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Brain structural damage in spinocerebellar ataxia type 2. A voxel‐based morphometry study

Identifieur interne : 002966 ( Main/Exploration ); précédent : 002965; suivant : 002967

Brain structural damage in spinocerebellar ataxia type 2. A voxel‐based morphometry study

Auteurs : Riccardo Della Nave [Italie] ; Andrea Ginestroni [Italie] ; Carlo Tessa [Italie] ; Mirco Cosottini [Italie] ; Marco Giannelli [Italie] ; Elena Salvatore [Italie] ; Ferdinando Sartucci [Italie] ; Giuseppe De Michele [Italie] ; Maria Teresa Dotti [Italie] ; Silvia Piacentini [Italie] ; Mario Mascalchi [Italie]

Source :

Movement Disorders [ 0885-3185 ] ; 2008-04-30.

RBID : ISTEX:27EAF0D80C242217DB4A7148709310C1F89D1595

Descripteurs français

Pascal (Inist)
- Ataxie spinocérébelleuse, Imagerie RMN, Morphométrie, Pathologie de l'encéphale, Pathologie du système nerveux, Voxel.

English descriptors

KwdEn :
- Adult, Brain (pathology), Cerebral disorder, Female, Humans, MR imaging, Magnetic Resonance Imaging, Male, Middle Aged, Morphometry, Nervous system diseases, Nuclear magnetic resonance imaging, Periaqueductal Gray (pathology), Spinocerebellar Ataxias (genetics), Spinocerebellar Ataxias (pathology), Spinocerebellar ataxia, Trinucleotide Repeat Expansion (genetics), Voxel, ataxia, spinocerebellar ataxia type 2, voxel‐based morphometry.
MESH :
- genetics : Spinocerebellar Ataxias, Trinucleotide Repeat Expansion.
- pathology : Brain, Periaqueductal Gray, Spinocerebellar Ataxias.
- Adult, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged.

Abstract

Voxel‐based morphometry (VBM) enables an unbiased in‐vivo whole‐brain quantitative analysis of differences in gray matter (GM), white matter (WM) and cerebro‐spinal fluid (CSF) volumes. We assessed with VBM 20 spinocerebellar ataxia Type 2 (SCA2) patients with mild or moderate cerebellar deficit and 20 age and sex‐matched healthy controls. SCA2 patients showed a significant (P < 0.05 corrected for multiple comparison) symmetric loss of GM in the cerebellar vermis and hemispheres sparing lobules I,II, Crus II,VII, and X, and of the WM in the peridentate region, middle cerebellar peduncles, dorsal pons, and cerebral peduncles. The CSF volume was increased in the posterior cranial fossa. No GM, WM or CSF volume changes were observed in the supratentorial compartment. A mild (P < 0.05, >0.01) correlation was observed between the GM and WM loss and severity of the neurological deficit. In SCA2 patients with mild to moderate cerebellar deficit, GM and WM volume loss and CSF volume increase are confined to the posterior cranial fossa. © 2008 Movement Disorder Society

Url:

https://api.istex.fr/document/27EAF0D80C242217DB4A7148709310C1F89D1595/fulltext/pdf

DOI: 10.1002/mds.21982

Affiliations:

Italie

Le document en format XML

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<term>Humans</term>
<term>MR imaging</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Morphometry</term>
<term>Nervous system diseases</term>
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<term>ataxia</term>
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<front><div type="abstract" xml:lang="en">Voxel‐based morphometry (VBM) enables an unbiased in‐vivo whole‐brain quantitative analysis of differences in gray matter (GM), white matter (WM) and cerebro‐spinal fluid (CSF) volumes. We assessed with VBM 20 spinocerebellar ataxia Type 2 (SCA2) patients with mild or moderate cerebellar deficit and 20 age and sex‐matched healthy controls. SCA2 patients showed a significant (P < 0.05 corrected for multiple comparison) symmetric loss of GM in the cerebellar vermis and hemispheres sparing lobules I,II, Crus II,VII, and X, and of the WM in the peridentate region, middle cerebellar peduncles, dorsal pons, and cerebral peduncles. The CSF volume was increased in the posterior cranial fossa. No GM, WM or CSF volume changes were observed in the supratentorial compartment. A mild (P < 0.05, >0.01) correlation was observed between the GM and WM loss and severity of the neurological deficit. In SCA2 patients with mild to moderate cerebellar deficit, GM and WM volume loss and CSF volume increase are confined to the posterior cranial fossa. © 2008 Movement Disorder Society</div>
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<name sortKey="Dotti, Maria Teresa" sort="Dotti, Maria Teresa" uniqKey="Dotti M" first="Maria Teresa" last="Dotti">Maria Teresa Dotti</name>
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<name sortKey="Piacentini, Silvia" sort="Piacentini, Silvia" uniqKey="Piacentini S" first="Silvia" last="Piacentini">Silvia Piacentini</name>
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Movement Disorders (revue)

Brain structural damage in spinocerebellar ataxia type 2. A voxel‐based morphometry study

Brain structural damage in spinocerebellar ataxia type 2. A voxel‐based morphometry study

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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	Movement Disorders (revue)
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