MovDisordV3, PascalFrancis, Corpus, bibRecord, 001032

Transplanted Dopaminergic Neurons Develop PD Pathologic Changes : A Second Case Report

Identifieur interne : 001032 ( PascalFrancis/Corpus ); précédent : 001031; suivant : 001033

Transplanted Dopaminergic Neurons Develop PD Pathologic Changes : A Second Case Report

Auteurs : Jeffrey H. Kordower ; YAPING CHU ; Robert A. Hauser ; C. Warren Olanow ; Thomas B. Freeman

Source :

Movement disorders [ 0885-3185 ] ; 2008.

RBID : Pascal:09-0058903

Descripteurs français

Pascal (Inist)
- Pathologie du système nerveux, Neurone dopaminergique, Etude cas, Transplantation, Corps Lewy.

English descriptors

KwdEn :
- Case study, Dopaminergic neuron, Lewy body, Nervous system diseases, Transplantation.

Abstract

This report describes pathological changes within the grafted neurons ot another patient with Parkinson's disease (PD) who died 14 years posttransplantation. Although numerous healthy appearing grafted neurons were present at this long-term time point, some displayed Lewy bodies as evidenced by alpha-synuclein, ubiquitin, and thioflavin-S staining. Additionally, there was a general loss of dopamine transporter-immunoreactivity in grafted neurons. Some grafted cell displayed a loss of tyrosine hydroxylase. These data support the emerging concept that PD-like pathology is seen in young grafted neurons when they survive long term.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`02`	`1`		`@1 YAPING CHU`
A11	`03`	`1`		`@1 HAUSER (Robert A.)`
A11	`04`	`1`		`@1 OLANOW (C. Warren)`
A11	`05`	`1`		`@1 FREEMAN (Thomas B.)`
A14	`01`			`@1 Department of Neurological Sciences, Rush University Medical Center @2 Chicago, Illinois @3 USA @Z 1 aut. @Z 2 aut.`
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C01	`01`		`ENG`	@0 This report describes pathological changes within the grafted neurons ot another patient with Parkinson's disease (PD) who died 14 years posttransplantation. Although numerous healthy appearing grafted neurons were present at this long-term time point, some displayed Lewy bodies as evidenced by alpha-synuclein, ubiquitin, and thioflavin-S staining. Additionally, there was a general loss of dopamine transporter-immunoreactivity in grafted neurons. Some grafted cell displayed a loss of tyrosine hydroxylase. These data support the emerging concept that PD-like pathology is seen in young grafted neurons when they survive long term.
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C03	`01`	`X`	`SPA`	`@0 Sistema nervioso patología @5 01`
C03	`02`	`X`	`FRE`	`@0 Neurone dopaminergique @5 09`
C03	`02`	`X`	`ENG`	`@0 Dopaminergic neuron @5 09`
C03	`02`	`X`	`SPA`	`@0 Neurona dopaminérgica @5 09`
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C03	`04`	`X`	`FRE`	`@0 Transplantation @5 11`
C03	`04`	`X`	`ENG`	`@0 Transplantation @5 11`
C03	`04`	`X`	`SPA`	`@0 Trasplantación @5 11`
C03	`05`	`X`	`FRE`	`@0 Corps Lewy @5 12`
C03	`05`	`X`	`ENG`	`@0 Lewy body @5 12`
C03	`05`	`X`	`SPA`	`@0 Cuerpo Lewy @5 12`
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N44	`01`			`@1 OTO`
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Format Inist (serveur)

NO :	PASCAL 09-0058903 INIST
ET :	Transplanted Dopaminergic Neurons Develop PD Pathologic Changes : A Second Case Report
AU :	KORDOWER (Jeffrey H.); YAPING CHU; HAUSER (Robert A.); OLANOW (C. Warren); FREEMAN (Thomas B.)
AF :	Department of Neurological Sciences, Rush University Medical Center/Chicago, Illinois/Etats-Unis (1 aut., 2 aut.); Department of Neurology, University of South Florida/Tampa, Florida/Etats-Unis (3 aut.); Department of Neurology, Mt. Sinai School of Medicine/New York, New York/Etats-Unis (4 aut.); Department of Neurosurgery, University of South Florida/Tampa, Florida/Etats-Unis (5 aut.)
DT :	Publication en série; Courte communication, note brève; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 16; Pp. 2303-2306; Bibl. 9 ref.
LA :	Anglais
EA :	This report describes pathological changes within the grafted neurons ot another patient with Parkinson's disease (PD) who died 14 years posttransplantation. Although numerous healthy appearing grafted neurons were present at this long-term time point, some displayed Lewy bodies as evidenced by alpha-synuclein, ubiquitin, and thioflavin-S staining. Additionally, there was a general loss of dopamine transporter-immunoreactivity in grafted neurons. Some grafted cell displayed a loss of tyrosine hydroxylase. These data support the emerging concept that PD-like pathology is seen in young grafted neurons when they survive long term.
CC :	002B17; 002B17E
FD :	Pathologie du système nerveux; Neurone dopaminergique; Etude cas; Transplantation; Corps Lewy
ED :	Nervous system diseases; Dopaminergic neuron; Case study; Transplantation; Lewy body
SD :	Sistema nervioso patología; Neurona dopaminérgica; Estudio caso; Trasplantación; Cuerpo Lewy
LO :	INIST-20953.354000196116650020
ID :	09-0058903

Links to Exploration step

Pascal:09-0058903

Le document en format XML

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<ET>Transplanted Dopaminergic Neurons Develop PD Pathologic Changes : A Second Case Report</ET>
<AU>KORDOWER (Jeffrey H.); YAPING CHU; HAUSER (Robert A.); OLANOW (C. Warren); FREEMAN (Thomas B.)</AU>
<AF>Department of Neurological Sciences, Rush University Medical Center/Chicago, Illinois/Etats-Unis (1 aut., 2 aut.); Department of Neurology, University of South Florida/Tampa, Florida/Etats-Unis (3 aut.); Department of Neurology, Mt. Sinai School of Medicine/New York, New York/Etats-Unis (4 aut.); Department of Neurosurgery, University of South Florida/Tampa, Florida/Etats-Unis (5 aut.)</AF>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Transplanted Dopaminergic Neurons Develop PD Pathologic Changes : A Second Case Report

Transplanted Dopaminergic Neurons Develop PD Pathologic Changes : A Second Case Report

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Abstract

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