MovDisordV3, Main, Curation, bibRecord, 001B03

Plasma selenium is positively related to performance in neurological tasks assessing coordination and motor speed

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Plasma selenium is positively related to performance in neurological tasks assessing coordination and motor speed

Auteurs : Avner Shahar [États-Unis, Israël] ; Kushang V. Patel [États-Unis] ; Richard D. Semba [États-Unis] ; Stefania Bandinelli [Italie] ; Danit R. Shahar [États-Unis, Israël] ; Louigi Ferrucci [États-Unis] ; Jack M. Guralnik [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2010-09-15.

RBID : ISTEX:77B47EEB9950D60C81C8C6D5DC30F1C892A2C7AE

Descripteurs français

Pascal (Inist)
- Antioxydant, Coordination, Maladie de Parkinson, Pathologie du système nerveux, Performance, Personne âgée, Sélénium, Vitesse déplacement.
Wicri :
- topic : Personne âgée.

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Antioxidant, Coordination, Elderly, Female, Humans, Linear Models, Male, Nervous system diseases, Neurologic Examination, Parkinson Disease (blood), Parkinson Disease (physiopathology), Parkinson disease, Parkinson's disease, Performance, Psychomotor Performance (physiology), Selenium, Selenium (blood), Speed, antioxidants, elderly, selenium, trace elements.
MESH :
- chemical , blood : Selenium.
- blood : Parkinson Disease.
- physiology : Psychomotor Performance.
- physiopathology : Parkinson Disease.
- Aged, Aged, 80 and over, Female, Humans, Linear Models, Male, Neurologic Examination.

Abstract

Parkinson's disease (PD) is a degenerative process affecting the striato nigral system (SN). Its etiology, although obscure, may involve oxidative damage. Selenium, an antioxidant, was shown to protect the SN in animal models. In the current study, we investigate the association between plasma selenium concentrations and the presence of “soft” neurological signs related to the SN. Plasma selenium concentration was assessed in participants of age ≥65 years in the InCHIANTI study, a population‐based cohort study in Tuscany, Italy. PD was defined based on standard criteria. “Soft” neurological signs were ascertained by physical examination. A total of 1,012 participants were included. No association was found between the presence of PD and plasma selenium. There was, however, a strong association between plasma selenium and timed performance‐based assessments. Lower levels of selenium were significantly associated withdecreased performance in neurological tests of coordination among older adults. Prospective studies are needed to further investigate the effects of selenium on SN dysfunction. © 2010 Movement Disorder Society

Url:

DOI: 10.1002/mds.23218

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ISTEX:77B47EEB9950D60C81C8C6D5DC30F1C892A2C7AE

Le document en format XML

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<front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is a degenerative process affecting the striato nigral system (SN). Its etiology, although obscure, may involve oxidative damage. Selenium, an antioxidant, was shown to protect the SN in animal models. In the current study, we investigate the association between plasma selenium concentrations and the presence of “soft” neurological signs related to the SN. Plasma selenium concentration was assessed in participants of age ≥65 years in the InCHIANTI study, a population‐based cohort study in Tuscany, Italy. PD was defined based on standard criteria. “Soft” neurological signs were ascertained by physical examination. A total of 1,012 participants were included. No association was found between the presence of PD and plasma selenium. There was, however, a strong association between plasma selenium and timed performance‐based assessments. Lower levels of selenium were significantly associated withdecreased performance in neurological tests of coordination among older adults. Prospective studies are needed to further investigate the effects of selenium on SN dysfunction. © 2010 Movement Disorder Society</div>
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<front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is a degenerative process affecting the striato nigral system (SN). Its etiology, although obscure, may involve oxidative damage. Selenium, an antioxidant, was shown to protect the SN in animal models. In the current study, we investigate the association between plasma selenium concentrations and the presence of "soft" neurological signs related to the SN. Plasma selenium concentration was assessed in participants of age ≥65 years in the InCHIANTI study, a population-based cohort study in Tuscany, Italy. PD was defined based on standard criteria. "Soft" neurological signs were ascertained by physical examination. A total of 1,012 participants were included. No association was found between the presence of PD and plasma selenium. There was, however, a strong association between plasma selenium and timed performance-based assessments. Lower levels of selenium were significantly associated with decreased performance in neurological tests of coordination among older adults. Prospective studies are needed to further investigate the effects of selenium on SN dysfunction.</div>
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<front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is a degenerative process affecting the striato nigral system (SN). Its etiology, although obscure, may involve oxidative damage. Selenium, an antioxidant, was shown to protect the SN in animal models. In the current study, we investigate the association between plasma selenium concentrations and the presence of “soft” neurological signs related to the SN. Plasma selenium concentration was assessed in participants of age ≥65 years in the InCHIANTI study, a population‐based cohort study in Tuscany, Italy. PD was defined based on standard criteria. “Soft” neurological signs were ascertained by physical examination. A total of 1,012 participants were included. No association was found between the presence of PD and plasma selenium. There was, however, a strong association between plasma selenium and timed performance‐based assessments. Lower levels of selenium were significantly associated withdecreased performance in neurological tests of coordination among older adults. Prospective studies are needed to further investigate the effects of selenium on SN dysfunction. © 2010 Movement Disorder Society</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Plasma selenium is positively related to performance in neurological tasks assessing coordination and motor speed

Plasma selenium is positively related to performance in neurological tasks assessing coordination and motor speed

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