Cerebral white matter alterations in idiopathic restless legs syndrome, as measured by diffusion tensor imaging
Identifieur interne : 003529 ( Main/Merge ); précédent : 003528; suivant : 003530Cerebral white matter alterations in idiopathic restless legs syndrome, as measured by diffusion tensor imaging
Auteurs : Alexander Unrath [Allemagne] ; Hans-Peter Müller [Allemagne] ; Albert C. Ludolph [Allemagne] ; Axel Riecker [Allemagne] ; Jan Kassubek [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-07-15.
English descriptors
- KwdEn :
- Aged, Anisotropy, Brain Mapping, Cerebral Cortex (metabolism), Cerebral Cortex (pathology), Chi-Square Distribution, Diffusion Magnetic Resonance Imaging (methods), Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Restless Legs Syndrome (pathology), diffusion tensor imaging, magnetic resonance imaging, motor and premotor region, restless legs syndrome, white matter.
- MESH :
- metabolism : Cerebral Cortex.
- methods : Diffusion Magnetic Resonance Imaging.
- pathology : Cerebral Cortex, Restless Legs Syndrome.
- Aged, Anisotropy, Brain Mapping, Chi-Square Distribution, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged.
Abstract
In search for the pathoanatomical correlate of the restless legs syndrome (RLS), various neuroimaging and electrophysiological techniques have demonstrated partly conflicting results of cortical, subcortical, brainstem, and spinal alterations. In a novel approach, the delineation of potential cerebral white matter tract disruption was investigated by application of quantitative whole brain‐based diffusion tensor imaging (DTI) to a well characterized group of 45 patients with idiopathic RLS. The data of patients and 30 healthy controls were statistically compared including computation of regional fractional anisotropy (FA) as a quantitative marker of white matter integrity by use of the tensor imaging and fiber tracking software. In the patient group, multiple subcortical areas of significantly reduced FA were observed bihemispherically in close proximity to the primary and associate motor and somatosensory cortices, in the right‐hemispheric thalamus (posterior ventral lateral nucleus), in motor projectional fibers and adjacent to the left anterior cingulum. Together with the results of a recent study by use of an MRI‐based gray matter analysis, which localized RLS‐associated changes in the sensorimotor cortices, these findings gave support to an altered subcortical network, with the major component of altered cerebral sensorimotor pathways, within a hodological concept of the RLS pathoanatomy. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22074
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001B67
- to stream Istex, to step Curation: 001B67
- to stream Istex, to step Checkpoint: 001507
- to stream PubMed, to step Corpus: 002225
- to stream PubMed, to step Curation: 002225
- to stream PubMed, to step Checkpoint: 002390
- to stream Ncbi, to step Merge: 002136
- to stream Ncbi, to step Curation: 002136
- to stream Ncbi, to step Checkpoint: 002136
Links to Exploration step
ISTEX:29454DDF5E7E412B3BB05D5E7A75AF5885FDDF16Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cerebral white matter alterations in idiopathic restless legs syndrome, as measured by diffusion tensor imaging</title>
<author><name sortKey="Unrath, Alexander" sort="Unrath, Alexander" uniqKey="Unrath A" first="Alexander" last="Unrath">Alexander Unrath</name>
</author>
<author><name sortKey="Muller, Hans Eter" sort="Muller, Hans Eter" uniqKey="Muller H" first="Hans-Peter" last="Müller">Hans-Peter Müller</name>
</author>
<author><name sortKey="Ludolph, Albert C" sort="Ludolph, Albert C" uniqKey="Ludolph A" first="Albert C." last="Ludolph">Albert C. Ludolph</name>
</author>
<author><name sortKey="Riecker, Axel" sort="Riecker, Axel" uniqKey="Riecker A" first="Axel" last="Riecker">Axel Riecker</name>
</author>
<author><name sortKey="Kassubek, Jan" sort="Kassubek, Jan" uniqKey="Kassubek J" first="Jan" last="Kassubek">Jan Kassubek</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:29454DDF5E7E412B3BB05D5E7A75AF5885FDDF16</idno>
<date when="2008" year="2008">2008</date>
<idno type="doi">10.1002/mds.22074</idno>
<idno type="url">https://api.istex.fr/document/29454DDF5E7E412B3BB05D5E7A75AF5885FDDF16/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001B67</idno>
<idno type="wicri:Area/Istex/Curation">001B67</idno>
<idno type="wicri:Area/Istex/Checkpoint">001507</idno>
<idno type="wicri:doubleKey">0885-3185:2008:Unrath A:cerebral:white:matter</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:18464282</idno>
<idno type="wicri:Area/PubMed/Corpus">002225</idno>
<idno type="wicri:Area/PubMed/Curation">002225</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002390</idno>
<idno type="wicri:Area/Ncbi/Merge">002136</idno>
<idno type="wicri:Area/Ncbi/Curation">002136</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002136</idno>
<idno type="wicri:Area/Main/Merge">003529</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Cerebral white matter alterations in idiopathic restless legs syndrome, as measured by diffusion tensor imaging</title>
<author><name sortKey="Unrath, Alexander" sort="Unrath, Alexander" uniqKey="Unrath A" first="Alexander" last="Unrath">Alexander Unrath</name>
<affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
<orgName type="university">Université d'Ulm</orgName>
</affiliation>
</author>
<author><name sortKey="Muller, Hans Eter" sort="Muller, Hans Eter" uniqKey="Muller H" first="Hans-Peter" last="Müller">Hans-Peter Müller</name>
<affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
<orgName type="university">Université d'Ulm</orgName>
</affiliation>
</author>
<author><name sortKey="Ludolph, Albert C" sort="Ludolph, Albert C" uniqKey="Ludolph A" first="Albert C." last="Ludolph">Albert C. Ludolph</name>
<affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
<orgName type="university">Université d'Ulm</orgName>
</affiliation>
</author>
<author><name sortKey="Riecker, Axel" sort="Riecker, Axel" uniqKey="Riecker A" first="Axel" last="Riecker">Axel Riecker</name>
<affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
<orgName type="university">Université d'Ulm</orgName>
</affiliation>
</author>
<author><name sortKey="Kassubek, Jan" sort="Kassubek, Jan" uniqKey="Kassubek J" first="Jan" last="Kassubek">Jan Kassubek</name>
<affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
<orgName type="university">Université d'Ulm</orgName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2008-07-15">2008-07-15</date>
<biblScope unit="vol">23</biblScope>
<biblScope unit="issue">9</biblScope>
<biblScope unit="page" from="1250">1250</biblScope>
<biblScope unit="page" to="1255">1255</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">29454DDF5E7E412B3BB05D5E7A75AF5885FDDF16</idno>
<idno type="DOI">10.1002/mds.22074</idno>
<idno type="ArticleID">MDS22074</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Anisotropy</term>
<term>Brain Mapping</term>
<term>Cerebral Cortex (metabolism)</term>
<term>Cerebral Cortex (pathology)</term>
<term>Chi-Square Distribution</term>
<term>Diffusion Magnetic Resonance Imaging (methods)</term>
<term>Female</term>
<term>Humans</term>
<term>Image Processing, Computer-Assisted</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Restless Legs Syndrome (pathology)</term>
<term>diffusion tensor imaging</term>
<term>magnetic resonance imaging</term>
<term>motor and premotor region</term>
<term>restless legs syndrome</term>
<term>white matter</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cerebral Cortex</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Diffusion Magnetic Resonance Imaging</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Cerebral Cortex</term>
<term>Restless Legs Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Anisotropy</term>
<term>Brain Mapping</term>
<term>Chi-Square Distribution</term>
<term>Female</term>
<term>Humans</term>
<term>Image Processing, Computer-Assisted</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">In search for the pathoanatomical correlate of the restless legs syndrome (RLS), various neuroimaging and electrophysiological techniques have demonstrated partly conflicting results of cortical, subcortical, brainstem, and spinal alterations. In a novel approach, the delineation of potential cerebral white matter tract disruption was investigated by application of quantitative whole brain‐based diffusion tensor imaging (DTI) to a well characterized group of 45 patients with idiopathic RLS. The data of patients and 30 healthy controls were statistically compared including computation of regional fractional anisotropy (FA) as a quantitative marker of white matter integrity by use of the tensor imaging and fiber tracking software. In the patient group, multiple subcortical areas of significantly reduced FA were observed bihemispherically in close proximity to the primary and associate motor and somatosensory cortices, in the right‐hemispheric thalamus (posterior ventral lateral nucleus), in motor projectional fibers and adjacent to the left anterior cingulum. Together with the results of a recent study by use of an MRI‐based gray matter analysis, which localized RLS‐associated changes in the sensorimotor cortices, these findings gave support to an altered subcortical network, with the major component of altered cerebral sensorimotor pathways, within a hodological concept of the RLS pathoanatomy. © 2008 Movement Disorder Society</div>
</front>
</TEI>
<double doi="10.1002/mds.22074"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cerebral white matter alterations in idiopathic restless legs syndrome, as measured by diffusion tensor imaging</title>
<author><name sortKey="Unrath, Alexander" sort="Unrath, Alexander" uniqKey="Unrath A" first="Alexander" last="Unrath">Alexander Unrath</name>
</author>
<author><name sortKey="Muller, Hans Eter" sort="Muller, Hans Eter" uniqKey="Muller H" first="Hans-Peter" last="Müller">Hans-Peter Müller</name>
</author>
<author><name sortKey="Ludolph, Albert C" sort="Ludolph, Albert C" uniqKey="Ludolph A" first="Albert C." last="Ludolph">Albert C. Ludolph</name>
</author>
<author><name sortKey="Riecker, Axel" sort="Riecker, Axel" uniqKey="Riecker A" first="Axel" last="Riecker">Axel Riecker</name>
</author>
<author><name sortKey="Kassubek, Jan" sort="Kassubek, Jan" uniqKey="Kassubek J" first="Jan" last="Kassubek">Jan Kassubek</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:29454DDF5E7E412B3BB05D5E7A75AF5885FDDF16</idno>
<date when="2008" year="2008">2008</date>
<idno type="doi">10.1002/mds.22074</idno>
<idno type="url">https://api.istex.fr/document/29454DDF5E7E412B3BB05D5E7A75AF5885FDDF16/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001B67</idno>
<idno type="wicri:Area/Istex/Curation">001B67</idno>
<idno type="wicri:Area/Istex/Checkpoint">001507</idno>
<idno type="wicri:doubleKey">0885-3185:2008:Unrath A:cerebral:white:matter</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Cerebral white matter alterations in idiopathic restless legs syndrome, as measured by diffusion tensor imaging</title>
<author><name sortKey="Unrath, Alexander" sort="Unrath, Alexander" uniqKey="Unrath A" first="Alexander" last="Unrath">Alexander Unrath</name>
<affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
<orgName type="university">Université d'Ulm</orgName>
</affiliation>
</author>
<author><name sortKey="Muller, Hans Eter" sort="Muller, Hans Eter" uniqKey="Muller H" first="Hans-Peter" last="Müller">Hans-Peter Müller</name>
<affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
<orgName type="university">Université d'Ulm</orgName>
</affiliation>
</author>
<author><name sortKey="Ludolph, Albert C" sort="Ludolph, Albert C" uniqKey="Ludolph A" first="Albert C." last="Ludolph">Albert C. Ludolph</name>
<affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
<orgName type="university">Université d'Ulm</orgName>
</affiliation>
</author>
<author><name sortKey="Riecker, Axel" sort="Riecker, Axel" uniqKey="Riecker A" first="Axel" last="Riecker">Axel Riecker</name>
<affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
<orgName type="university">Université d'Ulm</orgName>
</affiliation>
</author>
<author><name sortKey="Kassubek, Jan" sort="Kassubek, Jan" uniqKey="Kassubek J" first="Jan" last="Kassubek">Jan Kassubek</name>
<affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
<orgName type="university">Université d'Ulm</orgName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2008-07-15">2008-07-15</date>
<biblScope unit="vol">23</biblScope>
<biblScope unit="issue">9</biblScope>
<biblScope unit="page" from="1250">1250</biblScope>
<biblScope unit="page" to="1255">1255</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">29454DDF5E7E412B3BB05D5E7A75AF5885FDDF16</idno>
<idno type="DOI">10.1002/mds.22074</idno>
<idno type="ArticleID">MDS22074</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>diffusion tensor imaging</term>
<term>magnetic resonance imaging</term>
<term>motor and premotor region</term>
<term>restless legs syndrome</term>
<term>white matter</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">In search for the pathoanatomical correlate of the restless legs syndrome (RLS), various neuroimaging and electrophysiological techniques have demonstrated partly conflicting results of cortical, subcortical, brainstem, and spinal alterations. In a novel approach, the delineation of potential cerebral white matter tract disruption was investigated by application of quantitative whole brain‐based diffusion tensor imaging (DTI) to a well characterized group of 45 patients with idiopathic RLS. The data of patients and 30 healthy controls were statistically compared including computation of regional fractional anisotropy (FA) as a quantitative marker of white matter integrity by use of the tensor imaging and fiber tracking software. In the patient group, multiple subcortical areas of significantly reduced FA were observed bihemispherically in close proximity to the primary and associate motor and somatosensory cortices, in the right‐hemispheric thalamus (posterior ventral lateral nucleus), in motor projectional fibers and adjacent to the left anterior cingulum. Together with the results of a recent study by use of an MRI‐based gray matter analysis, which localized RLS‐associated changes in the sensorimotor cortices, these findings gave support to an altered subcortical network, with the major component of altered cerebral sensorimotor pathways, within a hodological concept of the RLS pathoanatomy. © 2008 Movement Disorder Society</div>
</front>
</TEI>
</ISTEX>
<PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cerebral white matter alterations in idiopathic restless legs syndrome, as measured by diffusion tensor imaging.</title>
<author><name sortKey="Unrath, Alexander" sort="Unrath, Alexander" uniqKey="Unrath A" first="Alexander" last="Unrath">Alexander Unrath</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, University of Ulm, Ulm, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
<orgName type="university">Université d'Ulm</orgName>
</affiliation>
</author>
<author><name sortKey="Muller, Hans Peter" sort="Muller, Hans Peter" uniqKey="Muller H" first="Hans-Peter" last="Müller">Hans-Peter Müller</name>
</author>
<author><name sortKey="Ludolph, Albert C" sort="Ludolph, Albert C" uniqKey="Ludolph A" first="Albert C" last="Ludolph">Albert C. Ludolph</name>
</author>
<author><name sortKey="Riecker, Axel" sort="Riecker, Axel" uniqKey="Riecker A" first="Axel" last="Riecker">Axel Riecker</name>
</author>
<author><name sortKey="Kassubek, Jan" sort="Kassubek, Jan" uniqKey="Kassubek J" first="Jan" last="Kassubek">Jan Kassubek</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2008">2008</date>
<idno type="doi">10.1002/mds.22074</idno>
<idno type="RBID">pubmed:18464282</idno>
<idno type="pmid">18464282</idno>
<idno type="wicri:Area/PubMed/Corpus">002225</idno>
<idno type="wicri:Area/PubMed/Curation">002225</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002390</idno>
<idno type="wicri:Area/Ncbi/Merge">002136</idno>
<idno type="wicri:Area/Ncbi/Curation">002136</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002136</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Cerebral white matter alterations in idiopathic restless legs syndrome, as measured by diffusion tensor imaging.</title>
<author><name sortKey="Unrath, Alexander" sort="Unrath, Alexander" uniqKey="Unrath A" first="Alexander" last="Unrath">Alexander Unrath</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, University of Ulm, Ulm, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
<orgName type="university">Université d'Ulm</orgName>
</affiliation>
</author>
<author><name sortKey="Muller, Hans Peter" sort="Muller, Hans Peter" uniqKey="Muller H" first="Hans-Peter" last="Müller">Hans-Peter Müller</name>
</author>
<author><name sortKey="Ludolph, Albert C" sort="Ludolph, Albert C" uniqKey="Ludolph A" first="Albert C" last="Ludolph">Albert C. Ludolph</name>
</author>
<author><name sortKey="Riecker, Axel" sort="Riecker, Axel" uniqKey="Riecker A" first="Axel" last="Riecker">Axel Riecker</name>
</author>
<author><name sortKey="Kassubek, Jan" sort="Kassubek, Jan" uniqKey="Kassubek J" first="Jan" last="Kassubek">Jan Kassubek</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2008" type="published">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Anisotropy</term>
<term>Brain Mapping</term>
<term>Cerebral Cortex (metabolism)</term>
<term>Cerebral Cortex (pathology)</term>
<term>Chi-Square Distribution</term>
<term>Diffusion Magnetic Resonance Imaging (methods)</term>
<term>Female</term>
<term>Humans</term>
<term>Image Processing, Computer-Assisted</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Restless Legs Syndrome (pathology)</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cerebral Cortex</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Diffusion Magnetic Resonance Imaging</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Cerebral Cortex</term>
<term>Restless Legs Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Anisotropy</term>
<term>Brain Mapping</term>
<term>Chi-Square Distribution</term>
<term>Female</term>
<term>Humans</term>
<term>Image Processing, Computer-Assisted</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">In search for the pathoanatomical correlate of the restless legs syndrome (RLS), various neuroimaging and electrophysiological techniques have demonstrated partly conflicting results of cortical, subcortical, brainstem, and spinal alterations. In a novel approach, the delineation of potential cerebral white matter tract disruption was investigated by application of quantitative whole brain-based diffusion tensor imaging (DTI) to a well characterized group of 45 patients with idiopathic RLS. The data of patients and 30 healthy controls were statistically compared including computation of regional fractional anisotropy (FA) as a quantitative marker of white matter integrity by use of the tensor imaging and fiber tracking software. In the patient group, multiple subcortical areas of significantly reduced FA were observed bihemispherically in close proximity to the primary and associate motor and somatosensory cortices, in the right-hemispheric thalamus (posterior ventral lateral nucleus), in motor projectional fibers and adjacent to the left anterior cingulum. Together with the results of a recent study by use of an MRI-based gray matter analysis, which localized RLS-associated changes in the sensorimotor cortices, these findings gave support to an altered subcortical network, with the major component of altered cerebral sensorimotor pathways, within a hodological concept of the RLS pathoanatomy.</div>
</front>
</TEI>
</PubMed>
</double>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003529 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 003529 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Main |étape= Merge |type= RBID |clé= ISTEX:29454DDF5E7E412B3BB05D5E7A75AF5885FDDF16 |texte= Cerebral white matter alterations in idiopathic restless legs syndrome, as measured by diffusion tensor imaging }}
![]() | This area was generated with Dilib version V0.6.23. | ![]() |