Cardiac and Noncardiac Fibrotic Reactions Caused by Ergot-and Nonergot-Derived Dopamine Agonists
Identifieur interne : 000F97 ( PascalFrancis/Corpus ); précédent : 000F96; suivant : 000F98Cardiac and Noncardiac Fibrotic Reactions Caused by Ergot-and Nonergot-Derived Dopamine Agonists
Auteurs : Frank Andersohn ; Edeltraut GarbeSource :
- Movement disorders [ 0885-3185 ] ; 2009.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
There is growing evidence that the ergot-derived dopamine agonists cabergoline and pergolide can cause fibrotic cardiac valvulopathy. Data on other fibrotic reactions and nonergot-derived dopamine agonists are sparse. Aim of this study was to investigate whether there are signals that dopamine agonists are related to cardiac and other fibrotic reactions. We identified all reports of fibrotic reactions at the heart, lung, and retroperitoneal space associated with dopamine agonists within the US Adverse Event Reporting System database. Disproportionality analyses were used to calculate adjusted reporting odds ratios (RORs). For ergot-derived dopamine agonists (bromocriptine, cabergoline, pergolide), the RORs of all reactions under study were increased, whereas no such increases were observed for nonergot-derived drugs (apomorphine, pramipexole, ropinirole, rotigotine). Fibrotic reactions due to ergot-derived dopamine agonists may not be limited to heart valves. For nonergot-derived dopamine agonists, no drug safety signals were evident.
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Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 09-0094116 INIST |
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ET : | Cardiac and Noncardiac Fibrotic Reactions Caused by Ergot-and Nonergot-Derived Dopamine Agonists |
AU : | ANDERSOHN (Frank); GARBE (Edeltraut) |
AF : | Bremen Institute for Prevention Research and Social Medicine, University of Bremen/Allemagne (1 aut., 2 aut.); Institute of Clinical Pharmacology and Toxicology, Charité Universitaetsmedizin Berlin/Allemagne (2 aut.) |
DT : | Publication en série; Courte communication, note brève; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2009; Vol. 24; No. 1; Pp. 129-133; Bibl. 19 ref. |
LA : | Anglais |
EA : | There is growing evidence that the ergot-derived dopamine agonists cabergoline and pergolide can cause fibrotic cardiac valvulopathy. Data on other fibrotic reactions and nonergot-derived dopamine agonists are sparse. Aim of this study was to investigate whether there are signals that dopamine agonists are related to cardiac and other fibrotic reactions. We identified all reports of fibrotic reactions at the heart, lung, and retroperitoneal space associated with dopamine agonists within the US Adverse Event Reporting System database. Disproportionality analyses were used to calculate adjusted reporting odds ratios (RORs). For ergot-derived dopamine agonists (bromocriptine, cabergoline, pergolide), the RORs of all reactions under study were increased, whereas no such increases were observed for nonergot-derived drugs (apomorphine, pramipexole, ropinirole, rotigotine). Fibrotic reactions due to ergot-derived dopamine agonists may not be limited to heart valves. For nonergot-derived dopamine agonists, no drug safety signals were evident. |
CC : | 002B17; 002B02B06 |
FD : | Pathologie du système nerveux; Stimulant dopaminergique; Fibrose |
ED : | Nervous system diseases; Dopamine agonist; Fibrosis |
SD : | Sistema nervioso patología; Estimulante dopaminérgico; Fibrosis |
LO : | INIST-20953.354000186473060210 |
ID : | 09-0094116 |
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Pascal:09-0094116Le document en format XML
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<ET>Cardiac and Noncardiac Fibrotic Reactions Caused by Ergot-and Nonergot-Derived Dopamine Agonists</ET>
<AU>ANDERSOHN (Frank); GARBE (Edeltraut)</AU>
<AF>Bremen Institute for Prevention Research and Social Medicine, University of Bremen/Allemagne (1 aut., 2 aut.); Institute of Clinical Pharmacology and Toxicology, Charité Universitaetsmedizin Berlin/Allemagne (2 aut.)</AF>
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