The role of the thalamus and basal ganglia in parkinsonian tremor.
Identifieur interne : 005050 ( Ncbi/Curation ); précédent : 005049; suivant : 005051The role of the thalamus and basal ganglia in parkinsonian tremor.
Auteurs : S. Hua [États-Unis] ; S G Reich ; A T Zirh ; V. Perry ; P M Dougherty ; F A LenzSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1998.
English descriptors
- KwdEn :
- MESH :
- chemical , adverse effects : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Dopamine Agents.
- chemically induced : Parkinson Disease, Secondary.
- drug effects : Basal Ganglia, Thalamus.
- Animals, Feedback.
Abstract
The mechanism of parkinsonian tremor may involve a central oscillator, peripheral feedback to the central nervous system (CNS), or both. The thalamus or the globus pallidus is the most likely site for a central oscillator and would be predicted to generate thalamic tremor-related activity characterized, respectively, by calcium spike-associated bursts and by maximal tremor-related activity in the pallidal relay nucleus of thalamus. Thalamic spike trains demonstrate neither of these characteristics. However, cross-correlation, latency, and transfer function analysis indicate that sensory feedback is a critical element in the relationship between thalamic activity and parkinsonian tremor. Therefore, thalamic spike train activity is most consistent with parkinsonian tremor being mediated by peripheral inputs involved in either an unstable reflex loop or sensory modulation of a central oscillator.
PubMed: 9827593
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pubmed:9827593Le document en format XML
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Perry</name></author><author><name sortKey="Dougherty, P M" sort="Dougherty, P M" uniqKey="Dougherty P" first="P M" last="Dougherty">P M Dougherty</name></author><author><name sortKey="Lenz, F A" sort="Lenz, F A" uniqKey="Lenz F" first="F A" last="Lenz">F A Lenz</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1998">1998</date><idno type="RBID">pubmed:9827593</idno><idno type="pmid">9827593</idno><idno type="wicri:Area/PubMed/Corpus">004333</idno><idno type="wicri:Area/PubMed/Curation">004333</idno><idno type="wicri:Area/PubMed/Checkpoint">004316</idno><idno type="wicri:Area/Ncbi/Merge">005050</idno><idno type="wicri:Area/Ncbi/Curation">005050</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The role of the thalamus and basal ganglia in parkinsonian tremor.</title><author><name sortKey="Hua, S" sort="Hua, S" uniqKey="Hua S" first="S" last="Hua">S. Hua</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Johns Hopkins University, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Reich, S G" sort="Reich, S G" uniqKey="Reich S" first="S G" last="Reich">S G Reich</name></author><author><name sortKey="Zirh, A T" sort="Zirh, A T" uniqKey="Zirh A" first="A T" last="Zirh">A T Zirh</name></author><author><name sortKey="Perry, V" sort="Perry, V" uniqKey="Perry V" first="V" last="Perry">V. Perry</name></author><author><name sortKey="Dougherty, P M" sort="Dougherty, P M" uniqKey="Dougherty P" first="P M" last="Dougherty">P M Dougherty</name></author><author><name sortKey="Lenz, F A" sort="Lenz, F A" uniqKey="Lenz F" first="F A" last="Lenz">F A Lenz</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1998" type="published">1998</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (adverse effects)</term><term>Animals</term><term>Basal Ganglia (drug effects)</term><term>Dopamine Agents (adverse effects)</term><term>Feedback</term><term>Parkinson Disease, Secondary (chemically induced)</term><term>Thalamus (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term><term>Dopamine Agents</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Basal Ganglia</term><term>Thalamus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Feedback</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The mechanism of parkinsonian tremor may involve a central oscillator, peripheral feedback to the central nervous system (CNS), or both. The thalamus or the globus pallidus is the most likely site for a central oscillator and would be predicted to generate thalamic tremor-related activity characterized, respectively, by calcium spike-associated bursts and by maximal tremor-related activity in the pallidal relay nucleus of thalamus. Thalamic spike trains demonstrate neither of these characteristics. However, cross-correlation, latency, and transfer function analysis indicate that sensory feedback is a critical element in the relationship between thalamic activity and parkinsonian tremor. Therefore, thalamic spike train activity is most consistent with parkinsonian tremor being mediated by peripheral inputs involved in either an unstable reflex loop or sensory modulation of a central oscillator.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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