Dopamine transporter single photon emission computerized tomography in the diagnosis of dementia with Lewy bodies
Identifieur interne : 002C04 ( Main/Merge ); précédent : 002C03; suivant : 002C05Dopamine transporter single photon emission computerized tomography in the diagnosis of dementia with Lewy bodies
Auteurs : Rodney W. H. Walker [Royaume-Uni] ; Zuzana Walker [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2009.
English descriptors
- KwdEn :
- Autopsy, Dopamine Plasma Membrane Transport Proteins (metabolism), Humans, Lewy Body Disease (diagnosis), Lewy Body Disease (radionuclide imaging), Lewy bodies, Neostriatum (radionuclide imaging), Neuropsychological Tests, SPECT, Substantia Nigra (radionuclide imaging), Tomography, Emission-Computed, Single-Photon (methods), dementia.
- MESH :
- chemical , metabolism : Dopamine Plasma Membrane Transport Proteins.
- diagnosis : Lewy Body Disease.
- methods : Tomography, Emission-Computed, Single-Photon.
- radionuclide imaging : Lewy Body Disease, Neostriatum, Substantia Nigra.
- Autopsy, Humans, Neuropsychological Tests.
Abstract
Dementia with Lewy bodies (DLB) is part of the spectrum of Lewy body disorders. However, it may be difficult to diagnose patients who have dementia but no Parkinsonism. Visual and semiquantitative assessment of the nigrostriatal dopaminergic nerve terminals in the putamen and caudate nuclei can be obtained with single photon emission computerized tomography (SPECT) using ligands that bind to the dopamine transporter molecule in the membranes of the nigrostriatal nerve terminals. This can be employed as a means of identifying subclinical degeneration of nigrostriatal neurones in patients with suspected DLB, increasing the probability of the diagnosis. In several studies, the sensitivity and specificity of abnormal dopamine transporter scans with regard to diagnosing probable DLB are better than 75 and 90%, respectively. This communication outlines the evidence for this and discusses some of the advantages, potential disadvantages, and areas of uncertainty with regard to the use of dopamine transporter SPECT in DLB diagnosis. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22591
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Walker</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurology, Barts and The London NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Walker, Zuzana" sort="Walker, Zuzana" uniqKey="Walker Z" first="Zuzana" last="Walker">Zuzana Walker</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Deparment of Mental Health Sciences, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009">2009</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">S2</biblScope><biblScope unit="page" from="S754">S754</biblScope><biblScope unit="page" to="S759">S759</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">F65510E731489E3F1BA4023C3B74F459D835E07D</idno><idno type="DOI">10.1002/mds.22591</idno><idno type="ArticleID">MDS22591</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Lewy bodies</term><term>SPECT</term><term>dementia</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dementia with Lewy bodies (DLB) is part of the spectrum of Lewy body disorders. However, it may be difficult to diagnose patients who have dementia but no Parkinsonism. Visual and semiquantitative assessment of the nigrostriatal dopaminergic nerve terminals in the putamen and caudate nuclei can be obtained with single photon emission computerized tomography (SPECT) using ligands that bind to the dopamine transporter molecule in the membranes of the nigrostriatal nerve terminals. This can be employed as a means of identifying subclinical degeneration of nigrostriatal neurones in patients with suspected DLB, increasing the probability of the diagnosis. In several studies, the sensitivity and specificity of abnormal dopamine transporter scans with regard to diagnosing probable DLB are better than 75 and 90%, respectively. This communication outlines the evidence for this and discusses some of the advantages, potential disadvantages, and areas of uncertainty with regard to the use of dopamine transporter SPECT in DLB diagnosis. © 2009 Movement Disorder Society</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Dopamine transporter single photon emission computerized tomography in the diagnosis of dementia with Lewy bodies.</title><author><name sortKey="Walker, Rodney W H" sort="Walker, Rodney W H" uniqKey="Walker R" first="Rodney W H" last="Walker">Rodney W H. Walker</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Barts and The London NHS Trust, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurology, Barts and The London NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Walker, Zuzana" sort="Walker, Zuzana" uniqKey="Walker Z" first="Zuzana" last="Walker">Zuzana Walker</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="doi">10.1002/mds.22591</idno><idno type="RBID">pubmed:19877236</idno><idno type="pmid">19877236</idno><idno type="wicri:Area/PubMed/Corpus">001B19</idno><idno type="wicri:Area/PubMed/Curation">001B19</idno><idno type="wicri:Area/PubMed/Checkpoint">001E46</idno><idno type="wicri:Area/Ncbi/Merge">002864</idno><idno type="wicri:Area/Ncbi/Curation">002864</idno><idno type="wicri:Area/Ncbi/Checkpoint">002864</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Dopamine transporter single photon emission computerized tomography in the diagnosis of dementia with Lewy bodies.</title><author><name sortKey="Walker, Rodney W H" sort="Walker, Rodney W H" uniqKey="Walker R" first="Rodney W H" last="Walker">Rodney W H. Walker</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Barts and The London NHS Trust, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurology, Barts and The London NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Walker, Zuzana" sort="Walker, Zuzana" uniqKey="Walker Z" first="Zuzana" last="Walker">Zuzana Walker</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Autopsy</term><term>Dopamine Plasma Membrane Transport Proteins (metabolism)</term><term>Humans</term><term>Lewy Body Disease (diagnosis)</term><term>Lewy Body Disease (radionuclide imaging)</term><term>Neostriatum (radionuclide imaging)</term><term>Neuropsychological Tests</term><term>Substantia Nigra (radionuclide imaging)</term><term>Tomography, Emission-Computed, Single-Photon (methods)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine Plasma Membrane Transport Proteins</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Lewy Body Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Lewy Body Disease</term><term>Neostriatum</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Autopsy</term><term>Humans</term><term>Neuropsychological Tests</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dementia with Lewy bodies (DLB) is part of the spectrum of Lewy body disorders. However, it may be difficult to diagnose patients who have dementia but no Parkinsonism. Visual and semiquantitative assessment of the nigrostriatal dopaminergic nerve terminals in the putamen and caudate nuclei can be obtained with single photon emission computerized tomography (SPECT) using ligands that bind to the dopamine transporter molecule in the membranes of the nigrostriatal nerve terminals. This can be employed as a means of identifying subclinical degeneration of nigrostriatal neurones in patients with suspected DLB, increasing the probability of the diagnosis. In several studies, the sensitivity and specificity of abnormal dopamine transporter scans with regard to diagnosing probable DLB are better than 75 and 90%, respectively. This communication outlines the evidence for this and discusses some of the advantages, potential disadvantages, and areas of uncertainty with regard to the use of dopamine transporter SPECT in DLB diagnosis.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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