The Role of the Thalamus and Basal Ganglia in Parkinsonian Tremor
Identifieur interne : 003544 ( Istex/Corpus ); précédent : 003543; suivant : 003545The Role of the Thalamus and Basal Ganglia in Parkinsonian Tremor
Auteurs : S. Hua ; S. G. Reich ; A. T. Zirh ; V. Perry ; P. M. Dougherty ; F. A. LenzSource :
- Movement Disorders [ 0885-3185 ] ; 1998.
English descriptors
- KwdEn :
Abstract
The mechanism of parkinsonian tremor may involve a central oscillator, peripheral feedback to the central nervous system (CNS), or both. The thalamus or the globus pallidus is the most likely site for a central oscillator and would be predicted to generate thalamic tremor‐related activity characterized, respectively, by calcium spike‐associated bursts and by maximal tremor‐related activity in the pallidal relay nucleus of thalamus. Thalamic spike trains demonstrate neither of these characteristics. However, cross‐correlation, latency, and transfer function analysis indicate that sensory feedback is a critical element in the relationship between thalamic activity and parkinsonian tremor. Therefore, thalamic spike train activity is most consistent with parkinsonian tremor being mediated by peripheral inputs involved in either an unstable reflex loop or sensory modulation of a central oscillator.
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DOI: 10.1002/mds.870131307
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ISTEX:AF5619CFF64685FA5DE9AE087F46FC0A46597527Le document en format XML
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The thalamus or the globus pallidus is the most likely site for a central oscillator and would be predicted to generate thalamic tremor‐related activity characterized, respectively, by calcium spike‐associated bursts and by maximal tremor‐related activity in the pallidal relay nucleus of thalamus. Thalamic spike trains demonstrate neither of these characteristics. However, cross‐correlation, latency, and transfer function analysis indicate that sensory feedback is a critical element in the relationship between thalamic activity and parkinsonian tremor. Therefore, thalamic spike train activity is most consistent with parkinsonian tremor being mediated by peripheral inputs involved in either an unstable reflex loop or sensory modulation of a central oscillator.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>S. Hua</name><affiliations><json:string>Departments of Neurology and Neurosurgery, Johns Hopkins University, Baltimore, Maryland, U.S.A.</json:string></affiliations></json:item><json:item><name>S. G. Reich</name><affiliations><json:string>Departments of Neurology and Neurosurgery, Johns Hopkins University, Baltimore, Maryland, U.S.A.</json:string></affiliations></json:item><json:item><name>A. T. Zirh</name><affiliations><json:string>Departments of Neurology and Neurosurgery, Johns Hopkins University, Baltimore, Maryland, U.S.A.</json:string></affiliations></json:item><json:item><name>V. Perry</name><affiliations><json:string>Departments of Neurology and Neurosurgery, Johns Hopkins University, Baltimore, Maryland, U.S.A.</json:string></affiliations></json:item><json:item><name>P. M. Dougherty</name><affiliations><json:string>Departments of Neurology and Neurosurgery, Johns Hopkins University, Baltimore, Maryland, U.S.A.</json:string></affiliations></json:item><json:item><name>F. A. 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A. Lenz at the Department of Neurosurgery, Meyer Building 7–113. Johns Hopkins Hospital. Baltimore, MD 21205. U.S.A</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS870131307.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="0"></count><count type="referenceTotal" number="20"></count></countGroup><titleGroup><title type="main" xml:lang="en">The Role of the Thalamus and Basal Ganglia in Parkinsonian Tremor</title><title type="short" xml:lang="en">THALAMUS AND BASAL GANGLIA IN PARKINSONIAN TREMOR</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>S.</givenNames><familyName>Hua</familyName></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>S. G.</givenNames><familyName>Reich</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>A. T.</givenNames><familyName>Zirh</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>V.</givenNames><familyName>Perry</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>P. M.</givenNames><familyName>Dougherty</familyName></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>F. A.</givenNames><familyName>Lenz</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="US" type="organization"><unparsedAffiliation>Departments of Neurology and Neurosurgery, Johns Hopkins University, Baltimore, Maryland, U.S.A.</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Thalamus</keyword><keyword xml:id="kwd2">Parkinson's disease</keyword><keyword xml:id="kwd3">Tremor</keyword><keyword xml:id="kwd4">Basal ganglia</keyword><keyword xml:id="kwd5">Neuronal oscillators</keyword><keyword xml:id="kwd6">Feedback processes</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>The mechanism of parkinsonian tremor may involve a central oscillator, peripheral feedback to the central nervous system (CNS), or both. The thalamus or the globus pallidus is the most likely site for a central oscillator and would be predicted to generate thalamic tremor‐related activity characterized, respectively, by calcium spike‐associated bursts and by maximal tremor‐related activity in the pallidal relay nucleus of thalamus. Thalamic spike trains demonstrate neither of these characteristics. However, cross‐correlation, latency, and transfer function analysis indicate that sensory feedback is a critical element in the relationship between thalamic activity and parkinsonian tremor. 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M.</namePart><namePart type="family">Dougherty</namePart><affiliation>Departments of Neurology and Neurosurgery, Johns Hopkins University, Baltimore, Maryland, U.S.A.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F. A.</namePart><namePart type="family">Lenz</namePart><affiliation>Departments of Neurology and Neurosurgery, Johns Hopkins University, Baltimore, Maryland, U.S.A.</affiliation><description>Correspondence: F. A. Lenz at the Department of Neurosurgery, Meyer Building 7–113. Johns Hopkins Hospital. Baltimore, MD 21205. U.S.A</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">1998</dateIssued><copyrightDate encoding="w3cdtf">1998</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="references">20</extent></physicalDescription><abstract lang="en">The mechanism of parkinsonian tremor may involve a central oscillator, peripheral feedback to the central nervous system (CNS), or both. The thalamus or the globus pallidus is the most likely site for a central oscillator and would be predicted to generate thalamic tremor‐related activity characterized, respectively, by calcium spike‐associated bursts and by maximal tremor‐related activity in the pallidal relay nucleus of thalamus. Thalamic spike trains demonstrate neither of these characteristics. However, cross‐correlation, latency, and transfer function analysis indicate that sensory feedback is a critical element in the relationship between thalamic activity and parkinsonian tremor. Therefore, thalamic spike train activity is most consistent with parkinsonian tremor being mediated by peripheral inputs involved in either an unstable reflex loop or sensory modulation of a central oscillator.</abstract><subject lang="en"><genre>Keywords</genre><topic>Thalamus</topic><topic>Parkinson's disease</topic><topic>Tremor</topic><topic>Basal ganglia</topic><topic>Neuronal oscillators</topic><topic>Feedback processes</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. 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|texte= The Role of the Thalamus and Basal Ganglia in Parkinsonian Tremor
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