The Role of the Thalamus and Basal Ganglia in Parkinsonian Tremor
Identifieur interne : 004E91 ( Main/Exploration ); précédent : 004E90; suivant : 004E92The Role of the Thalamus and Basal Ganglia in Parkinsonian Tremor
Auteurs : S. Hua [États-Unis] ; S. G. Reich [États-Unis] ; A. T. Zirh [États-Unis] ; V. Perry [États-Unis] ; P. M. Dougherty [États-Unis] ; F. A. Lenz [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 1998.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (adverse effects), Animals, Basal Ganglia (drug effects), Basal ganglia, Basal ganglion, Dopamine Agents (adverse effects), Feedback, Feedback processes, Feedback system, Human, Neuronal oscillators, Parkinson Disease, Secondary (chemically induced), Parkinson disease, Parkinson's disease, Parkinsonism, Pathogenesis, Thalamus, Thalamus (drug effects), Tremor.
- MESH :
- chemical , adverse effects : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Dopamine Agents.
- chemically induced : Parkinson Disease, Secondary.
- drug effects : Basal Ganglia, Thalamus.
- Animals, Feedback.
Abstract
The mechanism of parkinsonian tremor may involve a central oscillator, peripheral feedback to the central nervous system (CNS), or both. The thalamus or the globus pallidus is the most likely site for a central oscillator and would be predicted to generate thalamic tremor‐related activity characterized, respectively, by calcium spike‐associated bursts and by maximal tremor‐related activity in the pallidal relay nucleus of thalamus. Thalamic spike trains demonstrate neither of these characteristics. However, cross‐correlation, latency, and transfer function analysis indicate that sensory feedback is a critical element in the relationship between thalamic activity and parkinsonian tremor. Therefore, thalamic spike train activity is most consistent with parkinsonian tremor being mediated by peripheral inputs involved in either an unstable reflex loop or sensory modulation of a central oscillator.
Url:
DOI: 10.1002/mds.870131307
Affiliations:
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1998">1998</date><biblScope unit="vol">13</biblScope><biblScope unit="issue">S3</biblScope><biblScope unit="page" from="40">40</biblScope><biblScope unit="page" to="42">42</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">AF5619CFF64685FA5DE9AE087F46FC0A46597527</idno><idno type="DOI">10.1002/mds.870131307</idno><idno type="ArticleID">MDS870131307</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (adverse effects)</term><term>Animals</term><term>Basal Ganglia (drug effects)</term><term>Basal ganglia</term><term>Basal ganglion</term><term>Dopamine Agents (adverse effects)</term><term>Feedback</term><term>Feedback processes</term><term>Feedback system</term><term>Human</term><term>Neuronal oscillators</term><term>Parkinson Disease, Secondary (chemically induced)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Parkinsonism</term><term>Pathogenesis</term><term>Thalamus</term><term>Thalamus (drug effects)</term><term>Tremor</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term><term>Dopamine Agents</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Basal Ganglia</term><term>Thalamus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Feedback</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Homme</term><term>Noyau gris central</term><term>Parkinson maladie</term><term>Parkinsonisme</term><term>Pathogénie</term><term>Système asservi</term><term>Thalamus</term><term>Tremblement</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The mechanism of parkinsonian tremor may involve a central oscillator, peripheral feedback to the central nervous system (CNS), or both. The thalamus or the globus pallidus is the most likely site for a central oscillator and would be predicted to generate thalamic tremor‐related activity characterized, respectively, by calcium spike‐associated bursts and by maximal tremor‐related activity in the pallidal relay nucleus of thalamus. Thalamic spike trains demonstrate neither of these characteristics. However, cross‐correlation, latency, and transfer function analysis indicate that sensory feedback is a critical element in the relationship between thalamic activity and parkinsonian tremor. Therefore, thalamic spike train activity is most consistent with parkinsonian tremor being mediated by peripheral inputs involved in either an unstable reflex loop or sensory modulation of a central oscillator.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Hua, S" sort="Hua, S" uniqKey="Hua S" first="S." last="Hua">S. Hua</name></region><name sortKey="Dougherty, P M" sort="Dougherty, P M" uniqKey="Dougherty P" first="P. M." last="Dougherty">P. M. Dougherty</name><name sortKey="Lenz, F A" sort="Lenz, F A" uniqKey="Lenz F" first="F. A." last="Lenz">F. A. Lenz</name><name sortKey="Perry, V" sort="Perry, V" uniqKey="Perry V" first="V." last="Perry">V. Perry</name><name sortKey="Reich, S G" sort="Reich, S G" uniqKey="Reich S" first="S. G." last="Reich">S. G. Reich</name><name sortKey="Zirh, A T" sort="Zirh, A T" uniqKey="Zirh A" first="A. T." last="Zirh">A. T. Zirh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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