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Cardiac and Noncardiac Fibrotic Reactions Caused by Ergot-and Nonergot-Derived Dopamine Agonists

Identifieur interne : 000F58 ( PascalFrancis/Checkpoint ); précédent : 000F57; suivant : 000F59

Cardiac and Noncardiac Fibrotic Reactions Caused by Ergot-and Nonergot-Derived Dopamine Agonists

Auteurs : Frank Andersohn [Allemagne] ; Edeltraut Garbe [Allemagne]

Source :

Movement disorders [ 0885-3185 ] ; 2009.

RBID : Pascal:09-0094116

Descripteurs français

Pascal (Inist)
- Pathologie du système nerveux, Stimulant dopaminergique, Fibrose.

English descriptors

KwdEn :
- Dopamine agonist, Fibrosis, Nervous system diseases.

Abstract

There is growing evidence that the ergot-derived dopamine agonists cabergoline and pergolide can cause fibrotic cardiac valvulopathy. Data on other fibrotic reactions and nonergot-derived dopamine agonists are sparse. Aim of this study was to investigate whether there are signals that dopamine agonists are related to cardiac and other fibrotic reactions. We identified all reports of fibrotic reactions at the heart, lung, and retroperitoneal space associated with dopamine agonists within the US Adverse Event Reporting System database. Disproportionality analyses were used to calculate adjusted reporting odds ratios (RORs). For ergot-derived dopamine agonists (bromocriptine, cabergoline, pergolide), the RORs of all reactions under study were increased, whereas no such increases were observed for nonergot-derived drugs (apomorphine, pramipexole, ropinirole, rotigotine). Fibrotic reactions due to ergot-derived dopamine agonists may not be limited to heart valves. For nonergot-derived dopamine agonists, no drug safety signals were evident.

Affiliations:

Allemagne

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Le document en format XML

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	Movement Disorders (revue)
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Movement Disorders (revue)

Cardiac and Noncardiac Fibrotic Reactions Caused by Ergot-and Nonergot-Derived Dopamine Agonists

Cardiac and Noncardiac Fibrotic Reactions Caused by Ergot-and Nonergot-Derived Dopamine Agonists

Source :

Descripteurs français

English descriptors

Abstract

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