Dopamine Transporter Single Photon Emission Computerized Tomography in the Diagnosis of Dementia with Lewy Bodies
Identifieur interne : 000F05 ( PascalFrancis/Checkpoint ); précédent : 000F04; suivant : 000F06Dopamine Transporter Single Photon Emission Computerized Tomography in the Diagnosis of Dementia with Lewy Bodies
Auteurs : Rodney W. H. Walker [Royaume-Uni] ; Zuzana Walker [Royaume-Uni]Source :
- Movement disorders [ 0885-3185 ] ; 2009.
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Abstract
Dementia with Lewy bodies (DLB) is part of the spectrum of Lewy body disorders. However, it may be difficult to diagnose patients who have dementia but no Parkinsonism. Visual and semiquantitative assessment of the nigrostriatal dopaminergic nerve terminals in the putamen and caudate nuclei can be obtained with single photon emission computerized tomography (SPECT) using ligands that bind to the dopamine transporter molecule in the membranes of the nigrostriatal nerve terminals. This can be employed as a means of identifying subclinical degeneration of nigrostriatal neurones in patients with suspected DLB, increasing the probability of the diagnosis. In several studies, the sensitivity and specificity of abnormal dopamine transporter scans with regard to diagnosing probable DLB are better than 75 and 90%, respectively. This communication outlines the evidence for this and discusses some of the advantages, potential disadvantages, and areas of uncertainty with regard to the use of dopamine transporter SPECT in DLB diagnosis.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Dopamine Transporter Single Photon Emission Computerized Tomography in the Diagnosis of Dementia with Lewy Bodies</title><author><name sortKey="Walker, Rodney W H" sort="Walker, Rodney W H" uniqKey="Walker R" first="Rodney W. H." last="Walker">Rodney W. H. Walker</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Barts and The London NHS Trust</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Walker, Zuzana" sort="Walker, Zuzana" uniqKey="Walker Z" first="Zuzana" last="Walker">Zuzana Walker</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Deparment of Mental Health Sciences, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>2 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">10-0038125</idno><date when="2009">2009</date><idno type="stanalyst">PASCAL 10-0038125 INIST</idno><idno type="RBID">Pascal:10-0038125</idno><idno type="wicri:Area/PascalFrancis/Corpus">000C79</idno><idno type="wicri:Area/PascalFrancis/Curation">002040</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000F05</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Dopamine Transporter Single Photon Emission Computerized Tomography in the Diagnosis of Dementia with Lewy Bodies</title><author><name sortKey="Walker, Rodney W H" sort="Walker, Rodney W H" uniqKey="Walker R" first="Rodney W. H." last="Walker">Rodney W. H. Walker</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Barts and The London NHS Trust</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Walker, Zuzana" sort="Walker, Zuzana" uniqKey="Walker Z" first="Zuzana" last="Walker">Zuzana Walker</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Deparment of Mental Health Sciences, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>2 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Diagnosis</term><term>Dopamine</term><term>Lewy body</term><term>Lewy body dementia</term><term>Nervous system diseases</term><term>Photon</term><term>Single photon emission tomography</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Démence à corps de Lewy</term><term>Pathologie du système nerveux</term><term>Dopamine</term><term>Tomoscintigraphie émission monophotonique</term><term>Diagnostic</term><term>Corps Lewy</term><term>Photon</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dementia with Lewy bodies (DLB) is part of the spectrum of Lewy body disorders. However, it may be difficult to diagnose patients who have dementia but no Parkinsonism. Visual and semiquantitative assessment of the nigrostriatal dopaminergic nerve terminals in the putamen and caudate nuclei can be obtained with single photon emission computerized tomography (SPECT) using ligands that bind to the dopamine transporter molecule in the membranes of the nigrostriatal nerve terminals. This can be employed as a means of identifying subclinical degeneration of nigrostriatal neurones in patients with suspected DLB, increasing the probability of the diagnosis. In several studies, the sensitivity and specificity of abnormal dopamine transporter scans with regard to diagnosing probable DLB are better than 75 and 90%, respectively. This communication outlines the evidence for this and discusses some of the advantages, potential disadvantages, and areas of uncertainty with regard to the use of dopamine transporter SPECT in DLB diagnosis.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>24</s2></fA05><fA06><s2>14</s2><s3>SUP</s3></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Dopamine Transporter Single Photon Emission Computerized Tomography in the Diagnosis of Dementia with Lewy Bodies</s1></fA08><fA09 i1="01" i2="1" l="ENG"><s1>Imaging in Parkinson's Disease</s1></fA09><fA11 i1="01" i2="1"><s1>WALKER (Rodney W. 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H." last="Walker">Rodney W. H. Walker</name></region><name sortKey="Walker, Zuzana" sort="Walker, Zuzana" uniqKey="Walker Z" first="Zuzana" last="Walker">Zuzana Walker</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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