Cardiac and noncardiac fibrotic reactions caused by ergot‐and nonergot‐derived dopamine agonists
Identifieur interne : 002416 ( Main/Exploration ); précédent : 002415; suivant : 002417Cardiac and noncardiac fibrotic reactions caused by ergot‐and nonergot‐derived dopamine agonists
Auteurs : Frank Andersohn [Allemagne] ; Edeltraut Garbe [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-01-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- geographic : États-Unis.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Apomorphine (adverse effects), Benzothiazoles (adverse effects), Bromocriptine (adverse effects), Databases, Factual, Dopamine Agonists (adverse effects), Dopamine agonist, Endomyocardial Fibrosis (chemically induced), Endomyocardial Fibrosis (epidemiology), Ergolines (adverse effects), Female, Fibrosis, Fibrosis (chemically induced), Fibrosis (epidemiology), Heart Valve Diseases (chemically induced), Heart Valve Diseases (epidemiology), Heart Valve Diseases (pathology), Humans, Indoles (adverse effects), Male, Middle Aged, Nervous system diseases, Pergolide (adverse effects), Pericarditis (chemically induced), Pericarditis (epidemiology), Pericarditis (pathology), Pleural Diseases (chemically induced), Pleural Diseases (epidemiology), Pulmonary Fibrosis (chemically induced), Pulmonary Fibrosis (epidemiology), Retroperitoneal Fibrosis (chemically induced), Retroperitoneal Fibrosis (epidemiology), Tetrahydronaphthalenes (adverse effects), Thiophenes (adverse effects), United States (epidemiology), adverse drug reaction reporting systems, adverse effects, dopamine agonists, fibrosis.
- MESH :
- chemical , adverse effects : Apomorphine, Benzothiazoles, Bromocriptine, Dopamine Agonists, Ergolines, Indoles, Pergolide, Tetrahydronaphthalenes, Thiophenes.
- geographic , epidemiology : United States.
- chemically induced : Endomyocardial Fibrosis, Fibrosis, Heart Valve Diseases, Pericarditis, Pleural Diseases, Pulmonary Fibrosis, Retroperitoneal Fibrosis.
- epidemiology : Endomyocardial Fibrosis, Fibrosis, Heart Valve Diseases, Pericarditis, Pleural Diseases, Pulmonary Fibrosis, Retroperitoneal Fibrosis.
- pathology : Heart Valve Diseases, Pericarditis.
- Aged, Aged, 80 and over, Databases, Factual, Female, Humans, Male, Middle Aged.
Abstract
There is growing evidence that the ergot‐derived dopamine agonists cabergoline and pergolide can cause fibrotic cardiac valvulopathy. Data on other fibrotic reactions and nonergot‐derived dopamine agonists are sparse. Aim of this study was to investigate whether there are signals that dopamine agonists are related to cardiac and other fibrotic reactions. We identified all reports of fibrotic reactions at the heart, lung, and retroperitoneal space associated with dopamine agonists within the US Adverse Event Reporting System database. Disproportionality analyses were used to calculate adjusted reporting odds ratios (RORs). For ergot‐derived dopamine agonists (bromocriptine, cabergoline, pergolide), the RORs of all reactions under study were increased, whereas no such increases were observed for nonergot‐derived drugs (apomorphine, pramipexole, ropinirole, rotigotine). Fibrotic reactions due to ergot‐derived dopamine agonists may not be limited to heart valves. For nonergot‐derived dopamine agonists, no drug safety signals were evident. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22385
Affiliations:
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Le document en format XML
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<term>Bromocriptine (adverse effects)</term>
<term>Databases, Factual</term>
<term>Dopamine Agonists (adverse effects)</term>
<term>Dopamine agonist</term>
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<term>Heart Valve Diseases (chemically induced)</term>
<term>Heart Valve Diseases (epidemiology)</term>
<term>Heart Valve Diseases (pathology)</term>
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<term>Indoles (adverse effects)</term>
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<term>Nervous system diseases</term>
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<term>Tetrahydronaphthalenes (adverse effects)</term>
<term>Thiophenes (adverse effects)</term>
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<term>adverse drug reaction reporting systems</term>
<term>adverse effects</term>
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<term>Indoles</term>
<term>Pergolide</term>
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<term>Thiophenes</term>
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<term>Pericarditis</term>
<term>Pleural Diseases</term>
<term>Pulmonary Fibrosis</term>
<term>Retroperitoneal Fibrosis</term>
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<term>Fibrosis</term>
<term>Heart Valve Diseases</term>
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<term>Pulmonary Fibrosis</term>
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<front><div type="abstract" xml:lang="en">There is growing evidence that the ergot‐derived dopamine agonists cabergoline and pergolide can cause fibrotic cardiac valvulopathy. Data on other fibrotic reactions and nonergot‐derived dopamine agonists are sparse. Aim of this study was to investigate whether there are signals that dopamine agonists are related to cardiac and other fibrotic reactions. We identified all reports of fibrotic reactions at the heart, lung, and retroperitoneal space associated with dopamine agonists within the US Adverse Event Reporting System database. Disproportionality analyses were used to calculate adjusted reporting odds ratios (RORs). For ergot‐derived dopamine agonists (bromocriptine, cabergoline, pergolide), the RORs of all reactions under study were increased, whereas no such increases were observed for nonergot‐derived drugs (apomorphine, pramipexole, ropinirole, rotigotine). Fibrotic reactions due to ergot‐derived dopamine agonists may not be limited to heart valves. For nonergot‐derived dopamine agonists, no drug safety signals were evident. © 2008 Movement Disorder Society</div>
</front>
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