MovDisordV3, PascalFrancis, Corpus, bibRecord, 000A80

Progressive Supranuclear Palsy Syndrome Presenting as Progressive Nonfluent Aphasia: A Neuropsychological and Neuroimaging Analysis

Identifieur interne : 000A80 ( PascalFrancis/Corpus ); précédent : 000A79; suivant : 000A81

Progressive Supranuclear Palsy Syndrome Presenting as Progressive Nonfluent Aphasia: A Neuropsychological and Neuroimaging Analysis

Auteurs : Jonathan D. Rohrer ; Dominic Paviour ; Adolfo M. Bronstein ; Sean S. O'Sullivan ; Andrew Lees ; Jason D. Warren

Source :

Movement disorders [ 0885-3185 ] ; 2010.

RBID : Pascal:10-0303306

Descripteurs français

Pascal (Inist)
- Aphasie, Apraxie, Pathologie du système nerveux, Ophtalmoplégie supranucléaire, Parole.

English descriptors

KwdEn :
- Aphasia, Apraxia, Nervous system diseases, Speech, Supranuclear ophthalmoplegia.

Abstract

There is currently considerable interest in the clinical spectrum of progressive nonfluent aphasia (PNFA) and progressive supranuclear palsy (PSP) and the intersection of these two entities. Here, we undertook a detailed prospective clinical, neuropsychological, and neuroimaging analysis of 14 consecutive patients presenting with PNFA to identify cases meeting clinical criteria for PSP. These patients had further detailed assessment of extrapyramidal and oculomotor functions. All patients had high-resolution MR brain volumetry and a cortical thickness analysis was undertaken on the brain images. Four patients presenting with PNFA subsequently developed features of a PSP syndrome, including a typical oculomotor palsy. The neuropsychological profile in these cases was similar to other patients with PNFA, however, with more marked reduction in propositional speech, fewer speech errors, less marked impairment of literacy skills but more severe associated deficits of episodic memory and praxis. These PSP-PNFA cases had less prominent midbrain atrophy but more marked prefrontal atrophy than a comparison group of five patients with pathologically confirmed PSP without PNFA and more prominent midbrain atrophy but less marked perisylvian atrophy than other PNFA cases. In summary, although the PSP-PNFA syndrome overlaps with PNFA without PSP, certain neuropsychological and neuroanatomical differences may help predict the development of a PSP syndrome.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A03		`1`		`@0 Mov. disord.`
A05				`@2 25`
A06				`@2 2`
A08	`01`	`1`	`ENG`	`@1 Progressive Supranuclear Palsy Syndrome Presenting as Progressive Nonfluent Aphasia: A Neuropsychological and Neuroimaging Analysis`
A11	`01`	`1`		`@1 ROHRER (Jonathan D.)`
A11	`02`	`1`		`@1 PAVIOUR (Dominic)`
A11	`03`	`1`		`@1 BRONSTEIN (Adolfo M.)`
A11	`04`	`1`		`@1 O'SULLIVAN (Sean S.)`
A11	`05`	`1`		`@1 LEES (Andrew)`
A11	`06`	`1`		`@1 WARREN (Jason D.)`
A14	`01`			`@1 Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, University College London @2 London @3 GBR @Z 1 aut. @Z 2 aut. @Z 6 aut.`
A14	`02`			`@1 Reta Lila Weston Institute, UCL Institute of Neurology, University College London @2 London @3 GBR @Z 2 aut. @Z 4 aut. @Z 5 aut.`
A14	`03`			`@1 Department of Clinical Neuroscience, Charing Cross Hospital, Imperial College @2 London @3 GBR @Z 3 aut.`
A20				`@1 179-188`
A21				`@1 2010`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20953 @5 354000170495040060`
A44				`@0 0000 @1 © 2010 INIST-CNRS. All rights reserved.`
A45				`@0 40 ref.`
A47	`01`	`1`		`@0 10-0303306`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 There is currently considerable interest in the clinical spectrum of progressive nonfluent aphasia (PNFA) and progressive supranuclear palsy (PSP) and the intersection of these two entities. Here, we undertook a detailed prospective clinical, neuropsychological, and neuroimaging analysis of 14 consecutive patients presenting with PNFA to identify cases meeting clinical criteria for PSP. These patients had further detailed assessment of extrapyramidal and oculomotor functions. All patients had high-resolution MR brain volumetry and a cortical thickness analysis was undertaken on the brain images. Four patients presenting with PNFA subsequently developed features of a PSP syndrome, including a typical oculomotor palsy. The neuropsychological profile in these cases was similar to other patients with PNFA, however, with more marked reduction in propositional speech, fewer speech errors, less marked impairment of literacy skills but more severe associated deficits of episodic memory and praxis. These PSP-PNFA cases had less prominent midbrain atrophy but more marked prefrontal atrophy than a comparison group of five patients with pathologically confirmed PSP without PNFA and more prominent midbrain atrophy but less marked perisylvian atrophy than other PNFA cases. In summary, although the PSP-PNFA syndrome overlaps with PNFA without PSP, certain neuropsychological and neuroanatomical differences may help predict the development of a PSP syndrome.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B17G`
C03	`01`	`X`	`FRE`	`@0 Aphasie @5 01`
C03	`01`	`X`	`ENG`	`@0 Aphasia @5 01`
C03	`01`	`X`	`SPA`	`@0 Afasia @5 01`
C03	`02`	`X`	`FRE`	`@0 Apraxie @5 02`
C03	`02`	`X`	`ENG`	`@0 Apraxia @5 02`
C03	`02`	`X`	`SPA`	`@0 Apraxia @5 02`
C03	`03`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 03`
C03	`03`	`X`	`ENG`	`@0 Nervous system diseases @5 03`
C03	`03`	`X`	`SPA`	`@0 Sistema nervioso patología @5 03`
C03	`04`	`X`	`FRE`	`@0 Ophtalmoplégie supranucléaire @5 09`
C03	`04`	`X`	`ENG`	`@0 Supranuclear ophthalmoplegia @5 09`
C03	`04`	`X`	`SPA`	`@0 Oftalmoplejía supranuclear @5 09`
C03	`05`	`X`	`FRE`	`@0 Parole @5 10`
C03	`05`	`X`	`ENG`	`@0 Speech @5 10`
C03	`05`	`X`	`SPA`	`@0 Habla @5 10`
C07	`01`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 37`
C07	`01`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Maladie dégénérative @5 38`
C07	`02`	`X`	`ENG`	`@0 Degenerative disease @5 38`
C07	`02`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 38`
C07	`03`	`X`	`FRE`	`@0 Syndrome oculomoteur @5 39`
C07	`03`	`X`	`ENG`	`@0 Oculomotor syndrome @5 39`
C07	`03`	`X`	`SPA`	`@0 Oculomotricidad síndrome @5 39`
C07	`04`	`X`	`FRE`	`@0 Pathologie de l'oeil @5 40`
C07	`04`	`X`	`ENG`	`@0 Eye disease @5 40`
C07	`04`	`X`	`SPA`	`@0 Ojo patología @5 40`
C07	`05`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 41`
C07	`05`	`X`	`ENG`	`@0 Central nervous system disease @5 41`
C07	`05`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 41`
C07	`06`	`X`	`FRE`	`@0 Syndrome du tronc cérébral @5 43`
C07	`06`	`X`	`ENG`	`@0 Brain stem syndrome @5 43`
C07	`06`	`X`	`SPA`	`@0 Tallo encefalico sindrome @5 43`
C07	`07`	`X`	`FRE`	`@0 Trouble de la communication @5 44`
C07	`07`	`X`	`ENG`	`@0 Communication disorder @5 44`
C07	`07`	`X`	`SPA`	`@0 Trastorno comunicación @5 44`
C07	`08`	`X`	`FRE`	`@0 Trouble du langage @5 45`
C07	`08`	`X`	`ENG`	`@0 Language disorder @5 45`
C07	`08`	`X`	`SPA`	`@0 Trastorno lenguaje @5 45`
C07	`09`	`X`	`FRE`	`@0 Trouble neurologique @5 46`
C07	`09`	`X`	`ENG`	`@0 Neurological disorder @5 46`
C07	`09`	`X`	`SPA`	`@0 Trastorno neurológico @5 46`
N21				`@1 193`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 10-0303306 INIST
ET :	Progressive Supranuclear Palsy Syndrome Presenting as Progressive Nonfluent Aphasia: A Neuropsychological and Neuroimaging Analysis
AU :	ROHRER (Jonathan D.); PAVIOUR (Dominic); BRONSTEIN (Adolfo M.); O'SULLIVAN (Sean S.); LEES (Andrew); WARREN (Jason D.)
AF :	Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, University College London/London/Royaume-Uni (1 aut., 2 aut., 6 aut.); Reta Lila Weston Institute, UCL Institute of Neurology, University College London/London/Royaume-Uni (2 aut., 4 aut., 5 aut.); Department of Clinical Neuroscience, Charing Cross Hospital, Imperial College/London/Royaume-Uni (3 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 2; Pp. 179-188; Bibl. 40 ref.
LA :	Anglais
EA :	There is currently considerable interest in the clinical spectrum of progressive nonfluent aphasia (PNFA) and progressive supranuclear palsy (PSP) and the intersection of these two entities. Here, we undertook a detailed prospective clinical, neuropsychological, and neuroimaging analysis of 14 consecutive patients presenting with PNFA to identify cases meeting clinical criteria for PSP. These patients had further detailed assessment of extrapyramidal and oculomotor functions. All patients had high-resolution MR brain volumetry and a cortical thickness analysis was undertaken on the brain images. Four patients presenting with PNFA subsequently developed features of a PSP syndrome, including a typical oculomotor palsy. The neuropsychological profile in these cases was similar to other patients with PNFA, however, with more marked reduction in propositional speech, fewer speech errors, less marked impairment of literacy skills but more severe associated deficits of episodic memory and praxis. These PSP-PNFA cases had less prominent midbrain atrophy but more marked prefrontal atrophy than a comparison group of five patients with pathologically confirmed PSP without PNFA and more prominent midbrain atrophy but less marked perisylvian atrophy than other PNFA cases. In summary, although the PSP-PNFA syndrome overlaps with PNFA without PSP, certain neuropsychological and neuroanatomical differences may help predict the development of a PSP syndrome.
CC :	002B17; 002B17G
FD :	Aphasie; Apraxie; Pathologie du système nerveux; Ophtalmoplégie supranucléaire; Parole
FG :	Pathologie de l'encéphale; Maladie dégénérative; Syndrome oculomoteur; Pathologie de l'oeil; Pathologie du système nerveux central; Syndrome du tronc cérébral; Trouble de la communication; Trouble du langage; Trouble neurologique
ED :	Aphasia; Apraxia; Nervous system diseases; Supranuclear ophthalmoplegia; Speech
EG :	Cerebral disorder; Degenerative disease; Oculomotor syndrome; Eye disease; Central nervous system disease; Brain stem syndrome; Communication disorder; Language disorder; Neurological disorder
SD :	Afasia; Apraxia; Sistema nervioso patología; Oftalmoplejía supranuclear; Habla
LO :	INIST-20953.354000170495040060
ID :	10-0303306

Links to Exploration step

Pascal:10-0303306

Le document en format XML

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<front><div type="abstract" xml:lang="en">There is currently considerable interest in the clinical spectrum of progressive nonfluent aphasia (PNFA) and progressive supranuclear palsy (PSP) and the intersection of these two entities. Here, we undertook a detailed prospective clinical, neuropsychological, and neuroimaging analysis of 14 consecutive patients presenting with PNFA to identify cases meeting clinical criteria for PSP. These patients had further detailed assessment of extrapyramidal and oculomotor functions. All patients had high-resolution MR brain volumetry and a cortical thickness analysis was undertaken on the brain images. Four patients presenting with PNFA subsequently developed features of a PSP syndrome, including a typical oculomotor palsy. The neuropsychological profile in these cases was similar to other patients with PNFA, however, with more marked reduction in propositional speech, fewer speech errors, less marked impairment of literacy skills but more severe associated deficits of episodic memory and praxis. These PSP-PNFA cases had less prominent midbrain atrophy but more marked prefrontal atrophy than a comparison group of five patients with pathologically confirmed PSP without PNFA and more prominent midbrain atrophy but less marked perisylvian atrophy than other PNFA cases. In summary, although the PSP-PNFA syndrome overlaps with PNFA without PSP, certain neuropsychological and neuroanatomical differences may help predict the development of a PSP syndrome.</div>
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<s5>41</s5>
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<fC07 i1="06" i2="X" l="FRE"><s0>Syndrome du tronc cérébral</s0>
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</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Brain stem syndrome</s0>
<s5>43</s5>
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<fC07 i1="06" i2="X" l="SPA"><s0>Tallo encefalico sindrome</s0>
<s5>43</s5>
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<s5>45</s5>
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<fC07 i1="08" i2="X" l="SPA"><s0>Trastorno lenguaje</s0>
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<server><NO>PASCAL 10-0303306 INIST</NO>
<ET>Progressive Supranuclear Palsy Syndrome Presenting as Progressive Nonfluent Aphasia: A Neuropsychological and Neuroimaging Analysis</ET>
<AU>ROHRER (Jonathan D.); PAVIOUR (Dominic); BRONSTEIN (Adolfo M.); O'SULLIVAN (Sean S.); LEES (Andrew); WARREN (Jason D.)</AU>
<AF>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, University College London/London/Royaume-Uni (1 aut., 2 aut., 6 aut.); Reta Lila Weston Institute, UCL Institute of Neurology, University College London/London/Royaume-Uni (2 aut., 4 aut., 5 aut.); Department of Clinical Neuroscience, Charing Cross Hospital, Imperial College/London/Royaume-Uni (3 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 2; Pp. 179-188; Bibl. 40 ref.</SO>
<LA>Anglais</LA>
<EA>There is currently considerable interest in the clinical spectrum of progressive nonfluent aphasia (PNFA) and progressive supranuclear palsy (PSP) and the intersection of these two entities. Here, we undertook a detailed prospective clinical, neuropsychological, and neuroimaging analysis of 14 consecutive patients presenting with PNFA to identify cases meeting clinical criteria for PSP. These patients had further detailed assessment of extrapyramidal and oculomotor functions. All patients had high-resolution MR brain volumetry and a cortical thickness analysis was undertaken on the brain images. Four patients presenting with PNFA subsequently developed features of a PSP syndrome, including a typical oculomotor palsy. The neuropsychological profile in these cases was similar to other patients with PNFA, however, with more marked reduction in propositional speech, fewer speech errors, less marked impairment of literacy skills but more severe associated deficits of episodic memory and praxis. These PSP-PNFA cases had less prominent midbrain atrophy but more marked prefrontal atrophy than a comparison group of five patients with pathologically confirmed PSP without PNFA and more prominent midbrain atrophy but less marked perisylvian atrophy than other PNFA cases. In summary, although the PSP-PNFA syndrome overlaps with PNFA without PSP, certain neuropsychological and neuroanatomical differences may help predict the development of a PSP syndrome.</EA>
<CC>002B17; 002B17G</CC>
<FD>Aphasie; Apraxie; Pathologie du   système nerveux; Ophtalmoplégie supranucléaire; Parole</FD>
<FG>Pathologie de l'encéphale; Maladie dégénérative; Syndrome oculomoteur; Pathologie de l'oeil; Pathologie du   système nerveux central; Syndrome du tronc cérébral; Trouble de la communication; Trouble du langage; Trouble neurologique</FG>
<ED>Aphasia; Apraxia; Nervous system diseases; Supranuclear ophthalmoplegia; Speech</ED>
<EG>Cerebral disorder; Degenerative disease; Oculomotor syndrome; Eye disease; Central nervous system disease; Brain stem syndrome; Communication disorder; Language disorder; Neurological disorder</EG>
<SD>Afasia; Apraxia; Sistema nervioso patología; Oftalmoplejía supranuclear; Habla</SD>
<LO>INIST-20953.354000170495040060</LO>
<ID>10-0303306</ID>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Progressive Supranuclear Palsy Syndrome Presenting as Progressive Nonfluent Aphasia: A Neuropsychological and Neuroimaging Analysis

Progressive Supranuclear Palsy Syndrome Presenting as Progressive Nonfluent Aphasia: A Neuropsychological and Neuroimaging Analysis

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