, with more marked reduction in propositional speech, fewer speech errors, less marked impairment of literacy skills but more severe associated deficits of episodic memory and praxis. These PSP-PNFA cases had less prominent midbrain atrophy but more marked prefrontal atrophy than a comparison group of five patients with pathologically confirmed PSP without PNFA and more prominent midbrain atrophy but less marked perisylvian atrophy than other PNFA cases. In summary, although the PSP-PNFA syndrome overlaps with PNFA without PSP, certain neuropsychological and neuroanatomical differences may help predict the development of a PSP syndrome.

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Pascal:10-0303306

Le document en format XML

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<series><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aphasia</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Aphasie</term>
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<front><div type="abstract" xml:lang="en">There is currently considerable interest in the clinical spectrum of progressive nonfluent aphasia (PNFA) and progressive supranuclear palsy (PSP) and the intersection of these two entities. Here, we undertook a detailed prospective clinical, neuropsychological, and neuroimaging analysis of 14 consecutive patients presenting with PNFA to identify cases meeting clinical criteria for PSP. These patients had further detailed assessment of extrapyramidal and oculomotor functions. All patients had high-resolution MR brain volumetry and a cortical thickness analysis was undertaken on the brain images. Four patients presenting with PNFA subsequently developed features of a PSP syndrome, including a typical oculomotor palsy. The neuropsychological profile in these cases was similar to other patients with PNFA, however, with more marked reduction in propositional speech, fewer speech errors, less marked impairment of literacy skills but more severe associated deficits of episodic memory and praxis. These PSP-PNFA cases had less prominent midbrain atrophy but more marked prefrontal atrophy than a comparison group of five patients with pathologically confirmed PSP without PNFA and more prominent midbrain atrophy but less marked perisylvian atrophy than other PNFA cases. In summary, although the PSP-PNFA syndrome overlaps with PNFA without PSP, certain neuropsychological and neuroanatomical differences may help predict the development of a PSP syndrome.</div>
</front>
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<tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Rohrer, Jonathan D" sort="Rohrer, Jonathan D" uniqKey="Rohrer J" first="Jonathan D." last="Rohrer">Jonathan D. Rohrer</name>
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<name sortKey="Bronstein, Adolfo M" sort="Bronstein, Adolfo M" uniqKey="Bronstein A" first="Adolfo M." last="Bronstein">Adolfo M. Bronstein</name>
<name sortKey="Lees, Andrew" sort="Lees, Andrew" uniqKey="Lees A" first="Andrew" last="Lees">Andrew Lees (neurologue)</name>
<name sortKey="O Sullivan, Sean S" sort="O Sullivan, Sean S" uniqKey="O Sullivan S" first="Sean S." last="O'Sullivan">Sean S. O'Sullivan</name>
<name sortKey="Paviour, Dominic" sort="Paviour, Dominic" uniqKey="Paviour D" first="Dominic" last="Paviour">Dominic Paviour</name>
<name sortKey="Paviour, Dominic" sort="Paviour, Dominic" uniqKey="Paviour D" first="Dominic" last="Paviour">Dominic Paviour</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Progressive Supranuclear Palsy Syndrome Presenting as Progressive Nonfluent Aphasia: A Neuropsychological and Neuroimaging Analysis

Progressive Supranuclear Palsy Syndrome Presenting as Progressive Nonfluent Aphasia: A Neuropsychological and Neuroimaging Analysis

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri