Abnormal explicit but normal implicit sequence learning in premanifest and early Huntington's disease
Identifieur interne : 001A19 ( Istex/Corpus ); précédent : 001A18; suivant : 001A20Abnormal explicit but normal implicit sequence learning in premanifest and early Huntington's disease
Auteurs : Susanne A. Schneider ; Leonora Wilkinson ; Kailash P. Bhatia ; Susie M. D. Henley ; John C. Rothwell ; Sarah J. Tabrizi ; Marjan JahanshahiSource :
- Movement Disorders [ 0885-3185 ] ; 2010-07-30.
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- KwdEn :
Abstract
Learning may occur with or without awareness, as explicit (intentional) or implicit (incidental) learning. The caudate nucleus and the putamen, which are affected early in Huntington's disease (HD), are thought to be essential for motor sequence learning. However, the results of existing studies are inconsistent concerning presence/absence of deficits in implicit and explicit motor sequence learning in HD. We assessed implicit and explicit motor sequence learning using sequences of equivalent structure in 15 individuals with a positive HD genetic test (7 premanifest; 8 early stage disease) and 11 matched controls. The HD group showed evidence of normal implicit motor sequence learning, whereas explicit motor sequence learning was impaired in manifest and premanifest HD gene carriers, with progressive decline with progressive disease. Explicit sequence learning may be a useful cognitive biomarker for HD progression. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.22692
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<fundingInfo><fundingAgency>Astor Studentship by the Brain Research Trust, UK</fundingAgency>
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<p>Learning may occur with or without awareness, as explicit (intentional) or implicit (incidental) learning. The caudate nucleus and the putamen, which are affected early in Huntington's disease (HD), are thought to be essential for motor sequence learning. However, the results of existing studies are inconsistent concerning presence/absence of deficits in implicit and explicit motor sequence learning in HD. We assessed implicit and explicit motor sequence learning using sequences of equivalent structure in 15 individuals with a positive HD genetic test (7 premanifest; 8 early stage disease) and 11 matched controls. The HD group showed evidence of normal implicit motor sequence learning, whereas explicit motor sequence learning was impaired in manifest and premanifest HD gene carriers, with progressive decline with progressive disease. Explicit sequence learning may be a useful cognitive biomarker for HD progression. © 2010 Movement Disorder Society</p>
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<noteGroup><note xml:id="fn2"><p>Potential conflict of interest: The authors have no conflicts of interest.</p>
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<note xml:id="fn3"><p>Susanne A. Schneider and Leonora Wilkinson contributed equally to this work.</p>
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<name type="personal"><namePart type="given">Susanne A.</namePart>
<namePart type="family">Schneider</namePart>
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<affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square,London, United Kingdom</affiliation>
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<affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square,London, United Kingdom</affiliation>
<description>Susanne A. Schneider and Leonora Wilkinson contributed equally to this work.</description>
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<name type="personal"><namePart type="given">Kailash P.</namePart>
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<name type="personal"><namePart type="given">Sarah J.</namePart>
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<affiliation>Sobell Department of Motor Neuroscience and Movement Disorders, UCL, Institute of Neurology, Queen Square,London, United Kingdom</affiliation>
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<abstract lang="en">Learning may occur with or without awareness, as explicit (intentional) or implicit (incidental) learning. The caudate nucleus and the putamen, which are affected early in Huntington's disease (HD), are thought to be essential for motor sequence learning. However, the results of existing studies are inconsistent concerning presence/absence of deficits in implicit and explicit motor sequence learning in HD. We assessed implicit and explicit motor sequence learning using sequences of equivalent structure in 15 individuals with a positive HD genetic test (7 premanifest; 8 early stage disease) and 11 matched controls. The HD group showed evidence of normal implicit motor sequence learning, whereas explicit motor sequence learning was impaired in manifest and premanifest HD gene carriers, with progressive decline with progressive disease. Explicit sequence learning may be a useful cognitive biomarker for HD progression. © 2010 Movement Disorder Society</abstract>
<note type="content">*Potential conflict of interest: The authors have no conflicts of interest.</note>
<note type="funding">Astor Studentship by the Brain Research Trust, UK</note>
<note type="funding">Career Development Fellowship from the Parkinson's Disease Society, UK</note>
<note type="funding">Welcome Trust</note>
<note type="funding">National Institute of Neurological Disorders and Stroke</note>
<note type="funding">National Institute of Health, USA</note>
<note type="funding">Dementia Research Centre is an Alzheimer's Research Trust Co‐ordinating Centre</note>
<note type="funding">CHDI Inc.</note>
<note type="funding">Department of Health's NIHR Biomedical Research Centres</note>
<subject lang="en"><genre>Keywords</genre>
<topic>Huntington's disease</topic>
<topic>manifesting</topic>
<topic>presymptomatic</topic>
<topic>explicit sequence learning</topic>
<topic>implicit sequence learning</topic>
<topic>serial reaction time task</topic>
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<identifier type="ISSN">0885-3185</identifier>
<identifier type="eISSN">1531-8257</identifier>
<identifier type="DOI">10.1002/(ISSN)1531-8257</identifier>
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<part><date>2010</date>
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<number>25</number>
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