Brain structural damage in spinocerebellar ataxia type 2. A voxel‐based morphometry study
Identifieur interne : 002966 ( Main/Curation ); précédent : 002965; suivant : 002967Brain structural damage in spinocerebellar ataxia type 2. A voxel‐based morphometry study
Auteurs : Riccardo Della Nave [Italie] ; Andrea Ginestroni [Italie] ; Carlo Tessa [Italie] ; Mirco Cosottini [Italie] ; Marco Giannelli [Italie] ; Elena Salvatore [Italie] ; Ferdinando Sartucci [Italie] ; Giuseppe De Michele [Italie] ; Maria Teresa Dotti [Italie] ; Silvia Piacentini [Italie] ; Mario Mascalchi [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-04-30.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Brain (pathology), Cerebral disorder, Female, Humans, MR imaging, Magnetic Resonance Imaging, Male, Middle Aged, Morphometry, Nervous system diseases, Nuclear magnetic resonance imaging, Periaqueductal Gray (pathology), Spinocerebellar Ataxias (genetics), Spinocerebellar Ataxias (pathology), Spinocerebellar ataxia, Trinucleotide Repeat Expansion (genetics), Voxel, ataxia, spinocerebellar ataxia type 2, voxel‐based morphometry.
- MESH :
- genetics : Spinocerebellar Ataxias, Trinucleotide Repeat Expansion.
- pathology : Brain, Periaqueductal Gray, Spinocerebellar Ataxias.
- Adult, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged.
Abstract
Voxel‐based morphometry (VBM) enables an unbiased in‐vivo whole‐brain quantitative analysis of differences in gray matter (GM), white matter (WM) and cerebro‐spinal fluid (CSF) volumes. We assessed with VBM 20 spinocerebellar ataxia Type 2 (SCA2) patients with mild or moderate cerebellar deficit and 20 age and sex‐matched healthy controls. SCA2 patients showed a significant (P < 0.05 corrected for multiple comparison) symmetric loss of GM in the cerebellar vermis and hemispheres sparing lobules I,II, Crus II,VII, and X, and of the WM in the peridentate region, middle cerebellar peduncles, dorsal pons, and cerebral peduncles. The CSF volume was increased in the posterior cranial fossa. No GM, WM or CSF volume changes were observed in the supratentorial compartment. A mild (P < 0.05, >0.01) correlation was observed between the GM and WM loss and severity of the neurological deficit. In SCA2 patients with mild to moderate cerebellar deficit, GM and WM volume loss and CSF volume increase are confined to the posterior cranial fossa. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.21982
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<term>MR imaging</term>
<term>Magnetic Resonance Imaging</term>
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<front><div type="abstract" xml:lang="en">Voxel‐based morphometry (VBM) enables an unbiased in‐vivo whole‐brain quantitative analysis of differences in gray matter (GM), white matter (WM) and cerebro‐spinal fluid (CSF) volumes. We assessed with VBM 20 spinocerebellar ataxia Type 2 (SCA2) patients with mild or moderate cerebellar deficit and 20 age and sex‐matched healthy controls. SCA2 patients showed a significant (P < 0.05 corrected for multiple comparison) symmetric loss of GM in the cerebellar vermis and hemispheres sparing lobules I,II, Crus II,VII, and X, and of the WM in the peridentate region, middle cerebellar peduncles, dorsal pons, and cerebral peduncles. The CSF volume was increased in the posterior cranial fossa. No GM, WM or CSF volume changes were observed in the supratentorial compartment. A mild (P < 0.05, >0.01) correlation was observed between the GM and WM loss and severity of the neurological deficit. In SCA2 patients with mild to moderate cerebellar deficit, GM and WM volume loss and CSF volume increase are confined to the posterior cranial fossa. © 2008 Movement Disorder Society</div>
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<author><name sortKey="Nave, Riccardo Delia" sort="Nave, Riccardo Delia" uniqKey="Nave R" first="Riccardo Delia" last="Nave">Riccardo Delia Nave</name>
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<s2>Florence</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>11 aut.</sZ>
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</affiliation>
</author>
<author><name sortKey="Ginestroni, Andrea" sort="Ginestroni, Andrea" uniqKey="Ginestroni A" first="Andrea" last="Ginestroni">Andrea Ginestroni</name>
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<s2>Florence</s2>
<s3>ITA</s3>
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<author><name sortKey="Tessa, Carlo" sort="Tessa, Carlo" uniqKey="Tessa C" first="Carlo" last="Tessa">Carlo Tessa</name>
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</author>
<author><name sortKey="Cosottini, Mirco" sort="Cosottini, Mirco" uniqKey="Cosottini M" first="Mirco" last="Cosottini">Mirco Cosottini</name>
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<s2>Pisa</s2>
<s3>ITA</s3>
<sZ>4 aut.</sZ>
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<country>Italie</country>
<wicri:noRegion>Pisa</wicri:noRegion>
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</author>
<author><name sortKey="Giannelli, Marco" sort="Giannelli, Marco" uniqKey="Giannelli M" first="Marco" last="Giannelli">Marco Giannelli</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Medical Physics, Azienda Ospedaliera Universitaria Pisana</s1>
<s2>Pisa</s2>
<s3>ITA</s3>
<sZ>5 aut.</sZ>
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<country>Italie</country>
<wicri:noRegion>Pisa</wicri:noRegion>
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</author>
<author><name sortKey="Salvatore, Elena" sort="Salvatore, Elena" uniqKey="Salvatore E" first="Elena" last="Salvatore">Elena Salvatore</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Clinical Neurology, Department of Neurological Sciences, University Federico II</s1>
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<s3>ITA</s3>
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<country>Italie</country>
<wicri:noRegion>Naples</wicri:noRegion>
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</author>
<author><name sortKey="Sartucci, Ferdinando" sort="Sartucci, Ferdinando" uniqKey="Sartucci F" first="Ferdinando" last="Sartucci">Ferdinando Sartucci</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Clinical Neurology, Department of Neuroscience, Univeristy of Pisa</s1>
<s2>Pisa</s2>
<s3>ITA</s3>
<sZ>7 aut.</sZ>
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<wicri:noRegion>Pisa</wicri:noRegion>
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</author>
<author><name sortKey="De Michele, Giuseppe" sort="De Michele, Giuseppe" uniqKey="De Michele G" first="Giuseppe" last="De Michele">Giuseppe De Michele</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Clinical Neurology, Department of Neurological Sciences, University Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
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<country>Italie</country>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dotti, Maria Teresa" sort="Dotti, Maria Teresa" uniqKey="Dotti M" first="Maria Teresa" last="Dotti">Maria Teresa Dotti</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Clinical Neurology, Department of Neurological & Behavioural Sciences, Univeristy of Siena</s1>
<s2>Siena</s2>
<s3>ITA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Siena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Piacentini, Silvia" sort="Piacentini, Silvia" uniqKey="Piacentini S" first="Silvia" last="Piacentini">Silvia Piacentini</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Clinical Neurology, Department of Neurological Sciences, University of Florence</s1>
<s2>Florence</s2>
<s3>ITA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Florence</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mascalchi, Mario" sort="Mascalchi, Mario" uniqKey="Mascalchi M" first="Mario" last="Mascalchi">Mario Mascalchi</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Radiodiagnostic Section, Department of Clinical Physiopathology, University of Florence</s1>
<s2>Florence</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>11 aut.</sZ>
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<country>Italie</country>
<wicri:noRegion>Florence</wicri:noRegion>
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<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
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<seriesStmt><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cerebral disorder</term>
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<term>Nuclear magnetic resonance imaging</term>
<term>Spinocerebellar ataxia</term>
<term>Voxel</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Pathologie de l'encéphale</term>
<term>Pathologie du système nerveux</term>
<term>Ataxie spinocérébelleuse</term>
<term>Voxel</term>
<term>Morphométrie</term>
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<front><div type="abstract" xml:lang="en">Voxel-based morphometry (VBM) enables an unbiased in-vivo whole-brain quantitative analysis of differences in gray matter (GM), white matter (WM) and cerebro-spinal fluid (CSF) volumes. We assessed with VBM 20 spinocerebellar ataxia Type 2 (SCA2) patients with mild or moderate cerebellar deficit and 20 age and sex-matched healthy controls. SCA2 patients showed a significant (P < 0.05 corrected for multiple comparison) symmetric loss of GM in the cerebellar vermis and hemispheres sparing lobules I,II, Crus II,VII, and X, and of the WM in the peridentate region, middle cerebellar peduncles, dorsal pons, and cerebral peduncles. The CSF volume was increased in the posterior cranial fossa. No GM, WM or CSF volume changes were observed in the supratentorial compartment. A mild (P < 0.05, >0.01) correlation was observed between the GM and WM loss and severity of the neurological deficit. In SCA2 patients with mild to moderate cerebellar deficit, GM and WM volume loss and CSF volume increase are confined to the posterior cranial fossa.</div>
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<author><name sortKey="Giannelli, Marco" sort="Giannelli, Marco" uniqKey="Giannelli M" first="Marco" last="Giannelli">Marco Giannelli</name>
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<author><name sortKey="Salvatore, Elena" sort="Salvatore, Elena" uniqKey="Salvatore E" first="Elena" last="Salvatore">Elena Salvatore</name>
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<author><name sortKey="Dotti, Maria Teresa" sort="Dotti, Maria Teresa" uniqKey="Dotti M" first="Maria Teresa" last="Dotti">Maria Teresa Dotti</name>
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<author><name sortKey="Piacentini, Silvia" sort="Piacentini, Silvia" uniqKey="Piacentini S" first="Silvia" last="Piacentini">Silvia Piacentini</name>
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<series><title level="j">Movement Disorders</title>
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<term>Brain (pathology)</term>
<term>Female</term>
<term>Humans</term>
<term>MR imaging</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Periaqueductal Gray (pathology)</term>
<term>Spinocerebellar Ataxias (genetics)</term>
<term>Spinocerebellar Ataxias (pathology)</term>
<term>Trinucleotide Repeat Expansion (genetics)</term>
<term>ataxia</term>
<term>spinocerebellar ataxia type 2</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Spinocerebellar Ataxias</term>
<term>Trinucleotide Repeat Expansion</term>
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<term>Periaqueductal Gray</term>
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<term>Humans</term>
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<front><div type="abstract" xml:lang="en">Voxel‐based morphometry (VBM) enables an unbiased in‐vivo whole‐brain quantitative analysis of differences in gray matter (GM), white matter (WM) and cerebro‐spinal fluid (CSF) volumes. We assessed with VBM 20 spinocerebellar ataxia Type 2 (SCA2) patients with mild or moderate cerebellar deficit and 20 age and sex‐matched healthy controls. SCA2 patients showed a significant (P < 0.05 corrected for multiple comparison) symmetric loss of GM in the cerebellar vermis and hemispheres sparing lobules I,II, Crus II,VII, and X, and of the WM in the peridentate region, middle cerebellar peduncles, dorsal pons, and cerebral peduncles. The CSF volume was increased in the posterior cranial fossa. No GM, WM or CSF volume changes were observed in the supratentorial compartment. A mild (P < 0.05, >0.01) correlation was observed between the GM and WM loss and severity of the neurological deficit. In SCA2 patients with mild to moderate cerebellar deficit, GM and WM volume loss and CSF volume increase are confined to the posterior cranial fossa. © 2008 Movement Disorder Society</div>
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