MovDisordV3, Main, Curation, bibRecord, 005228

The “cold hands sign” in multiple system atrophy

Identifieur interne : 005228 ( Main/Curation ); précédent : 005227; suivant : 005229

The “cold hands sign” in multiple system atrophy

Auteurs : Christine Klein [Royaume-Uni] ; Richard Brown [Royaume-Uni] ; Gregor Wenning [Royaume-Uni] ; Quinn [Royaume-Uni]

Source :

Movement Disorders [ 0885-3185 ] ; 1997-07.

RBID : ISTEX:D763791306404D4B8A24789938351722C6C4C5AB

Descripteurs français

Pascal (Inist)
- Atrophie multisystématisée, Diagnostic différentiel, Homme, Main, Parkinson maladie, Signe mains froides, Symptomatologie, Température corporelle.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Atrophy (complications), Atrophy (diagnosis), Atrophy (physiopathology), Autonomic Nervous System (physiopathology), Body temperature, Case-Control Studies, Cold Temperature (adverse effects), Diagnosis, Differential, Differential diagnostic, Female, Hand, Hand (blood supply), Hand (physiopathology), Human, Humans, Male, Multiple system atrophy, Nerve Degeneration, Nervous System (pathology), Parkinson Disease (complications), Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Parkinson disease, Parkinson's disease, Pressure (adverse effects), Skin Temperature, Symptomatology, cold hands sign, skin temperature.
MESH :
- adverse effects : Cold Temperature, Pressure.
- blood supply : Hand.
- complications : Atrophy, Parkinson Disease.
- diagnosis : Atrophy, Parkinson Disease.
- pathology : Nervous System.
- physiopathology : Atrophy, Autonomic Nervous System, Hand, Parkinson Disease.
- Case-Control Studies, Diagnosis, Differential, Female, Humans, Male, Nerve Degeneration, Skin Temperature.

Abstract

Patients with multiple system atrophy (MSA) often have cold, dusky, violaceous hands, with poor circulatory return after blanching by pressure. We therefore compared hand skin temperature in nine age‐matched subjects with probable MSA, 10 with idiopathic Parkinson's disease (PD), and 10 healthy controls both at rest and following a standard cooling procedure. Baseline skin temperature in the MSA group was significantly lower than in both the PD and control groups, and four of the nine MSA patients were colder at baseline than the coldest control value. After cooling, the MSA group also showed a significantly greater reduction in skin temperature than the PD group. The rate of skin temperature recovery did not differ between the three groups, although the MSA group required more time to return completely to their baseline temperature. Changes in skin colour or temperature are easily detected, and suggest a defect in neurovascular control of distal extremities. The “cold hands sign” is another clinical “red flag” that helps to raise the suspicion of MSA.

Url:

https://api.istex.fr/document/D763791306404D4B8A24789938351722C6C4C5AB/fulltext/pdf

DOI: 10.1002/mds.870120407

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ISTEX:D763791306404D4B8A24789938351722C6C4C5AB

Le document en format XML

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<author><name sortKey="Wenning, Gregor" sort="Wenning, Gregor" uniqKey="Wenning G" first="Gregor" last="Wenning">Gregor Wenning</name>
<affiliation wicri:level="2"><country>Royaume-Uni</country>
<placeName><region type="country">Angleterre</region>
</placeName>
<wicri:cityArea>University Department of Clinical Neurology, Queen Square, London</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Quinn" sort="Quinn" uniqKey="Quinn" last="Quinn">Quinn</name>
<affiliation wicri:level="2"><country>Royaume-Uni</country>
<placeName><region type="country">Angleterre</region>
</placeName>
<wicri:cityArea>University Department of Clinical Neurology, Queen Square, London</wicri:cityArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="1997-07">1997-07</date>
<biblScope unit="vol">12</biblScope>
<biblScope unit="issue">4</biblScope>
<biblScope unit="page" from="514">514</biblScope>
<biblScope unit="page" to="518">518</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">D763791306404D4B8A24789938351722C6C4C5AB</idno>
<idno type="DOI">10.1002/mds.870120407</idno>
<idno type="ArticleID">MDS870120407</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Atrophy (complications)</term>
<term>Atrophy (diagnosis)</term>
<term>Atrophy (physiopathology)</term>
<term>Autonomic Nervous System (physiopathology)</term>
<term>Case-Control Studies</term>
<term>Cold Temperature (adverse effects)</term>
<term>Diagnosis, Differential</term>
<term>Female</term>
<term>Hand (blood supply)</term>
<term>Hand (physiopathology)</term>
<term>Humans</term>
<term>Male</term>
<term>Multiple system atrophy</term>
<term>Nerve Degeneration</term>
<term>Nervous System (pathology)</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson's disease</term>
<term>Pressure (adverse effects)</term>
<term>Skin Temperature</term>
<term>cold hands sign</term>
<term>skin temperature</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Cold Temperature</term>
<term>Pressure</term>
</keywords>
<keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Hand</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Atrophy</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Atrophy</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Nervous System</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Atrophy</term>
<term>Autonomic Nervous System</term>
<term>Hand</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Case-Control Studies</term>
<term>Diagnosis, Differential</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Nerve Degeneration</term>
<term>Skin Temperature</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Patients with multiple system atrophy (MSA) often have cold, dusky, violaceous hands, with poor circulatory return after blanching by pressure. We therefore compared hand skin temperature in nine age‐matched subjects with probable MSA, 10 with idiopathic Parkinson's disease (PD), and 10 healthy controls both at rest and following a standard cooling procedure. Baseline skin temperature in the MSA group was significantly lower than in both the PD and control groups, and four of the nine MSA patients were colder at baseline than the coldest control value. After cooling, the MSA group also showed a significantly greater reduction in skin temperature than the PD group. The rate of skin temperature recovery did not differ between the three groups, although the MSA group required more time to return completely to their baseline temperature. Changes in skin colour or temperature are easily detected, and suggest a defect in neurovascular control of distal extremities. The “cold hands sign” is another clinical “red flag” that helps to raise the suspicion of MSA.</div>
</front>
</TEI>
</ISTEX>
</double>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

The “cold hands sign” in multiple system atrophy

The “cold hands sign” in multiple system atrophy

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