The “cold hands sign” in multiple system atrophy
Identifieur interne : 002A51 ( Istex/Curation ); précédent : 002A50; suivant : 002A52The “cold hands sign” in multiple system atrophy
Auteurs : Christine Klein [Royaume-Uni] ; Richard Brown [Royaume-Uni] ; Gregor Wenning [Royaume-Uni] ; Quinn [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 1997-07.
English descriptors
Abstract
Patients with multiple system atrophy (MSA) often have cold, dusky, violaceous hands, with poor circulatory return after blanching by pressure. We therefore compared hand skin temperature in nine age‐matched subjects with probable MSA, 10 with idiopathic Parkinson's disease (PD), and 10 healthy controls both at rest and following a standard cooling procedure. Baseline skin temperature in the MSA group was significantly lower than in both the PD and control groups, and four of the nine MSA patients were colder at baseline than the coldest control value. After cooling, the MSA group also showed a significantly greater reduction in skin temperature than the PD group. The rate of skin temperature recovery did not differ between the three groups, although the MSA group required more time to return completely to their baseline temperature. Changes in skin colour or temperature are easily detected, and suggest a defect in neurovascular control of distal extremities. The “cold hands sign” is another clinical “red flag” that helps to raise the suspicion of MSA.
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DOI: 10.1002/mds.870120407
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">The “cold hands sign” in multiple system atrophy</title><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><affiliation wicri:level="2"><mods:affiliation>University Department of Clinical Neurology, Queen Square, London, England</mods:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University Department of Clinical Neurology, Queen Square, London</wicri:cityArea></affiliation></author><author><name sortKey="Brown, Richard" sort="Brown, Richard" uniqKey="Brown R" first="Richard" last="Brown">Richard Brown</name><affiliation wicri:level="2"><mods:affiliation>MRC Human Movement and Balance Unit, Institute of Neurology, Queen Square, London, England</mods:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>MRC Human Movement and Balance Unit, Institute of Neurology, Queen Square, London</wicri:cityArea></affiliation></author><author><name sortKey="Wenning, Gregor" sort="Wenning, Gregor" uniqKey="Wenning G" first="Gregor" last="Wenning">Gregor Wenning</name><affiliation wicri:level="2"><mods:affiliation>University Department of Clinical Neurology, Queen Square, London, England</mods:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University Department of Clinical Neurology, Queen Square, London</wicri:cityArea></affiliation></author><author><name sortKey="Quinn" sort="Quinn" uniqKey="Quinn" last="Quinn">Quinn</name><affiliation wicri:level="2"><mods:affiliation>University Department of Clinical Neurology, Queen Square, London, England</mods:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University Department of Clinical Neurology, Queen Square, London</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D763791306404D4B8A24789938351722C6C4C5AB</idno><date when="1997" year="1997">1997</date><idno type="doi">10.1002/mds.870120407</idno><idno type="url">https://api.istex.fr/document/D763791306404D4B8A24789938351722C6C4C5AB/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002A51</idno><idno type="wicri:Area/Istex/Curation">002A51</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">The “cold hands sign” in multiple system atrophy</title><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><affiliation wicri:level="2"><mods:affiliation>University Department of Clinical Neurology, Queen Square, London, England</mods:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University Department of Clinical Neurology, Queen Square, London</wicri:cityArea></affiliation></author><author><name sortKey="Brown, Richard" sort="Brown, Richard" uniqKey="Brown R" first="Richard" last="Brown">Richard Brown</name><affiliation wicri:level="2"><mods:affiliation>MRC Human Movement and Balance Unit, Institute of Neurology, Queen Square, London, England</mods:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>MRC Human Movement and Balance Unit, Institute of Neurology, Queen Square, London</wicri:cityArea></affiliation></author><author><name sortKey="Wenning, Gregor" sort="Wenning, Gregor" uniqKey="Wenning G" first="Gregor" last="Wenning">Gregor Wenning</name><affiliation wicri:level="2"><mods:affiliation>University Department of Clinical Neurology, Queen Square, London, England</mods:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University Department of Clinical Neurology, Queen Square, London</wicri:cityArea></affiliation></author><author><name sortKey="Quinn" sort="Quinn" uniqKey="Quinn" last="Quinn">Quinn</name><affiliation wicri:level="2"><mods:affiliation>University Department of Clinical Neurology, Queen Square, London, England</mods:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University Department of Clinical Neurology, Queen Square, London</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1997-07">1997-07</date><biblScope unit="vol">12</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="514">514</biblScope><biblScope unit="page" to="518">518</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">D763791306404D4B8A24789938351722C6C4C5AB</idno><idno type="DOI">10.1002/mds.870120407</idno><idno type="ArticleID">MDS870120407</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Multiple system atrophy</term><term>Parkinson's disease</term><term>cold hands sign</term><term>skin temperature</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patients with multiple system atrophy (MSA) often have cold, dusky, violaceous hands, with poor circulatory return after blanching by pressure. We therefore compared hand skin temperature in nine age‐matched subjects with probable MSA, 10 with idiopathic Parkinson's disease (PD), and 10 healthy controls both at rest and following a standard cooling procedure. Baseline skin temperature in the MSA group was significantly lower than in both the PD and control groups, and four of the nine MSA patients were colder at baseline than the coldest control value. After cooling, the MSA group also showed a significantly greater reduction in skin temperature than the PD group. The rate of skin temperature recovery did not differ between the three groups, although the MSA group required more time to return completely to their baseline temperature. Changes in skin colour or temperature are easily detected, and suggest a defect in neurovascular control of distal extremities. The “cold hands sign” is another clinical “red flag” that helps to raise the suspicion of MSA.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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