Somatosensory Evoked Potentials Recorded from the Human Pedunculopontine Nucleus Region
Identifieur interne : 000832 ( PascalFrancis/Checkpoint ); précédent : 000831; suivant : 000833Somatosensory Evoked Potentials Recorded from the Human Pedunculopontine Nucleus Region
Auteurs : I-Jin Yeh [Canada, Taïwan] ; Eric W. Tsang [Canada] ; Clement Hamani [Canada] ; Elena Moro [Canada] ; Filomena Mazzella [Canada] ; Yu-Yan Poon [Canada] ; Andres M. Lozano [Canada] ; Robert Chen [Canada]Source :
- Movement disorders [ 0885-3185 ] ; 2010.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
The pedunculopontine nucleus region (PPNR) is an integral component of the midbrain locomotor region and has widespread connections with the cortex, thalamus, brain stem, cerebellum, spinal cord, and especially, the basal ganglia. No previous study examined the somatosensory connection of the PPNR in human. We recorded somatosensory evoked potentials (SEP) from median nerve stimulation through deep brain stimulation (DBS) electrodes implanted in the PPNR in 8 patients (6 with Parkinson's disease, 2 with progressive supranuclear palsy). Monopolar recordings from the PPNR contacts showed triphasic or biphasic potentials. The latency of the largest negative peak was between 16.8 and 18.7 milliseconds. Bipolar derivation revealed phase reversal with median nerve stimulation contralateral to the DBS electrode in 6 patients. There was no difference in SEP amplitude and latency between on and off medication states. We also studied the high frequency oscillations (HFOs) by filtering the signal between 500 and 2,500 Hz. The HFOs could be identified only from contralateral stimulation and had intraburst frequencies of 1061 ± 121 Hz, onset latencies of 13.8 ± 1.2 milliseconds, and burst durations of 7.3 + 1.1 milliseconds. Among the 10 recordings with HFOs, only 1 had possible phase reversal in the bipolar derivation. Our results suggest that there are direct somatosensory inputs to the PPNR. The slow components and HFOs of the SEP have different origins.
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Somatosensory Evoked Potentials Recorded from the Human Pedunculopontine Nucleus Region</title>
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<orgName type="university">Université de Toronto</orgName>
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</author>
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<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2010">2010</date>
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<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Deep brain stimulation</term>
<term>High frequency</term>
<term>Human</term>
<term>Nervous system diseases</term>
<term>Oscillation</term>
<term>Parkinson disease</term>
<term>Somatosensory evoked potential</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du système nerveux</term>
<term>Potentiel évoqué somatosensoriel</term>
<term>Homme</term>
<term>Haute fréquence</term>
<term>Oscillation</term>
<term>Stimulation cérébrale profonde</term>
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<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
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<front><div type="abstract" xml:lang="en">The pedunculopontine nucleus region (PPNR) is an integral component of the midbrain locomotor region and has widespread connections with the cortex, thalamus, brain stem, cerebellum, spinal cord, and especially, the basal ganglia. No previous study examined the somatosensory connection of the PPNR in human. We recorded somatosensory evoked potentials (SEP) from median nerve stimulation through deep brain stimulation (DBS) electrodes implanted in the PPNR in 8 patients (6 with Parkinson's disease, 2 with progressive supranuclear palsy). Monopolar recordings from the PPNR contacts showed triphasic or biphasic potentials. The latency of the largest negative peak was between 16.8 and 18.7 milliseconds. Bipolar derivation revealed phase reversal with median nerve stimulation contralateral to the DBS electrode in 6 patients. There was no difference in SEP amplitude and latency between on and off medication states. We also studied the high frequency oscillations (HFOs) by filtering the signal between 500 and 2,500 Hz. The HFOs could be identified only from contralateral stimulation and had intraburst frequencies of 1061 ± 121 Hz, onset latencies of 13.8 ± 1.2 milliseconds, and burst durations of 7.3 + 1.1 milliseconds. Among the 10 recordings with HFOs, only 1 had possible phase reversal in the bipolar derivation. Our results suggest that there are direct somatosensory inputs to the PPNR. The slow components and HFOs of the SEP have different origins.</div>
</front>
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<fA08 i1="01" i2="1" l="ENG"><s1>Somatosensory Evoked Potentials Recorded from the Human Pedunculopontine Nucleus Region</s1>
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<fA11 i1="01" i2="1"><s1>YEH (I-Jin)</s1>
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<fA11 i1="04" i2="1"><s1>MORO (Elena)</s1>
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<fA11 i1="05" i2="1"><s1>MAZZELLA (Filomena)</s1>
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<fA11 i1="06" i2="1"><s1>POON (Yu-Yan)</s1>
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<fA11 i1="07" i2="1"><s1>LOZANO (Andres M.)</s1>
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<fA11 i1="08" i2="1"><s1>CHEN (Robert)</s1>
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<fA14 i1="02"><s1>Division of Neurology, Department of Medicine, University of Toronto</s1>
<s2>Toronto, Ontario</s2>
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<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
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<fA14 i1="03"><s1>Department of Neurology, Songde Branch, Taipei City Hospital</s1>
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<s3>TWN</s3>
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<fA14 i1="05"><s1>Division of Neurosurgery, Department of Surgery, University of Toronto</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
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<fA20><s1>2076-2083</s1>
</fA20>
<fA21><s1>2010</s1>
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<fC01 i1="01" l="ENG"><s0>The pedunculopontine nucleus region (PPNR) is an integral component of the midbrain locomotor region and has widespread connections with the cortex, thalamus, brain stem, cerebellum, spinal cord, and especially, the basal ganglia. No previous study examined the somatosensory connection of the PPNR in human. We recorded somatosensory evoked potentials (SEP) from median nerve stimulation through deep brain stimulation (DBS) electrodes implanted in the PPNR in 8 patients (6 with Parkinson's disease, 2 with progressive supranuclear palsy). Monopolar recordings from the PPNR contacts showed triphasic or biphasic potentials. The latency of the largest negative peak was between 16.8 and 18.7 milliseconds. Bipolar derivation revealed phase reversal with median nerve stimulation contralateral to the DBS electrode in 6 patients. There was no difference in SEP amplitude and latency between on and off medication states. We also studied the high frequency oscillations (HFOs) by filtering the signal between 500 and 2,500 Hz. The HFOs could be identified only from contralateral stimulation and had intraburst frequencies of 1061 ± 121 Hz, onset latencies of 13.8 ± 1.2 milliseconds, and burst durations of 7.3 + 1.1 milliseconds. Among the 10 recordings with HFOs, only 1 had possible phase reversal in the bipolar derivation. Our results suggest that there are direct somatosensory inputs to the PPNR. The slow components and HFOs of the SEP have different origins.</s0>
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<li>Taïwan</li>
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<settlement><li>Toronto</li>
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<tree><country name="Canada"><noRegion><name sortKey="Yeh, I Jin" sort="Yeh, I Jin" uniqKey="Yeh I" first="I-Jin" last="Yeh">I-Jin Yeh</name>
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