Somatosensory evoked potentials recorded from the human pedunculopontine nucleus region
Identifieur interne : 000770 ( Istex/Corpus ); précédent : 000769; suivant : 000771Somatosensory evoked potentials recorded from the human pedunculopontine nucleus region
Auteurs : I-Jin Yeh ; Eric W. Tsang ; Clement Hamani ; Elena Moro ; Filomena Mazzella ; Yu-Yan Poon ; Andres M. Lozano ; Robert ChenSource :
- Movement Disorders [ 0885-3185 ] ; 2010-10-15.
English descriptors
- KwdEn :
Abstract
The pedunculopontine nucleus region (PPNR) is an integral component of the midbrain locomotor region and has widespread connections with the cortex, thalamus, brain stem, cerebellum, spinal cord, and especially, the basal ganglia. No previous study examined the somatosensory connection of the PPNR in human. We recorded somatosensory evoked potentials (SEP) from median nerve stimulation through deep brain stimulation (DBS) electrodes implanted in the PPNR in 8 patients (6 with Parkinson's disease, 2 with progressive supranuclear palsy). Monopolar recordings from the PPNR contacts showed triphasic or biphasic potentials. The latency of the largest negative peak was between 16.8 and 18.7 milliseconds. Bipolar derivation revealed phase reversal with median nerve stimulation contralateral to the DBS electrode in 6 patients. There was no difference in SEP amplitude and latency between on and off medication states. We also studied the high frequency oscillations (HFOs) by filtering the signal between 500 and 2,500 Hz. The HFOs could be identified only from contralateral stimulation and had intraburst frequencies of 1061 ± 121 Hz, onset latencies of 13.8 ± 1.2 milliseconds, and burst durations of 7.3 ± 1.1 milliseconds. Among the 10 recordings with HFOs, only 1 had possible phase reversal in the bipolar derivation. Our results suggest that there are direct somatosensory inputs to the PPNR. The slow components and HFOs of the SEP have different origins. © 2010 Movement Disorder Society.
Url:
DOI: 10.1002/mds.23233
Links to Exploration step
ISTEX:0DCCA870B61879E5C129B0F19031B3EA1A01EBB6Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Somatosensory evoked potentials recorded from the human pedunculopontine nucleus region</title><author><name sortKey="Yeh, I In" sort="Yeh, I In" uniqKey="Yeh I" first="I-Jin" last="Yeh">I-Jin Yeh</name><affiliation><mods:affiliation>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Songde Branch, Taipei City Hospital, Taipei, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Tsang, Eric W" sort="Tsang, Eric W" uniqKey="Tsang E" first="Eric W." last="Tsang">Eric W. Tsang</name><affiliation><mods:affiliation>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Hamani, Clement" sort="Hamani, Clement" uniqKey="Hamani C" first="Clement" last="Hamani">Clement Hamani</name><affiliation><mods:affiliation>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name><affiliation><mods:affiliation>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Mazzella, Filomena" sort="Mazzella, Filomena" uniqKey="Mazzella F" first="Filomena" last="Mazzella">Filomena Mazzella</name><affiliation><mods:affiliation>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Poon, Yu An" sort="Poon, Yu An" uniqKey="Poon Y" first="Yu-Yan" last="Poon">Yu-Yan Poon</name><affiliation><mods:affiliation>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name><affiliation><mods:affiliation>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name><affiliation><mods:affiliation>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:0DCCA870B61879E5C129B0F19031B3EA1A01EBB6</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1002/mds.23233</idno><idno type="url">https://api.istex.fr/document/0DCCA870B61879E5C129B0F19031B3EA1A01EBB6/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000770</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Somatosensory evoked potentials recorded from the human pedunculopontine nucleus region</title><author><name sortKey="Yeh, I In" sort="Yeh, I In" uniqKey="Yeh I" first="I-Jin" last="Yeh">I-Jin Yeh</name><affiliation><mods:affiliation>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Songde Branch, Taipei City Hospital, Taipei, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Tsang, Eric W" sort="Tsang, Eric W" uniqKey="Tsang E" first="Eric W." last="Tsang">Eric W. Tsang</name><affiliation><mods:affiliation>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Hamani, Clement" sort="Hamani, Clement" uniqKey="Hamani C" first="Clement" last="Hamani">Clement Hamani</name><affiliation><mods:affiliation>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name><affiliation><mods:affiliation>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Mazzella, Filomena" sort="Mazzella, Filomena" uniqKey="Mazzella F" first="Filomena" last="Mazzella">Filomena Mazzella</name><affiliation><mods:affiliation>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Poon, Yu An" sort="Poon, Yu An" uniqKey="Poon Y" first="Yu-Yan" last="Poon">Yu-Yan Poon</name><affiliation><mods:affiliation>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name><affiliation><mods:affiliation>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name><affiliation><mods:affiliation>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-10-15">2010-10-15</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">13</biblScope><biblScope unit="page" from="2076">2076</biblScope><biblScope unit="page" to="2083">2083</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">0DCCA870B61879E5C129B0F19031B3EA1A01EBB6</idno><idno type="DOI">10.1002/mds.23233</idno><idno type="ArticleID">MDS23233</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>deep brain stimulation</term><term>high frequency oscillations</term><term>pedunculopontine nucleus</term><term>somatosensory evoked potentials</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The pedunculopontine nucleus region (PPNR) is an integral component of the midbrain locomotor region and has widespread connections with the cortex, thalamus, brain stem, cerebellum, spinal cord, and especially, the basal ganglia. No previous study examined the somatosensory connection of the PPNR in human. We recorded somatosensory evoked potentials (SEP) from median nerve stimulation through deep brain stimulation (DBS) electrodes implanted in the PPNR in 8 patients (6 with Parkinson's disease, 2 with progressive supranuclear palsy). Monopolar recordings from the PPNR contacts showed triphasic or biphasic potentials. The latency of the largest negative peak was between 16.8 and 18.7 milliseconds. Bipolar derivation revealed phase reversal with median nerve stimulation contralateral to the DBS electrode in 6 patients. There was no difference in SEP amplitude and latency between on and off medication states. We also studied the high frequency oscillations (HFOs) by filtering the signal between 500 and 2,500 Hz. The HFOs could be identified only from contralateral stimulation and had intraburst frequencies of 1061 ± 121 Hz, onset latencies of 13.8 ± 1.2 milliseconds, and burst durations of 7.3 ± 1.1 milliseconds. Among the 10 recordings with HFOs, only 1 had possible phase reversal in the bipolar derivation. Our results suggest that there are direct somatosensory inputs to the PPNR. The slow components and HFOs of the SEP have different origins. © 2010 Movement Disorder Society.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>I‐Jin Yeh MD</name><affiliations><json:string>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</json:string><json:string>Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada</json:string><json:string>Department of Neurology, Songde Branch, Taipei City Hospital, Taipei, Taiwan</json:string></affiliations></json:item><json:item><name>Eric W. Tsang MSc</name><affiliations><json:string>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</json:string><json:string>Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada</json:string></affiliations></json:item><json:item><name>Clement Hamani MD, PhD</name><affiliations><json:string>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</json:string><json:string>Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada</json:string></affiliations></json:item><json:item><name>Elena Moro MD, PhD</name><affiliations><json:string>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</json:string><json:string>Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada</json:string></affiliations></json:item><json:item><name>Filomena Mazzella RN</name><affiliations><json:string>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</json:string></affiliations></json:item><json:item><name>Yu‐Yan Poon RN</name><affiliations><json:string>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</json:string></affiliations></json:item><json:item><name>Andres M. Lozano MD, PhD, FRCSC</name><affiliations><json:string>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</json:string><json:string>Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada</json:string><json:string>Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada</json:string></affiliations></json:item><json:item><name>Robert Chen MA, MBBChir, MSc, FRCPC</name><affiliations><json:string>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</json:string><json:string>Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada</json:string><json:string>Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>pedunculopontine nucleus</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>somatosensory evoked potentials</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>high frequency oscillations</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>deep brain stimulation</value></json:item></subject><language><json:string>eng</json:string></language><abstract>The pedunculopontine nucleus region (PPNR) is an integral component of the midbrain locomotor region and has widespread connections with the cortex, thalamus, brain stem, cerebellum, spinal cord, and especially, the basal ganglia. No previous study examined the somatosensory connection of the PPNR in human. We recorded somatosensory evoked potentials (SEP) from median nerve stimulation through deep brain stimulation (DBS) electrodes implanted in the PPNR in 8 patients (6 with Parkinson's disease, 2 with progressive supranuclear palsy). Monopolar recordings from the PPNR contacts showed triphasic or biphasic potentials. The latency of the largest negative peak was between 16.8 and 18.7 milliseconds. Bipolar derivation revealed phase reversal with median nerve stimulation contralateral to the DBS electrode in 6 patients. There was no difference in SEP amplitude and latency between on and off medication states. We also studied the high frequency oscillations (HFOs) by filtering the signal between 500 and 2,500 Hz. The HFOs could be identified only from contralateral stimulation and had intraburst frequencies of 1061 ± 121 Hz, onset latencies of 13.8 ± 1.2 milliseconds, and burst durations of 7.3 ± 1.1 milliseconds. Among the 10 recordings with HFOs, only 1 had possible phase reversal in the bipolar derivation. Our results suggest that there are direct somatosensory inputs to the PPNR. The slow components and HFOs of the SEP have different origins. © 2010 Movement Disorder Society.</abstract><qualityIndicators><score>7.262</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1502</abstractCharCount><pdfWordCount>4550</pdfWordCount><pdfCharCount>30223</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>226</abstractWordCount></qualityIndicators><title>Somatosensory evoked potentials recorded from the human pedunculopontine nucleus region</title><genre><json:string>Serial article</json:string></genre><host><volume>25</volume><pages><total>8</total><last>2083</last><first>2076</first></pages><issn><json:string>0885-3185</json:string></issn><issue>13</issue><subject><json:item><value>Research Article</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2010</publicationDate><copyrightDate>2010</copyrightDate><doi><json:string>10.1002/mds.23233</json:string></doi><id>0DCCA870B61879E5C129B0F19031B3EA1A01EBB6</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/0DCCA870B61879E5C129B0F19031B3EA1A01EBB6/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/0DCCA870B61879E5C129B0F19031B3EA1A01EBB6/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/0DCCA870B61879E5C129B0F19031B3EA1A01EBB6/fulltext/tei"><teiHeader type="text"><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Somatosensory evoked potentials recorded from the human pedunculopontine nucleus region</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Wiley Subscription Services, Inc., A Wiley Company</p></availability><date>2010</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: Funded by the Canadian Institutes of Health Research grant number MOP15128.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Somatosensory evoked potentials recorded from the human pedunculopontine nucleus region</title><author><persName><forename type="first">I‐Jin</forename><surname>Yeh</surname><roleName type="degree">MD</roleName></persName><affiliation>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</affiliation><affiliation>Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada</affiliation><affiliation>Department of Neurology, Songde Branch, Taipei City Hospital, Taipei, Taiwan</affiliation></author><author><persName><forename type="first">Eric W.</forename><surname>Tsang</surname><roleName type="degree">MSc</roleName></persName><affiliation>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</affiliation><affiliation>Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada</affiliation></author><author><persName><forename type="first">Clement</forename><surname>Hamani</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</affiliation><affiliation>Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada</affiliation></author><author><persName><forename type="first">Elena</forename><surname>Moro</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</affiliation><affiliation>Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada</affiliation></author><author><persName><forename type="first">Filomena</forename><surname>Mazzella</surname><roleName type="degree">RN</roleName></persName><affiliation>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</affiliation></author><author><persName><forename type="first">Yu‐Yan</forename><surname>Poon</surname><roleName type="degree">RN</roleName></persName><affiliation>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</affiliation></author><author><persName><forename type="first">Andres M.</forename><surname>Lozano</surname><roleName type="degree">MD, PhD, FRCSC</roleName></persName><affiliation>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</affiliation><affiliation>Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada</affiliation><affiliation>Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada</affiliation></author><author><persName><forename type="first">Robert</forename><surname>Chen</surname><roleName type="degree">MA, MBBChir, MSc, FRCPC</roleName></persName><note type="correspondence"><p>Correspondence: Toronto Western Hospital, McLaughlin Pavilion, 7th Floor Room 411, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada</p></note><affiliation>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</affiliation><affiliation>Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada</affiliation><affiliation>Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-10-15"></date><biblScope unit="vol">25</biblScope><biblScope unit="issue">13</biblScope><biblScope unit="page" from="2076">2076</biblScope><biblScope unit="page" to="2083">2083</biblScope></imprint></monogr><idno type="istex">0DCCA870B61879E5C129B0F19031B3EA1A01EBB6</idno><idno type="DOI">10.1002/mds.23233</idno><idno type="ArticleID">MDS23233</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2010</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>The pedunculopontine nucleus region (PPNR) is an integral component of the midbrain locomotor region and has widespread connections with the cortex, thalamus, brain stem, cerebellum, spinal cord, and especially, the basal ganglia. No previous study examined the somatosensory connection of the PPNR in human. We recorded somatosensory evoked potentials (SEP) from median nerve stimulation through deep brain stimulation (DBS) electrodes implanted in the PPNR in 8 patients (6 with Parkinson's disease, 2 with progressive supranuclear palsy). Monopolar recordings from the PPNR contacts showed triphasic or biphasic potentials. The latency of the largest negative peak was between 16.8 and 18.7 milliseconds. Bipolar derivation revealed phase reversal with median nerve stimulation contralateral to the DBS electrode in 6 patients. There was no difference in SEP amplitude and latency between on and off medication states. We also studied the high frequency oscillations (HFOs) by filtering the signal between 500 and 2,500 Hz. The HFOs could be identified only from contralateral stimulation and had intraburst frequencies of 1061 ± 121 Hz, onset latencies of 13.8 ± 1.2 milliseconds, and burst durations of 7.3 ± 1.1 milliseconds. Among the 10 recordings with HFOs, only 1 had possible phase reversal in the bipolar derivation. Our results suggest that there are direct somatosensory inputs to the PPNR. The slow components and HFOs of the SEP have different origins. © 2010 Movement Disorder Society.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>pedunculopontine nucleus</term></item><item><term>somatosensory evoked potentials</term></item><item><term>high frequency oscillations</term></item><item><term>Parkinson's disease</term></item><item><term>deep brain stimulation</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2009-07-23">Received</change><change when="2010-04-09">Registration</change><change when="2010-10-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/0DCCA870B61879E5C129B0F19031B3EA1A01EBB6/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="130"><doi origin="wiley" registered="yes">10.1002/mds.v25:13</doi><numberingGroup><numbering type="journalVolume" number="25">25</numbering><numbering type="journalIssue">13</numbering></numberingGroup><coverDate startDate="2010-10-15">15 October 2010</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="100" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.23233</doi><idGroup><id type="unit" value="MDS23233"></id></idGroup><countGroup><count type="pageTotal" number="8"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2010 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2009-07-23"></event><event type="manuscriptRevised" date="2010-01-29"></event><event type="manuscriptAccepted" date="2010-04-09"></event><event type="firstOnline" date="2010-07-28"></event><event type="publishedOnlineAcceptedOrEarlyUnpaginated" date="2010-07-28"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.5.2 mode:FullText source:FullText result:FullText" date="2011-07-06"></event><event type="publishedOnlineFinalForm" date="2010-07-28"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">2076</numbering><numbering type="pageLast">2083</numbering></numberingGroup><correspondenceTo>Toronto Western Hospital, McLaughlin Pavilion, 7th Floor Room 411, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS23233.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="3"></count><count type="referenceTotal" number="55"></count><count type="wordTotal" number="5764"></count></countGroup><titleGroup><title type="main" xml:lang="en">Somatosensory evoked potentials recorded from the human pedunculopontine nucleus region<link href="#fn7"></link></title><title type="short" xml:lang="en">SEP<sc>S</sc> in PPNR</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2 #af3"><personName><givenNames>I‐Jin</givenNames><familyName>Yeh</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1 #af4"><personName><givenNames>Eric W.</givenNames><familyName>Tsang</familyName><degrees>MSc</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1 #af5"><personName><givenNames>Clement</givenNames><familyName>Hamani</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Elena</givenNames><familyName>Moro</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Filomena</givenNames><familyName>Mazzella</familyName><degrees>RN</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Yu‐Yan</givenNames><familyName>Poon</familyName><degrees>RN</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1 #af4 #af5"><personName><givenNames>Andres M.</givenNames><familyName>Lozano</familyName><degrees>MD, PhD, FRCSC</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af1 #af2 #af4" corresponding="yes"><personName><givenNames>Robert</givenNames><familyName>Chen</familyName><degrees>MA, MBBChir, MSc, FRCPC</degrees></personName><contactDetails><email>robert.chen@uhn.on.ca</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="CA" type="organization"><unparsedAffiliation>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="CA" type="organization"><unparsedAffiliation>Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="TW" type="organization"><unparsedAffiliation>Department of Neurology, Songde Branch, Taipei City Hospital, Taipei, Taiwan</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="CA" type="organization"><unparsedAffiliation>Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="CA" type="organization"><unparsedAffiliation>Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">pedunculopontine nucleus</keyword><keyword xml:id="kwd2">somatosensory evoked potentials</keyword><keyword xml:id="kwd3">high frequency oscillations</keyword><keyword xml:id="kwd4">Parkinson's disease</keyword><keyword xml:id="kwd5">deep brain stimulation</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>The pedunculopontine nucleus region (PPNR) is an integral component of the midbrain locomotor region and has widespread connections with the cortex, thalamus, brain stem, cerebellum, spinal cord, and especially, the basal ganglia. No previous study examined the somatosensory connection of the PPNR in human. We recorded somatosensory evoked potentials (SEP) from median nerve stimulation through deep brain stimulation (DBS) electrodes implanted in the PPNR in 8 patients (6 with Parkinson's disease, 2 with progressive supranuclear palsy). Monopolar recordings from the PPNR contacts showed triphasic or biphasic potentials. The latency of the largest negative peak was between 16.8 and 18.7 milliseconds. Bipolar derivation revealed phase reversal with median nerve stimulation contralateral to the DBS electrode in 6 patients. There was no difference in SEP amplitude and latency between on and off medication states. We also studied the high frequency oscillations (HFOs) by filtering the signal between 500 and 2,500 Hz. The HFOs could be identified only from contralateral stimulation and had intraburst frequencies of 1061 ± 121 Hz, onset latencies of 13.8 ± 1.2 milliseconds, and burst durations of 7.3 ± 1.1 milliseconds. Among the 10 recordings with HFOs, only 1 had possible phase reversal in the bipolar derivation. Our results suggest that there are direct somatosensory inputs to the PPNR. The slow components and HFOs of the SEP have different origins. © 2010 Movement Disorder Society.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn7"><p>Potential conflict of interest: Funded by the Canadian Institutes of Health Research grant number MOP15128.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Somatosensory evoked potentials recorded from the human pedunculopontine nucleus region</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>SEPS in PPNR</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Somatosensory evoked potentials recorded from the human pedunculopontine nucleus region</title></titleInfo><name type="personal"><namePart type="given">I‐Jin</namePart><namePart type="family">Yeh</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</affiliation><affiliation>Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada</affiliation><affiliation>Department of Neurology, Songde Branch, Taipei City Hospital, Taipei, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eric W.</namePart><namePart type="family">Tsang</namePart><namePart type="termsOfAddress">MSc</namePart><affiliation>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</affiliation><affiliation>Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Clement</namePart><namePart type="family">Hamani</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</affiliation><affiliation>Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Elena</namePart><namePart type="family">Moro</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</affiliation><affiliation>Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Filomena</namePart><namePart type="family">Mazzella</namePart><namePart type="termsOfAddress">RN</namePart><affiliation>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yu‐Yan</namePart><namePart type="family">Poon</namePart><namePart type="termsOfAddress">RN</namePart><affiliation>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andres M.</namePart><namePart type="family">Lozano</namePart><namePart type="termsOfAddress">MD, PhD, FRCSC</namePart><affiliation>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</affiliation><affiliation>Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada</affiliation><affiliation>Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Robert</namePart><namePart type="family">Chen</namePart><namePart type="termsOfAddress">MA, MBBChir, MSc, FRCPC</namePart><affiliation>Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada</affiliation><affiliation>Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada</affiliation><affiliation>Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada</affiliation><description>Correspondence: Toronto Western Hospital, McLaughlin Pavilion, 7th Floor Room 411, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2010-10-15</dateIssued><dateCaptured encoding="w3cdtf">2009-07-23</dateCaptured><dateValid encoding="w3cdtf">2010-04-09</dateValid><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">3</extent><extent unit="references">55</extent><extent unit="words">5764</extent></physicalDescription><abstract lang="en">The pedunculopontine nucleus region (PPNR) is an integral component of the midbrain locomotor region and has widespread connections with the cortex, thalamus, brain stem, cerebellum, spinal cord, and especially, the basal ganglia. No previous study examined the somatosensory connection of the PPNR in human. We recorded somatosensory evoked potentials (SEP) from median nerve stimulation through deep brain stimulation (DBS) electrodes implanted in the PPNR in 8 patients (6 with Parkinson's disease, 2 with progressive supranuclear palsy). Monopolar recordings from the PPNR contacts showed triphasic or biphasic potentials. The latency of the largest negative peak was between 16.8 and 18.7 milliseconds. Bipolar derivation revealed phase reversal with median nerve stimulation contralateral to the DBS electrode in 6 patients. There was no difference in SEP amplitude and latency between on and off medication states. We also studied the high frequency oscillations (HFOs) by filtering the signal between 500 and 2,500 Hz. The HFOs could be identified only from contralateral stimulation and had intraburst frequencies of 1061 ± 121 Hz, onset latencies of 13.8 ± 1.2 milliseconds, and burst durations of 7.3 ± 1.1 milliseconds. Among the 10 recordings with HFOs, only 1 had possible phase reversal in the bipolar derivation. Our results suggest that there are direct somatosensory inputs to the PPNR. The slow components and HFOs of the SEP have different origins. © 2010 Movement Disorder Society.</abstract><note type="content">*Potential conflict of interest: Funded by the Canadian Institutes of Health Research grant number MOP15128.</note><subject lang="en"><genre>Keywords</genre><topic>pedunculopontine nucleus</topic><topic>somatosensory evoked potentials</topic><topic>high frequency oscillations</topic><topic>Parkinson's disease</topic><topic>deep brain stimulation</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><detail type="issue"><caption>no.</caption><number>13</number></detail><extent unit="pages"><start>2076</start><end>2083</end><total>8</total></extent></part></relatedItem><identifier type="istex">0DCCA870B61879E5C129B0F19031B3EA1A01EBB6</identifier><identifier type="DOI">10.1002/mds.23233</identifier><identifier type="ArticleID">MDS23233</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2010 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000770 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 000770 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:0DCCA870B61879E5C129B0F19031B3EA1A01EBB6
|texte= Somatosensory evoked potentials recorded from the human pedunculopontine nucleus region
}}
| This area was generated with Dilib version V0.6.23. |  |