Transplanted dopaminergic neurons develop PD pathologic changes: A second case report
Identifieur interne : 003791 ( Istex/Corpus ); précédent : 003790; suivant : 003792Transplanted dopaminergic neurons develop PD pathologic changes: A second case report
Auteurs : Jeffrey H. Kordower ; Yaping Chu ; Robert A. Hauser ; C. Warren Olanow ; Thomas B. FreemanSource :
- Movement Disorders [ 0885-3185 ] ; 2008-12-15.
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- KwdEn :
Abstract
This report describes pathological changes within the grafted neurons of another patient with Parkinson's disease (PD) who died 14 years posttransplantation. Although numerous healthy appearing grafted neurons were present at this long‐term time point, some displayed Lewy bodies as evidenced by alpha‐synuclein, ubiquitin, and thioflavin‐S staining. Additionally, there was a general loss of dopamine transporter‐immunoreactivity in grafted neurons. Some grafted cell displayed a loss of tyrosine hydroxylase. These data support the emerging concept that PD‐like pathology is seen in young grafted neurons when they survive long term. © 2008 Movement Disorder Society
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DOI: 10.1002/mds.22369
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ISTEX:FD904C1A47D553F5E78C5D3BDF738492EBB760A0Le document en format XML
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Although numerous healthy appearing grafted neurons were present at this long‐term time point, some displayed Lewy bodies as evidenced by alpha‐synuclein, ubiquitin, and thioflavin‐S staining. Additionally, there was a general loss of dopamine transporter‐immunoreactivity in grafted neurons. Some grafted cell displayed a loss of tyrosine hydroxylase. These data support the emerging concept that PD‐like pathology is seen in young grafted neurons when they survive long term. © 2008 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Jeffrey H. Kordower PhD</name><affiliations><json:string>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA</json:string></affiliations></json:item><json:item><name>Yaping Chu MD</name><affiliations><json:string>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA</json:string></affiliations></json:item><json:item><name>Robert A. Hauser MD</name><affiliations><json:string>Department of Neurology, University of South Florida, Tampa, Florida, USA</json:string></affiliations></json:item><json:item><name>C.Warren Olanow MD</name><affiliations><json:string>Department of Neurology, Mt. Sinai School of Medicine, New York, New York, USA</json:string></affiliations></json:item><json:item><name>Thomas B. 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Additionally, there was a general loss of dopamine transporter‐immunoreactivity in grafted neurons. Some grafted cell displayed a loss of tyrosine hydroxylase. 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