Cerebral white matter alterations in idiopathic restless legs syndrome, as measured by diffusion tensor imaging
Identifieur interne : 001B67 ( Istex/Corpus ); précédent : 001B66; suivant : 001B68Cerebral white matter alterations in idiopathic restless legs syndrome, as measured by diffusion tensor imaging
Auteurs : Alexander Unrath ; Hans-Peter Müller ; Albert C. Ludolph ; Axel Riecker ; Jan KassubekSource :
- Movement Disorders [ 0885-3185 ] ; 2008-07-15.
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- KwdEn :
Abstract
In search for the pathoanatomical correlate of the restless legs syndrome (RLS), various neuroimaging and electrophysiological techniques have demonstrated partly conflicting results of cortical, subcortical, brainstem, and spinal alterations. In a novel approach, the delineation of potential cerebral white matter tract disruption was investigated by application of quantitative whole brain‐based diffusion tensor imaging (DTI) to a well characterized group of 45 patients with idiopathic RLS. The data of patients and 30 healthy controls were statistically compared including computation of regional fractional anisotropy (FA) as a quantitative marker of white matter integrity by use of the tensor imaging and fiber tracking software. In the patient group, multiple subcortical areas of significantly reduced FA were observed bihemispherically in close proximity to the primary and associate motor and somatosensory cortices, in the right‐hemispheric thalamus (posterior ventral lateral nucleus), in motor projectional fibers and adjacent to the left anterior cingulum. Together with the results of a recent study by use of an MRI‐based gray matter analysis, which localized RLS‐associated changes in the sensorimotor cortices, these findings gave support to an altered subcortical network, with the major component of altered cerebral sensorimotor pathways, within a hodological concept of the RLS pathoanatomy. © 2008 Movement Disorder Society
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DOI: 10.1002/mds.22074
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In a novel approach, the delineation of potential cerebral white matter tract disruption was investigated by application of quantitative whole brain‐based diffusion tensor imaging (DTI) to a well characterized group of 45 patients with idiopathic RLS. The data of patients and 30 healthy controls were statistically compared including computation of regional fractional anisotropy (FA) as a quantitative marker of white matter integrity by use of the tensor imaging and fiber tracking software. In the patient group, multiple subcortical areas of significantly reduced FA were observed bihemispherically in close proximity to the primary and associate motor and somatosensory cortices, in the right‐hemispheric thalamus (posterior ventral lateral nucleus), in motor projectional fibers and adjacent to the left anterior cingulum. Together with the results of a recent study by use of an MRI‐based gray matter analysis, which localized RLS‐associated changes in the sensorimotor cortices, these findings gave support to an altered subcortical network, with the major component of altered cerebral sensorimotor pathways, within a hodological concept of the RLS pathoanatomy. © 2008 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Alexander Unrath MD</name><affiliations><json:string>Department of Neurology, University of Ulm, Ulm, Germany</json:string></affiliations></json:item><json:item><name>Hans‐Peter Müller PhD</name><affiliations><json:string>Department of Neurology, University of Ulm, Ulm, Germany</json:string></affiliations></json:item><json:item><name>Albert C. 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Together with the results of a recent study by use of an MRI‐based gray matter analysis, which localized RLS‐associated changes in the sensorimotor cortices, these findings gave support to an altered subcortical network, with the major component of altered cerebral sensorimotor pathways, within a hodological concept of the RLS pathoanatomy. © 2008 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Cerebral white matter alterations in idiopathic restless legs syndrome, as measured by diffusion tensor imaging</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>DTI in RLS</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Cerebral white matter alterations in idiopathic restless legs syndrome, as measured by diffusion tensor imaging</title></titleInfo><name type="personal"><namePart type="given">Alexander</namePart><namePart type="family">Unrath</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University of Ulm, Ulm, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hans‐Peter</namePart><namePart type="family">Müller</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurology, University of Ulm, Ulm, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Albert C.</namePart><namePart type="family">Ludolph</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University of Ulm, Ulm, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Axel</namePart><namePart type="family">Riecker</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University of Ulm, Ulm, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jan</namePart><namePart type="family">Kassubek</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University of Ulm, Ulm, Germany</affiliation><description>Correspondence: Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2008-07-15</dateIssued><dateCaptured encoding="w3cdtf">2007-12-10</dateCaptured><dateValid encoding="w3cdtf">2008-03-15</dateValid><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">1</extent><extent unit="references">29</extent><extent unit="words">4217</extent></physicalDescription><abstract lang="en">In search for the pathoanatomical correlate of the restless legs syndrome (RLS), various neuroimaging and electrophysiological techniques have demonstrated partly conflicting results of cortical, subcortical, brainstem, and spinal alterations. In a novel approach, the delineation of potential cerebral white matter tract disruption was investigated by application of quantitative whole brain‐based diffusion tensor imaging (DTI) to a well characterized group of 45 patients with idiopathic RLS. The data of patients and 30 healthy controls were statistically compared including computation of regional fractional anisotropy (FA) as a quantitative marker of white matter integrity by use of the tensor imaging and fiber tracking software. In the patient group, multiple subcortical areas of significantly reduced FA were observed bihemispherically in close proximity to the primary and associate motor and somatosensory cortices, in the right‐hemispheric thalamus (posterior ventral lateral nucleus), in motor projectional fibers and adjacent to the left anterior cingulum. Together with the results of a recent study by use of an MRI‐based gray matter analysis, which localized RLS‐associated changes in the sensorimotor cortices, these findings gave support to an altered subcortical network, with the major component of altered cerebral sensorimotor pathways, within a hodological concept of the RLS pathoanatomy. © 2008 Movement Disorder Society</abstract><subject lang="en"><genre>Keywords</genre><topic>magnetic resonance imaging</topic><topic>diffusion tensor imaging</topic><topic>white matter</topic><topic>motor and premotor region</topic><topic>restless legs syndrome</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><detail type="issue"><caption>no.</caption><number>9</number></detail><extent unit="pages"><start>1250</start><end>1255</end><total>6</total></extent></part></relatedItem><identifier type="istex">29454DDF5E7E412B3BB05D5E7A75AF5885FDDF16</identifier><identifier type="DOI">10.1002/mds.22074</identifier><identifier type="ArticleID">MDS22074</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2008 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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