Abnormal explicit but normal implicit sequence learning in premanifest and early Huntington's disease
Identifieur interne : 001A19 ( Istex/Corpus ); précédent : 001A18; suivant : 001A20Abnormal explicit but normal implicit sequence learning in premanifest and early Huntington's disease
Auteurs : Susanne A. Schneider ; Leonora Wilkinson ; Kailash P. Bhatia ; Susie M. D. Henley ; John C. Rothwell ; Sarah J. Tabrizi ; Marjan JahanshahiSource :
- Movement Disorders [ 0885-3185 ] ; 2010-07-30.
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- KwdEn :
Abstract
Learning may occur with or without awareness, as explicit (intentional) or implicit (incidental) learning. The caudate nucleus and the putamen, which are affected early in Huntington's disease (HD), are thought to be essential for motor sequence learning. However, the results of existing studies are inconsistent concerning presence/absence of deficits in implicit and explicit motor sequence learning in HD. We assessed implicit and explicit motor sequence learning using sequences of equivalent structure in 15 individuals with a positive HD genetic test (7 premanifest; 8 early stage disease) and 11 matched controls. The HD group showed evidence of normal implicit motor sequence learning, whereas explicit motor sequence learning was impaired in manifest and premanifest HD gene carriers, with progressive decline with progressive disease. Explicit sequence learning may be a useful cognitive biomarker for HD progression. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.22692
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ISTEX:839BF11695DED630C7260C0F7F986BFF334CB305Le document en format XML
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Schneider</name><affiliation><mods:affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square,London, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Wilkinson, Leonora" sort="Wilkinson, Leonora" uniqKey="Wilkinson L" first="Leonora" last="Wilkinson">Leonora Wilkinson</name><affiliation><mods:affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square,London, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Bhatia, Kailash P" sort="Bhatia, Kailash P" uniqKey="Bhatia K" first="Kailash P." last="Bhatia">Kailash P. 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The caudate nucleus and the putamen, which are affected early in Huntington's disease (HD), are thought to be essential for motor sequence learning. However, the results of existing studies are inconsistent concerning presence/absence of deficits in implicit and explicit motor sequence learning in HD. We assessed implicit and explicit motor sequence learning using sequences of equivalent structure in 15 individuals with a positive HD genetic test (7 premanifest; 8 early stage disease) and 11 matched controls. The HD group showed evidence of normal implicit motor sequence learning, whereas explicit motor sequence learning was impaired in manifest and premanifest HD gene carriers, with progressive decline with progressive disease. Explicit sequence learning may be a useful cognitive biomarker for HD progression. © 2010 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Susanne A. 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The caudate nucleus and the putamen, which are affected early in Huntington's disease (HD), are thought to be essential for motor sequence learning. However, the results of existing studies are inconsistent concerning presence/absence of deficits in implicit and explicit motor sequence learning in HD. We assessed implicit and explicit motor sequence learning using sequences of equivalent structure in 15 individuals with a positive HD genetic test (7 premanifest; 8 early stage disease) and 11 matched controls. The HD group showed evidence of normal implicit motor sequence learning, whereas explicit motor sequence learning was impaired in manifest and premanifest HD gene carriers, with progressive decline with progressive disease. Explicit sequence learning may be a useful cognitive biomarker for HD progression. © 2010 Movement Disorder Society</abstract><qualityIndicators><score>5.827</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>961</abstractCharCount><pdfWordCount>4171</pdfWordCount><pdfCharCount>26538</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>138</abstractWordCount></qualityIndicators><title>Abnormal explicit but normal implicit sequence learning in premanifest and early Huntington's disease</title><genre><json:string>Serial article</json:string></genre><host><volume>25</volume><pages><total>7</total><last>1349</last><first>1343</first></pages><issn><json:string>0885-3185</json:string></issn><issue>10</issue><subject><json:item><value>Research Article</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2010</publicationDate><copyrightDate>2010</copyrightDate><doi><json:string>10.1002/mds.22692</json:string></doi><id>839BF11695DED630C7260C0F7F986BFF334CB305</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/839BF11695DED630C7260C0F7F986BFF334CB305/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/839BF11695DED630C7260C0F7F986BFF334CB305/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/839BF11695DED630C7260C0F7F986BFF334CB305/fulltext/tei"><teiHeader type="text"><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Abnormal explicit but normal implicit sequence learning in premanifest and early Huntington's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Wiley Subscription Services, Inc., A Wiley Company</p></availability><date>2010</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: The authors have no conflicts of interest.</note><note>Astor Studentship by the Brain Research Trust, UK</note><note>Career Development Fellowship from the Parkinson's Disease Society, UK</note><note>Welcome Trust</note><note>National Institute of Neurological Disorders and Stroke</note><note>National Institute of Health, USA</note><note>Dementia Research Centre is an Alzheimer's Research Trust Co‐ordinating Centre</note><note>CHDI Inc.</note><note>Department of Health's NIHR Biomedical Research Centres</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Abnormal explicit but normal implicit sequence learning in premanifest and early Huntington's disease</title><author><persName><forename type="first">Susanne A.</forename><surname>Schneider</surname><roleName type="degree">MD, PhD</roleName></persName><note type="biography">Susanne A. Schneider and Leonora Wilkinson contributed equally to this work.</note><affiliation>Susanne A. Schneider and Leonora Wilkinson contributed equally to this work.</affiliation><affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square,London, United Kingdom</affiliation></author><author><persName><forename type="first">Leonora</forename><surname>Wilkinson</surname><roleName type="degree">PhD</roleName></persName><note type="biography">Susanne A. Schneider and Leonora Wilkinson contributed equally to this work.</note><affiliation>Susanne A. Schneider and Leonora Wilkinson contributed equally to this work.</affiliation><affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square,London, United Kingdom</affiliation></author><author><persName><forename type="first">Kailash P.</forename><surname>Bhatia</surname><roleName type="degree">MD, FRCP</roleName></persName><affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square,London, United Kingdom</affiliation></author><author><persName><forename type="first">Susie M. 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The caudate nucleus and the putamen, which are affected early in Huntington's disease (HD), are thought to be essential for motor sequence learning. However, the results of existing studies are inconsistent concerning presence/absence of deficits in implicit and explicit motor sequence learning in HD. We assessed implicit and explicit motor sequence learning using sequences of equivalent structure in 15 individuals with a positive HD genetic test (7 premanifest; 8 early stage disease) and 11 matched controls. The HD group showed evidence of normal implicit motor sequence learning, whereas explicit motor sequence learning was impaired in manifest and premanifest HD gene carriers, with progressive decline with progressive disease. Explicit sequence learning may be a useful cognitive biomarker for HD progression. © 2010 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Huntington's disease</term></item><item><term>manifesting</term></item><item><term>presymptomatic</term></item><item><term>explicit sequence learning</term></item><item><term>implicit sequence learning</term></item><item><term>serial reaction time task</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2009-03-10">Received</change><change when="2009-06-10">Registration</change><change when="2010-07-30">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/839BF11695DED630C7260C0F7F986BFF334CB305/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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D.</givenNames><familyName>Henley</familyName><degrees>MA</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>John C.</givenNames><familyName>Rothwell</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Sarah J.</givenNames><familyName>Tabrizi</familyName><degrees>MD, FRCP, PhD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Marjan</givenNames><familyName>Jahanshahi</familyName><degrees>DClinPsy, PhD</degrees></personName><contactDetails><email>m.jahanshahi@ion.ucl.ac.uk.</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="GB" type="organization"><unparsedAffiliation>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square,London, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="GB" type="organization"><unparsedAffiliation>Department of Neurodegenerative Disease, UCL, Institute of Neurology, Queen Square, London, United Kingdom</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Huntington's disease</keyword><keyword xml:id="kwd2">manifesting</keyword><keyword xml:id="kwd3">presymptomatic</keyword><keyword xml:id="kwd4">explicit sequence learning</keyword><keyword xml:id="kwd5">implicit sequence learning</keyword><keyword xml:id="kwd6">serial reaction time task</keyword></keywordGroup><fundingInfo><fundingAgency>Astor Studentship by the Brain Research Trust, UK</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Career Development Fellowship from the Parkinson's Disease Society, UK</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Welcome Trust</fundingAgency></fundingInfo><fundingInfo><fundingAgency>National Institute of Neurological Disorders and Stroke</fundingAgency></fundingInfo><fundingInfo><fundingAgency>National Institute of Health, USA</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Dementia Research Centre is an Alzheimer's Research Trust Co‐ordinating Centre</fundingAgency></fundingInfo><fundingInfo><fundingAgency>CHDI Inc.</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Department of Health's NIHR Biomedical Research Centres</fundingAgency></fundingInfo><supportingInformation><p> Additional Supporting Information may be found in the online version of this article. </p><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds22692:MDS_22692_sm_SupInfo"></mediaResource><caption>Supplemental Information.</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Learning may occur with or without awareness, as explicit (intentional) or implicit (incidental) learning. The caudate nucleus and the putamen, which are affected early in Huntington's disease (HD), are thought to be essential for motor sequence learning. However, the results of existing studies are inconsistent concerning presence/absence of deficits in implicit and explicit motor sequence learning in HD. We assessed implicit and explicit motor sequence learning using sequences of equivalent structure in 15 individuals with a positive HD genetic test (7 premanifest; 8 early stage disease) and 11 matched controls. The HD group showed evidence of normal implicit motor sequence learning, whereas explicit motor sequence learning was impaired in manifest and premanifest HD gene carriers, with progressive decline with progressive disease. Explicit sequence learning may be a useful cognitive biomarker for HD progression. © 2010 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn2"><p>Potential conflict of interest: The authors have no conflicts of interest.</p></note><note xml:id="fn3"><p>Susanne A. Schneider and Leonora Wilkinson contributed equally to this work.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Abnormal explicit but normal implicit sequence learning in premanifest and early Huntington's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Implicit and Explicit Sequence Learning in HD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Abnormal explicit but normal implicit sequence learning in premanifest and early Huntington's disease</title></titleInfo><name type="personal"><namePart type="given">Susanne A.</namePart><namePart type="family">Schneider</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square,London, United Kingdom</affiliation><description>Susanne A. Schneider and Leonora Wilkinson contributed equally to this work.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Leonora</namePart><namePart type="family">Wilkinson</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square,London, United Kingdom</affiliation><description>Susanne A. Schneider and Leonora Wilkinson contributed equally to this work.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kailash P.</namePart><namePart type="family">Bhatia</namePart><namePart type="termsOfAddress">MD, FRCP</namePart><affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square,London, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Susie M. D.</namePart><namePart type="family">Henley</namePart><namePart type="termsOfAddress">MA</namePart><affiliation>Department of Neurodegenerative Disease, UCL, Institute of Neurology, Queen Square, London, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">John C.</namePart><namePart type="family">Rothwell</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square,London, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sarah J.</namePart><namePart type="family">Tabrizi</namePart><namePart type="termsOfAddress">MD, FRCP, PhD</namePart><affiliation>Department of Neurodegenerative Disease, UCL, Institute of Neurology, Queen Square, London, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marjan</namePart><namePart type="family">Jahanshahi</namePart><namePart type="termsOfAddress">DClinPsy, PhD</namePart><affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square,London, United Kingdom</affiliation><description>Correspondence: Sobell Department of Motor Neuroscience and Movement Disorders, The National Hospital for Neurology and Neurosurgery, Institute of Neurology, UCL, 33 Queen Square, London WC1N 3 BG, United Kingdom</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2010-07-30</dateIssued><dateCaptured encoding="w3cdtf">2009-03-10</dateCaptured><dateValid encoding="w3cdtf">2009-06-10</dateValid><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">1</extent><extent unit="references">27</extent><extent unit="words">5144</extent></physicalDescription><abstract lang="en">Learning may occur with or without awareness, as explicit (intentional) or implicit (incidental) learning. The caudate nucleus and the putamen, which are affected early in Huntington's disease (HD), are thought to be essential for motor sequence learning. However, the results of existing studies are inconsistent concerning presence/absence of deficits in implicit and explicit motor sequence learning in HD. We assessed implicit and explicit motor sequence learning using sequences of equivalent structure in 15 individuals with a positive HD genetic test (7 premanifest; 8 early stage disease) and 11 matched controls. The HD group showed evidence of normal implicit motor sequence learning, whereas explicit motor sequence learning was impaired in manifest and premanifest HD gene carriers, with progressive decline with progressive disease. Explicit sequence learning may be a useful cognitive biomarker for HD progression. © 2010 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: The authors have no conflicts of interest.</note><note type="funding">Astor Studentship by the Brain Research Trust, UK</note><note type="funding">Career Development Fellowship from the Parkinson's Disease Society, UK</note><note type="funding">Welcome Trust</note><note type="funding">National Institute of Neurological Disorders and Stroke</note><note type="funding">National Institute of Health, USA</note><note type="funding">Dementia Research Centre is an Alzheimer's Research Trust Co‐ordinating Centre</note><note type="funding">CHDI Inc.</note><note type="funding">Department of Health's NIHR Biomedical Research Centres</note><subject lang="en"><genre>Keywords</genre><topic>Huntington's disease</topic><topic>manifesting</topic><topic>presymptomatic</topic><topic>explicit sequence learning</topic><topic>implicit sequence learning</topic><topic>serial reaction time task</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><note type="content"> Additional Supporting Information may be found in the online version of this article.Supporting Info Item: Supplemental Information. - </note><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><detail type="issue"><caption>no.</caption><number>10</number></detail><extent unit="pages"><start>1343</start><end>1349</end><total>7</total></extent></part></relatedItem><identifier type="istex">839BF11695DED630C7260C0F7F986BFF334CB305</identifier><identifier type="DOI">10.1002/mds.22692</identifier><identifier type="ArticleID">MDS22692</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2010 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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