Cerebral white matter alterations in idiopathic restless legs syndrome, as measured by diffusion tensor imaging
Identifieur interne : 002950 ( Main/Exploration ); précédent : 002949; suivant : 002951Cerebral white matter alterations in idiopathic restless legs syndrome, as measured by diffusion tensor imaging
Auteurs : Alexander Unrath [Allemagne] ; Hans-Peter Müller [Allemagne] ; Albert C. Ludolph [Allemagne] ; Axel Riecker [Allemagne] ; Jan Kassubek [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-07-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Anisotropy, Brain Mapping, Cerebral Cortex (metabolism), Cerebral Cortex (pathology), Chi-Square Distribution, Diffusion Magnetic Resonance Imaging (methods), Diffusion imaging, Diffusion tensor, Encephalon, Female, Humans, Idiopathic, Image Processing, Computer-Assisted, Male, Middle Aged, Nervous system diseases, Nuclear magnetic resonance imaging, Restless Legs Syndrome (pathology), Restless legs syndrome, White matter, diffusion tensor imaging, magnetic resonance imaging, motor and premotor region, restless legs syndrome, white matter.
- MESH :
- metabolism : Cerebral Cortex.
- methods : Diffusion Magnetic Resonance Imaging.
- pathology : Cerebral Cortex, Restless Legs Syndrome.
- Aged, Anisotropy, Brain Mapping, Chi-Square Distribution, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged.
Abstract
In search for the pathoanatomical correlate of the restless legs syndrome (RLS), various neuroimaging and electrophysiological techniques have demonstrated partly conflicting results of cortical, subcortical, brainstem, and spinal alterations. In a novel approach, the delineation of potential cerebral white matter tract disruption was investigated by application of quantitative whole brain‐based diffusion tensor imaging (DTI) to a well characterized group of 45 patients with idiopathic RLS. The data of patients and 30 healthy controls were statistically compared including computation of regional fractional anisotropy (FA) as a quantitative marker of white matter integrity by use of the tensor imaging and fiber tracking software. In the patient group, multiple subcortical areas of significantly reduced FA were observed bihemispherically in close proximity to the primary and associate motor and somatosensory cortices, in the right‐hemispheric thalamus (posterior ventral lateral nucleus), in motor projectional fibers and adjacent to the left anterior cingulum. Together with the results of a recent study by use of an MRI‐based gray matter analysis, which localized RLS‐associated changes in the sensorimotor cortices, these findings gave support to an altered subcortical network, with the major component of altered cerebral sensorimotor pathways, within a hodological concept of the RLS pathoanatomy. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22074
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-07-15">2008-07-15</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1250">1250</biblScope><biblScope unit="page" to="1255">1255</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">29454DDF5E7E412B3BB05D5E7A75AF5885FDDF16</idno><idno type="DOI">10.1002/mds.22074</idno><idno type="ArticleID">MDS22074</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Anisotropy</term><term>Brain Mapping</term><term>Cerebral Cortex (metabolism)</term><term>Cerebral Cortex (pathology)</term><term>Chi-Square Distribution</term><term>Diffusion Magnetic Resonance Imaging (methods)</term><term>Diffusion imaging</term><term>Diffusion tensor</term><term>Encephalon</term><term>Female</term><term>Humans</term><term>Idiopathic</term><term>Image Processing, Computer-Assisted</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Nuclear magnetic resonance imaging</term><term>Restless Legs Syndrome (pathology)</term><term>Restless legs syndrome</term><term>White matter</term><term>diffusion tensor imaging</term><term>magnetic resonance imaging</term><term>motor and premotor region</term><term>restless legs syndrome</term><term>white matter</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cerebral Cortex</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Diffusion Magnetic Resonance Imaging</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Cerebral Cortex</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Anisotropy</term><term>Brain Mapping</term><term>Chi-Square Distribution</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Encéphale</term><term>Idiopathique</term><term>Imagerie RMN</term><term>Imagerie de diffusion</term><term>Pathologie du système nerveux</term><term>Substance blanche</term><term>Syndrome des jambes sans repos</term><term>Tenseur de diffusion</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In search for the pathoanatomical correlate of the restless legs syndrome (RLS), various neuroimaging and electrophysiological techniques have demonstrated partly conflicting results of cortical, subcortical, brainstem, and spinal alterations. In a novel approach, the delineation of potential cerebral white matter tract disruption was investigated by application of quantitative whole brain‐based diffusion tensor imaging (DTI) to a well characterized group of 45 patients with idiopathic RLS. The data of patients and 30 healthy controls were statistically compared including computation of regional fractional anisotropy (FA) as a quantitative marker of white matter integrity by use of the tensor imaging and fiber tracking software. In the patient group, multiple subcortical areas of significantly reduced FA were observed bihemispherically in close proximity to the primary and associate motor and somatosensory cortices, in the right‐hemispheric thalamus (posterior ventral lateral nucleus), in motor projectional fibers and adjacent to the left anterior cingulum. Together with the results of a recent study by use of an MRI‐based gray matter analysis, which localized RLS‐associated changes in the sensorimotor cortices, these findings gave support to an altered subcortical network, with the major component of altered cerebral sensorimotor pathways, within a hodological concept of the RLS pathoanatomy. © 2008 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bade-Wurtemberg</li><li>District de Tübingen</li></region><settlement><li>Ulm</li></settlement><orgName><li>Université d'Ulm</li></orgName></list><tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Unrath, Alexander" sort="Unrath, Alexander" uniqKey="Unrath A" first="Alexander" last="Unrath">Alexander Unrath</name></region><name sortKey="Kassubek, Jan" sort="Kassubek, Jan" uniqKey="Kassubek J" first="Jan" last="Kassubek">Jan Kassubek</name><name sortKey="Ludolph, Albert C" sort="Ludolph, Albert C" uniqKey="Ludolph A" first="Albert C." last="Ludolph">Albert C. Ludolph</name><name sortKey="Muller, Hans Eter" sort="Muller, Hans Eter" uniqKey="Muller H" first="Hans-Peter" last="Müller">Hans-Peter Müller</name><name sortKey="Riecker, Axel" sort="Riecker, Axel" uniqKey="Riecker A" first="Axel" last="Riecker">Axel Riecker</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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