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Somatosensory evoked potentials recorded from the human pedunculopontine nucleus region

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Somatosensory evoked potentials recorded from the human pedunculopontine nucleus region

Auteurs : I-Jin Yeh [Canada, Taïwan] ; Eric W. Tsang [Canada] ; Clement Hamani [Canada] ; Elena Moro [Canada] ; Filomena Mazzella [Canada] ; Yu-Yan Poon [Canada] ; Andres M. Lozano [Canada] ; Robert Chen [Canada]

Source :

Movement Disorders [ 0885-3185 ] ; 2010-10-15.

RBID : ISTEX:0DCCA870B61879E5C129B0F19031B3EA1A01EBB6

Descripteurs français

Pascal (Inist)
- Haute fréquence, Homme, Maladie de Parkinson, Oscillation, Pathologie du système nerveux, Potentiel évoqué somatosensoriel, Stimulation cérébrale profonde.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Aged, Analysis of Variance, Biophysical Phenomena (physiology), Deep Brain Stimulation (methods), Deep brain stimulation, Electrodes, Implanted, Evoked Potentials, Somatosensory (physiology), Female, Functional Laterality, High frequency, Human, Humans, Male, Median Nerve (physiology), Middle Aged, Nervous system diseases, Oscillation, Parkinson Disease (pathology), Parkinson disease, Parkinson's disease, Pedunculopontine Tegmental Nucleus (physiopathology), Reaction Time (physiology), Somatosensory evoked potential, Supranuclear Palsy, Progressive (pathology), deep brain stimulation, high frequency oscillations, pedunculopontine nucleus, somatosensory evoked potentials.
MESH :
- methods : Deep Brain Stimulation.
- pathology : Parkinson Disease, Supranuclear Palsy, Progressive.
- physiology : Biophysical Phenomena, Evoked Potentials, Somatosensory, Median Nerve, Reaction Time.
- physiopathology : Pedunculopontine Tegmental Nucleus.
- Aged, Analysis of Variance, Electrodes, Implanted, Female, Functional Laterality, Humans, Male, Middle Aged.

Abstract

The pedunculopontine nucleus region (PPNR) is an integral component of the midbrain locomotor region and has widespread connections with the cortex, thalamus, brain stem, cerebellum, spinal cord, and especially, the basal ganglia. No previous study examined the somatosensory connection of the PPNR in human. We recorded somatosensory evoked potentials (SEP) from median nerve stimulation through deep brain stimulation (DBS) electrodes implanted in the PPNR in 8 patients (6 with Parkinson's disease, 2 with progressive supranuclear palsy). Monopolar recordings from the PPNR contacts showed triphasic or biphasic potentials. The latency of the largest negative peak was between 16.8 and 18.7 milliseconds. Bipolar derivation revealed phase reversal with median nerve stimulation contralateral to the DBS electrode in 6 patients. There was no difference in SEP amplitude and latency between on and off medication states. We also studied the high frequency oscillations (HFOs) by filtering the signal between 500 and 2,500 Hz. The HFOs could be identified only from contralateral stimulation and had intraburst frequencies of 1061 ± 121 Hz, onset latencies of 13.8 ± 1.2 milliseconds, and burst durations of 7.3 ± 1.1 milliseconds. Among the 10 recordings with HFOs, only 1 had possible phase reversal in the bipolar derivation. Our results suggest that there are direct somatosensory inputs to the PPNR. The slow components and HFOs of the SEP have different origins. © 2010 Movement Disorder Society.

Url:

https://api.istex.fr/document/0DCCA870B61879E5C129B0F19031B3EA1A01EBB6/fulltext/pdf

DOI: 10.1002/mds.23233

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<front><div type="abstract" xml:lang="en">The pedunculopontine nucleus region (PPNR) is an integral component of the midbrain locomotor region and has widespread connections with the cortex, thalamus, brain stem, cerebellum, spinal cord, and especially, the basal ganglia. No previous study examined the somatosensory connection of the PPNR in human. We recorded somatosensory evoked potentials (SEP) from median nerve stimulation through deep brain stimulation (DBS) electrodes implanted in the PPNR in 8 patients (6 with Parkinson's disease, 2 with progressive supranuclear palsy). Monopolar recordings from the PPNR contacts showed triphasic or biphasic potentials. The latency of the largest negative peak was between 16.8 and 18.7 milliseconds. Bipolar derivation revealed phase reversal with median nerve stimulation contralateral to the DBS electrode in 6 patients. There was no difference in SEP amplitude and latency between on and off medication states. We also studied the high frequency oscillations (HFOs) by filtering the signal between 500 and 2,500 Hz. The HFOs could be identified only from contralateral stimulation and had intraburst frequencies of 1061 ± 121 Hz, onset latencies of 13.8 ± 1.2 milliseconds, and burst durations of 7.3 ± 1.1 milliseconds. Among the 10 recordings with HFOs, only 1 had possible phase reversal in the bipolar derivation. Our results suggest that there are direct somatosensory inputs to the PPNR. The slow components and HFOs of the SEP have different origins. © 2010 Movement Disorder Society.</div>
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</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2010">2010</date>
</imprint>
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<seriesStmt><title level="j" type="main">Movement disorders</title>
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</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Deep brain stimulation</term>
<term>High frequency</term>
<term>Human</term>
<term>Nervous system diseases</term>
<term>Oscillation</term>
<term>Parkinson disease</term>
<term>Somatosensory evoked potential</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Potentiel évoqué somatosensoriel</term>
<term>Homme</term>
<term>Haute fréquence</term>
<term>Oscillation</term>
<term>Stimulation cérébrale profonde</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
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<front><div type="abstract" xml:lang="en">The pedunculopontine nucleus region (PPNR) is an integral component of the midbrain locomotor region and has widespread connections with the cortex, thalamus, brain stem, cerebellum, spinal cord, and especially, the basal ganglia. No previous study examined the somatosensory connection of the PPNR in human. We recorded somatosensory evoked potentials (SEP) from median nerve stimulation through deep brain stimulation (DBS) electrodes implanted in the PPNR in 8 patients (6 with Parkinson's disease, 2 with progressive supranuclear palsy). Monopolar recordings from the PPNR contacts showed triphasic or biphasic potentials. The latency of the largest negative peak was between 16.8 and 18.7 milliseconds. Bipolar derivation revealed phase reversal with median nerve stimulation contralateral to the DBS electrode in 6 patients. There was no difference in SEP amplitude and latency between on and off medication states. We also studied the high frequency oscillations (HFOs) by filtering the signal between 500 and 2,500 Hz. The HFOs could be identified only from contralateral stimulation and had intraburst frequencies of 1061 ± 121 Hz, onset latencies of 13.8 ± 1.2 milliseconds, and burst durations of 7.3 + 1.1 milliseconds. Among the 10 recordings with HFOs, only 1 had possible phase reversal in the bipolar derivation. Our results suggest that there are direct somatosensory inputs to the PPNR. The slow components and HFOs of the SEP have different origins.</div>
</front>
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<author><name sortKey="Tsang, Eric W" sort="Tsang, Eric W" uniqKey="Tsang E" first="Eric W." last="Tsang">Eric W. Tsang</name>
</author>
<author><name sortKey="Hamani, Clement" sort="Hamani, Clement" uniqKey="Hamani C" first="Clement" last="Hamani">Clement Hamani</name>
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<author><name sortKey="Poon, Yu An" sort="Poon, Yu An" uniqKey="Poon Y" first="Yu-Yan" last="Poon">Yu-Yan Poon</name>
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<author><name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name>
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</affiliation>
<affiliation wicri:level="4"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
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</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country>
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<author><name sortKey="Tsang, Eric W" sort="Tsang, Eric W" uniqKey="Tsang E" first="Eric W." last="Tsang">Eric W. Tsang</name>
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<affiliation wicri:level="4"><country xml:lang="fr">Canada</country>
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<author><name sortKey="Hamani, Clement" sort="Hamani, Clement" uniqKey="Hamani C" first="Clement" last="Hamani">Clement Hamani</name>
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<affiliation wicri:level="4"><country xml:lang="fr">Canada</country>
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<author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name>
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<author><name sortKey="Mazzella, Filomena" sort="Mazzella, Filomena" uniqKey="Mazzella F" first="Filomena" last="Mazzella">Filomena Mazzella</name>
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<author><name sortKey="Poon, Yu An" sort="Poon, Yu An" uniqKey="Poon Y" first="Yu-Yan" last="Poon">Yu-Yan Poon</name>
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<author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name>
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<author><name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name>
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<affiliation wicri:level="4"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
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<orgName type="university">Université de Toronto</orgName>
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<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2010-10-15">2010-10-15</date>
<biblScope unit="vol">25</biblScope>
<biblScope unit="issue">13</biblScope>
<biblScope unit="page" from="2076">2076</biblScope>
<biblScope unit="page" to="2083">2083</biblScope>
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<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">0DCCA870B61879E5C129B0F19031B3EA1A01EBB6</idno>
<idno type="DOI">10.1002/mds.23233</idno>
<idno type="ArticleID">MDS23233</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Analysis of Variance</term>
<term>Biophysical Phenomena (physiology)</term>
<term>Deep Brain Stimulation (methods)</term>
<term>Electrodes, Implanted</term>
<term>Evoked Potentials, Somatosensory (physiology)</term>
<term>Female</term>
<term>Functional Laterality</term>
<term>Humans</term>
<term>Male</term>
<term>Median Nerve (physiology)</term>
<term>Middle Aged</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson's disease</term>
<term>Pedunculopontine Tegmental Nucleus (physiopathology)</term>
<term>Reaction Time (physiology)</term>
<term>Supranuclear Palsy, Progressive (pathology)</term>
<term>deep brain stimulation</term>
<term>high frequency oscillations</term>
<term>pedunculopontine nucleus</term>
<term>somatosensory evoked potentials</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term>
<term>Supranuclear Palsy, Progressive</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Biophysical Phenomena</term>
<term>Evoked Potentials, Somatosensory</term>
<term>Median Nerve</term>
<term>Reaction Time</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Pedunculopontine Tegmental Nucleus</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Analysis of Variance</term>
<term>Electrodes, Implanted</term>
<term>Female</term>
<term>Functional Laterality</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
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<front><div type="abstract" xml:lang="en">The pedunculopontine nucleus region (PPNR) is an integral component of the midbrain locomotor region and has widespread connections with the cortex, thalamus, brain stem, cerebellum, spinal cord, and especially, the basal ganglia. No previous study examined the somatosensory connection of the PPNR in human. We recorded somatosensory evoked potentials (SEP) from median nerve stimulation through deep brain stimulation (DBS) electrodes implanted in the PPNR in 8 patients (6 with Parkinson's disease, 2 with progressive supranuclear palsy). Monopolar recordings from the PPNR contacts showed triphasic or biphasic potentials. The latency of the largest negative peak was between 16.8 and 18.7 milliseconds. Bipolar derivation revealed phase reversal with median nerve stimulation contralateral to the DBS electrode in 6 patients. There was no difference in SEP amplitude and latency between on and off medication states. We also studied the high frequency oscillations (HFOs) by filtering the signal between 500 and 2,500 Hz. The HFOs could be identified only from contralateral stimulation and had intraburst frequencies of 1061 ± 121 Hz, onset latencies of 13.8 ± 1.2 milliseconds, and burst durations of 7.3 ± 1.1 milliseconds. Among the 10 recordings with HFOs, only 1 had possible phase reversal in the bipolar derivation. Our results suggest that there are direct somatosensory inputs to the PPNR. The slow components and HFOs of the SEP have different origins. © 2010 Movement Disorder Society.</div>
</front>
</TEI>
</ISTEX>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Somatosensory evoked potentials recorded from the human pedunculopontine nucleus region

Somatosensory evoked potentials recorded from the human pedunculopontine nucleus region

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