Abnormal explicit but normal implicit sequence learning in premanifest and early Huntington's disease.
Identifieur interne : 001810 ( PubMed/Corpus ); précédent : 001809; suivant : 001811Abnormal explicit but normal implicit sequence learning in premanifest and early Huntington's disease.
Auteurs : Susanne A. Schneider ; Leonora Wilkinson ; Kailash P. Bhatia ; Susie M D. Henley ; John C. Rothwell ; Sarah J. Tabrizi ; Marjan JahanshahiSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- Adult, Age of Onset, Executive Function (physiology), Female, Humans, Huntington Disease (complications), Huntington Disease (genetics), Learning Disorders (classification), Learning Disorders (etiology), Male, Memory, Short-Term (physiology), Middle Aged, Neuropsychological Tests, Serial Learning (physiology), Statistics as Topic, Trinucleotide Repeat Expansion (genetics).
- MESH :
- classification : Learning Disorders.
- complications : Huntington Disease.
- etiology : Learning Disorders.
- genetics : Huntington Disease, Trinucleotide Repeat Expansion.
- physiology : Executive Function, Memory, Short-Term, Serial Learning.
- Adult, Age of Onset, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Statistics as Topic.
Abstract
Learning may occur with or without awareness, as explicit (intentional) or implicit (incidental) learning. The caudate nucleus and the putamen, which are affected early in Huntington's disease (HD), are thought to be essential for motor sequence learning. However, the results of existing studies are inconsistent concerning presence/absence of deficits in implicit and explicit motor sequence learning in HD. We assessed implicit and explicit motor sequence learning using sequences of equivalent structure in 15 individuals with a positive HD genetic test (7 premanifest; 8 early stage disease) and 11 matched controls. The HD group showed evidence of normal implicit motor sequence learning, whereas explicit motor sequence learning was impaired in manifest and premanifest HD gene carriers, with progressive decline with progressive disease. Explicit sequence learning may be a useful cognitive biomarker for HD progression.
DOI: 10.1002/mds.22692
PubMed: 20544716
Links to Exploration step
pubmed:20544716Le document en format XML
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<affiliation><nlm:affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square,London, United Kingdom.</nlm:affiliation>
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<author><name sortKey="Wilkinson, Leonora" sort="Wilkinson, Leonora" uniqKey="Wilkinson L" first="Leonora" last="Wilkinson">Leonora Wilkinson</name>
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<author><name sortKey="Bhatia, Kailash P" sort="Bhatia, Kailash P" uniqKey="Bhatia K" first="Kailash P" last="Bhatia">Kailash P. Bhatia</name>
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<author><name sortKey="Tabrizi, Sarah J" sort="Tabrizi, Sarah J" uniqKey="Tabrizi S" first="Sarah J" last="Tabrizi">Sarah J. Tabrizi</name>
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<author><name sortKey="Jahanshahi, Marjan" sort="Jahanshahi, Marjan" uniqKey="Jahanshahi M" first="Marjan" last="Jahanshahi">Marjan Jahanshahi</name>
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<term>Trinucleotide Repeat Expansion (genetics)</term>
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<term>Trinucleotide Repeat Expansion</term>
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<front><div type="abstract" xml:lang="en">Learning may occur with or without awareness, as explicit (intentional) or implicit (incidental) learning. The caudate nucleus and the putamen, which are affected early in Huntington's disease (HD), are thought to be essential for motor sequence learning. However, the results of existing studies are inconsistent concerning presence/absence of deficits in implicit and explicit motor sequence learning in HD. We assessed implicit and explicit motor sequence learning using sequences of equivalent structure in 15 individuals with a positive HD genetic test (7 premanifest; 8 early stage disease) and 11 matched controls. The HD group showed evidence of normal implicit motor sequence learning, whereas explicit motor sequence learning was impaired in manifest and premanifest HD gene carriers, with progressive decline with progressive disease. Explicit sequence learning may be a useful cognitive biomarker for HD progression.</div>
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<Abstract><AbstractText>Learning may occur with or without awareness, as explicit (intentional) or implicit (incidental) learning. The caudate nucleus and the putamen, which are affected early in Huntington's disease (HD), are thought to be essential for motor sequence learning. However, the results of existing studies are inconsistent concerning presence/absence of deficits in implicit and explicit motor sequence learning in HD. We assessed implicit and explicit motor sequence learning using sequences of equivalent structure in 15 individuals with a positive HD genetic test (7 premanifest; 8 early stage disease) and 11 matched controls. The HD group showed evidence of normal implicit motor sequence learning, whereas explicit motor sequence learning was impaired in manifest and premanifest HD gene carriers, with progressive decline with progressive disease. Explicit sequence learning may be a useful cognitive biomarker for HD progression.</AbstractText>
<CopyrightInformation>(c) 2010 Movement Disorder Society.</CopyrightInformation>
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