Plasma selenium is positively related to performance in neurological tasks assessing coordination and motor speed
Identifieur interne : 001B03 ( Main/Curation ); précédent : 001B02; suivant : 001B04Plasma selenium is positively related to performance in neurological tasks assessing coordination and motor speed
Auteurs : Avner Shahar [États-Unis, Israël] ; Kushang V. Patel [États-Unis] ; Richard D. Semba [États-Unis] ; Stefania Bandinelli [Italie] ; Danit R. Shahar [États-Unis, Israël] ; Louigi Ferrucci [États-Unis] ; Jack M. Guralnik [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-09-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Personne âgée.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Antioxidant, Coordination, Elderly, Female, Humans, Linear Models, Male, Nervous system diseases, Neurologic Examination, Parkinson Disease (blood), Parkinson Disease (physiopathology), Parkinson disease, Parkinson's disease, Performance, Psychomotor Performance (physiology), Selenium, Selenium (blood), Speed, antioxidants, elderly, selenium, trace elements.
- MESH :
- chemical , blood : Selenium.
- blood : Parkinson Disease.
- physiology : Psychomotor Performance.
- physiopathology : Parkinson Disease.
- Aged, Aged, 80 and over, Female, Humans, Linear Models, Male, Neurologic Examination.
Abstract
Parkinson's disease (PD) is a degenerative process affecting the striato nigral system (SN). Its etiology, although obscure, may involve oxidative damage. Selenium, an antioxidant, was shown to protect the SN in animal models. In the current study, we investigate the association between plasma selenium concentrations and the presence of “soft” neurological signs related to the SN. Plasma selenium concentration was assessed in participants of age ≥65 years in the InCHIANTI study, a population‐based cohort study in Tuscany, Italy. PD was defined based on standard criteria. “Soft” neurological signs were ascertained by physical examination. A total of 1,012 participants were included. No association was found between the presence of PD and plasma selenium. There was, however, a strong association between plasma selenium and timed performance‐based assessments. Lower levels of selenium were significantly associated withdecreased performance in neurological tests of coordination among older adults. Prospective studies are needed to further investigate the effects of selenium on SN dysfunction. © 2010 Movement Disorder Society
Url:
- https://api.istex.fr/document/77B47EEB9950D60C81C8C6D5DC30F1C892A2C7AE/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270688
DOI: 10.1002/mds.23218
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ISTEX:77B47EEB9950D60C81C8C6D5DC30F1C892A2C7AELe document en format XML
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<front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is a degenerative process affecting the striato nigral system (SN). Its etiology, although obscure, may involve oxidative damage. Selenium, an antioxidant, was shown to protect the SN in animal models. In the current study, we investigate the association between plasma selenium concentrations and the presence of “soft” neurological signs related to the SN. Plasma selenium concentration was assessed in participants of age ≥65 years in the InCHIANTI study, a population‐based cohort study in Tuscany, Italy. PD was defined based on standard criteria. “Soft” neurological signs were ascertained by physical examination. A total of 1,012 participants were included. No association was found between the presence of PD and plasma selenium. There was, however, a strong association between plasma selenium and timed performance‐based assessments. Lower levels of selenium were significantly associated withdecreased performance in neurological tests of coordination among older adults. Prospective studies are needed to further investigate the effects of selenium on SN dysfunction. © 2010 Movement Disorder Society</div>
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<front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is a degenerative process affecting the striato nigral system (SN). Its etiology, although obscure, may involve oxidative damage. Selenium, an antioxidant, was shown to protect the SN in animal models. In the current study, we investigate the association between plasma selenium concentrations and the presence of "soft" neurological signs related to the SN. Plasma selenium concentration was assessed in participants of age ≥65 years in the InCHIANTI study, a population-based cohort study in Tuscany, Italy. PD was defined based on standard criteria. "Soft" neurological signs were ascertained by physical examination. A total of 1,012 participants were included. No association was found between the presence of PD and plasma selenium. There was, however, a strong association between plasma selenium and timed performance-based assessments. Lower levels of selenium were significantly associated with decreased performance in neurological tests of coordination among older adults. Prospective studies are needed to further investigate the effects of selenium on SN dysfunction.</div>
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<front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is a degenerative process affecting the striato nigral system (SN). Its etiology, although obscure, may involve oxidative damage. Selenium, an antioxidant, was shown to protect the SN in animal models. In the current study, we investigate the association between plasma selenium concentrations and the presence of “soft” neurological signs related to the SN. Plasma selenium concentration was assessed in participants of age ≥65 years in the InCHIANTI study, a population‐based cohort study in Tuscany, Italy. PD was defined based on standard criteria. “Soft” neurological signs were ascertained by physical examination. A total of 1,012 participants were included. No association was found between the presence of PD and plasma selenium. There was, however, a strong association between plasma selenium and timed performance‐based assessments. Lower levels of selenium were significantly associated withdecreased performance in neurological tests of coordination among older adults. Prospective studies are needed to further investigate the effects of selenium on SN dysfunction. © 2010 Movement Disorder Society</div>
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