Dopamine transporter single photon emission computerized tomography in the diagnosis of dementia with Lewy bodies
Identifieur interne : 002343 ( Main/Exploration ); précédent : 002342; suivant : 002344Dopamine transporter single photon emission computerized tomography in the diagnosis of dementia with Lewy bodies
Auteurs : Rodney W. H. Walker [Royaume-Uni] ; Zuzana Walker [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2009.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Autopsy, Diagnosis, Dopamine, Dopamine Plasma Membrane Transport Proteins (metabolism), Humans, Lewy Body Disease (diagnosis), Lewy Body Disease (radionuclide imaging), Lewy bodies, Lewy body, Lewy body dementia, Neostriatum (radionuclide imaging), Nervous system diseases, Neuropsychological Tests, Photon, SPECT, Single photon emission tomography, Substantia Nigra (radionuclide imaging), Tomography, Emission-Computed, Single-Photon (methods), dementia.
- MESH :
- chemical , metabolism : Dopamine Plasma Membrane Transport Proteins.
- diagnosis : Lewy Body Disease.
- methods : Tomography, Emission-Computed, Single-Photon.
- radionuclide imaging : Lewy Body Disease, Neostriatum, Substantia Nigra.
- Autopsy, Humans, Neuropsychological Tests.
Abstract
Dementia with Lewy bodies (DLB) is part of the spectrum of Lewy body disorders. However, it may be difficult to diagnose patients who have dementia but no Parkinsonism. Visual and semiquantitative assessment of the nigrostriatal dopaminergic nerve terminals in the putamen and caudate nuclei can be obtained with single photon emission computerized tomography (SPECT) using ligands that bind to the dopamine transporter molecule in the membranes of the nigrostriatal nerve terminals. This can be employed as a means of identifying subclinical degeneration of nigrostriatal neurones in patients with suspected DLB, increasing the probability of the diagnosis. In several studies, the sensitivity and specificity of abnormal dopamine transporter scans with regard to diagnosing probable DLB are better than 75 and 90%, respectively. This communication outlines the evidence for this and discusses some of the advantages, potential disadvantages, and areas of uncertainty with regard to the use of dopamine transporter SPECT in DLB diagnosis. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22591
Affiliations:
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009">2009</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">S2</biblScope><biblScope unit="page" from="S754">S754</biblScope><biblScope unit="page" to="S759">S759</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">F65510E731489E3F1BA4023C3B74F459D835E07D</idno><idno type="DOI">10.1002/mds.22591</idno><idno type="ArticleID">MDS22591</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Autopsy</term><term>Diagnosis</term><term>Dopamine</term><term>Dopamine Plasma Membrane Transport Proteins (metabolism)</term><term>Humans</term><term>Lewy Body Disease (diagnosis)</term><term>Lewy Body Disease (radionuclide imaging)</term><term>Lewy bodies</term><term>Lewy body</term><term>Lewy body dementia</term><term>Neostriatum (radionuclide imaging)</term><term>Nervous system diseases</term><term>Neuropsychological Tests</term><term>Photon</term><term>SPECT</term><term>Single photon emission tomography</term><term>Substantia Nigra (radionuclide imaging)</term><term>Tomography, Emission-Computed, Single-Photon (methods)</term><term>dementia</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine Plasma Membrane Transport Proteins</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Lewy Body Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Lewy Body Disease</term><term>Neostriatum</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Autopsy</term><term>Humans</term><term>Neuropsychological Tests</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Corps Lewy</term><term>Diagnostic</term><term>Dopamine</term><term>Démence à corps de Lewy</term><term>Pathologie du système nerveux</term><term>Photon</term><term>Tomoscintigraphie émission monophotonique</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dementia with Lewy bodies (DLB) is part of the spectrum of Lewy body disorders. However, it may be difficult to diagnose patients who have dementia but no Parkinsonism. Visual and semiquantitative assessment of the nigrostriatal dopaminergic nerve terminals in the putamen and caudate nuclei can be obtained with single photon emission computerized tomography (SPECT) using ligands that bind to the dopamine transporter molecule in the membranes of the nigrostriatal nerve terminals. This can be employed as a means of identifying subclinical degeneration of nigrostriatal neurones in patients with suspected DLB, increasing the probability of the diagnosis. In several studies, the sensitivity and specificity of abnormal dopamine transporter scans with regard to diagnosing probable DLB are better than 75 and 90%, respectively. This communication outlines the evidence for this and discusses some of the advantages, potential disadvantages, and areas of uncertainty with regard to the use of dopamine transporter SPECT in DLB diagnosis. © 2009 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Walker, Rodney W H" sort="Walker, Rodney W H" uniqKey="Walker R" first="Rodney W. H." last="Walker">Rodney W. H. Walker</name></region><name sortKey="Walker, Zuzana" sort="Walker, Zuzana" uniqKey="Walker Z" first="Zuzana" last="Walker">Zuzana Walker</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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