The "cold hands sign" in multiple system atrophy.
Identifieur interne : 004D40 ( Ncbi/Curation ); précédent : 004D39; suivant : 004D41The "cold hands sign" in multiple system atrophy.
Auteurs : C. Klein [Royaume-Uni] ; R. Brown ; G. Wenning ; N. QuinnSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1997.
English descriptors
- KwdEn :
- Atrophy (complications), Atrophy (diagnosis), Atrophy (physiopathology), Autonomic Nervous System (physiopathology), Case-Control Studies, Cold Temperature (adverse effects), Diagnosis, Differential, Female, Hand (blood supply), Hand (physiopathology), Humans, Male, Nerve Degeneration, Nervous System (pathology), Parkinson Disease (complications), Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Pressure (adverse effects), Skin Temperature.
- MESH :
- adverse effects : Cold Temperature, Pressure.
- blood supply : Hand.
- complications : Atrophy, Parkinson Disease.
- diagnosis : Atrophy, Parkinson Disease.
- pathology : Nervous System.
- physiopathology : Atrophy, Autonomic Nervous System, Hand, Parkinson Disease.
- Case-Control Studies, Diagnosis, Differential, Female, Humans, Male, Nerve Degeneration, Skin Temperature.
Abstract
Patients with multiple system atrophy (MSA) often have cold, dusky, violaceous hands, with poor circulatory return after blanching by pressure. We therefore compared hand skin temperature in nine age-matched subjects with probable MSA, 10 with idiopathic Parkinson's disease (PD), and 10 healthy controls both at rest and following a standard cooling procedure. Baseline skin temperature in the MSA group was significantly lower than in both the PD and control groups, and four of the nine MSA patients were colder at baseline than the coldest control value. After cooling, the MSA group also showed a significantly greater reduction in skin temperature than the PD group. The rate of skin temperature recovery did not differ between the three groups, although the MSA group required more time to return completely to their baseline temperature. Changes in skin colour or temperature are easily detected, and suggest a defect in neurovascular control of distal extremities. The "cold hands sign" is another clinical "red flag" that helps to raise the suspicion of MSA.
DOI: 10.1002/mds.870120407
PubMed: 9251069
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The "cold hands sign" in multiple system atrophy.</title><author><name sortKey="Klein, C" sort="Klein, C" uniqKey="Klein C" first="C" last="Klein">C. Klein</name><affiliation wicri:level="2"><nlm:affiliation>University Department of Clinical Neurology, Institute of Neurology, London, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University Department of Clinical Neurology, Institute of Neurology, London</wicri:cityArea></affiliation></author><author><name sortKey="Brown, R" sort="Brown, R" uniqKey="Brown R" first="R" last="Brown">R. Brown</name></author><author><name sortKey="Wenning, G" sort="Wenning, G" uniqKey="Wenning G" first="G" last="Wenning">G. Wenning</name></author><author><name sortKey="Quinn, N" sort="Quinn, N" uniqKey="Quinn N" first="N" last="Quinn">N. Quinn</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1997">1997</date><idno type="RBID">pubmed:9251069</idno><idno type="pmid">9251069</idno><idno type="doi">10.1002/mds.870120407</idno><idno type="wicri:Area/PubMed/Corpus">004643</idno><idno type="wicri:Area/PubMed/Curation">004643</idno><idno type="wicri:Area/PubMed/Checkpoint">004558</idno><idno type="wicri:Area/Ncbi/Merge">004D40</idno><idno type="wicri:Area/Ncbi/Curation">004D40</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The "cold hands sign" in multiple system atrophy.</title><author><name sortKey="Klein, C" sort="Klein, C" uniqKey="Klein C" first="C" last="Klein">C. Klein</name><affiliation wicri:level="2"><nlm:affiliation>University Department of Clinical Neurology, Institute of Neurology, London, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University Department of Clinical Neurology, Institute of Neurology, London</wicri:cityArea></affiliation></author><author><name sortKey="Brown, R" sort="Brown, R" uniqKey="Brown R" first="R" last="Brown">R. Brown</name></author><author><name sortKey="Wenning, G" sort="Wenning, G" uniqKey="Wenning G" first="G" last="Wenning">G. Wenning</name></author><author><name sortKey="Quinn, N" sort="Quinn, N" uniqKey="Quinn N" first="N" last="Quinn">N. Quinn</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1997" type="published">1997</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Atrophy (complications)</term><term>Atrophy (diagnosis)</term><term>Atrophy (physiopathology)</term><term>Autonomic Nervous System (physiopathology)</term><term>Case-Control Studies</term><term>Cold Temperature (adverse effects)</term><term>Diagnosis, Differential</term><term>Female</term><term>Hand (blood supply)</term><term>Hand (physiopathology)</term><term>Humans</term><term>Male</term><term>Nerve Degeneration</term><term>Nervous System (pathology)</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (physiopathology)</term><term>Pressure (adverse effects)</term><term>Skin Temperature</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Cold Temperature</term><term>Pressure</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Hand</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Atrophy</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Atrophy</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Nervous System</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Atrophy</term><term>Autonomic Nervous System</term><term>Hand</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Case-Control Studies</term><term>Diagnosis, Differential</term><term>Female</term><term>Humans</term><term>Male</term><term>Nerve Degeneration</term><term>Skin Temperature</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patients with multiple system atrophy (MSA) often have cold, dusky, violaceous hands, with poor circulatory return after blanching by pressure. We therefore compared hand skin temperature in nine age-matched subjects with probable MSA, 10 with idiopathic Parkinson's disease (PD), and 10 healthy controls both at rest and following a standard cooling procedure. Baseline skin temperature in the MSA group was significantly lower than in both the PD and control groups, and four of the nine MSA patients were colder at baseline than the coldest control value. After cooling, the MSA group also showed a significantly greater reduction in skin temperature than the PD group. The rate of skin temperature recovery did not differ between the three groups, although the MSA group required more time to return completely to their baseline temperature. Changes in skin colour or temperature are easily detected, and suggest a defect in neurovascular control of distal extremities. The "cold hands sign" is another clinical "red flag" that helps to raise the suspicion of MSA.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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