MovDisordV3, PubMed, Corpus, bibRecord, 002295

Brain structural damage in spinocerebellar ataxia type 2. A voxel-based morphometry study.

Identifieur interne : 002295 ( PubMed/Corpus ); précédent : 002294; suivant : 002296

Brain structural damage in spinocerebellar ataxia type 2. A voxel-based morphometry study.

Auteurs : Riccardo Della Nave ; Andrea Ginestroni ; Carlo Tessa ; Mirco Cosottini ; Marco Giannelli ; Elena Salvatore ; Ferdinando Sartucci ; Giuseppe De Michele ; Maria Teresa Dotti ; Silvia Piacentini ; Mario Mascalchi

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.

RBID : pubmed:18311829

English descriptors

KwdEn :
- Adult, Brain (pathology), Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Periaqueductal Gray (pathology), Spinocerebellar Ataxias (genetics), Spinocerebellar Ataxias (pathology), Trinucleotide Repeat Expansion (genetics).
MESH :
- genetics : Spinocerebellar Ataxias, Trinucleotide Repeat Expansion.
- pathology : Brain, Periaqueductal Gray, Spinocerebellar Ataxias.
- Adult, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged.

Abstract

Voxel-based morphometry (VBM) enables an unbiased in-vivo whole-brain quantitative analysis of differences in gray matter (GM), white matter (WM) and cerebro-spinal fluid (CSF) volumes. We assessed with VBM 20 spinocerebellar ataxia Type 2 (SCA2) patients with mild or moderate cerebellar deficit and 20 age and sex-matched healthy controls. SCA2 patients showed a significant (P < 0.05 corrected for multiple comparison) symmetric loss of GM in the cerebellar vermis and hemispheres sparing lobules I,II, Crus II,VII, and X, and of the WM in the peridentate region, middle cerebellar peduncles, dorsal pons, and cerebral peduncles. The CSF volume was increased in the posterior cranial fossa. No GM, WM or CSF volume changes were observed in the supratentorial compartment. A mild (P < 0.05, >0.01) correlation was observed between the GM and WM loss and severity of the neurological deficit. In SCA2 patients with mild to moderate cerebellar deficit, GM and WM volume loss and CSF volume increase are confined to the posterior cranial fossa.

DOI: 10.1002/mds.21982
PubMed: 18311829

Links to Exploration step

pubmed:18311829

Le document en format XML

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<author><name sortKey="Della Nave, Riccardo" sort="Della Nave, Riccardo" uniqKey="Della Nave R" first="Riccardo" last="Della Nave">Riccardo Della Nave</name>
<affiliation><nlm:affiliation>Radiodiagnostic Section, Department of Clinical Physiopathology, University of Florence, Florence, Italy. rdellanave@sirm.org</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ginestroni, Andrea" sort="Ginestroni, Andrea" uniqKey="Ginestroni A" first="Andrea" last="Ginestroni">Andrea Ginestroni</name>
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<author><name sortKey="Tessa, Carlo" sort="Tessa, Carlo" uniqKey="Tessa C" first="Carlo" last="Tessa">Carlo Tessa</name>
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<author><name sortKey="Cosottini, Mirco" sort="Cosottini, Mirco" uniqKey="Cosottini M" first="Mirco" last="Cosottini">Mirco Cosottini</name>
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<author><name sortKey="Giannelli, Marco" sort="Giannelli, Marco" uniqKey="Giannelli M" first="Marco" last="Giannelli">Marco Giannelli</name>
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<author><name sortKey="Salvatore, Elena" sort="Salvatore, Elena" uniqKey="Salvatore E" first="Elena" last="Salvatore">Elena Salvatore</name>
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<author><name sortKey="Sartucci, Ferdinando" sort="Sartucci, Ferdinando" uniqKey="Sartucci F" first="Ferdinando" last="Sartucci">Ferdinando Sartucci</name>
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<author><name sortKey="De Michele, Giuseppe" sort="De Michele, Giuseppe" uniqKey="De Michele G" first="Giuseppe" last="De Michele">Giuseppe De Michele</name>
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<author><name sortKey="Dotti, Maria Teresa" sort="Dotti, Maria Teresa" uniqKey="Dotti M" first="Maria Teresa" last="Dotti">Maria Teresa Dotti</name>
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<author><name sortKey="Piacentini, Silvia" sort="Piacentini, Silvia" uniqKey="Piacentini S" first="Silvia" last="Piacentini">Silvia Piacentini</name>
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<author><name sortKey="Mascalchi, Mario" sort="Mascalchi, Mario" uniqKey="Mascalchi M" first="Mario" last="Mascalchi">Mario Mascalchi</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Brain structural damage in spinocerebellar ataxia type 2. A voxel-based morphometry study.</title>
<author><name sortKey="Della Nave, Riccardo" sort="Della Nave, Riccardo" uniqKey="Della Nave R" first="Riccardo" last="Della Nave">Riccardo Della Nave</name>
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<author><name sortKey="Ginestroni, Andrea" sort="Ginestroni, Andrea" uniqKey="Ginestroni A" first="Andrea" last="Ginestroni">Andrea Ginestroni</name>
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<author><name sortKey="Tessa, Carlo" sort="Tessa, Carlo" uniqKey="Tessa C" first="Carlo" last="Tessa">Carlo Tessa</name>
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<author><name sortKey="Cosottini, Mirco" sort="Cosottini, Mirco" uniqKey="Cosottini M" first="Mirco" last="Cosottini">Mirco Cosottini</name>
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<author><name sortKey="Giannelli, Marco" sort="Giannelli, Marco" uniqKey="Giannelli M" first="Marco" last="Giannelli">Marco Giannelli</name>
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<author><name sortKey="Salvatore, Elena" sort="Salvatore, Elena" uniqKey="Salvatore E" first="Elena" last="Salvatore">Elena Salvatore</name>
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<author><name sortKey="Sartucci, Ferdinando" sort="Sartucci, Ferdinando" uniqKey="Sartucci F" first="Ferdinando" last="Sartucci">Ferdinando Sartucci</name>
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<author><name sortKey="De Michele, Giuseppe" sort="De Michele, Giuseppe" uniqKey="De Michele G" first="Giuseppe" last="De Michele">Giuseppe De Michele</name>
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<author><name sortKey="Dotti, Maria Teresa" sort="Dotti, Maria Teresa" uniqKey="Dotti M" first="Maria Teresa" last="Dotti">Maria Teresa Dotti</name>
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<author><name sortKey="Piacentini, Silvia" sort="Piacentini, Silvia" uniqKey="Piacentini S" first="Silvia" last="Piacentini">Silvia Piacentini</name>
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<author><name sortKey="Mascalchi, Mario" sort="Mascalchi, Mario" uniqKey="Mascalchi M" first="Mario" last="Mascalchi">Mario Mascalchi</name>
</author>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Periaqueductal Gray (pathology)</term>
<term>Spinocerebellar Ataxias (genetics)</term>
<term>Spinocerebellar Ataxias (pathology)</term>
<term>Trinucleotide Repeat Expansion (genetics)</term>
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<term>Trinucleotide Repeat Expansion</term>
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<term>Periaqueductal Gray</term>
<term>Spinocerebellar Ataxias</term>
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<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Female</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
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<front><div type="abstract" xml:lang="en">Voxel-based morphometry (VBM) enables an unbiased in-vivo whole-brain quantitative analysis of differences in gray matter (GM), white matter (WM) and cerebro-spinal fluid (CSF) volumes. We assessed with VBM 20 spinocerebellar ataxia Type 2 (SCA2) patients with mild or moderate cerebellar deficit and 20 age and sex-matched healthy controls. SCA2 patients showed a significant (P < 0.05 corrected for multiple comparison) symmetric loss of GM in the cerebellar vermis and hemispheres sparing lobules I,II, Crus II,VII, and X, and of the WM in the peridentate region, middle cerebellar peduncles, dorsal pons, and cerebral peduncles. The CSF volume was increased in the posterior cranial fossa. No GM, WM or CSF volume changes were observed in the supratentorial compartment. A mild (P < 0.05, >0.01) correlation was observed between the GM and WM loss and severity of the neurological deficit. In SCA2 patients with mild to moderate cerebellar deficit, GM and WM volume loss and CSF volume increase are confined to the posterior cranial fossa.</div>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
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<ArticleTitle>Brain structural damage in spinocerebellar ataxia type 2. A voxel-based morphometry study.</ArticleTitle>
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<Abstract><AbstractText>Voxel-based morphometry (VBM) enables an unbiased in-vivo whole-brain quantitative analysis of differences in gray matter (GM), white matter (WM) and cerebro-spinal fluid (CSF) volumes. We assessed with VBM 20 spinocerebellar ataxia Type 2 (SCA2) patients with mild or moderate cerebellar deficit and 20 age and sex-matched healthy controls. SCA2 patients showed a significant (P < 0.05 corrected for multiple comparison) symmetric loss of GM in the cerebellar vermis and hemispheres sparing lobules I,II, Crus II,VII, and X, and of the WM in the peridentate region, middle cerebellar peduncles, dorsal pons, and cerebral peduncles. The CSF volume was increased in the posterior cranial fossa. No GM, WM or CSF volume changes were observed in the supratentorial compartment. A mild (P < 0.05, >0.01) correlation was observed between the GM and WM loss and severity of the neurological deficit. In SCA2 patients with mild to moderate cerebellar deficit, GM and WM volume loss and CSF volume increase are confined to the posterior cranial fossa.</AbstractText>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Brain structural damage in spinocerebellar ataxia type 2. A voxel-based morphometry study.

Brain structural damage in spinocerebellar ataxia type 2. A voxel-based morphometry study.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki