Transplanted dopaminergic neurons develop PD pathologic changes: A second case report
Identifieur interne : 002559 ( Main/Curation ); précédent : 002558; suivant : 002560Transplanted dopaminergic neurons develop PD pathologic changes: A second case report
Auteurs : Jeffrey H. Kordower [États-Unis] ; Yaping Chu [États-Unis] ; Robert A. Hauser [États-Unis] ; C. Warren Olanow [États-Unis] ; Thomas B. Freeman [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-12-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Brain (pathology), Case study, Cell Transplantation (physiology), Dopamine (metabolism), Dopaminergic neuron, Humans, Lewy body, Male, Nervous system diseases, Neurons (metabolism), Parkinson Disease (metabolism), Parkinson Disease (pathology), Parkinson Disease (surgery), Transplantation, Tyrosine 3-Monooxygenase (metabolism), Vesicular Monoamine Transport Proteins (metabolism), substantial nigra, transplantation.
- MESH :
- chemical , metabolism : Dopamine, Tyrosine 3-Monooxygenase, Vesicular Monoamine Transport Proteins.
- metabolism : Neurons, Parkinson Disease.
- pathology : Brain, Parkinson Disease.
- physiology : Cell Transplantation.
- surgery : Parkinson Disease.
- Adult, Humans, Male.
Abstract
This report describes pathological changes within the grafted neurons of another patient with Parkinson's disease (PD) who died 14 years posttransplantation. Although numerous healthy appearing grafted neurons were present at this long‐term time point, some displayed Lewy bodies as evidenced by alpha‐synuclein, ubiquitin, and thioflavin‐S staining. Additionally, there was a general loss of dopamine transporter‐immunoreactivity in grafted neurons. Some grafted cell displayed a loss of tyrosine hydroxylase. These data support the emerging concept that PD‐like pathology is seen in young grafted neurons when they survive long term. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22369
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :003791
- to stream Istex, to step Curation: Pour aller vers cette notice dans l'étape Curation :003791
- to stream Istex, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001115
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001F28
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :001F28
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002015
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :002436
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :002436
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002436
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :003137
- to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001032
- to stream PascalFrancis, to step Curation: Pour aller vers cette notice dans l'étape Curation :001C87
- to stream PascalFrancis, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001036
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :003644
Links to Exploration step
ISTEX:FD904C1A47D553F5E78C5D3BDF738492EBB760A0Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Transplanted dopaminergic neurons develop PD pathologic changes: A second case report</title>
<author><name sortKey="Kordower, Jeffrey H" sort="Kordower, Jeffrey H" uniqKey="Kordower J" first="Jeffrey H." last="Kordower">Jeffrey H. Kordower</name>
</author>
<author><name sortKey="Chu, Yaping" sort="Chu, Yaping" uniqKey="Chu Y" first="Yaping" last="Chu">Yaping Chu</name>
</author>
<author><name sortKey="Hauser, Robert A" sort="Hauser, Robert A" uniqKey="Hauser R" first="Robert A." last="Hauser">Robert A. Hauser</name>
</author>
<author><name sortKey="Olanow, C Warren" sort="Olanow, C Warren" uniqKey="Olanow C" first="C. Warren" last="Olanow">C. Warren Olanow</name>
</author>
<author><name sortKey="Freeman, Thomas B" sort="Freeman, Thomas B" uniqKey="Freeman T" first="Thomas B." last="Freeman">Thomas B. Freeman</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:FD904C1A47D553F5E78C5D3BDF738492EBB760A0</idno>
<date when="2008" year="2008">2008</date>
<idno type="doi">10.1002/mds.22369</idno>
<idno type="url">https://api.istex.fr/document/FD904C1A47D553F5E78C5D3BDF738492EBB760A0/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">003791</idno>
<idno type="wicri:Area/Istex/Curation">003791</idno>
<idno type="wicri:Area/Istex/Checkpoint">001115</idno>
<idno type="wicri:doubleKey">0885-3185:2008:Kordower J:transplanted:dopaminergic:neurons</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:19006193</idno>
<idno type="wicri:Area/PubMed/Corpus">001F28</idno>
<idno type="wicri:Area/PubMed/Curation">001F28</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002015</idno>
<idno type="wicri:Area/Ncbi/Merge">002436</idno>
<idno type="wicri:Area/Ncbi/Curation">002436</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002436</idno>
<idno type="wicri:Area/Main/Merge">003137</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:09-0058903</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001032</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001C87</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001036</idno>
<idno type="wicri:doubleKey">0885-3185:2008:Kordower J:transplanted:dopaminergic:neurons</idno>
<idno type="wicri:Area/Main/Merge">003644</idno>
<idno type="wicri:Area/Main/Curation">002559</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Transplanted dopaminergic neurons develop PD pathologic changes: A second case report</title>
<author><name sortKey="Kordower, Jeffrey H" sort="Kordower, Jeffrey H" uniqKey="Kordower J" first="Jeffrey H." last="Kordower">Jeffrey H. Kordower</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chu, Yaping" sort="Chu, Yaping" uniqKey="Chu Y" first="Yaping" last="Chu">Yaping Chu</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hauser, Robert A" sort="Hauser, Robert A" uniqKey="Hauser R" first="Robert A." last="Hauser">Robert A. Hauser</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of South Florida, Tampa, Florida</wicri:regionArea>
<placeName><region type="state">Floride</region>
<settlement type="city">Tampa</settlement>
</placeName>
<orgName type="university">Université de Floride du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Olanow, C Warren" sort="Olanow, C Warren" uniqKey="Olanow C" first="C. Warren" last="Olanow">C. Warren Olanow</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Mt. Sinai School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Freeman, Thomas B" sort="Freeman, Thomas B" uniqKey="Freeman T" first="Thomas B." last="Freeman">Thomas B. Freeman</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurosurgery, University of South Florida, Tampa, Florida</wicri:regionArea>
<placeName><region type="state">Floride</region>
<settlement type="city">Tampa</settlement>
</placeName>
<orgName type="university">Université de Floride du Sud</orgName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2008-12-15">2008-12-15</date>
<biblScope unit="vol">23</biblScope>
<biblScope unit="issue">16</biblScope>
<biblScope unit="page" from="2303">2303</biblScope>
<biblScope unit="page" to="2306">2306</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">FD904C1A47D553F5E78C5D3BDF738492EBB760A0</idno>
<idno type="DOI">10.1002/mds.22369</idno>
<idno type="ArticleID">MDS22369</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Brain (pathology)</term>
<term>Case study</term>
<term>Cell Transplantation (physiology)</term>
<term>Dopamine (metabolism)</term>
<term>Dopaminergic neuron</term>
<term>Humans</term>
<term>Lewy body</term>
<term>Male</term>
<term>Nervous system diseases</term>
<term>Neurons (metabolism)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (surgery)</term>
<term>Transplantation</term>
<term>Tyrosine 3-Monooxygenase (metabolism)</term>
<term>Vesicular Monoamine Transport Proteins (metabolism)</term>
<term>substantial nigra</term>
<term>transplantation</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term>
<term>Tyrosine 3-Monooxygenase</term>
<term>Vesicular Monoamine Transport Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Neurons</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cell Transplantation</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Humans</term>
<term>Male</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Corps Lewy</term>
<term>Etude cas</term>
<term>Neurone dopaminergique</term>
<term>Pathologie du système nerveux</term>
<term>Transplantation</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">This report describes pathological changes within the grafted neurons of another patient with Parkinson's disease (PD) who died 14 years posttransplantation. Although numerous healthy appearing grafted neurons were present at this long‐term time point, some displayed Lewy bodies as evidenced by alpha‐synuclein, ubiquitin, and thioflavin‐S staining. Additionally, there was a general loss of dopamine transporter‐immunoreactivity in grafted neurons. Some grafted cell displayed a loss of tyrosine hydroxylase. These data support the emerging concept that PD‐like pathology is seen in young grafted neurons when they survive long term. © 2008 Movement Disorder Society</div>
</front>
</TEI>
<double idat="0885-3185:2008:Kordower J:transplanted:dopaminergic:neurons"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Transplanted Dopaminergic Neurons Develop PD Pathologic Changes : A Second Case Report</title>
<author><name sortKey="Kordower, Jeffrey H" sort="Kordower, Jeffrey H" uniqKey="Kordower J" first="Jeffrey H." last="Kordower">Jeffrey H. Kordower</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurological Sciences, Rush University Medical Center</s1>
<s2>Chicago, Illinois</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yaping Chu" sort="Yaping Chu" uniqKey="Yaping Chu" last="Yaping Chu">YAPING CHU</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurological Sciences, Rush University Medical Center</s1>
<s2>Chicago, Illinois</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hauser, Robert A" sort="Hauser, Robert A" uniqKey="Hauser R" first="Robert A." last="Hauser">Robert A. Hauser</name>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Neurology, University of South Florida</s1>
<s2>Tampa, Florida</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Floride</region>
<settlement type="city">Tampa</settlement>
</placeName>
<orgName type="university">Université de Floride du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Olanow, C Warren" sort="Olanow, C Warren" uniqKey="Olanow C" first="C. Warren" last="Olanow">C. Warren Olanow</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Neurology, Mt. Sinai School of Medicine</s1>
<s2>New York, New York</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Freeman, Thomas B" sort="Freeman, Thomas B" uniqKey="Freeman T" first="Thomas B." last="Freeman">Thomas B. Freeman</name>
<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Neurosurgery, University of South Florida</s1>
<s2>Tampa, Florida</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Floride</region>
<settlement type="city">Tampa</settlement>
</placeName>
<orgName type="university">Université de Floride du Sud</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">09-0058903</idno>
<date when="2008">2008</date>
<idno type="stanalyst">PASCAL 09-0058903 INIST</idno>
<idno type="RBID">Pascal:09-0058903</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001032</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001C87</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001036</idno>
<idno type="wicri:doubleKey">0885-3185:2008:Kordower J:transplanted:dopaminergic:neurons</idno>
<idno type="wicri:Area/Main/Merge">003644</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Transplanted Dopaminergic Neurons Develop PD Pathologic Changes : A Second Case Report</title>
<author><name sortKey="Kordower, Jeffrey H" sort="Kordower, Jeffrey H" uniqKey="Kordower J" first="Jeffrey H." last="Kordower">Jeffrey H. Kordower</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurological Sciences, Rush University Medical Center</s1>
<s2>Chicago, Illinois</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yaping Chu" sort="Yaping Chu" uniqKey="Yaping Chu" last="Yaping Chu">YAPING CHU</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurological Sciences, Rush University Medical Center</s1>
<s2>Chicago, Illinois</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hauser, Robert A" sort="Hauser, Robert A" uniqKey="Hauser R" first="Robert A." last="Hauser">Robert A. Hauser</name>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Neurology, University of South Florida</s1>
<s2>Tampa, Florida</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Floride</region>
<settlement type="city">Tampa</settlement>
</placeName>
<orgName type="university">Université de Floride du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Olanow, C Warren" sort="Olanow, C Warren" uniqKey="Olanow C" first="C. Warren" last="Olanow">C. Warren Olanow</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Department of Neurology, Mt. Sinai School of Medicine</s1>
<s2>New York, New York</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Freeman, Thomas B" sort="Freeman, Thomas B" uniqKey="Freeman T" first="Thomas B." last="Freeman">Thomas B. Freeman</name>
<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Neurosurgery, University of South Florida</s1>
<s2>Tampa, Florida</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Floride</region>
<settlement type="city">Tampa</settlement>
</placeName>
<orgName type="university">Université de Floride du Sud</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Case study</term>
<term>Dopaminergic neuron</term>
<term>Lewy body</term>
<term>Nervous system diseases</term>
<term>Transplantation</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Pathologie du système nerveux</term>
<term>Neurone dopaminergique</term>
<term>Etude cas</term>
<term>Transplantation</term>
<term>Corps Lewy</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">This report describes pathological changes within the grafted neurons ot another patient with Parkinson's disease (PD) who died 14 years posttransplantation. Although numerous healthy appearing grafted neurons were present at this long-term time point, some displayed Lewy bodies as evidenced by alpha-synuclein, ubiquitin, and thioflavin-S staining. Additionally, there was a general loss of dopamine transporter-immunoreactivity in grafted neurons. Some grafted cell displayed a loss of tyrosine hydroxylase. These data support the emerging concept that PD-like pathology is seen in young grafted neurons when they survive long term.</div>
</front>
</TEI>
</INIST>
<ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Transplanted dopaminergic neurons develop PD pathologic changes: A second case report</title>
<author><name sortKey="Kordower, Jeffrey H" sort="Kordower, Jeffrey H" uniqKey="Kordower J" first="Jeffrey H." last="Kordower">Jeffrey H. Kordower</name>
</author>
<author><name sortKey="Chu, Yaping" sort="Chu, Yaping" uniqKey="Chu Y" first="Yaping" last="Chu">Yaping Chu</name>
</author>
<author><name sortKey="Hauser, Robert A" sort="Hauser, Robert A" uniqKey="Hauser R" first="Robert A." last="Hauser">Robert A. Hauser</name>
</author>
<author><name sortKey="Olanow, C Warren" sort="Olanow, C Warren" uniqKey="Olanow C" first="C. Warren" last="Olanow">C. Warren Olanow</name>
</author>
<author><name sortKey="Freeman, Thomas B" sort="Freeman, Thomas B" uniqKey="Freeman T" first="Thomas B." last="Freeman">Thomas B. Freeman</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:FD904C1A47D553F5E78C5D3BDF738492EBB760A0</idno>
<date when="2008" year="2008">2008</date>
<idno type="doi">10.1002/mds.22369</idno>
<idno type="url">https://api.istex.fr/document/FD904C1A47D553F5E78C5D3BDF738492EBB760A0/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">003791</idno>
<idno type="wicri:Area/Istex/Curation">003791</idno>
<idno type="wicri:Area/Istex/Checkpoint">001115</idno>
<idno type="wicri:doubleKey">0885-3185:2008:Kordower J:transplanted:dopaminergic:neurons</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:19006193</idno>
<idno type="wicri:Area/PubMed/Corpus">001F28</idno>
<idno type="wicri:Area/PubMed/Curation">001F28</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002015</idno>
<idno type="wicri:Area/Ncbi/Merge">002436</idno>
<idno type="wicri:Area/Ncbi/Curation">002436</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002436</idno>
<idno type="wicri:Area/Main/Merge">003137</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Transplanted dopaminergic neurons develop PD pathologic changes: A second case report</title>
<author><name sortKey="Kordower, Jeffrey H" sort="Kordower, Jeffrey H" uniqKey="Kordower J" first="Jeffrey H." last="Kordower">Jeffrey H. Kordower</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chu, Yaping" sort="Chu, Yaping" uniqKey="Chu Y" first="Yaping" last="Chu">Yaping Chu</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hauser, Robert A" sort="Hauser, Robert A" uniqKey="Hauser R" first="Robert A." last="Hauser">Robert A. Hauser</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of South Florida, Tampa, Florida</wicri:regionArea>
<placeName><region type="state">Floride</region>
<settlement type="city">Tampa</settlement>
</placeName>
<orgName type="university">Université de Floride du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Olanow, C Warren" sort="Olanow, C Warren" uniqKey="Olanow C" first="C. Warren" last="Olanow">C. Warren Olanow</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Mt. Sinai School of Medicine, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Freeman, Thomas B" sort="Freeman, Thomas B" uniqKey="Freeman T" first="Thomas B." last="Freeman">Thomas B. Freeman</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurosurgery, University of South Florida, Tampa, Florida</wicri:regionArea>
<placeName><region type="state">Floride</region>
<settlement type="city">Tampa</settlement>
</placeName>
<orgName type="university">Université de Floride du Sud</orgName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2008-12-15">2008-12-15</date>
<biblScope unit="vol">23</biblScope>
<biblScope unit="issue">16</biblScope>
<biblScope unit="page" from="2303">2303</biblScope>
<biblScope unit="page" to="2306">2306</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">FD904C1A47D553F5E78C5D3BDF738492EBB760A0</idno>
<idno type="DOI">10.1002/mds.22369</idno>
<idno type="ArticleID">MDS22369</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Brain (pathology)</term>
<term>Cell Transplantation (physiology)</term>
<term>Dopamine (metabolism)</term>
<term>Humans</term>
<term>Lewy body</term>
<term>Male</term>
<term>Neurons (metabolism)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (surgery)</term>
<term>Tyrosine 3-Monooxygenase (metabolism)</term>
<term>Vesicular Monoamine Transport Proteins (metabolism)</term>
<term>substantial nigra</term>
<term>transplantation</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term>
<term>Tyrosine 3-Monooxygenase</term>
<term>Vesicular Monoamine Transport Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Neurons</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cell Transplantation</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Humans</term>
<term>Male</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">This report describes pathological changes within the grafted neurons of another patient with Parkinson's disease (PD) who died 14 years posttransplantation. Although numerous healthy appearing grafted neurons were present at this long‐term time point, some displayed Lewy bodies as evidenced by alpha‐synuclein, ubiquitin, and thioflavin‐S staining. Additionally, there was a general loss of dopamine transporter‐immunoreactivity in grafted neurons. Some grafted cell displayed a loss of tyrosine hydroxylase. These data support the emerging concept that PD‐like pathology is seen in young grafted neurons when they survive long term. © 2008 Movement Disorder Society</div>
</front>
</TEI>
</ISTEX>
</double>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002559 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 002559 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Main |étape= Curation |type= RBID |clé= ISTEX:FD904C1A47D553F5E78C5D3BDF738492EBB760A0 |texte= Transplanted dopaminergic neurons develop PD pathologic changes: A second case report }}
This area was generated with Dilib version V0.6.23. |