Plasma selenium is positively related to performance in neurological tasks assessing coordination and motor speed.
Identifieur interne : 001644 ( PubMed/Curation ); précédent : 001643; suivant : 001645Plasma selenium is positively related to performance in neurological tasks assessing coordination and motor speed.
Auteurs : Avner Shahar [États-Unis] ; Kushang V. Patel ; Richard D. Semba ; Stefania Bandinelli ; Danit R. Shahar ; Louigi Ferrucci ; Jack M. GuralnikSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Selenium.
- blood : Parkinson Disease.
- physiology : Psychomotor Performance.
- physiopathology : Parkinson Disease.
- Aged, Aged, 80 and over, Female, Humans, Linear Models, Male, Neurologic Examination.
Abstract
Parkinson's disease (PD) is a degenerative process affecting the striato nigral system (SN). Its etiology, although obscure, may involve oxidative damage. Selenium, an antioxidant, was shown to protect the SN in animal models. In the current study, we investigate the association between plasma selenium concentrations and the presence of "soft" neurological signs related to the SN. Plasma selenium concentration was assessed in participants of age ≥65 years in the InCHIANTI study, a population-based cohort study in Tuscany, Italy. PD was defined based on standard criteria. "Soft" neurological signs were ascertained by physical examination. A total of 1,012 participants were included. No association was found between the presence of PD and plasma selenium. There was, however, a strong association between plasma selenium and timed performance-based assessments. Lower levels of selenium were significantly associated withdecreased performance in neurological tests of coordination among older adults. Prospective studies are needed to further investigate the effects of selenium on SN dysfunction.
DOI: 10.1002/mds.23218
PubMed: 20687175
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Semba</name></author><author><name sortKey="Bandinelli, Stefania" sort="Bandinelli, Stefania" uniqKey="Bandinelli S" first="Stefania" last="Bandinelli">Stefania Bandinelli</name></author><author><name sortKey="Shahar, Danit R" sort="Shahar, Danit R" uniqKey="Shahar D" first="Danit R" last="Shahar">Danit R. Shahar</name></author><author><name sortKey="Ferrucci, Louigi" sort="Ferrucci, Louigi" uniqKey="Ferrucci L" first="Louigi" last="Ferrucci">Louigi Ferrucci</name></author><author><name sortKey="Guralnik, Jack M" sort="Guralnik, Jack M" uniqKey="Guralnik J" first="Jack M" last="Guralnik">Jack M. Guralnik</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="doi">10.1002/mds.23218</idno><idno type="RBID">pubmed:20687175</idno><idno type="pmid">20687175</idno><idno type="wicri:Area/PubMed/Corpus">001644</idno><idno type="wicri:Area/PubMed/Curation">001644</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Plasma selenium is positively related to performance in neurological tasks assessing coordination and motor speed.</title><author><name sortKey="Shahar, Avner" sort="Shahar, Avner" uniqKey="Shahar A" first="Avner" last="Shahar">Avner Shahar</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethesda, Maryland, USA. dvsst@netvision.net.il</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethesda, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Patel, Kushang V" sort="Patel, Kushang V" uniqKey="Patel K" first="Kushang V" last="Patel">Kushang V. Patel</name></author><author><name sortKey="Semba, Richard D" sort="Semba, Richard D" uniqKey="Semba R" first="Richard D" last="Semba">Richard D. Semba</name></author><author><name sortKey="Bandinelli, Stefania" sort="Bandinelli, Stefania" uniqKey="Bandinelli S" first="Stefania" last="Bandinelli">Stefania Bandinelli</name></author><author><name sortKey="Shahar, Danit R" sort="Shahar, Danit R" uniqKey="Shahar D" first="Danit R" last="Shahar">Danit R. Shahar</name></author><author><name sortKey="Ferrucci, Louigi" sort="Ferrucci, Louigi" uniqKey="Ferrucci L" first="Louigi" last="Ferrucci">Louigi Ferrucci</name></author><author><name sortKey="Guralnik, Jack M" sort="Guralnik, Jack M" uniqKey="Guralnik J" first="Jack M" last="Guralnik">Jack M. Guralnik</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Linear Models</term><term>Male</term><term>Neurologic Examination</term><term>Parkinson Disease (blood)</term><term>Parkinson Disease (physiopathology)</term><term>Psychomotor Performance (physiology)</term><term>Selenium (blood)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Selenium</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Psychomotor Performance</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Linear Models</term><term>Male</term><term>Neurologic Examination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is a degenerative process affecting the striato nigral system (SN). Its etiology, although obscure, may involve oxidative damage. Selenium, an antioxidant, was shown to protect the SN in animal models. In the current study, we investigate the association between plasma selenium concentrations and the presence of "soft" neurological signs related to the SN. Plasma selenium concentration was assessed in participants of age ≥65 years in the InCHIANTI study, a population-based cohort study in Tuscany, Italy. PD was defined based on standard criteria. "Soft" neurological signs were ascertained by physical examination. A total of 1,012 participants were included. No association was found between the presence of PD and plasma selenium. There was, however, a strong association between plasma selenium and timed performance-based assessments. Lower levels of selenium were significantly associated withdecreased performance in neurological tests of coordination among older adults. Prospective studies are needed to further investigate the effects of selenium on SN dysfunction.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">20687175</PMID><DateCreated><Year>2010</Year><Month>09</Month><Day>14</Day></DateCreated><DateCompleted><Year>2010</Year><Month>12</Month><Day>28</Day></DateCompleted><DateRevised><Year>2015</Year><Month>08</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>25</Volume><Issue>12</Issue><PubDate><Year>2010</Year><Month>Sep</Month><Day>15</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Plasma selenium is positively related to performance in neurological tasks assessing coordination and motor speed.</ArticleTitle><Pagination><MedlinePgn>1909-15</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.23218</ELocationID><Abstract><AbstractText>Parkinson's disease (PD) is a degenerative process affecting the striato nigral system (SN). Its etiology, although obscure, may involve oxidative damage. Selenium, an antioxidant, was shown to protect the SN in animal models. In the current study, we investigate the association between plasma selenium concentrations and the presence of "soft" neurological signs related to the SN. Plasma selenium concentration was assessed in participants of age ≥65 years in the InCHIANTI study, a population-based cohort study in Tuscany, Italy. PD was defined based on standard criteria. "Soft" neurological signs were ascertained by physical examination. A total of 1,012 participants were included. No association was found between the presence of PD and plasma selenium. There was, however, a strong association between plasma selenium and timed performance-based assessments. Lower levels of selenium were significantly associated withdecreased performance in neurological tests of coordination among older adults. Prospective studies are needed to further investigate the effects of selenium on SN dysfunction.</AbstractText><CopyrightInformation>© 2010 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Shahar</LastName><ForeName>Avner</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Laboratory of Epidemiology, Demography and Biometry, National Institue on Aging, Bethesda, Maryland, USA. dvsst@netvision.net.il</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Patel</LastName><ForeName>Kushang V</ForeName><Initials>KV</Initials></Author><Author ValidYN="Y"><LastName>Semba</LastName><ForeName>Richard D</ForeName><Initials>RD</Initials></Author><Author ValidYN="Y"><LastName>Bandinelli</LastName><ForeName>Stefania</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Shahar</LastName><ForeName>Danit R</ForeName><Initials>DR</Initials></Author><Author ValidYN="Y"><LastName>Ferrucci</LastName><ForeName>Louigi</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Guralnik</LastName><ForeName>Jack M</ForeName><Initials>JM</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>263 MD 821336</GrantID><Acronym>MD</Acronym><Agency>NIMHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N.1-AG-1-1</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N.1-AG-1-2111</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01 AG050002</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01-AG-5-0002</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AG027012</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><Agency>Intramural NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D052060">Research Support, N.I.H., Intramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>H6241UJ22B</RegistryNumber><NameOfSubstance UI="D012643">Selenium</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Parkinsonism Relat Disord. 2006 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