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Transplanted dopaminergic neurons develop PD pathologic changes: a second case report.

Identifieur interne : 002436 ( Ncbi/Curation ); précédent : 002435; suivant : 002437

Transplanted dopaminergic neurons develop PD pathologic changes: a second case report.

Auteurs : Jeffrey H. Kordower [États-Unis] ; Yaping Chu ; Robert A. Hauser ; C Warren Olanow ; Thomas B. Freeman

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.

RBID : pubmed:19006193

English descriptors

KwdEn :
- Adult, Brain (pathology), Cell Transplantation (physiology), Dopamine (metabolism), Humans, Male, Neurons (metabolism), Parkinson Disease (metabolism), Parkinson Disease (pathology), Parkinson Disease (surgery), Tyrosine 3-Monooxygenase (metabolism), Vesicular Monoamine Transport Proteins (metabolism).
MESH :
- chemical , metabolism : Dopamine, Tyrosine 3-Monooxygenase, Vesicular Monoamine Transport Proteins.
- metabolism : Neurons, Parkinson Disease.
- pathology : Brain, Parkinson Disease.
- physiology : Cell Transplantation.
- surgery : Parkinson Disease.
- Adult, Humans, Male.

Abstract

This report describes pathological changes within the grafted neurons of another patient with Parkinson's disease (PD) who died 14 years posttransplantation. Although numerous healthy appearing grafted neurons were present at this long-term time point, some displayed Lewy bodies as evidenced by alpha-synuclein, ubiquitin, and thioflavin-S staining. Additionally, there was a general loss of dopamine transporter-immunoreactivity in grafted neurons. Some grafted cell displayed a loss of tyrosine hydroxylase. These data support the emerging concept that PD-like pathology is seen in young grafted neurons when they survive long term.

DOI: 10.1002/mds.22369
PubMed: 19006193

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pubmed:19006193

Le document en format XML

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<author><name sortKey="Kordower, Jeffrey H" sort="Kordower, Jeffrey H" uniqKey="Kordower J" first="Jeffrey H" last="Kordower">Jeffrey H. Kordower</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA. jkordowe@rush.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612</wicri:regionArea>
<wicri:noRegion>Illinois 60612</wicri:noRegion>
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</author>
<author><name sortKey="Chu, Yaping" sort="Chu, Yaping" uniqKey="Chu Y" first="Yaping" last="Chu">Yaping Chu</name>
</author>
<author><name sortKey="Hauser, Robert A" sort="Hauser, Robert A" uniqKey="Hauser R" first="Robert A" last="Hauser">Robert A. Hauser</name>
</author>
<author><name sortKey="Olanow, C Warren" sort="Olanow, C Warren" uniqKey="Olanow C" first="C Warren" last="Olanow">C Warren Olanow</name>
</author>
<author><name sortKey="Freeman, Thomas B" sort="Freeman, Thomas B" uniqKey="Freeman T" first="Thomas B" last="Freeman">Thomas B. Freeman</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Transplanted dopaminergic neurons develop PD pathologic changes: a second case report.</title>
<author><name sortKey="Kordower, Jeffrey H" sort="Kordower, Jeffrey H" uniqKey="Kordower J" first="Jeffrey H" last="Kordower">Jeffrey H. Kordower</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA. jkordowe@rush.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612</wicri:regionArea>
<wicri:noRegion>Illinois 60612</wicri:noRegion>
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<author><name sortKey="Chu, Yaping" sort="Chu, Yaping" uniqKey="Chu Y" first="Yaping" last="Chu">Yaping Chu</name>
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<author><name sortKey="Hauser, Robert A" sort="Hauser, Robert A" uniqKey="Hauser R" first="Robert A" last="Hauser">Robert A. Hauser</name>
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<author><name sortKey="Olanow, C Warren" sort="Olanow, C Warren" uniqKey="Olanow C" first="C Warren" last="Olanow">C Warren Olanow</name>
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<author><name sortKey="Freeman, Thomas B" sort="Freeman, Thomas B" uniqKey="Freeman T" first="Thomas B" last="Freeman">Thomas B. Freeman</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2008" type="published">2008</date>
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<term>Brain (pathology)</term>
<term>Cell Transplantation (physiology)</term>
<term>Dopamine (metabolism)</term>
<term>Humans</term>
<term>Male</term>
<term>Neurons (metabolism)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (surgery)</term>
<term>Tyrosine 3-Monooxygenase (metabolism)</term>
<term>Vesicular Monoamine Transport Proteins (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term>
<term>Tyrosine 3-Monooxygenase</term>
<term>Vesicular Monoamine Transport Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Neurons</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cell Transplantation</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Humans</term>
<term>Male</term>
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</teiHeader>
<front><div type="abstract" xml:lang="en">This report describes pathological changes within the grafted neurons of another patient with Parkinson's disease (PD) who died 14 years posttransplantation. Although numerous healthy appearing grafted neurons were present at this long-term time point, some displayed Lewy bodies as evidenced by alpha-synuclein, ubiquitin, and thioflavin-S staining. Additionally, there was a general loss of dopamine transporter-immunoreactivity in grafted neurons. Some grafted cell displayed a loss of tyrosine hydroxylase. These data support the emerging concept that PD-like pathology is seen in young grafted neurons when they survive long term.</div>
</front>
</TEI>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Transplanted dopaminergic neurons develop PD pathologic changes: a second case report.

Transplanted dopaminergic neurons develop PD pathologic changes: a second case report.

Source :

English descriptors

Abstract

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