MovDisordV3, Main, Curation, bibRecord, 001E72

Abnormal explicit but normal implicit sequence learning in premanifest and early Huntington's disease

Identifieur interne : 001E72 ( Main/Curation ); précédent : 001E71; suivant : 001E73

Abnormal explicit but normal implicit sequence learning in premanifest and early Huntington's disease

Auteurs : Susanne A. Schneider [Royaume-Uni] ; Leonora Wilkinson [Royaume-Uni] ; Kailash P. Bhatia [Royaume-Uni] ; Susie M. D. Henley [Royaume-Uni] ; John C. Rothwell [Royaume-Uni] ; Sarah J. Tabrizi [Royaume-Uni] ; Marjan Jahanshahi [Royaume-Uni]

Source :

Movement Disorders [ 0885-3185 ] ; 2010-07-30.

RBID : ISTEX:839BF11695DED630C7260C0F7F986BFF334CB305

Descripteurs français

Pascal (Inist)
- Apprentissage implicite, Chorée de Huntington, Pathologie du système nerveux, Temps réaction.

English descriptors

KwdEn :
- Adult, Age of Onset, Executive Function (physiology), Female, Humans, Huntington Disease (complications), Huntington Disease (genetics), Huntington disease, Huntington's disease, Implicit learning, Learning Disorders (classification), Learning Disorders (etiology), Male, Memory, Short-Term (physiology), Middle Aged, Nervous system diseases, Neuropsychological Tests, Reaction time, Serial Learning (physiology), Statistics as Topic, Trinucleotide Repeat Expansion (genetics), explicit sequence learning, implicit sequence learning, manifesting, presymptomatic, serial reaction time task.
MESH :
- classification : Learning Disorders.
- complications : Huntington Disease.
- etiology : Learning Disorders.
- genetics : Huntington Disease, Trinucleotide Repeat Expansion.
- physiology : Executive Function, Memory, Short-Term, Serial Learning.
- Adult, Age of Onset, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Statistics as Topic.

Abstract

Learning may occur with or without awareness, as explicit (intentional) or implicit (incidental) learning. The caudate nucleus and the putamen, which are affected early in Huntington's disease (HD), are thought to be essential for motor sequence learning. However, the results of existing studies are inconsistent concerning presence/absence of deficits in implicit and explicit motor sequence learning in HD. We assessed implicit and explicit motor sequence learning using sequences of equivalent structure in 15 individuals with a positive HD genetic test (7 premanifest; 8 early stage disease) and 11 matched controls. The HD group showed evidence of normal implicit motor sequence learning, whereas explicit motor sequence learning was impaired in manifest and premanifest HD gene carriers, with progressive decline with progressive disease. Explicit sequence learning may be a useful cognitive biomarker for HD progression. © 2010 Movement Disorder Society

Url:

DOI: 10.1002/mds.22692

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001A19
to stream Istex, to step Curation: Pour aller vers cette notice dans l'étape Curation :001A19
to stream Istex, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000B51
to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000223
to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000223
to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000371
to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001810
to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :001810
to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001A63
to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :002B92
to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :002B92
to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002B92
to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :002308
to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000A06
to stream PascalFrancis, to step Curation: Pour aller vers cette notice dans l'étape Curation :002313
to stream PascalFrancis, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000C22
to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :002809

Links to Exploration step

ISTEX:839BF11695DED630C7260C0F7F986BFF334CB305

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Abnormal explicit but normal implicit sequence learning in premanifest and early Huntington's disease</title>
<author><name sortKey="Schneider, Susanne A" sort="Schneider, Susanne A" uniqKey="Schneider S" first="Susanne A." last="Schneider">Susanne A. Schneider</name>
</author>
<author><name sortKey="Wilkinson, Leonora" sort="Wilkinson, Leonora" uniqKey="Wilkinson L" first="Leonora" last="Wilkinson">Leonora Wilkinson</name>
</author>
<author><name sortKey="Bhatia, Kailash P" sort="Bhatia, Kailash P" uniqKey="Bhatia K" first="Kailash P." last="Bhatia">Kailash P. Bhatia</name>
</author>
<author><name sortKey="Henley, Susie M D" sort="Henley, Susie M D" uniqKey="Henley S" first="Susie M. D." last="Henley">Susie M. D. Henley</name>
</author>
<author><name sortKey="Rothwell, John C" sort="Rothwell, John C" uniqKey="Rothwell J" first="John C." last="Rothwell">John C. Rothwell</name>
</author>
<author><name sortKey="Tabrizi, Sarah J" sort="Tabrizi, Sarah J" uniqKey="Tabrizi S" first="Sarah J." last="Tabrizi">Sarah J. Tabrizi</name>
</author>
<author><name sortKey="Jahanshahi, Marjan" sort="Jahanshahi, Marjan" uniqKey="Jahanshahi M" first="Marjan" last="Jahanshahi">Marjan Jahanshahi</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:839BF11695DED630C7260C0F7F986BFF334CB305</idno>
<date when="2010" year="2010">2010</date>
<idno type="doi">10.1002/mds.22692</idno>
<idno type="url">https://api.istex.fr/document/839BF11695DED630C7260C0F7F986BFF334CB305/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001A19</idno>
<idno type="wicri:Area/Istex/Curation">001A19</idno>
<idno type="wicri:Area/Istex/Checkpoint">000B51</idno>
<idno type="wicri:doubleKey">0885-3185:2010:Schneider S:abnormal:explicit:but</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997693</idno>
<idno type="RBID">PMC:2997693</idno>
<idno type="wicri:Area/Pmc/Corpus">000223</idno>
<idno type="wicri:Area/Pmc/Curation">000223</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000371</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">001810</idno>
<idno type="wicri:Area/PubMed/Curation">001810</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001A63</idno>
<idno type="wicri:Area/Ncbi/Merge">002B92</idno>
<idno type="wicri:Area/Ncbi/Curation">002B92</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002B92</idno>
<idno type="wicri:doubleKey">0885-3185:2010:Schneider S:abnormal:explicit:but</idno>
<idno type="wicri:Area/Main/Merge">002308</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:10-0377326</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000A06</idno>
<idno type="wicri:Area/PascalFrancis/Curation">002313</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000C22</idno>
<idno type="wicri:doubleKey">0885-3185:2010:Schneider S:abnormal:explicit:but</idno>
<idno type="wicri:Area/Main/Merge">002809</idno>
<idno type="wicri:Area/Main/Curation">001E72</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Abnormal explicit but normal implicit sequence learning in premanifest and early Huntington's disease</title>
<author><name sortKey="Schneider, Susanne A" sort="Schneider, Susanne A" uniqKey="Schneider S" first="Susanne A." last="Schneider">Susanne A. Schneider</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square,London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wilkinson, Leonora" sort="Wilkinson, Leonora" uniqKey="Wilkinson L" first="Leonora" last="Wilkinson">Leonora Wilkinson</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square,London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bhatia, Kailash P" sort="Bhatia, Kailash P" uniqKey="Bhatia K" first="Kailash P." last="Bhatia">Kailash P. Bhatia</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square,London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Henley, Susie M D" sort="Henley, Susie M D" uniqKey="Henley S" first="Susie M. D." last="Henley">Susie M. D. Henley</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Neurodegenerative Disease, UCL, Institute of Neurology, Queen Square, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rothwell, John C" sort="Rothwell, John C" uniqKey="Rothwell J" first="John C." last="Rothwell">John C. Rothwell</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square,London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tabrizi, Sarah J" sort="Tabrizi, Sarah J" uniqKey="Tabrizi S" first="Sarah J." last="Tabrizi">Sarah J. Tabrizi</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Neurodegenerative Disease, UCL, Institute of Neurology, Queen Square, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jahanshahi, Marjan" sort="Jahanshahi, Marjan" uniqKey="Jahanshahi M" first="Marjan" last="Jahanshahi">Marjan Jahanshahi</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square,London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2010-07-30">2010-07-30</date>
<biblScope unit="vol">25</biblScope>
<biblScope unit="issue">10</biblScope>
<biblScope unit="page" from="1343">1343</biblScope>
<biblScope unit="page" to="1349">1349</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">839BF11695DED630C7260C0F7F986BFF334CB305</idno>
<idno type="DOI">10.1002/mds.22692</idno>
<idno type="ArticleID">MDS22692</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Age of Onset</term>
<term>Executive Function (physiology)</term>
<term>Female</term>
<term>Humans</term>
<term>Huntington Disease (complications)</term>
<term>Huntington Disease (genetics)</term>
<term>Huntington disease</term>
<term>Huntington's disease</term>
<term>Implicit learning</term>
<term>Learning Disorders (classification)</term>
<term>Learning Disorders (etiology)</term>
<term>Male</term>
<term>Memory, Short-Term (physiology)</term>
<term>Middle Aged</term>
<term>Nervous system diseases</term>
<term>Neuropsychological Tests</term>
<term>Reaction time</term>
<term>Serial Learning (physiology)</term>
<term>Statistics as Topic</term>
<term>Trinucleotide Repeat Expansion (genetics)</term>
<term>explicit sequence learning</term>
<term>implicit sequence learning</term>
<term>manifesting</term>
<term>presymptomatic</term>
<term>serial reaction time task</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Learning Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Huntington Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Learning Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Huntington Disease</term>
<term>Trinucleotide Repeat Expansion</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Executive Function</term>
<term>Memory, Short-Term</term>
<term>Serial Learning</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Age of Onset</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neuropsychological Tests</term>
<term>Statistics as Topic</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Apprentissage implicite</term>
<term>Chorée de Huntington</term>
<term>Pathologie du   système nerveux</term>
<term>Temps réaction</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Learning may occur with or without awareness, as explicit (intentional) or implicit (incidental) learning. The caudate nucleus and the putamen, which are affected early in Huntington's disease (HD), are thought to be essential for motor sequence learning. However, the results of existing studies are inconsistent concerning presence/absence of deficits in implicit and explicit motor sequence learning in HD. We assessed implicit and explicit motor sequence learning using sequences of equivalent structure in 15 individuals with a positive HD genetic test (7 premanifest; 8 early stage disease) and 11 matched controls. The HD group showed evidence of normal implicit motor sequence learning, whereas explicit motor sequence learning was impaired in manifest and premanifest HD gene carriers, with progressive decline with progressive disease. Explicit sequence learning may be a useful cognitive biomarker for HD progression. © 2010 Movement Disorder Society</div>
</front>
</TEI>
<double idat="0885-3185:2010:Schneider S:abnormal:explicit:but"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Abnormal Explicit But Normal Implicit Sequence Learning in Premanifest and Early Huntington's Disease</title>
<author><name sortKey="Schneider, Susanne A" sort="Schneider, Susanne A" uniqKey="Schneider S" first="Susanne A." last="Schneider">Susanne A. Schneider</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wilkinson, Leonora" sort="Wilkinson, Leonora" uniqKey="Wilkinson L" first="Leonora" last="Wilkinson">Leonora Wilkinson</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bhatia, Kailash P" sort="Bhatia, Kailash P" uniqKey="Bhatia K" first="Kailash P." last="Bhatia">Kailash P. Bhatia</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Henley, Susie M D" sort="Henley, Susie M D" uniqKey="Henley S" first="Susie M. D." last="Henley">Susie M. D. Henley</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurodegenerative Disease, UCL, Institute of Neurology, Queen Square</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rothwell, John C" sort="Rothwell, John C" uniqKey="Rothwell J" first="John C." last="Rothwell">John C. Rothwell</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tabrizi, Sarah J" sort="Tabrizi, Sarah J" uniqKey="Tabrizi S" first="Sarah J." last="Tabrizi">Sarah J. Tabrizi</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurodegenerative Disease, UCL, Institute of Neurology, Queen Square</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jahanshahi, Marjan" sort="Jahanshahi, Marjan" uniqKey="Jahanshahi M" first="Marjan" last="Jahanshahi">Marjan Jahanshahi</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">10-0377326</idno>
<date when="2010">2010</date>
<idno type="stanalyst">PASCAL 10-0377326 INIST</idno>
<idno type="RBID">Pascal:10-0377326</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000A06</idno>
<idno type="wicri:Area/PascalFrancis/Curation">002313</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000C22</idno>
<idno type="wicri:doubleKey">0885-3185:2010:Schneider S:abnormal:explicit:but</idno>
<idno type="wicri:Area/Main/Merge">002809</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Abnormal Explicit But Normal Implicit Sequence Learning in Premanifest and Early Huntington's Disease</title>
<author><name sortKey="Schneider, Susanne A" sort="Schneider, Susanne A" uniqKey="Schneider S" first="Susanne A." last="Schneider">Susanne A. Schneider</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wilkinson, Leonora" sort="Wilkinson, Leonora" uniqKey="Wilkinson L" first="Leonora" last="Wilkinson">Leonora Wilkinson</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bhatia, Kailash P" sort="Bhatia, Kailash P" uniqKey="Bhatia K" first="Kailash P." last="Bhatia">Kailash P. Bhatia</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Henley, Susie M D" sort="Henley, Susie M D" uniqKey="Henley S" first="Susie M. D." last="Henley">Susie M. D. Henley</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurodegenerative Disease, UCL, Institute of Neurology, Queen Square</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rothwell, John C" sort="Rothwell, John C" uniqKey="Rothwell J" first="John C." last="Rothwell">John C. Rothwell</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tabrizi, Sarah J" sort="Tabrizi, Sarah J" uniqKey="Tabrizi S" first="Sarah J." last="Tabrizi">Sarah J. Tabrizi</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurodegenerative Disease, UCL, Institute of Neurology, Queen Square</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jahanshahi, Marjan" sort="Jahanshahi, Marjan" uniqKey="Jahanshahi M" first="Marjan" last="Jahanshahi">Marjan Jahanshahi</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Huntington disease</term>
<term>Implicit learning</term>
<term>Nervous system diseases</term>
<term>Reaction time</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Chorée de Huntington</term>
<term>Pathologie du   système nerveux</term>
<term>Apprentissage implicite</term>
<term>Temps réaction</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Learning may occur with or without awareness, as explicit (intentional) or implicit (incidental) learning. The caudate nucleus and the putamen, which are affected early in Huntington's disease (HD), are thought to be essential for motor sequence learning. However, the results of existing studies are inconsistent concerning presence/absence of deficits in implicit and explicit motor sequence learning in HD. We assessed implicit and explicit motor sequence learning using sequences of equivalent structure in 15 individuals with a positive HD genetic test (7 premanifest; 8 early stage disease) and 11 matched controls. The HD group showed evidence of normal implicit motor sequence learning, whereas explicit motor sequence learning was impaired in manifest and premanifest HD gene carriers, with progressive decline with progressive disease. Explicit sequence learning may be a useful cognitive biomarker for HD progression.</div>
</front>
</TEI>
</INIST>
<ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Abnormal explicit but normal implicit sequence learning in premanifest and early Huntington's disease</title>
<author><name sortKey="Schneider, Susanne A" sort="Schneider, Susanne A" uniqKey="Schneider S" first="Susanne A." last="Schneider">Susanne A. Schneider</name>
</author>
<author><name sortKey="Wilkinson, Leonora" sort="Wilkinson, Leonora" uniqKey="Wilkinson L" first="Leonora" last="Wilkinson">Leonora Wilkinson</name>
</author>
<author><name sortKey="Bhatia, Kailash P" sort="Bhatia, Kailash P" uniqKey="Bhatia K" first="Kailash P." last="Bhatia">Kailash P. Bhatia</name>
</author>
<author><name sortKey="Henley, Susie M D" sort="Henley, Susie M D" uniqKey="Henley S" first="Susie M. D." last="Henley">Susie M. D. Henley</name>
</author>
<author><name sortKey="Rothwell, John C" sort="Rothwell, John C" uniqKey="Rothwell J" first="John C." last="Rothwell">John C. Rothwell</name>
</author>
<author><name sortKey="Tabrizi, Sarah J" sort="Tabrizi, Sarah J" uniqKey="Tabrizi S" first="Sarah J." last="Tabrizi">Sarah J. Tabrizi</name>
</author>
<author><name sortKey="Jahanshahi, Marjan" sort="Jahanshahi, Marjan" uniqKey="Jahanshahi M" first="Marjan" last="Jahanshahi">Marjan Jahanshahi</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:839BF11695DED630C7260C0F7F986BFF334CB305</idno>
<date when="2010" year="2010">2010</date>
<idno type="doi">10.1002/mds.22692</idno>
<idno type="url">https://api.istex.fr/document/839BF11695DED630C7260C0F7F986BFF334CB305/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001A19</idno>
<idno type="wicri:Area/Istex/Curation">001A19</idno>
<idno type="wicri:Area/Istex/Checkpoint">000B51</idno>
<idno type="wicri:doubleKey">0885-3185:2010:Schneider S:abnormal:explicit:but</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997693</idno>
<idno type="RBID">PMC:2997693</idno>
<idno type="wicri:Area/Pmc/Corpus">000223</idno>
<idno type="wicri:Area/Pmc/Curation">000223</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000371</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">001810</idno>
<idno type="wicri:Area/PubMed/Curation">001810</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001A63</idno>
<idno type="wicri:Area/Ncbi/Merge">002B92</idno>
<idno type="wicri:Area/Ncbi/Curation">002B92</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002B92</idno>
<idno type="wicri:doubleKey">0885-3185:2010:Schneider S:abnormal:explicit:but</idno>
<idno type="wicri:Area/Main/Merge">002308</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Abnormal explicit but normal implicit sequence learning in premanifest and early Huntington's disease</title>
<author><name sortKey="Schneider, Susanne A" sort="Schneider, Susanne A" uniqKey="Schneider S" first="Susanne A." last="Schneider">Susanne A. Schneider</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square,London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wilkinson, Leonora" sort="Wilkinson, Leonora" uniqKey="Wilkinson L" first="Leonora" last="Wilkinson">Leonora Wilkinson</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square,London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bhatia, Kailash P" sort="Bhatia, Kailash P" uniqKey="Bhatia K" first="Kailash P." last="Bhatia">Kailash P. Bhatia</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square,London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Henley, Susie M D" sort="Henley, Susie M D" uniqKey="Henley S" first="Susie M. D." last="Henley">Susie M. D. Henley</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Neurodegenerative Disease, UCL, Institute of Neurology, Queen Square, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rothwell, John C" sort="Rothwell, John C" uniqKey="Rothwell J" first="John C." last="Rothwell">John C. Rothwell</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square,London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tabrizi, Sarah J" sort="Tabrizi, Sarah J" uniqKey="Tabrizi S" first="Sarah J." last="Tabrizi">Sarah J. Tabrizi</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Neurodegenerative Disease, UCL, Institute of Neurology, Queen Square, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jahanshahi, Marjan" sort="Jahanshahi, Marjan" uniqKey="Jahanshahi M" first="Marjan" last="Jahanshahi">Marjan Jahanshahi</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square,London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2010-07-30">2010-07-30</date>
<biblScope unit="vol">25</biblScope>
<biblScope unit="issue">10</biblScope>
<biblScope unit="page" from="1343">1343</biblScope>
<biblScope unit="page" to="1349">1349</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">839BF11695DED630C7260C0F7F986BFF334CB305</idno>
<idno type="DOI">10.1002/mds.22692</idno>
<idno type="ArticleID">MDS22692</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Age of Onset</term>
<term>Executive Function (physiology)</term>
<term>Female</term>
<term>Humans</term>
<term>Huntington Disease (complications)</term>
<term>Huntington Disease (genetics)</term>
<term>Huntington's disease</term>
<term>Learning Disorders (classification)</term>
<term>Learning Disorders (etiology)</term>
<term>Male</term>
<term>Memory, Short-Term (physiology)</term>
<term>Middle Aged</term>
<term>Neuropsychological Tests</term>
<term>Serial Learning (physiology)</term>
<term>Statistics as Topic</term>
<term>Trinucleotide Repeat Expansion (genetics)</term>
<term>explicit sequence learning</term>
<term>implicit sequence learning</term>
<term>manifesting</term>
<term>presymptomatic</term>
<term>serial reaction time task</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Learning Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Huntington Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Learning Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Huntington Disease</term>
<term>Trinucleotide Repeat Expansion</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Executive Function</term>
<term>Memory, Short-Term</term>
<term>Serial Learning</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Age of Onset</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neuropsychological Tests</term>
<term>Statistics as Topic</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Learning may occur with or without awareness, as explicit (intentional) or implicit (incidental) learning. The caudate nucleus and the putamen, which are affected early in Huntington's disease (HD), are thought to be essential for motor sequence learning. However, the results of existing studies are inconsistent concerning presence/absence of deficits in implicit and explicit motor sequence learning in HD. We assessed implicit and explicit motor sequence learning using sequences of equivalent structure in 15 individuals with a positive HD genetic test (7 premanifest; 8 early stage disease) and 11 matched controls. The HD group showed evidence of normal implicit motor sequence learning, whereas explicit motor sequence learning was impaired in manifest and premanifest HD gene carriers, with progressive decline with progressive disease. Explicit sequence learning may be a useful cognitive biomarker for HD progression. © 2010 Movement Disorder Society</div>
</front>
</TEI>
</ISTEX>
</double>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001E72 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 001E72 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Curation
   |type=    RBID
   |clé=     ISTEX:839BF11695DED630C7260C0F7F986BFF334CB305
   |texte=   Abnormal explicit but normal implicit sequence learning in premanifest and early Huntington's disease
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Movement Disorders (revue)

Abnormal explicit but normal implicit sequence learning in premanifest and early Huntington's disease

Abnormal explicit but normal implicit sequence learning in premanifest and early Huntington's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri