MovDisordV3, PascalFrancis, Corpus, bibRecord, 001201

Cerebral White Matter Alterations in Idiopathic Restless Legs Syndrome, as Measured by Diffusion Tensor Imaging

Identifieur interne : 001201 ( PascalFrancis/Corpus ); précédent : 001200; suivant : 001202

Cerebral White Matter Alterations in Idiopathic Restless Legs Syndrome, as Measured by Diffusion Tensor Imaging

Auteurs : Alexander Unrath ; Hans-Peter Müller ; Albert C. Ludolph ; Axel Riecker ; Jan Kassubek

Source :

Movement disorders [ 0885-3185 ] ; 2008.

RBID : Pascal:08-0396182

Descripteurs français

Pascal (Inist)
- Syndrome des jambes sans repos, Pathologie du système nerveux, Encéphale, Substance blanche, Idiopathique, Tenseur de diffusion, Imagerie RMN, Imagerie de diffusion.

English descriptors

KwdEn :
- Diffusion imaging, Diffusion tensor, Encephalon, Idiopathic, Nervous system diseases, Nuclear magnetic resonance imaging, Restless legs syndrome, White matter.

Abstract

: In search for the pathoanatomical correlate of the restless legs syndrome (RLS), various neuroimaging and electrophysiological techniques have demonstrated partly conflicting results of cortical, subcortical, brainstem, and spinal alterations. In a novel approach, the delineation of potential cerebral white matter tract disruption was investigated by application of quantitative whole brain-based diffusion tensor imaging (DTI) to a well characterized group of 45 patients with idiopathic RLS. The data of patients and 30 healthy controls were statistically compared including computation of regional fractional anisotropy (FA) as a quantitative marker of white matter integrity by use of the tensor imaging and fiber tracking software. In the patient group, multiple subcortical areas of significantly reduced FA were observed bihemispherically in close proximity to the primary and associate motor and somatosensory cortices, in the right-hemispheric thalamus (posterior ventral lateral nucleus), in motor projectional fibers and adjacent to the left anterior cingulum. Together with the results of a recent study by use of an MRI-based gray matter analysis, which localized RLS-associated changes in the sensorimotor cortices, these findings gave support to an altered subcortical network, with the major component of altered cerebral sensorimotor pathways, within a hodological concept of the RLS pathoanatomy.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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C01	`01`		`ENG`	@0 : In search for the pathoanatomical correlate of the restless legs syndrome (RLS), various neuroimaging and electrophysiological techniques have demonstrated partly conflicting results of cortical, subcortical, brainstem, and spinal alterations. In a novel approach, the delineation of potential cerebral white matter tract disruption was investigated by application of quantitative whole brain-based diffusion tensor imaging (DTI) to a well characterized group of 45 patients with idiopathic RLS. The data of patients and 30 healthy controls were statistically compared including computation of regional fractional anisotropy (FA) as a quantitative marker of white matter integrity by use of the tensor imaging and fiber tracking software. In the patient group, multiple subcortical areas of significantly reduced FA were observed bihemispherically in close proximity to the primary and associate motor and somatosensory cortices, in the right-hemispheric thalamus (posterior ventral lateral nucleus), in motor projectional fibers and adjacent to the left anterior cingulum. Together with the results of a recent study by use of an MRI-based gray matter analysis, which localized RLS-associated changes in the sensorimotor cortices, these findings gave support to an altered subcortical network, with the major component of altered cerebral sensorimotor pathways, within a hodological concept of the RLS pathoanatomy.
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Format Inist (serveur)

NO :	PASCAL 08-0396182 INIST
ET :	Cerebral White Matter Alterations in Idiopathic Restless Legs Syndrome, as Measured by Diffusion Tensor Imaging
AU :	UNRATH (Alexander); MÜLLER (Hans-Peter); LUDOLPH (Albert C.); RIECKER (Axel); KASSUBEK (Jan)
AF :	Department of Neurology, University of Ulm/Ulm/Allemagne (1 aut., 2 aut., 3 aut., 4 aut., 5 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 9; Pp. 1250-1255; Bibl. 29 ref.
LA :	Anglais
EA :	: In search for the pathoanatomical correlate of the restless legs syndrome (RLS), various neuroimaging and electrophysiological techniques have demonstrated partly conflicting results of cortical, subcortical, brainstem, and spinal alterations. In a novel approach, the delineation of potential cerebral white matter tract disruption was investigated by application of quantitative whole brain-based diffusion tensor imaging (DTI) to a well characterized group of 45 patients with idiopathic RLS. The data of patients and 30 healthy controls were statistically compared including computation of regional fractional anisotropy (FA) as a quantitative marker of white matter integrity by use of the tensor imaging and fiber tracking software. In the patient group, multiple subcortical areas of significantly reduced FA were observed bihemispherically in close proximity to the primary and associate motor and somatosensory cortices, in the right-hemispheric thalamus (posterior ventral lateral nucleus), in motor projectional fibers and adjacent to the left anterior cingulum. Together with the results of a recent study by use of an MRI-based gray matter analysis, which localized RLS-associated changes in the sensorimotor cortices, these findings gave support to an altered subcortical network, with the major component of altered cerebral sensorimotor pathways, within a hodological concept of the RLS pathoanatomy.
CC :	002B17; 002B17C
FD :	Syndrome des jambes sans repos; Pathologie du système nerveux; Encéphale; Substance blanche; Idiopathique; Tenseur de diffusion; Imagerie RMN; Imagerie de diffusion
FG :	Système nerveux central; Trouble neurologique; Trouble de la sensibilité
ED :	Restless legs syndrome; Nervous system diseases; Encephalon; White matter; Idiopathic; Diffusion tensor; Nuclear magnetic resonance imaging; Diffusion imaging
EG :	Central nervous system; Neurological disorder; Sensitivity disorder
SD :	Acroparestesia nocturna; Sistema nervioso patología; Encéfalo; Substancia blanca; Idiopático; Tensor de difusión; Imaginería RMN
LO :	INIST-20953.354000196264160080
ID :	08-0396182

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Pascal:08-0396182

Le document en format XML

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<front><div type="abstract" xml:lang="en">: In search for the pathoanatomical correlate of the restless legs syndrome (RLS), various neuroimaging and electrophysiological techniques have demonstrated partly conflicting results of cortical, subcortical, brainstem, and spinal alterations. In a novel approach, the delineation of potential cerebral white matter tract disruption was investigated by application of quantitative whole brain-based diffusion tensor imaging (DTI) to a well characterized group of 45 patients with idiopathic RLS. The data of patients and 30 healthy controls were statistically compared including computation of regional fractional anisotropy (FA) as a quantitative marker of white matter integrity by use of the tensor imaging and fiber tracking software. In the patient group, multiple subcortical areas of significantly reduced FA were observed bihemispherically in close proximity to the primary and associate motor and somatosensory cortices, in the right-hemispheric thalamus (posterior ventral lateral nucleus), in motor projectional fibers and adjacent to the left anterior cingulum. Together with the results of a recent study by use of an MRI-based gray matter analysis, which localized RLS-associated changes in the sensorimotor cortices, these findings gave support to an altered subcortical network, with the major component of altered cerebral sensorimotor pathways, within a hodological concept of the RLS pathoanatomy.</div>
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<server><NO>PASCAL 08-0396182 INIST</NO>
<ET>Cerebral White Matter Alterations in Idiopathic Restless Legs Syndrome, as Measured by Diffusion Tensor Imaging</ET>
<AU>UNRATH (Alexander); MÜLLER (Hans-Peter); LUDOLPH (Albert C.); RIECKER (Axel); KASSUBEK (Jan)</AU>
<AF>Department of Neurology, University of Ulm/Ulm/Allemagne (1 aut., 2 aut., 3 aut., 4 aut., 5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 9; Pp. 1250-1255; Bibl. 29 ref.</SO>
<LA>Anglais</LA>
<EA>: In search for the pathoanatomical correlate of the restless legs syndrome (RLS), various neuroimaging and electrophysiological techniques have demonstrated partly conflicting results of cortical, subcortical, brainstem, and spinal alterations. In a novel approach, the delineation of potential cerebral white matter tract disruption was investigated by application of quantitative whole brain-based diffusion tensor imaging (DTI) to a well characterized group of 45 patients with idiopathic RLS. The data of patients and 30 healthy controls were statistically compared including computation of regional fractional anisotropy (FA) as a quantitative marker of white matter integrity by use of the tensor imaging and fiber tracking software. In the patient group, multiple subcortical areas of significantly reduced FA were observed bihemispherically in close proximity to the primary and associate motor and somatosensory cortices, in the right-hemispheric thalamus (posterior ventral lateral nucleus), in motor projectional fibers and adjacent to the left anterior cingulum. Together with the results of a recent study by use of an MRI-based gray matter analysis, which localized RLS-associated changes in the sensorimotor cortices, these findings gave support to an altered subcortical network, with the major component of altered cerebral sensorimotor pathways, within a hodological concept of the RLS pathoanatomy.</EA>
<CC>002B17; 002B17C</CC>
<FD>Syndrome des jambes sans repos; Pathologie du   système nerveux; Encéphale; Substance blanche; Idiopathique; Tenseur de diffusion; Imagerie RMN; Imagerie de diffusion</FD>
<FG>Système nerveux central; Trouble neurologique; Trouble de la sensibilité</FG>
<ED>Restless legs syndrome; Nervous system diseases; Encephalon; White matter; Idiopathic; Diffusion tensor; Nuclear magnetic resonance imaging; Diffusion imaging</ED>
<EG>Central nervous system; Neurological disorder; Sensitivity disorder</EG>
<SD>Acroparestesia nocturna; Sistema nervioso patología; Encéfalo; Substancia blanca; Idiopático; Tensor de difusión; Imaginería RMN</SD>
<LO>INIST-20953.354000196264160080</LO>
<ID>08-0396182</ID>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Cerebral White Matter Alterations in Idiopathic Restless Legs Syndrome, as Measured by Diffusion Tensor Imaging

Cerebral White Matter Alterations in Idiopathic Restless Legs Syndrome, as Measured by Diffusion Tensor Imaging

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