Untargeted metabolite analysis-based UHPLC-Q-TOF-MS reveals significant enrichment of p-hydroxybenzyl dimers of citric acids in fresh beige-scape Gastrodia elata (Wutianma).
Identifieur interne : 001999 ( Ncbi/Merge ); précédent : 001998; suivant : 001A00Untargeted metabolite analysis-based UHPLC-Q-TOF-MS reveals significant enrichment of p-hydroxybenzyl dimers of citric acids in fresh beige-scape Gastrodia elata (Wutianma).
Auteurs : Chang-Jiang-Sheng Lai [République populaire de Chine] ; Yuan Yuan [République populaire de Chine] ; Da-Hui Liu [République populaire de Chine] ; Chuan-Zhi Kang [République populaire de Chine] ; Yu Zhang [République populaire de Chine] ; Liangping Zha [République populaire de Chine] ; Liping Kang [République populaire de Chine] ; Tong Chen [République populaire de Chine] ; Tie-Gui Nan [République populaire de Chine] ; Qing-Xiu Hao [République populaire de Chine] ; Lu-Qi Huang [République populaire de Chine]Source :
- Journal of pharmaceutical and biomedical analysis [ 1873-264X ] ; 2017.
Descripteurs français
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English descriptors
- KwdEn :
- MESH :
Abstract
In order to comprehensively elucidate the chemical biosynthesis process of the beige-scape Gastrodia elata Blume (Wutianma) as a traditional herbal medicines, the untargeted analysis-based UHPLC-PDA-ESI-Q-TOF-MS reveals the metabolites ranging from the skeletons to novel dimers of citric acids in fresh and dried immature/mature stem tubers. Interestingly, two novel types of dimers for citric acids with the anhydride groups at sn-1 and/or sn-5 were discovered in fresh samples. Moreover, the classical mono- versus novel di-mers, and the aglycons versus the glycosides could be easily discriminated by signature fragmentation patterns and some novel adduct ions. The heat map of contents demonstrated more p-hydroxybenzyl metabolites than gastroxyl ones were determined in fresh Wutianma revealing a significant specificity with the lack of the sufficient gastrodin and gastroxyl products in biosynthetic pathway.
DOI: 10.1016/j.jpba.2017.03.055
PubMed: 28380386
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pubmed:28380386Le document en format XML
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<term>Gastrodia</term>
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<term>Chromatographie en phase liquide à haute performance</term>
<term>Dimérisation</term>
<term>Extraits de plantes</term>
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<front><div type="abstract" xml:lang="en">In order to comprehensively elucidate the chemical biosynthesis process of the beige-scape Gastrodia elata Blume (Wutianma) as a traditional herbal medicines, the untargeted analysis-based UHPLC-PDA-ESI-Q-TOF-MS reveals the metabolites ranging from the skeletons to novel dimers of citric acids in fresh and dried immature/mature stem tubers. Interestingly, two novel types of dimers for citric acids with the anhydride groups at sn-1 and/or sn-5 were discovered in fresh samples. Moreover, the classical mono- versus novel di-mers, and the aglycons versus the glycosides could be easily discriminated by signature fragmentation patterns and some novel adduct ions. The heat map of contents demonstrated more p-hydroxybenzyl metabolites than gastroxyl ones were determined in fresh Wutianma revealing a significant specificity with the lack of the sufficient gastrodin and gastroxyl products in biosynthetic pathway.</div>
</front>
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<Abstract><AbstractText>In order to comprehensively elucidate the chemical biosynthesis process of the beige-scape Gastrodia elata Blume (Wutianma) as a traditional herbal medicines, the untargeted analysis-based UHPLC-PDA-ESI-Q-TOF-MS reveals the metabolites ranging from the skeletons to novel dimers of citric acids in fresh and dried immature/mature stem tubers. Interestingly, two novel types of dimers for citric acids with the anhydride groups at sn-1 and/or sn-5 were discovered in fresh samples. Moreover, the classical mono- versus novel di-mers, and the aglycons versus the glycosides could be easily discriminated by signature fragmentation patterns and some novel adduct ions. The heat map of contents demonstrated more p-hydroxybenzyl metabolites than gastroxyl ones were determined in fresh Wutianma revealing a significant specificity with the lack of the sufficient gastrodin and gastroxyl products in biosynthetic pathway.</AbstractText>
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<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Tong</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, State Key Laboratory Breeding Base of Dao-di Herbs, Beijng, 100700, PR China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nan</LastName>
<ForeName>Tie-Gui</ForeName>
<Initials>TG</Initials>
<AffiliationInfo><Affiliation>National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, State Key Laboratory Breeding Base of Dao-di Herbs, Beijng, 100700, PR China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hao</LastName>
<ForeName>Qing-Xiu</ForeName>
<Initials>QX</Initials>
<AffiliationInfo><Affiliation>National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, State Key Laboratory Breeding Base of Dao-di Herbs, Beijng, 100700, PR China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huang</LastName>
<ForeName>Lu-Qi</ForeName>
<Initials>LQ</Initials>
<AffiliationInfo><Affiliation>National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, State Key Laboratory Breeding Base of Dao-di Herbs, Beijng, 100700, PR China. Electronic address: huangluqi01@126.com.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2017</Year>
<Month>03</Month>
<Day>29</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>J Pharm Biomed Anal</MedlineTA>
<NlmUniqueID>8309336</NlmUniqueID>
<ISSNLinking>0731-7085</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>2968PHW8QP</RegistryNumber>
<NameOfSubstance UI="D019343">Citric Acid</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D002851" MajorTopicYN="N">Chromatography, High Pressure Liquid</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019343" MajorTopicYN="N">Citric Acid</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019281" MajorTopicYN="N">Dimerization</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D031668" MajorTopicYN="Y">Gastrodia</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013058" MajorTopicYN="N">Mass Spectrometry</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D035281" MajorTopicYN="N">Plant Tubers</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010946" MajorTopicYN="N">Plants, Medicinal</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Citric acids</Keyword>
<Keyword MajorTopicYN="N">Gastrodia elata</Keyword>
<Keyword MajorTopicYN="N">Gastrodin</Keyword>
<Keyword MajorTopicYN="N">Parishins</Keyword>
<Keyword MajorTopicYN="N">UHPLC-PDA-ESI-Q-TOF-MS</Keyword>
<Keyword MajorTopicYN="N">p-Hydroxybenzyl alcohol</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year>
<Month>02</Month>
<Day>26</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2017</Year>
<Month>03</Month>
<Day>27</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2017</Year>
<Month>03</Month>
<Day>27</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2017</Year>
<Month>4</Month>
<Day>6</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2018</Year>
<Month>1</Month>
<Day>25</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2017</Year>
<Month>4</Month>
<Day>6</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">28380386</ArticleId>
<ArticleId IdType="pii">S0731-7085(17)30482-X</ArticleId>
<ArticleId IdType="doi">10.1016/j.jpba.2017.03.055</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Lai, Chang Jiang Sheng" sort="Lai, Chang Jiang Sheng" uniqKey="Lai C" first="Chang-Jiang-Sheng" last="Lai">Chang-Jiang-Sheng Lai</name>
</noRegion>
<name sortKey="Chen, Tong" sort="Chen, Tong" uniqKey="Chen T" first="Tong" last="Chen">Tong Chen</name>
<name sortKey="Hao, Qing Xiu" sort="Hao, Qing Xiu" uniqKey="Hao Q" first="Qing-Xiu" last="Hao">Qing-Xiu Hao</name>
<name sortKey="Huang, Lu Qi" sort="Huang, Lu Qi" uniqKey="Huang L" first="Lu-Qi" last="Huang">Lu-Qi Huang</name>
<name sortKey="Kang, Chuan Zhi" sort="Kang, Chuan Zhi" uniqKey="Kang C" first="Chuan-Zhi" last="Kang">Chuan-Zhi Kang</name>
<name sortKey="Kang, Liping" sort="Kang, Liping" uniqKey="Kang L" first="Liping" last="Kang">Liping Kang</name>
<name sortKey="Liu, Da Hui" sort="Liu, Da Hui" uniqKey="Liu D" first="Da-Hui" last="Liu">Da-Hui Liu</name>
<name sortKey="Nan, Tie Gui" sort="Nan, Tie Gui" uniqKey="Nan T" first="Tie-Gui" last="Nan">Tie-Gui Nan</name>
<name sortKey="Yuan, Yuan" sort="Yuan, Yuan" uniqKey="Yuan Y" first="Yuan" last="Yuan">Yuan Yuan</name>
<name sortKey="Zha, Liangping" sort="Zha, Liangping" uniqKey="Zha L" first="Liangping" last="Zha">Liangping Zha</name>
<name sortKey="Zhang, Yu" sort="Zhang, Yu" uniqKey="Zhang Y" first="Yu" last="Zhang">Yu Zhang</name>
</country>
</tree>
</affiliations>
</record>
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