Clinical and Epidemiologic Characteristics of Spreaders of Middle East Respiratory Syndrome Coronavirus during the 2015 Outbreak in Korea
Identifieur interne : 001998 ( Ncbi/Merge ); précédent : 001997; suivant : 001999Clinical and Epidemiologic Characteristics of Spreaders of Middle East Respiratory Syndrome Coronavirus during the 2015 Outbreak in Korea
Auteurs : Chang Kyung Kang [Corée du Sud] ; Kyoung-Ho Song [Corée du Sud] ; Pyoeng Gyun Choe [Corée du Sud] ; Wan Beom Park [Corée du Sud] ; Ji Hwan Bang [Corée du Sud] ; Eu Suk Kim [Corée du Sud] ; Sang Won Park [Corée du Sud] ; Hong Bin Kim [Corée du Sud] ; Nam Joong Kim [Corée du Sud] ; Sung-Il Cho [Corée du Sud] ; Jong-Koo Lee [Corée du Sud] ; Myoung-Don Oh [Corée du Sud]Source :
- Journal of Korean Medical Science [ 1011-8934 ] ; 2017.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Analyse multivariée, Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Durée du séjour, Facteurs de risque, Femelle, Flambées de maladies, Humains, Infection croisée (épidémiologie), Infections à coronavirus (anatomopathologie), Infections à coronavirus (microbiologie), Infections à coronavirus (transmission), Infections à coronavirus (épidémiologie), Mâle, Odds ratio, Poumon (virologie), République de Corée (épidémiologie), Sujet âgé, Température du corps.
- MESH :
- anatomopathologie : Infections à coronavirus.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- microbiologie : Infections à coronavirus.
- virologie : Poumon.
- épidémiologie : Infection croisée, Infections à coronavirus, République de Corée.
- Adulte, Adulte d'âge moyen, Analyse multivariée, Durée du séjour, Facteurs de risque, Femelle, Flambées de maladies, Humains, Mâle, Odds ratio, Sujet âgé, Température du corps.
English descriptors
- KwdEn :
- Adult, Aged, Body Temperature, Coronavirus Infections (epidemiology), Coronavirus Infections (microbiology), Coronavirus Infections (pathology), Coronavirus Infections (transmission), Cross Infection (epidemiology), Disease Outbreaks, Female, Humans, Length of Stay, Lung (virology), Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus (isolation & purification), Multivariate Analysis, Odds Ratio, Republic of Korea (epidemiology), Risk Factors.
- MESH :
- epidemiology : Coronavirus Infections, Cross Infection, Republic of Korea.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- microbiology : Coronavirus Infections.
- pathology : Coronavirus Infections.
- transmission : Coronavirus Infections.
- virology : Lung.
- Adult, Aged, Body Temperature, Disease Outbreaks, Female, Humans, Length of Stay, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Risk Factors.
Abstract
Nosocomial transmission is an important characteristic of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection. Risk factors for transmission of MERS-CoV in healthcare settings are not well defined. During the Korean outbreak in 2015, 186 patients had laboratory-confirmed MERS-CoV infection. Those suspected as a source of viral transmission were categorized into the spreader groups (super-spreader [n = 5] and usual-spreader [n = 10]) and compared to the non-spreader group (n = 171). Body temperature of ≥ 38.5°C (adjusted odds ratio [aOR], 5.54; 95% confidence interval [CI], 1.38–22.30;
Url:
DOI: 10.3346/jkms.2017.32.5.744
PubMed: 28378546
PubMed Central: 5383605
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PMC:5383605Le document en format XML
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</keywords>
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<front><div type="abstract" xml:lang="en"><p>Nosocomial transmission is an important characteristic of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection. Risk factors for transmission of MERS-CoV in healthcare settings are not well defined. During the Korean outbreak in 2015, 186 patients had laboratory-confirmed MERS-CoV infection. Those suspected as a source of viral transmission were categorized into the spreader groups (super-spreader [n = 5] and usual-spreader [n = 10]) and compared to the non-spreader group (n = 171). Body temperature of ≥ 38.5°C (adjusted odds ratio [aOR], 5.54; 95% confidence interval [CI], 1.38–22.30; <italic>P</italic>
= 0.016), pulmonary infiltration of ≥ 3 lung zones (aOR, 7.33; 95% CI, 1.93–27.79; <italic>P</italic>
= 0.003), and a more nonisolated in-hospital days (aOR, 1.32 per 1 day; 95% CI, 1.09–1.60; <italic>P</italic>
= 0.004) were significant risk factors in the spreader group. There was no different clinical factor between super-spreaders and usual-spreaders. Nonisolated in-hospital days was the only factor which tended to be higher in super-spreaders than usual-spreaders (Mean, 6.6 vs. 2.9 days; <italic>P</italic>
= 0.061). Early active quarantine might help reducing the size of an outbreak.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name>
</author>
<author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name>
</author>
<author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name>
</author>
<author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name>
</author>
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<author><name sortKey="Kang, Chang Kyung" sort="Kang, Chang Kyung" uniqKey="Kang C" first="Chang Kyung" last="Kang">Chang Kyung Kang</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Seoul National University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Song, Kyoung Ho" sort="Song, Kyoung Ho" uniqKey="Song K" first="Kyoung-Ho" last="Song">Kyoung-Ho Song</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Seoul National University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Choe, Pyoeng Gyun" sort="Choe, Pyoeng Gyun" uniqKey="Choe P" first="Pyoeng Gyun" last="Choe">Pyoeng Gyun Choe</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Seoul National University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Park, Wan Beom" sort="Park, Wan Beom" uniqKey="Park W" first="Wan Beom" last="Park">Wan Beom Park</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Seoul National University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bang, Ji Hwan" sort="Bang, Ji Hwan" uniqKey="Bang J" first="Ji Hwan" last="Bang">Ji Hwan Bang</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Seoul National University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kim, Eu Suk" sort="Kim, Eu Suk" uniqKey="Kim E" first="Eu Suk" last="Kim">Eu Suk Kim</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Seoul National University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Park, Sang Won" sort="Park, Sang Won" uniqKey="Park S" first="Sang Won" last="Park">Sang Won Park</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Seoul National University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kim, Hong Bin" sort="Kim, Hong Bin" uniqKey="Kim H" first="Hong Bin" last="Kim">Hong Bin Kim</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Seoul National University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kim, Nam Joong" sort="Kim, Nam Joong" uniqKey="Kim N" first="Nam Joong" last="Kim">Nam Joong Kim</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Seoul National University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cho, Sung Il" sort="Cho, Sung Il" uniqKey="Cho S" first="Sung-Il" last="Cho">Sung-Il Cho</name>
<affiliation wicri:level="1"><nlm:aff id="A2">JW Lee Center for Global Medicine, Seoul National University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A3">Graduate School of Public Health and Institute of Health and Environment, Seoul National University, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lee, Jong Koo" sort="Lee, Jong Koo" uniqKey="Lee J" first="Jong-Koo" last="Lee">Jong-Koo Lee</name>
<affiliation wicri:level="1"><nlm:aff id="A2">JW Lee Center for Global Medicine, Seoul National University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A3">Graduate School of Public Health and Institute of Health and Environment, Seoul National University, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Oh, Myoung Don" sort="Oh, Myoung Don" uniqKey="Oh M" first="Myoung-Don" last="Oh">Myoung-Don Oh</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Seoul National University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">JW Lee Center for Global Medicine, Seoul National University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Clinical and Epidemiologic Characteristics of Spreaders of Middle East Respiratory Syndrome Coronavirus during the 2015 Outbreak in Korea</title>
<author><name sortKey="Kang, Chang Kyung" sort="Kang, Chang Kyung" uniqKey="Kang C" first="Chang Kyung" last="Kang">Chang Kyung Kang</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Seoul National University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Song, Kyoung Ho" sort="Song, Kyoung Ho" uniqKey="Song K" first="Kyoung-Ho" last="Song">Kyoung-Ho Song</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Seoul National University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Choe, Pyoeng Gyun" sort="Choe, Pyoeng Gyun" uniqKey="Choe P" first="Pyoeng Gyun" last="Choe">Pyoeng Gyun Choe</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Seoul National University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Park, Wan Beom" sort="Park, Wan Beom" uniqKey="Park W" first="Wan Beom" last="Park">Wan Beom Park</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Seoul National University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bang, Ji Hwan" sort="Bang, Ji Hwan" uniqKey="Bang J" first="Ji Hwan" last="Bang">Ji Hwan Bang</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Seoul National University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kim, Eu Suk" sort="Kim, Eu Suk" uniqKey="Kim E" first="Eu Suk" last="Kim">Eu Suk Kim</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Seoul National University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Park, Sang Won" sort="Park, Sang Won" uniqKey="Park S" first="Sang Won" last="Park">Sang Won Park</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Seoul National University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kim, Hong Bin" sort="Kim, Hong Bin" uniqKey="Kim H" first="Hong Bin" last="Kim">Hong Bin Kim</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Seoul National University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kim, Nam Joong" sort="Kim, Nam Joong" uniqKey="Kim N" first="Nam Joong" last="Kim">Nam Joong Kim</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Seoul National University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cho, Sung Il" sort="Cho, Sung Il" uniqKey="Cho S" first="Sung-Il" last="Cho">Sung-Il Cho</name>
<affiliation wicri:level="1"><nlm:aff id="A2">JW Lee Center for Global Medicine, Seoul National University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A3">Graduate School of Public Health and Institute of Health and Environment, Seoul National University, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lee, Jong Koo" sort="Lee, Jong Koo" uniqKey="Lee J" first="Jong-Koo" last="Lee">Jong-Koo Lee</name>
<affiliation wicri:level="1"><nlm:aff id="A2">JW Lee Center for Global Medicine, Seoul National University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A3">Graduate School of Public Health and Institute of Health and Environment, Seoul National University, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Oh, Myoung Don" sort="Oh, Myoung Don" uniqKey="Oh M" first="Myoung-Don" last="Oh">Myoung-Don Oh</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Internal Medicine, Seoul National University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">JW Lee Center for Global Medicine, Seoul National University College of Medicine, Seoul,<country>Korea</country>
.</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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</analytic>
<series><title level="j">Journal of Korean Medical Science</title>
<idno type="ISSN">1011-8934</idno>
<idno type="eISSN">1598-6357</idno>
<imprint><date when="2017">2017</date>
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</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Nosocomial transmission is an important characteristic of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection. Risk factors for transmission of MERS-CoV in healthcare settings are not well defined. During the Korean outbreak in 2015, 186 patients had laboratory-confirmed MERS-CoV infection. Those suspected as a source of viral transmission were categorized into the spreader groups (super-spreader [n = 5] and usual-spreader [n = 10]) and compared to the non-spreader group (n = 171). Body temperature of ≥ 38.5°C (adjusted odds ratio [aOR], 5.54; 95% confidence interval [CI], 1.38–22.30; <italic>P</italic>
= 0.016), pulmonary infiltration of ≥ 3 lung zones (aOR, 7.33; 95% CI, 1.93–27.79; <italic>P</italic>
= 0.003), and a more nonisolated in-hospital days (aOR, 1.32 per 1 day; 95% CI, 1.09–1.60; <italic>P</italic>
= 0.004) were significant risk factors in the spreader group. There was no different clinical factor between super-spreaders and usual-spreaders. Nonisolated in-hospital days was the only factor which tended to be higher in super-spreaders than usual-spreaders (Mean, 6.6 vs. 2.9 days; <italic>P</italic>
= 0.061). Early active quarantine might help reducing the size of an outbreak.</p>
</div>
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<author><name sortKey="Kim, Eu Suk" sort="Kim, Eu Suk" uniqKey="Kim E" first="Eu Suk" last="Kim">Eu Suk Kim</name>
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<author><name sortKey="Park, Sang Won" sort="Park, Sang Won" uniqKey="Park S" first="Sang Won" last="Park">Sang Won Park</name>
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<author><name sortKey="Kim, Hong Bin" sort="Kim, Hong Bin" uniqKey="Kim H" first="Hong Bin" last="Kim">Hong Bin Kim</name>
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<author><name sortKey="Kim, Nam Joong" sort="Kim, Nam Joong" uniqKey="Kim N" first="Nam Joong" last="Kim">Nam Joong Kim</name>
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<author><name sortKey="Cho, Sung Il" sort="Cho, Sung Il" uniqKey="Cho S" first="Sung Il" last="Cho">Sung Il Cho</name>
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<author><name sortKey="Oh, Myoung Don" sort="Oh, Myoung Don" uniqKey="Oh M" first="Myoung Don" last="Oh">Myoung Don Oh</name>
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<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Coronavirus Infections</term>
</keywords>
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<term>Aged</term>
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<front><div type="abstract" xml:lang="en">Nosocomial transmission is an important characteristic of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection. Risk factors for transmission of MERS-CoV in healthcare settings are not well defined. During the Korean outbreak in 2015, 186 patients had laboratory-confirmed MERS-CoV infection. Those suspected as a source of viral transmission were categorized into the spreader groups (super-spreader [n = 5] and usual-spreader [n = 10]) and compared to the non-spreader group (n = 171). Body temperature of ≥ 38.5°C (adjusted odds ratio [aOR], 5.54; 95% confidence interval [CI], 1.38-22.30; P = 0.016), pulmonary infiltration of ≥ 3 lung zones (aOR, 7.33; 95% CI, 1.93-27.79; P = 0.003), and a more nonisolated in-hospital days (aOR, 1.32 per 1 day; 95% CI, 1.09-1.60; P = 0.004) were significant risk factors in the spreader group. There was no different clinical factor between super-spreaders and usual-spreaders. Nonisolated in-hospital days was the only factor which tended to be higher in super-spreaders than usual-spreaders (Mean, 6.6 vs. 2.9 days; P = 0.061). Early active quarantine might help reducing the size of an outbreak.</div>
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