BuChE‐K and APOE ϵ4 allele frequencies in Lewy body dementias, and influence of genotype and hyperhomocysteinemia on cognitive decline
Identifieur interne : 002417 ( Main/Exploration ); précédent : 002416; suivant : 002418BuChE‐K and APOE ϵ4 allele frequencies in Lewy body dementias, and influence of genotype and hyperhomocysteinemia on cognitive decline
Auteurs : Roger Lane [États-Unis] ; Yunsheng He [États-Unis] ; Christopher Morris [Royaume-Uni] ; James B. Leverenz [États-Unis] ; Murat Emre [Turquie] ; Clive Ballard [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-02-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Apolipoprotein E, Apolipoprotein E4 (genetics), Butyrylcholinesterase (genetics), Cognition Disorders (diagnosis), Cognition Disorders (epidemiology), Cognitive disorder, Female, Gene Frequency, Genotype, Humans, Hyperhomocysteinemia, Hyperhomocysteinemia (epidemiology), Lewy Body Disease (drug therapy), Lewy Body Disease (epidemiology), Lewy Body Disease (genetics), Lewy body dementia, Male, Nervous system diseases, Neuroprotective Agents (therapeutic use), Neuropsychological Tests, Parkinson disease, Parkinson's disease dementia, Phenylcarbamates (therapeutic use), Psychomotor Disorders (diagnosis), Psychomotor Disorders (epidemiology), Randomized Controlled Trials as Topic, Severity of Illness Index, apolipoprotein E, butyrylcholinesterase, dementia with Lewy bodies.
- MESH :
- chemical , genetics : Apolipoprotein E4, Butyrylcholinesterase.
- diagnosis : Cognition Disorders, Psychomotor Disorders.
- drug therapy : Lewy Body Disease.
- epidemiology : Cognition Disorders, Hyperhomocysteinemia, Lewy Body Disease, Psychomotor Disorders.
- genetics : Lewy Body Disease.
- chemical , therapeutic use : Neuroprotective Agents, Phenylcarbamates.
- Aged, Female, Gene Frequency, Genotype, Humans, Male, Neuropsychological Tests, Randomized Controlled Trials as Topic, Severity of Illness Index.
Abstract
Apolipoprotein E (APOE) ε4 and butyrylcholinesterase‐K (BuChE‐K) are associated with an increased risk for Alzheimer's disease. The primary objective was to evaluate frequencies of these alleles in dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD). A secondary objective was to evaluate influences on rate of cognitive decline. This analysis used data from participants consenting to pharmacogenetic testing in placebo‐controlled rivastigmine studies. Allele frequencies in DLB and PDD were compared using logistic regression. Within the PDD placebo sample, associations with cognitive decline were evaluated (the DLB sample was too small for these evaluations). Fifty‐seven DLB and 323 PDD subjects provided APOE and BuChE data. Allelic frequencies were higher in DLB, relative to PDD subjects, for BuChE‐K (P = 0.06), APOE ε4 (P < 0.001), or both alleles together (P < 0.001). More rapid cognitive decline was seen in PDD patients carrying both alleles, compared with other genotypes. Subjects with hyperhomocysteinemia were associated with more rapid decline in the presence of BuChE‐K, with or without APOE ε4. These results suggest that genetic and biochemical risk factors for AD and PDD pathology may be important in dementia onset and progression in these Lewy body disorders. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22357
Affiliations:
- Royaume-Uni, Turquie, États-Unis
- Angleterre, Grand Londres, Massachusetts, New Jersey, Washington (État)
- Londres, Seattle
- Université de Washington
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Le document en format XML
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<term>Cognition Disorders (diagnosis)</term>
<term>Cognition Disorders (epidemiology)</term>
<term>Cognitive disorder</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genotype</term>
<term>Humans</term>
<term>Hyperhomocysteinemia</term>
<term>Hyperhomocysteinemia (epidemiology)</term>
<term>Lewy Body Disease (drug therapy)</term>
<term>Lewy Body Disease (epidemiology)</term>
<term>Lewy Body Disease (genetics)</term>
<term>Lewy body dementia</term>
<term>Male</term>
<term>Nervous system diseases</term>
<term>Neuroprotective Agents (therapeutic use)</term>
<term>Neuropsychological Tests</term>
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<term>Parkinson's disease dementia</term>
<term>Phenylcarbamates (therapeutic use)</term>
<term>Psychomotor Disorders (diagnosis)</term>
<term>Psychomotor Disorders (epidemiology)</term>
<term>Randomized Controlled Trials as Topic</term>
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<term>apolipoprotein E</term>
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<front><div type="abstract" xml:lang="en">Apolipoprotein E (APOE) ε4 and butyrylcholinesterase‐K (BuChE‐K) are associated with an increased risk for Alzheimer's disease. The primary objective was to evaluate frequencies of these alleles in dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD). A secondary objective was to evaluate influences on rate of cognitive decline. This analysis used data from participants consenting to pharmacogenetic testing in placebo‐controlled rivastigmine studies. Allele frequencies in DLB and PDD were compared using logistic regression. Within the PDD placebo sample, associations with cognitive decline were evaluated (the DLB sample was too small for these evaluations). Fifty‐seven DLB and 323 PDD subjects provided APOE and BuChE data. Allelic frequencies were higher in DLB, relative to PDD subjects, for BuChE‐K (P = 0.06), APOE ε4 (P < 0.001), or both alleles together (P < 0.001). More rapid cognitive decline was seen in PDD patients carrying both alleles, compared with other genotypes. Subjects with hyperhomocysteinemia were associated with more rapid decline in the presence of BuChE‐K, with or without APOE ε4. These results suggest that genetic and biochemical risk factors for AD and PDD pathology may be important in dementia onset and progression in these Lewy body disorders. © 2008 Movement Disorder Society</div>
</front>
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