MovDisordV3, Main, Merge, bibRecord, 003947

Brain Structural Damage in Spinocerebellar Ataxia Type 2. A Voxel-Based Morphometry Study

Identifieur interne : 003947 ( Main/Merge ); précédent : 003946; suivant : 003948

Brain Structural Damage in Spinocerebellar Ataxia Type 2. A Voxel-Based Morphometry Study

Auteurs : Riccardo Delia Nave [Italie] ; Andrea Ginestroni [Italie] ; Carlo Tessa [Italie] ; Mirco Cosottini [Italie] ; Marco Giannelli [Italie] ; Elena Salvatore [Italie] ; Ferdinando Sartucci [Italie] ; Giuseppe De Michele [Italie] ; Maria Teresa Dotti [Italie] ; Silvia Piacentini [Italie] ; Mario Mascalchi [Italie]

Source :

Movement disorders [ 0885-3185 ] ; 2008.

RBID : Pascal:08-0251873

Descripteurs français

Pascal (Inist)
- Pathologie de l'encéphale, Pathologie du système nerveux, Ataxie spinocérébelleuse, Voxel, Morphométrie, Imagerie RMN.

English descriptors

KwdEn :
- Cerebral disorder, Morphometry, Nervous system diseases, Nuclear magnetic resonance imaging, Spinocerebellar ataxia, Voxel.

Abstract

Voxel-based morphometry (VBM) enables an unbiased in-vivo whole-brain quantitative analysis of differences in gray matter (GM), white matter (WM) and cerebro-spinal fluid (CSF) volumes. We assessed with VBM 20 spinocerebellar ataxia Type 2 (SCA2) patients with mild or moderate cerebellar deficit and 20 age and sex-matched healthy controls. SCA2 patients showed a significant (P < 0.05 corrected for multiple comparison) symmetric loss of GM in the cerebellar vermis and hemispheres sparing lobules I,II, Crus II,VII, and X, and of the WM in the peridentate region, middle cerebellar peduncles, dorsal pons, and cerebral peduncles. The CSF volume was increased in the posterior cranial fossa. No GM, WM or CSF volume changes were observed in the supratentorial compartment. A mild (P < 0.05, >0.01) correlation was observed between the GM and WM loss and severity of the neurological deficit. In SCA2 patients with mild to moderate cerebellar deficit, GM and WM volume loss and CSF volume increase are confined to the posterior cranial fossa.

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 001260
to stream PascalFrancis, to step Curation: 001A59
to stream PascalFrancis, to step Checkpoint: 001339

Links to Exploration step

Pascal:08-0251873

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Brain Structural Damage in Spinocerebellar Ataxia Type 2. A Voxel-Based Morphometry Study</title>
<author><name sortKey="Nave, Riccardo Delia" sort="Nave, Riccardo Delia" uniqKey="Nave R" first="Riccardo Delia" last="Nave">Riccardo Delia Nave</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Radiodiagnostic Section, Department of Clinical Physiopathology, University of Florence</s1>
<s2>Florence</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Florence</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ginestroni, Andrea" sort="Ginestroni, Andrea" uniqKey="Ginestroni A" first="Andrea" last="Ginestroni">Andrea Ginestroni</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Radiodiagnostic Section, Department of Clinical Physiopathology, University of Florence</s1>
<s2>Florence</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Florence</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tessa, Carlo" sort="Tessa, Carlo" uniqKey="Tessa C" first="Carlo" last="Tessa">Carlo Tessa</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Radiodiagnostic Section, Department of Clinical Physiopathology, University of Florence</s1>
<s2>Florence</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Florence</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cosottini, Mirco" sort="Cosottini, Mirco" uniqKey="Cosottini M" first="Mirco" last="Cosottini">Mirco Cosottini</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Neuroradiology, Department of Neuroscience, University of Pisa</s1>
<s2>Pisa</s2>
<s3>ITA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Pisa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Giannelli, Marco" sort="Giannelli, Marco" uniqKey="Giannelli M" first="Marco" last="Giannelli">Marco Giannelli</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Medical Physics, Azienda Ospedaliera Universitaria Pisana</s1>
<s2>Pisa</s2>
<s3>ITA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Pisa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Salvatore, Elena" sort="Salvatore, Elena" uniqKey="Salvatore E" first="Elena" last="Salvatore">Elena Salvatore</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Clinical Neurology, Department of Neurological Sciences, University Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sartucci, Ferdinando" sort="Sartucci, Ferdinando" uniqKey="Sartucci F" first="Ferdinando" last="Sartucci">Ferdinando Sartucci</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Clinical Neurology, Department of Neuroscience, Univeristy of Pisa</s1>
<s2>Pisa</s2>
<s3>ITA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Pisa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="De Michele, Giuseppe" sort="De Michele, Giuseppe" uniqKey="De Michele G" first="Giuseppe" last="De Michele">Giuseppe De Michele</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Clinical Neurology, Department of Neurological Sciences, University Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dotti, Maria Teresa" sort="Dotti, Maria Teresa" uniqKey="Dotti M" first="Maria Teresa" last="Dotti">Maria Teresa Dotti</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Clinical Neurology, Department of Neurological & Behavioural Sciences, Univeristy of Siena</s1>
<s2>Siena</s2>
<s3>ITA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Siena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Piacentini, Silvia" sort="Piacentini, Silvia" uniqKey="Piacentini S" first="Silvia" last="Piacentini">Silvia Piacentini</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Clinical Neurology, Department of Neurological Sciences, University of Florence</s1>
<s2>Florence</s2>
<s3>ITA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Florence</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mascalchi, Mario" sort="Mascalchi, Mario" uniqKey="Mascalchi M" first="Mario" last="Mascalchi">Mario Mascalchi</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Radiodiagnostic Section, Department of Clinical Physiopathology, University of Florence</s1>
<s2>Florence</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Florence</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">08-0251873</idno>
<date when="2008">2008</date>
<idno type="stanalyst">PASCAL 08-0251873 INIST</idno>
<idno type="RBID">Pascal:08-0251873</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001260</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001A59</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001339</idno>
<idno type="wicri:doubleKey">0885-3185:2008:Nave R:brain:structural:damage</idno>
<idno type="wicri:Area/Main/Merge">003947</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Brain Structural Damage in Spinocerebellar Ataxia Type 2. A Voxel-Based Morphometry Study</title>
<author><name sortKey="Nave, Riccardo Delia" sort="Nave, Riccardo Delia" uniqKey="Nave R" first="Riccardo Delia" last="Nave">Riccardo Delia Nave</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Radiodiagnostic Section, Department of Clinical Physiopathology, University of Florence</s1>
<s2>Florence</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Florence</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ginestroni, Andrea" sort="Ginestroni, Andrea" uniqKey="Ginestroni A" first="Andrea" last="Ginestroni">Andrea Ginestroni</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Radiodiagnostic Section, Department of Clinical Physiopathology, University of Florence</s1>
<s2>Florence</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Florence</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tessa, Carlo" sort="Tessa, Carlo" uniqKey="Tessa C" first="Carlo" last="Tessa">Carlo Tessa</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Radiodiagnostic Section, Department of Clinical Physiopathology, University of Florence</s1>
<s2>Florence</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Florence</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cosottini, Mirco" sort="Cosottini, Mirco" uniqKey="Cosottini M" first="Mirco" last="Cosottini">Mirco Cosottini</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Neuroradiology, Department of Neuroscience, University of Pisa</s1>
<s2>Pisa</s2>
<s3>ITA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Pisa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Giannelli, Marco" sort="Giannelli, Marco" uniqKey="Giannelli M" first="Marco" last="Giannelli">Marco Giannelli</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Medical Physics, Azienda Ospedaliera Universitaria Pisana</s1>
<s2>Pisa</s2>
<s3>ITA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Pisa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Salvatore, Elena" sort="Salvatore, Elena" uniqKey="Salvatore E" first="Elena" last="Salvatore">Elena Salvatore</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Clinical Neurology, Department of Neurological Sciences, University Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sartucci, Ferdinando" sort="Sartucci, Ferdinando" uniqKey="Sartucci F" first="Ferdinando" last="Sartucci">Ferdinando Sartucci</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Clinical Neurology, Department of Neuroscience, Univeristy of Pisa</s1>
<s2>Pisa</s2>
<s3>ITA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Pisa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="De Michele, Giuseppe" sort="De Michele, Giuseppe" uniqKey="De Michele G" first="Giuseppe" last="De Michele">Giuseppe De Michele</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Clinical Neurology, Department of Neurological Sciences, University Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dotti, Maria Teresa" sort="Dotti, Maria Teresa" uniqKey="Dotti M" first="Maria Teresa" last="Dotti">Maria Teresa Dotti</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Clinical Neurology, Department of Neurological & Behavioural Sciences, Univeristy of Siena</s1>
<s2>Siena</s2>
<s3>ITA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Siena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Piacentini, Silvia" sort="Piacentini, Silvia" uniqKey="Piacentini S" first="Silvia" last="Piacentini">Silvia Piacentini</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Clinical Neurology, Department of Neurological Sciences, University of Florence</s1>
<s2>Florence</s2>
<s3>ITA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Florence</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mascalchi, Mario" sort="Mascalchi, Mario" uniqKey="Mascalchi M" first="Mario" last="Mascalchi">Mario Mascalchi</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Radiodiagnostic Section, Department of Clinical Physiopathology, University of Florence</s1>
<s2>Florence</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Florence</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cerebral disorder</term>
<term>Morphometry</term>
<term>Nervous system diseases</term>
<term>Nuclear magnetic resonance imaging</term>
<term>Spinocerebellar ataxia</term>
<term>Voxel</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Pathologie de l'encéphale</term>
<term>Pathologie du   système nerveux</term>
<term>Ataxie spinocérébelleuse</term>
<term>Voxel</term>
<term>Morphométrie</term>
<term>Imagerie RMN</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Voxel-based morphometry (VBM) enables an unbiased in-vivo whole-brain quantitative analysis of differences in gray matter (GM), white matter (WM) and cerebro-spinal fluid (CSF) volumes. We assessed with VBM 20 spinocerebellar ataxia Type 2 (SCA2) patients with mild or moderate cerebellar deficit and 20 age and sex-matched healthy controls. SCA2 patients showed a significant (P < 0.05 corrected for multiple comparison) symmetric loss of GM in the cerebellar vermis and hemispheres sparing lobules I,II, Crus II,VII, and X, and of the WM in the peridentate region, middle cerebellar peduncles, dorsal pons, and cerebral peduncles. The CSF volume was increased in the posterior cranial fossa. No GM, WM or CSF volume changes were observed in the supratentorial compartment. A mild (P < 0.05, >0.01) correlation was observed between the GM and WM loss and severity of the neurological deficit. In SCA2 patients with mild to moderate cerebellar deficit, GM and WM volume loss and CSF volume increase are confined to the posterior cranial fossa.</div>
</front>
</TEI>
<affiliations><list><country><li>Italie</li>
</country>
</list>
<tree><country name="Italie"><noRegion><name sortKey="Nave, Riccardo Delia" sort="Nave, Riccardo Delia" uniqKey="Nave R" first="Riccardo Delia" last="Nave">Riccardo Delia Nave</name>
</noRegion>
<name sortKey="Cosottini, Mirco" sort="Cosottini, Mirco" uniqKey="Cosottini M" first="Mirco" last="Cosottini">Mirco Cosottini</name>
<name sortKey="De Michele, Giuseppe" sort="De Michele, Giuseppe" uniqKey="De Michele G" first="Giuseppe" last="De Michele">Giuseppe De Michele</name>
<name sortKey="Dotti, Maria Teresa" sort="Dotti, Maria Teresa" uniqKey="Dotti M" first="Maria Teresa" last="Dotti">Maria Teresa Dotti</name>
<name sortKey="Giannelli, Marco" sort="Giannelli, Marco" uniqKey="Giannelli M" first="Marco" last="Giannelli">Marco Giannelli</name>
<name sortKey="Ginestroni, Andrea" sort="Ginestroni, Andrea" uniqKey="Ginestroni A" first="Andrea" last="Ginestroni">Andrea Ginestroni</name>
<name sortKey="Mascalchi, Mario" sort="Mascalchi, Mario" uniqKey="Mascalchi M" first="Mario" last="Mascalchi">Mario Mascalchi</name>
<name sortKey="Piacentini, Silvia" sort="Piacentini, Silvia" uniqKey="Piacentini S" first="Silvia" last="Piacentini">Silvia Piacentini</name>
<name sortKey="Salvatore, Elena" sort="Salvatore, Elena" uniqKey="Salvatore E" first="Elena" last="Salvatore">Elena Salvatore</name>
<name sortKey="Sartucci, Ferdinando" sort="Sartucci, Ferdinando" uniqKey="Sartucci F" first="Ferdinando" last="Sartucci">Ferdinando Sartucci</name>
<name sortKey="Tessa, Carlo" sort="Tessa, Carlo" uniqKey="Tessa C" first="Carlo" last="Tessa">Carlo Tessa</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Merge

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003947 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 003947 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Merge
   |type=    RBID
   |clé=     Pascal:08-0251873
   |texte=   Brain Structural Damage in Spinocerebellar Ataxia Type 2. A Voxel-Based Morphometry Study
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Movement Disorders (revue)

Brain Structural Damage in Spinocerebellar Ataxia Type 2. A Voxel-Based Morphometry Study

Brain Structural Damage in Spinocerebellar Ataxia Type 2. A Voxel-Based Morphometry Study

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri