Progressive supranuclear palsy syndrome presenting as progressive nonfluent aphasia: a neuropsychological and neuroimaging analysis.
Identifieur interne : 001A17 ( PubMed/Curation ); précédent : 001A16; suivant : 001A18Progressive supranuclear palsy syndrome presenting as progressive nonfluent aphasia: a neuropsychological and neuroimaging analysis.
Auteurs : Jonathan D. Rohrer [Royaume-Uni] ; Dominic Paviour ; Adolfo M. Bronstein ; Sean S. O'Sullivan ; Andrew Lees ; Jason D. WarrenSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Atrophy, Brain (pathology), Cognition, Extrapyramidal Tracts (physiopathology), Female, Humans, Magnetic Resonance Imaging, Male, Memory, Mesencephalon (pathology), Neuropsychological Tests, Oculomotor Muscles (physiopathology), Prefrontal Cortex (pathology), Primary Progressive Nonfluent Aphasia (etiology), Primary Progressive Nonfluent Aphasia (physiopathology), Primary Progressive Nonfluent Aphasia (psychology), Prospective Studies, Supranuclear Palsy, Progressive (complications), Supranuclear Palsy, Progressive (etiology), Supranuclear Palsy, Progressive (pathology), Supranuclear Palsy, Progressive (physiopathology), Syndrome, Verbal Behavior.
- MESH :
- complications : Supranuclear Palsy, Progressive.
- etiology : Primary Progressive Nonfluent Aphasia, Supranuclear Palsy, Progressive.
- pathology : Brain, Mesencephalon, Prefrontal Cortex, Supranuclear Palsy, Progressive.
- physiopathology : Extrapyramidal Tracts, Oculomotor Muscles, Primary Progressive Nonfluent Aphasia, Supranuclear Palsy, Progressive.
- psychology : Primary Progressive Nonfluent Aphasia.
- Aged, Aged, 80 and over, Atrophy, Cognition, Female, Humans, Magnetic Resonance Imaging, Male, Memory, Neuropsychological Tests, Prospective Studies, Syndrome, Verbal Behavior.
Abstract
There is currently considerable interest in the clinical spectrum of progressive nonfluent aphasia (PNFA) and progressive supranuclear palsy (PSP) and the intersection of these two entities. Here, we undertook a detailed prospective clinical, neuropsychological, and neuroimaging analysis of 14 consecutive patients presenting with PNFA to identify cases meeting clinical criteria for PSP. These patients had further detailed assessment of extrapyramidal and oculomotor functions. All patients had high-resolution MR brain volumetry and a cortical thickness analysis was undertaken on the brain images. Four patients presenting with PNFA subsequently developed features of a PSP syndrome, including a typical oculomotor palsy. The neuropsychological profile in these cases was similar to other patients with PNFA, however, with more marked reduction in propositional speech, fewer speech errors, less marked impairment of literacy skills but more severe associated deficits of episodic memory and praxis. These PSP-PNFA cases had less prominent midbrain atrophy but more marked prefrontal atrophy than a comparison group of five patients with pathologically confirmed PSP without PNFA and more prominent midbrain atrophy but less marked perisylvian atrophy than other PNFA cases. In summary, although the PSP-PNFA syndrome overlaps with PNFA without PSP, certain neuropsychological and neuroanatomical differences may help predict the development of a PSP syndrome.
DOI: 10.1002/mds.22946
PubMed: 20077483
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Rohrer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, University College London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, University College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Paviour, Dominic" sort="Paviour, Dominic" uniqKey="Paviour D" first="Dominic" last="Paviour">Dominic Paviour</name></author><author><name sortKey="Bronstein, Adolfo M" sort="Bronstein, Adolfo M" uniqKey="Bronstein A" first="Adolfo M" last="Bronstein">Adolfo M. Bronstein</name></author><author><name sortKey="O Sullivan, Sean S" sort="O Sullivan, Sean S" uniqKey="O Sullivan S" first="Sean S" last="O'Sullivan">Sean S. O'Sullivan</name></author><author><name sortKey="Lees, Andrew" sort="Lees, Andrew" uniqKey="Lees A" first="Andrew" last="Lees">Andrew Lees</name></author><author><name sortKey="Warren, Jason D" sort="Warren, Jason D" uniqKey="Warren J" first="Jason D" last="Warren">Jason D. Warren</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="doi">10.1002/mds.22946</idno><idno type="RBID">pubmed:20077483</idno><idno type="pmid">20077483</idno><idno type="wicri:Area/PubMed/Corpus">001A17</idno><idno type="wicri:Area/PubMed/Curation">001A17</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Progressive supranuclear palsy syndrome presenting as progressive nonfluent aphasia: a neuropsychological and neuroimaging analysis.</title><author><name sortKey="Rohrer, Jonathan D" sort="Rohrer, Jonathan D" uniqKey="Rohrer J" first="Jonathan D" last="Rohrer">Jonathan D. Rohrer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, University College London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, University College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Paviour, Dominic" sort="Paviour, Dominic" uniqKey="Paviour D" first="Dominic" last="Paviour">Dominic Paviour</name></author><author><name sortKey="Bronstein, Adolfo M" sort="Bronstein, Adolfo M" uniqKey="Bronstein A" first="Adolfo M" last="Bronstein">Adolfo M. Bronstein</name></author><author><name sortKey="O Sullivan, Sean S" sort="O Sullivan, Sean S" uniqKey="O Sullivan S" first="Sean S" last="O'Sullivan">Sean S. O'Sullivan</name></author><author><name sortKey="Lees, Andrew" sort="Lees, Andrew" uniqKey="Lees A" first="Andrew" last="Lees">Andrew Lees</name></author><author><name sortKey="Warren, Jason D" sort="Warren, Jason D" uniqKey="Warren J" first="Jason D" last="Warren">Jason D. Warren</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Atrophy</term><term>Brain (pathology)</term><term>Cognition</term><term>Extrapyramidal Tracts (physiopathology)</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Memory</term><term>Mesencephalon (pathology)</term><term>Neuropsychological Tests</term><term>Oculomotor Muscles (physiopathology)</term><term>Prefrontal Cortex (pathology)</term><term>Primary Progressive Nonfluent Aphasia (etiology)</term><term>Primary Progressive Nonfluent Aphasia (physiopathology)</term><term>Primary Progressive Nonfluent Aphasia (psychology)</term><term>Prospective Studies</term><term>Supranuclear Palsy, Progressive (complications)</term><term>Supranuclear Palsy, Progressive (etiology)</term><term>Supranuclear Palsy, Progressive (pathology)</term><term>Supranuclear Palsy, Progressive (physiopathology)</term><term>Syndrome</term><term>Verbal Behavior</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Primary Progressive Nonfluent Aphasia</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Mesencephalon</term><term>Prefrontal Cortex</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Extrapyramidal Tracts</term><term>Oculomotor Muscles</term><term>Primary Progressive Nonfluent Aphasia</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Primary Progressive Nonfluent Aphasia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Atrophy</term><term>Cognition</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Memory</term><term>Neuropsychological Tests</term><term>Prospective Studies</term><term>Syndrome</term><term>Verbal Behavior</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There is currently considerable interest in the clinical spectrum of progressive nonfluent aphasia (PNFA) and progressive supranuclear palsy (PSP) and the intersection of these two entities. Here, we undertook a detailed prospective clinical, neuropsychological, and neuroimaging analysis of 14 consecutive patients presenting with PNFA to identify cases meeting clinical criteria for PSP. These patients had further detailed assessment of extrapyramidal and oculomotor functions. All patients had high-resolution MR brain volumetry and a cortical thickness analysis was undertaken on the brain images. Four patients presenting with PNFA subsequently developed features of a PSP syndrome, including a typical oculomotor palsy. The neuropsychological profile in these cases was similar to other patients with PNFA, however, with more marked reduction in propositional speech, fewer speech errors, less marked impairment of literacy skills but more severe associated deficits of episodic memory and praxis. These PSP-PNFA cases had less prominent midbrain atrophy but more marked prefrontal atrophy than a comparison group of five patients with pathologically confirmed PSP without PNFA and more prominent midbrain atrophy but less marked perisylvian atrophy than other PNFA cases. In summary, although the PSP-PNFA syndrome overlaps with PNFA without PSP, certain neuropsychological and neuroanatomical differences may help predict the development of a PSP syndrome.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">20077483</PMID><DateCreated><Year>2010</Year><Month>03</Month><Day>02</Day></DateCreated><DateCompleted><Year>2010</Year><Month>06</Month><Day>16</Day></DateCompleted><DateRevised><Year>2015</Year><Month>10</Month><Day>26</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>25</Volume><Issue>2</Issue><PubDate><Year>2010</Year><Month>Jan</Month><Day>30</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Progressive supranuclear palsy syndrome presenting as progressive nonfluent aphasia: a neuropsychological and neuroimaging analysis.</ArticleTitle><Pagination><MedlinePgn>179-88</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.22946</ELocationID><Abstract><AbstractText>There is currently considerable interest in the clinical spectrum of progressive nonfluent aphasia (PNFA) and progressive supranuclear palsy (PSP) and the intersection of these two entities. Here, we undertook a detailed prospective clinical, neuropsychological, and neuroimaging analysis of 14 consecutive patients presenting with PNFA to identify cases meeting clinical criteria for PSP. These patients had further detailed assessment of extrapyramidal and oculomotor functions. All patients had high-resolution MR brain volumetry and a cortical thickness analysis was undertaken on the brain images. Four patients presenting with PNFA subsequently developed features of a PSP syndrome, including a typical oculomotor palsy. The neuropsychological profile in these cases was similar to other patients with PNFA, however, with more marked reduction in propositional speech, fewer speech errors, less marked impairment of literacy skills but more severe associated deficits of episodic memory and praxis. These PSP-PNFA cases had less prominent midbrain atrophy but more marked prefrontal atrophy than a comparison group of five patients with pathologically confirmed PSP without PNFA and more prominent midbrain atrophy but less marked perisylvian atrophy than other PNFA cases. 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ValidYN="Y"><LastName>Lees</LastName><ForeName>Andrew</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Warren</LastName><ForeName>Jason D</ForeName><Initials>JD</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>091673</GrantID><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>G0600183</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>G0601846</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>G0801306</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><Agency>Department of Health</Agency><Country>United Kingdom</Country></Grant><Grant><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000369">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001284">Atrophy</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001921">Brain</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" 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