Movement Disorders (revue)

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The “cold hands sign” in multiple system atrophy

Identifieur interne : 002A51 ( Istex/Corpus ); précédent : 002A50; suivant : 002A52

The “cold hands sign” in multiple system atrophy

Auteurs : Christine Klein ; Richard Brown ; Gregor Wenning ; Quinn

Source :

RBID : ISTEX:D763791306404D4B8A24789938351722C6C4C5AB

English descriptors

Abstract

Patients with multiple system atrophy (MSA) often have cold, dusky, violaceous hands, with poor circulatory return after blanching by pressure. We therefore compared hand skin temperature in nine age‐matched subjects with probable MSA, 10 with idiopathic Parkinson's disease (PD), and 10 healthy controls both at rest and following a standard cooling procedure. Baseline skin temperature in the MSA group was significantly lower than in both the PD and control groups, and four of the nine MSA patients were colder at baseline than the coldest control value. After cooling, the MSA group also showed a significantly greater reduction in skin temperature than the PD group. The rate of skin temperature recovery did not differ between the three groups, although the MSA group required more time to return completely to their baseline temperature. Changes in skin colour or temperature are easily detected, and suggest a defect in neurovascular control of distal extremities. The “cold hands sign” is another clinical “red flag” that helps to raise the suspicion of MSA.

Url:
DOI: 10.1002/mds.870120407

Links to Exploration step

ISTEX:D763791306404D4B8A24789938351722C6C4C5AB

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<abstract lang="en">Patients with multiple system atrophy (MSA) often have cold, dusky, violaceous hands, with poor circulatory return after blanching by pressure. We therefore compared hand skin temperature in nine age‐matched subjects with probable MSA, 10 with idiopathic Parkinson's disease (PD), and 10 healthy controls both at rest and following a standard cooling procedure. Baseline skin temperature in the MSA group was significantly lower than in both the PD and control groups, and four of the nine MSA patients were colder at baseline than the coldest control value. After cooling, the MSA group also showed a significantly greater reduction in skin temperature than the PD group. The rate of skin temperature recovery did not differ between the three groups, although the MSA group required more time to return completely to their baseline temperature. Changes in skin colour or temperature are easily detected, and suggest a defect in neurovascular control of distal extremities. The “cold hands sign” is another clinical “red flag” that helps to raise the suspicion of MSA.</abstract>
<subject lang="en">
<genre>Keywords</genre>
<topic>Multiple system atrophy</topic>
<topic>Parkinson's disease</topic>
<topic>skin temperature</topic>
<topic>cold hands sign</topic>
</subject>
<relatedItem type="host">
<titleInfo>
<title>Movement Disorders</title>
<subTitle>Official Journal of the Movement Disorder Society</subTitle>
</titleInfo>
<titleInfo type="abbreviated">
<title>Mov. Disord.</title>
</titleInfo>
<subject>
<genre>article category</genre>
<topic>Article</topic>
</subject>
<identifier type="ISSN">0885-3185</identifier>
<identifier type="eISSN">1531-8257</identifier>
<identifier type="DOI">10.1002/(ISSN)1531-8257</identifier>
<identifier type="PublisherID">MDS</identifier>
<part>
<date>1997</date>
<detail type="volume">
<caption>vol.</caption>
<number>12</number>
</detail>
<detail type="issue">
<caption>no.</caption>
<number>4</number>
</detail>
<extent unit="pages">
<start>514</start>
<end>518</end>
<total>5</total>
</extent>
</part>
</relatedItem>
<identifier type="istex">D763791306404D4B8A24789938351722C6C4C5AB</identifier>
<identifier type="DOI">10.1002/mds.870120407</identifier>
<identifier type="ArticleID">MDS870120407</identifier>
<accessCondition type="use and reproduction" contentType="copyright">Copyright © 1997 Movement Disorder Society</accessCondition>
<recordInfo>
<recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin>
<recordContentSource>WILEY</recordContentSource>
</recordInfo>
</mods>
</metadata>
<serie></serie>
</istex>
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