Somatosensory evoked potentials recorded from the human pedunculopontine nucleus region.
Identifieur interne : 002D64 ( Ncbi/Checkpoint ); précédent : 002D63; suivant : 002D65Somatosensory evoked potentials recorded from the human pedunculopontine nucleus region.
Auteurs : I-Jin Yeh [Canada] ; Eric W. Tsang ; Clement Hamani ; Elena Moro ; Filomena Mazzella ; Yu-Yan Poon ; Andres M. Lozano ; Robert ChenSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- Aged, Analysis of Variance, Biophysical Phenomena (physiology), Deep Brain Stimulation (methods), Electrodes, Implanted, Evoked Potentials, Somatosensory (physiology), Female, Functional Laterality, Humans, Male, Median Nerve (physiology), Middle Aged, Parkinson Disease (pathology), Pedunculopontine Tegmental Nucleus (physiopathology), Reaction Time (physiology), Supranuclear Palsy, Progressive (pathology).
- MESH :
- methods : Deep Brain Stimulation.
- pathology : Parkinson Disease, Supranuclear Palsy, Progressive.
- physiology : Biophysical Phenomena, Evoked Potentials, Somatosensory, Median Nerve, Reaction Time.
- physiopathology : Pedunculopontine Tegmental Nucleus.
- Aged, Analysis of Variance, Electrodes, Implanted, Female, Functional Laterality, Humans, Male, Middle Aged.
Abstract
The pedunculopontine nucleus region (PPNR) is an integral component of the midbrain locomotor region and has widespread connections with the cortex, thalamus, brain stem, cerebellum, spinal cord, and especially, the basal ganglia. No previous study examined the somatosensory connection of the PPNR in human. We recorded somatosensory evoked potentials (SEP) from median nerve stimulation through deep brain stimulation (DBS) electrodes implanted in the PPNR in 8 patients (6 with Parkinson's disease, 2 with progressive supranuclear palsy). Monopolar recordings from the PPNR contacts showed triphasic or biphasic potentials. The latency of the largest negative peak was between 16.8 and 18.7 milliseconds. Bipolar derivation revealed phase reversal with median nerve stimulation contralateral to the DBS electrode in 6 patients. There was no difference in SEP amplitude and latency between on and off medication states. We also studied the high frequency oscillations (HFOs) by filtering the signal between 500 and 2,500 Hz. The HFOs could be identified only from contralateral stimulation and had intraburst frequencies of 1061 ± 121 Hz, onset latencies of 13.8 ± 1.2 milliseconds, and burst durations of 7.3 ± 1.1 milliseconds. Among the 10 recordings with HFOs, only 1 had possible phase reversal in the bipolar derivation. Our results suggest that there are direct somatosensory inputs to the PPNR. The slow components and HFOs of the SEP have different origins.
DOI: 10.1002/mds.23233
PubMed: 20669321
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Somatosensory evoked potentials recorded from the human pedunculopontine nucleus region.</title><author><name sortKey="Yeh, I Jin" sort="Yeh, I Jin" uniqKey="Yeh I" first="I-Jin" last="Yeh">I-Jin Yeh</name><affiliation wicri:level="1"><nlm:affiliation>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto Western Research Institute, University Health Network, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Tsang, Eric W" sort="Tsang, Eric W" uniqKey="Tsang E" first="Eric W" last="Tsang">Eric W. Tsang</name></author><author><name sortKey="Hamani, Clement" sort="Hamani, Clement" uniqKey="Hamani C" first="Clement" last="Hamani">Clement Hamani</name></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name></author><author><name sortKey="Mazzella, Filomena" sort="Mazzella, Filomena" uniqKey="Mazzella F" first="Filomena" last="Mazzella">Filomena Mazzella</name></author><author><name sortKey="Poon, Yu Yan" sort="Poon, Yu Yan" uniqKey="Poon Y" first="Yu-Yan" last="Poon">Yu-Yan Poon</name></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name></author><author><name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="doi">10.1002/mds.23233</idno><idno type="RBID">pubmed:20669321</idno><idno type="pmid">20669321</idno><idno type="wicri:Area/PubMed/Corpus">001653</idno><idno type="wicri:Area/PubMed/Curation">001653</idno><idno type="wicri:Area/PubMed/Checkpoint">001607</idno><idno type="wicri:Area/Ncbi/Merge">002D64</idno><idno type="wicri:Area/Ncbi/Curation">002D64</idno><idno type="wicri:Area/Ncbi/Checkpoint">002D64</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Somatosensory evoked potentials recorded from the human pedunculopontine nucleus region.</title><author><name sortKey="Yeh, I Jin" sort="Yeh, I Jin" uniqKey="Yeh I" first="I-Jin" last="Yeh">I-Jin Yeh</name><affiliation wicri:level="1"><nlm:affiliation>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto Western Research Institute, University Health Network, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Tsang, Eric W" sort="Tsang, Eric W" uniqKey="Tsang E" first="Eric W" last="Tsang">Eric W. Tsang</name></author><author><name sortKey="Hamani, Clement" sort="Hamani, Clement" uniqKey="Hamani C" first="Clement" last="Hamani">Clement Hamani</name></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name></author><author><name sortKey="Mazzella, Filomena" sort="Mazzella, Filomena" uniqKey="Mazzella F" first="Filomena" last="Mazzella">Filomena Mazzella</name></author><author><name sortKey="Poon, Yu Yan" sort="Poon, Yu Yan" uniqKey="Poon Y" first="Yu-Yan" last="Poon">Yu-Yan Poon</name></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name></author><author><name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Biophysical Phenomena (physiology)</term><term>Deep Brain Stimulation (methods)</term><term>Electrodes, Implanted</term><term>Evoked Potentials, Somatosensory (physiology)</term><term>Female</term><term>Functional Laterality</term><term>Humans</term><term>Male</term><term>Median Nerve (physiology)</term><term>Middle Aged</term><term>Parkinson Disease (pathology)</term><term>Pedunculopontine Tegmental Nucleus (physiopathology)</term><term>Reaction Time (physiology)</term><term>Supranuclear Palsy, Progressive (pathology)</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Biophysical Phenomena</term><term>Evoked Potentials, Somatosensory</term><term>Median Nerve</term><term>Reaction Time</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Pedunculopontine Tegmental Nucleus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Electrodes, Implanted</term><term>Female</term><term>Functional Laterality</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The pedunculopontine nucleus region (PPNR) is an integral component of the midbrain locomotor region and has widespread connections with the cortex, thalamus, brain stem, cerebellum, spinal cord, and especially, the basal ganglia. No previous study examined the somatosensory connection of the PPNR in human. We recorded somatosensory evoked potentials (SEP) from median nerve stimulation through deep brain stimulation (DBS) electrodes implanted in the PPNR in 8 patients (6 with Parkinson's disease, 2 with progressive supranuclear palsy). Monopolar recordings from the PPNR contacts showed triphasic or biphasic potentials. The latency of the largest negative peak was between 16.8 and 18.7 milliseconds. Bipolar derivation revealed phase reversal with median nerve stimulation contralateral to the DBS electrode in 6 patients. There was no difference in SEP amplitude and latency between on and off medication states. We also studied the high frequency oscillations (HFOs) by filtering the signal between 500 and 2,500 Hz. The HFOs could be identified only from contralateral stimulation and had intraburst frequencies of 1061 ± 121 Hz, onset latencies of 13.8 ± 1.2 milliseconds, and burst durations of 7.3 ± 1.1 milliseconds. Among the 10 recordings with HFOs, only 1 had possible phase reversal in the bipolar derivation. Our results suggest that there are direct somatosensory inputs to the PPNR. The slow components and HFOs of the SEP have different origins.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name><name sortKey="Hamani, Clement" sort="Hamani, Clement" uniqKey="Hamani C" first="Clement" last="Hamani">Clement Hamani</name><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name><name sortKey="Mazzella, Filomena" sort="Mazzella, Filomena" uniqKey="Mazzella F" first="Filomena" last="Mazzella">Filomena Mazzella</name><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name><name sortKey="Poon, Yu Yan" sort="Poon, Yu Yan" uniqKey="Poon Y" first="Yu-Yan" last="Poon">Yu-Yan Poon</name><name sortKey="Tsang, Eric W" sort="Tsang, Eric W" uniqKey="Tsang E" first="Eric W" last="Tsang">Eric W. Tsang</name></noCountry><country name="Canada"><noRegion><name sortKey="Yeh, I Jin" sort="Yeh, I Jin" uniqKey="Yeh I" first="I-Jin" last="Yeh">I-Jin Yeh</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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