Dopamine Transporter Single Photon Emission Computerized Tomography in the Diagnosis of Dementia with Lewy Bodies
Identifieur interne : 003002 ( Main/Merge ); précédent : 003001; suivant : 003003Dopamine Transporter Single Photon Emission Computerized Tomography in the Diagnosis of Dementia with Lewy Bodies
Auteurs : Rodney W. H. Walker [Royaume-Uni] ; Zuzana Walker [Royaume-Uni]Source :
- Movement disorders [ 0885-3185 ] ; 2009.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Dementia with Lewy bodies (DLB) is part of the spectrum of Lewy body disorders. However, it may be difficult to diagnose patients who have dementia but no Parkinsonism. Visual and semiquantitative assessment of the nigrostriatal dopaminergic nerve terminals in the putamen and caudate nuclei can be obtained with single photon emission computerized tomography (SPECT) using ligands that bind to the dopamine transporter molecule in the membranes of the nigrostriatal nerve terminals. This can be employed as a means of identifying subclinical degeneration of nigrostriatal neurones in patients with suspected DLB, increasing the probability of the diagnosis. In several studies, the sensitivity and specificity of abnormal dopamine transporter scans with regard to diagnosing probable DLB are better than 75 and 90%, respectively. This communication outlines the evidence for this and discusses some of the advantages, potential disadvantages, and areas of uncertainty with regard to the use of dopamine transporter SPECT in DLB diagnosis.
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000C79
- to stream PascalFrancis, to step Curation: 002040
- to stream PascalFrancis, to step Checkpoint: 000F05
Links to Exploration step
Pascal:10-0038125Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Dopamine Transporter Single Photon Emission Computerized Tomography in the Diagnosis of Dementia with Lewy Bodies</title><author><name sortKey="Walker, Rodney W H" sort="Walker, Rodney W H" uniqKey="Walker R" first="Rodney W. H." last="Walker">Rodney W. H. Walker</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Barts and The London NHS Trust</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Walker, Zuzana" sort="Walker, Zuzana" uniqKey="Walker Z" first="Zuzana" last="Walker">Zuzana Walker</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Deparment of Mental Health Sciences, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>2 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">10-0038125</idno><date when="2009">2009</date><idno type="stanalyst">PASCAL 10-0038125 INIST</idno><idno type="RBID">Pascal:10-0038125</idno><idno type="wicri:Area/PascalFrancis/Corpus">000C79</idno><idno type="wicri:Area/PascalFrancis/Curation">002040</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000F05</idno><idno type="wicri:doubleKey">0885-3185:2009:Walker R:dopamine:transporter:single</idno><idno type="wicri:Area/Main/Merge">003002</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Dopamine Transporter Single Photon Emission Computerized Tomography in the Diagnosis of Dementia with Lewy Bodies</title><author><name sortKey="Walker, Rodney W H" sort="Walker, Rodney W H" uniqKey="Walker R" first="Rodney W. H." last="Walker">Rodney W. H. Walker</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Barts and The London NHS Trust</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Walker, Zuzana" sort="Walker, Zuzana" uniqKey="Walker Z" first="Zuzana" last="Walker">Zuzana Walker</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Deparment of Mental Health Sciences, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>2 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Diagnosis</term><term>Dopamine</term><term>Lewy body</term><term>Lewy body dementia</term><term>Nervous system diseases</term><term>Photon</term><term>Single photon emission tomography</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Démence à corps de Lewy</term><term>Pathologie du système nerveux</term><term>Dopamine</term><term>Tomoscintigraphie émission monophotonique</term><term>Diagnostic</term><term>Corps Lewy</term><term>Photon</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dementia with Lewy bodies (DLB) is part of the spectrum of Lewy body disorders. However, it may be difficult to diagnose patients who have dementia but no Parkinsonism. Visual and semiquantitative assessment of the nigrostriatal dopaminergic nerve terminals in the putamen and caudate nuclei can be obtained with single photon emission computerized tomography (SPECT) using ligands that bind to the dopamine transporter molecule in the membranes of the nigrostriatal nerve terminals. This can be employed as a means of identifying subclinical degeneration of nigrostriatal neurones in patients with suspected DLB, increasing the probability of the diagnosis. In several studies, the sensitivity and specificity of abnormal dopamine transporter scans with regard to diagnosing probable DLB are better than 75 and 90%, respectively. This communication outlines the evidence for this and discusses some of the advantages, potential disadvantages, and areas of uncertainty with regard to the use of dopamine transporter SPECT in DLB diagnosis.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Walker, Rodney W H" sort="Walker, Rodney W H" uniqKey="Walker R" first="Rodney W. H." last="Walker">Rodney W. H. Walker</name></region><name sortKey="Walker, Zuzana" sort="Walker, Zuzana" uniqKey="Walker Z" first="Zuzana" last="Walker">Zuzana Walker</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003002 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 003002 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Merge
|type= RBID
|clé= Pascal:10-0038125
|texte= Dopamine Transporter Single Photon Emission Computerized Tomography in the Diagnosis of Dementia with Lewy Bodies
}}
| This area was generated with Dilib version V0.6.23. |  |