Plasma selenium is positively related to performance in neurological tasks assessing coordination and motor speed
Identifieur interne : 002D73 ( Ncbi/Merge ); précédent : 002D72; suivant : 002D74Plasma selenium is positively related to performance in neurological tasks assessing coordination and motor speed
Auteurs : A. Shahar [États-Unis, Israël] ; Kv Patel [États-Unis] ; Rd Semba [États-Unis] ; S. Bandinelli [Italie] ; Dr Shahar [États-Unis, Israël] ; L. Ferrucci [États-Unis] ; Jm Guralnik [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2010.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Selenium.
- blood : Parkinson Disease.
- physiology : Psychomotor Performance.
- physiopathology : Parkinson Disease.
- Aged, Aged, 80 and over, Female, Humans, Linear Models, Male, Neurologic Examination.
Abstract
Parkinson’s disease [PD] is a degenerative process affecting the striato nigral system [SN]. Its etiology, although obscure may involve oxidative damage. Selenium, an anti-oxidant, was shown to protect the SN in animal models. In the current study we investigate the association between plasma selenium concentrations and the presence of “soft” neurological signs related to the SN.
Plasma selenium concentration was assessed in participants age ≥65y in the InCHIANTI study, a population-based cohort study in Tuscany, Italy. PD was defined based on standard criteria. “Soft” neurological signs were ascertained by physical examination.
A total of 1012 participants were included. No association was found between the presence of PD and plasma selenium. There was, however, a strong association between plasma selenium and timed performance-based assessments.
Lower levels of selenium were significantly associated with decreased performance in neurological tests of coordination among older adults. Prospective studies are needed to further investigate the effects of selenium on SN dysfunction.
Url:
DOI: 10.1002/mds.23218
PubMed: 20687175
PubMed Central: 3270688
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000155
- to stream Pmc, to step Curation: 000155
- to stream Pmc, to step Checkpoint: 000317
- to stream PubMed, to step Corpus: 001644
- to stream PubMed, to step Curation: 001644
- to stream PubMed, to step Checkpoint: 001699
Links to Exploration step
PMC:3270688Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Plasma selenium is positively related to performance in neurological tasks assessing coordination and motor speed</title><author><name sortKey="Shahar, A" sort="Shahar, A" uniqKey="Shahar A" first="A" last="Shahar">A. Shahar</name><affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethsda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethsda</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">South district Geriatric physician, Ministry of Health, Beer-Sheva, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>South district Geriatric physician, Ministry of Health, Beer-Sheva</wicri:regionArea><wicri:noRegion>Beer-Sheva</wicri:noRegion></affiliation></author><author><name sortKey="Patel, Kv" sort="Patel, Kv" uniqKey="Patel K" first="Kv" last="Patel">Kv Patel</name><affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethsda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethsda</wicri:cityArea></affiliation></author><author><name sortKey="Semba, Rd" sort="Semba, Rd" uniqKey="Semba R" first="Rd" last="Semba">Rd Semba</name><affiliation wicri:level="2"><nlm:aff id="A3">Johns Hopkins University School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Bandinelli, S" sort="Bandinelli, S" uniqKey="Bandinelli S" first="S" last="Bandinelli">S. Bandinelli</name><affiliation wicri:level="1"><nlm:aff id="A4">Geriatric Rehabilitation Unit, Azienda Sanitaria Firenze, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Geriatric Rehabilitation Unit, Azienda Sanitaria Firenze</wicri:regionArea><wicri:noRegion>Azienda Sanitaria Firenze</wicri:noRegion></affiliation></author><author><name sortKey="Shahar, Dr" sort="Shahar, Dr" uniqKey="Shahar D" first="Dr" last="Shahar">Dr Shahar</name><affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethsda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethsda</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">The S. Daniel Abraham International Center for health and Nutrition, Ben-Gurion University of the Negev, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>The S. Daniel Abraham International Center for health and Nutrition, Ben-Gurion University of the Negev</wicri:regionArea><wicri:noRegion>Ben-Gurion University of the Negev</wicri:noRegion></affiliation></author><author><name sortKey="Ferrucci, L" sort="Ferrucci, L" uniqKey="Ferrucci L" first="L" last="Ferrucci">L. Ferrucci</name><affiliation wicri:level="2"><nlm:aff id="A6">Clinical Research Branch, National Institute on Aging, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Clinical Research Branch, National Institute on Aging, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Guralnik, Jm" sort="Guralnik, Jm" uniqKey="Guralnik J" first="Jm" last="Guralnik">Jm Guralnik</name><affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethsda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethsda</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20687175</idno><idno type="pmc">3270688</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270688</idno><idno type="RBID">PMC:3270688</idno><idno type="doi">10.1002/mds.23218</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000155</idno><idno type="wicri:Area/Pmc/Curation">000155</idno><idno type="wicri:Area/Pmc/Checkpoint">000317</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">001644</idno><idno type="wicri:Area/PubMed/Curation">001644</idno><idno type="wicri:Area/PubMed/Checkpoint">001699</idno><idno type="wicri:Area/Ncbi/Merge">002D73</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Plasma selenium is positively related to performance in neurological tasks assessing coordination and motor speed</title><author><name sortKey="Shahar, A" sort="Shahar, A" uniqKey="Shahar A" first="A" last="Shahar">A. Shahar</name><affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethsda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethsda</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">South district Geriatric physician, Ministry of Health, Beer-Sheva, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>South district Geriatric physician, Ministry of Health, Beer-Sheva</wicri:regionArea><wicri:noRegion>Beer-Sheva</wicri:noRegion></affiliation></author><author><name sortKey="Patel, Kv" sort="Patel, Kv" uniqKey="Patel K" first="Kv" last="Patel">Kv Patel</name><affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethsda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethsda</wicri:cityArea></affiliation></author><author><name sortKey="Semba, Rd" sort="Semba, Rd" uniqKey="Semba R" first="Rd" last="Semba">Rd Semba</name><affiliation wicri:level="2"><nlm:aff id="A3">Johns Hopkins University School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Bandinelli, S" sort="Bandinelli, S" uniqKey="Bandinelli S" first="S" last="Bandinelli">S. Bandinelli</name><affiliation wicri:level="1"><nlm:aff id="A4">Geriatric Rehabilitation Unit, Azienda Sanitaria Firenze, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Geriatric Rehabilitation Unit, Azienda Sanitaria Firenze</wicri:regionArea><wicri:noRegion>Azienda Sanitaria Firenze</wicri:noRegion></affiliation></author><author><name sortKey="Shahar, Dr" sort="Shahar, Dr" uniqKey="Shahar D" first="Dr" last="Shahar">Dr Shahar</name><affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethsda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethsda</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">The S. Daniel Abraham International Center for health and Nutrition, Ben-Gurion University of the Negev, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>The S. Daniel Abraham International Center for health and Nutrition, Ben-Gurion University of the Negev</wicri:regionArea><wicri:noRegion>Ben-Gurion University of the Negev</wicri:noRegion></affiliation></author><author><name sortKey="Ferrucci, L" sort="Ferrucci, L" uniqKey="Ferrucci L" first="L" last="Ferrucci">L. Ferrucci</name><affiliation wicri:level="2"><nlm:aff id="A6">Clinical Research Branch, National Institute on Aging, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Clinical Research Branch, National Institute on Aging, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Guralnik, Jm" sort="Guralnik, Jm" uniqKey="Guralnik J" first="Jm" last="Guralnik">Jm Guralnik</name><affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethsda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethsda</wicri:cityArea></affiliation></author></analytic><series><title level="j">Movement Disorders</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Linear Models</term><term>Male</term><term>Neurologic Examination</term><term>Parkinson Disease (blood)</term><term>Parkinson Disease (physiopathology)</term><term>Psychomotor Performance (physiology)</term><term>Selenium (blood)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Selenium</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Psychomotor Performance</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Linear Models</term><term>Male</term><term>Neurologic Examination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Parkinson’s disease [PD] is a degenerative process affecting the striato nigral system [SN]. Its etiology, although obscure may involve oxidative damage. Selenium, an anti-oxidant, was shown to protect the SN in animal models. In the current study we investigate the association between plasma selenium concentrations and the presence of “soft” neurological signs related to the SN.</p></sec><sec sec-type="methods" id="S2"><title>Methods</title><p id="P2">Plasma selenium concentration was assessed in participants age ≥65y in the InCHIANTI study, a population-based cohort study in Tuscany, Italy. PD was defined based on standard criteria. “Soft” neurological signs were ascertained by physical examination.</p></sec><sec id="S3"><title>Results</title><p id="P3">A total of 1012 participants were included. No association was found between the presence of PD and plasma selenium. There was, however, a strong association between plasma selenium and timed performance-based assessments.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Lower levels of selenium were significantly associated with decreased performance in neurological tests of coordination among older adults. Prospective studies are needed to further investigate the effects of selenium on SN dysfunction.</p></sec></div></front></TEI><double pmid="20687175"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Plasma selenium is positively related to performance in neurological tasks assessing coordination and motor speed</title><author><name sortKey="Shahar, A" sort="Shahar, A" uniqKey="Shahar A" first="A" last="Shahar">A. Shahar</name><affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethsda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethsda</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">South district Geriatric physician, Ministry of Health, Beer-Sheva, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>South district Geriatric physician, Ministry of Health, Beer-Sheva</wicri:regionArea><wicri:noRegion>Beer-Sheva</wicri:noRegion></affiliation></author><author><name sortKey="Patel, Kv" sort="Patel, Kv" uniqKey="Patel K" first="Kv" last="Patel">Kv Patel</name><affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethsda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethsda</wicri:cityArea></affiliation></author><author><name sortKey="Semba, Rd" sort="Semba, Rd" uniqKey="Semba R" first="Rd" last="Semba">Rd Semba</name><affiliation wicri:level="2"><nlm:aff id="A3">Johns Hopkins University School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Bandinelli, S" sort="Bandinelli, S" uniqKey="Bandinelli S" first="S" last="Bandinelli">S. Bandinelli</name><affiliation wicri:level="1"><nlm:aff id="A4">Geriatric Rehabilitation Unit, Azienda Sanitaria Firenze, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Geriatric Rehabilitation Unit, Azienda Sanitaria Firenze</wicri:regionArea><wicri:noRegion>Azienda Sanitaria Firenze</wicri:noRegion></affiliation></author><author><name sortKey="Shahar, Dr" sort="Shahar, Dr" uniqKey="Shahar D" first="Dr" last="Shahar">Dr Shahar</name><affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethsda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethsda</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">The S. Daniel Abraham International Center for health and Nutrition, Ben-Gurion University of the Negev, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>The S. Daniel Abraham International Center for health and Nutrition, Ben-Gurion University of the Negev</wicri:regionArea><wicri:noRegion>Ben-Gurion University of the Negev</wicri:noRegion></affiliation></author><author><name sortKey="Ferrucci, L" sort="Ferrucci, L" uniqKey="Ferrucci L" first="L" last="Ferrucci">L. Ferrucci</name><affiliation wicri:level="2"><nlm:aff id="A6">Clinical Research Branch, National Institute on Aging, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Clinical Research Branch, National Institute on Aging, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Guralnik, Jm" sort="Guralnik, Jm" uniqKey="Guralnik J" first="Jm" last="Guralnik">Jm Guralnik</name><affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethsda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethsda</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20687175</idno><idno type="pmc">3270688</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270688</idno><idno type="RBID">PMC:3270688</idno><idno type="doi">10.1002/mds.23218</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000155</idno><idno type="wicri:Area/Pmc/Curation">000155</idno><idno type="wicri:Area/Pmc/Checkpoint">000317</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Plasma selenium is positively related to performance in neurological tasks assessing coordination and motor speed</title><author><name sortKey="Shahar, A" sort="Shahar, A" uniqKey="Shahar A" first="A" last="Shahar">A. Shahar</name><affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethsda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethsda</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">South district Geriatric physician, Ministry of Health, Beer-Sheva, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>South district Geriatric physician, Ministry of Health, Beer-Sheva</wicri:regionArea><wicri:noRegion>Beer-Sheva</wicri:noRegion></affiliation></author><author><name sortKey="Patel, Kv" sort="Patel, Kv" uniqKey="Patel K" first="Kv" last="Patel">Kv Patel</name><affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethsda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethsda</wicri:cityArea></affiliation></author><author><name sortKey="Semba, Rd" sort="Semba, Rd" uniqKey="Semba R" first="Rd" last="Semba">Rd Semba</name><affiliation wicri:level="2"><nlm:aff id="A3">Johns Hopkins University School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Johns Hopkins University School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Bandinelli, S" sort="Bandinelli, S" uniqKey="Bandinelli S" first="S" last="Bandinelli">S. Bandinelli</name><affiliation wicri:level="1"><nlm:aff id="A4">Geriatric Rehabilitation Unit, Azienda Sanitaria Firenze, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Geriatric Rehabilitation Unit, Azienda Sanitaria Firenze</wicri:regionArea><wicri:noRegion>Azienda Sanitaria Firenze</wicri:noRegion></affiliation></author><author><name sortKey="Shahar, Dr" sort="Shahar, Dr" uniqKey="Shahar D" first="Dr" last="Shahar">Dr Shahar</name><affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethsda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethsda</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">The S. Daniel Abraham International Center for health and Nutrition, Ben-Gurion University of the Negev, Israel</nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea>The S. Daniel Abraham International Center for health and Nutrition, Ben-Gurion University of the Negev</wicri:regionArea><wicri:noRegion>Ben-Gurion University of the Negev</wicri:noRegion></affiliation></author><author><name sortKey="Ferrucci, L" sort="Ferrucci, L" uniqKey="Ferrucci L" first="L" last="Ferrucci">L. Ferrucci</name><affiliation wicri:level="2"><nlm:aff id="A6">Clinical Research Branch, National Institute on Aging, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Clinical Research Branch, National Institute on Aging, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Guralnik, Jm" sort="Guralnik, Jm" uniqKey="Guralnik J" first="Jm" last="Guralnik">Jm Guralnik</name><affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethsda, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethsda</wicri:cityArea></affiliation></author></analytic><series><title level="j">Movement Disorders</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Parkinson’s disease [PD] is a degenerative process affecting the striato nigral system [SN]. Its etiology, although obscure may involve oxidative damage. Selenium, an anti-oxidant, was shown to protect the SN in animal models. In the current study we investigate the association between plasma selenium concentrations and the presence of “soft” neurological signs related to the SN.</p></sec><sec sec-type="methods" id="S2"><title>Methods</title><p id="P2">Plasma selenium concentration was assessed in participants age ≥65y in the InCHIANTI study, a population-based cohort study in Tuscany, Italy. PD was defined based on standard criteria. “Soft” neurological signs were ascertained by physical examination.</p></sec><sec id="S3"><title>Results</title><p id="P3">A total of 1012 participants were included. No association was found between the presence of PD and plasma selenium. There was, however, a strong association between plasma selenium and timed performance-based assessments.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Lower levels of selenium were significantly associated with decreased performance in neurological tests of coordination among older adults. Prospective studies are needed to further investigate the effects of selenium on SN dysfunction.</p></sec></div></front></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Plasma selenium is positively related to performance in neurological tasks assessing coordination and motor speed.</title><author><name sortKey="Shahar, Avner" sort="Shahar, Avner" uniqKey="Shahar A" first="Avner" last="Shahar">Avner Shahar</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethesda, Maryland, USA. dvsst@netvision.net.il</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Patel, Kushang V" sort="Patel, Kushang V" uniqKey="Patel K" first="Kushang V" last="Patel">Kushang V. Patel</name></author><author><name sortKey="Semba, Richard D" sort="Semba, Richard D" uniqKey="Semba R" first="Richard D" last="Semba">Richard D. Semba</name></author><author><name sortKey="Bandinelli, Stefania" sort="Bandinelli, Stefania" uniqKey="Bandinelli S" first="Stefania" last="Bandinelli">Stefania Bandinelli</name></author><author><name sortKey="Shahar, Danit R" sort="Shahar, Danit R" uniqKey="Shahar D" first="Danit R" last="Shahar">Danit R. Shahar</name></author><author><name sortKey="Ferrucci, Louigi" sort="Ferrucci, Louigi" uniqKey="Ferrucci L" first="Louigi" last="Ferrucci">Louigi Ferrucci</name></author><author><name sortKey="Guralnik, Jack M" sort="Guralnik, Jack M" uniqKey="Guralnik J" first="Jack M" last="Guralnik">Jack M. Guralnik</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="doi">10.1002/mds.23218</idno><idno type="RBID">pubmed:20687175</idno><idno type="pmid">20687175</idno><idno type="wicri:Area/PubMed/Corpus">001644</idno><idno type="wicri:Area/PubMed/Curation">001644</idno><idno type="wicri:Area/PubMed/Checkpoint">001699</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Plasma selenium is positively related to performance in neurological tasks assessing coordination and motor speed.</title><author><name sortKey="Shahar, Avner" sort="Shahar, Avner" uniqKey="Shahar A" first="Avner" last="Shahar">Avner Shahar</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethesda, Maryland, USA. dvsst@netvision.net.il</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Patel, Kushang V" sort="Patel, Kushang V" uniqKey="Patel K" first="Kushang V" last="Patel">Kushang V. Patel</name></author><author><name sortKey="Semba, Richard D" sort="Semba, Richard D" uniqKey="Semba R" first="Richard D" last="Semba">Richard D. Semba</name></author><author><name sortKey="Bandinelli, Stefania" sort="Bandinelli, Stefania" uniqKey="Bandinelli S" first="Stefania" last="Bandinelli">Stefania Bandinelli</name></author><author><name sortKey="Shahar, Danit R" sort="Shahar, Danit R" uniqKey="Shahar D" first="Danit R" last="Shahar">Danit R. Shahar</name></author><author><name sortKey="Ferrucci, Louigi" sort="Ferrucci, Louigi" uniqKey="Ferrucci L" first="Louigi" last="Ferrucci">Louigi Ferrucci</name></author><author><name sortKey="Guralnik, Jack M" sort="Guralnik, Jack M" uniqKey="Guralnik J" first="Jack M" last="Guralnik">Jack M. Guralnik</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Linear Models</term><term>Male</term><term>Neurologic Examination</term><term>Parkinson Disease (blood)</term><term>Parkinson Disease (physiopathology)</term><term>Psychomotor Performance (physiology)</term><term>Selenium (blood)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Selenium</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Psychomotor Performance</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Linear Models</term><term>Male</term><term>Neurologic Examination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is a degenerative process affecting the striato nigral system (SN). Its etiology, although obscure, may involve oxidative damage. Selenium, an antioxidant, was shown to protect the SN in animal models. In the current study, we investigate the association between plasma selenium concentrations and the presence of "soft" neurological signs related to the SN. Plasma selenium concentration was assessed in participants of age ≥65 years in the InCHIANTI study, a population-based cohort study in Tuscany, Italy. PD was defined based on standard criteria. "Soft" neurological signs were ascertained by physical examination. A total of 1,012 participants were included. No association was found between the presence of PD and plasma selenium. There was, however, a strong association between plasma selenium and timed performance-based assessments. Lower levels of selenium were significantly associated withdecreased performance in neurological tests of coordination among older adults. Prospective studies are needed to further investigate the effects of selenium on SN dysfunction.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002D73 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 002D73 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= PMC:3270688
|texte= Plasma selenium is positively related to performance in neurological tasks assessing coordination and motor speed
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:20687175" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a MovDisordV3
| This area was generated with Dilib version V0.6.23. |  |