MersV1, PubMed, Checkpoint, bibRecord, 000D64

Clinical and Epidemiologic Characteristics of Spreaders of Middle East Respiratory Syndrome Coronavirus during the 2015 Outbreak in Korea.

Identifieur interne : 000D64 ( PubMed/Checkpoint ); précédent : 000D63; suivant : 000D65

Clinical and Epidemiologic Characteristics of Spreaders of Middle East Respiratory Syndrome Coronavirus during the 2015 Outbreak in Korea.

Auteurs : Chang Kyung Kang [Corée du Sud] ; Kyoung Ho Song [Corée du Sud] ; Pyoeng Gyun Choe [Corée du Sud] ; Wan Beom Park [Corée du Sud] ; Ji Hwan Bang [Corée du Sud] ; Eu Suk Kim [Corée du Sud] ; Sang Won Park [Corée du Sud] ; Hong Bin Kim [Corée du Sud] ; Nam Joong Kim [Corée du Sud] ; Sung Il Cho [Corée du Sud] ; Jong Koo Lee [Corée du Sud] ; Myoung Don Oh [Corée du Sud]

Source :

Journal of Korean medical science [ 1598-6357 ] ; 2017.

RBID : pubmed:28378546

Descripteurs français

KwdFr :
- Adulte, Adulte d'âge moyen, Analyse multivariée, Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Durée du séjour, Facteurs de risque, Femelle, Flambées de maladies, Humains, Infection croisée (épidémiologie), Infections à coronavirus (anatomopathologie), Infections à coronavirus (microbiologie), Infections à coronavirus (transmission), Infections à coronavirus (épidémiologie), Mâle, Odds ratio, Poumon (virologie), République de Corée (épidémiologie), Sujet âgé, Température du corps.
MESH :
- anatomopathologie : Infections à coronavirus.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- microbiologie : Infections à coronavirus.
- virologie : Poumon.
- épidémiologie : Infection croisée, Infections à coronavirus, République de Corée.
- Adulte, Adulte d'âge moyen, Analyse multivariée, Durée du séjour, Facteurs de risque, Femelle, Flambées de maladies, Humains, Mâle, Odds ratio, Sujet âgé, Température du corps.

English descriptors

KwdEn :
- Adult, Aged, Body Temperature, Coronavirus Infections (epidemiology), Coronavirus Infections (microbiology), Coronavirus Infections (pathology), Coronavirus Infections (transmission), Cross Infection (epidemiology), Disease Outbreaks, Female, Humans, Length of Stay, Lung (virology), Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus (isolation & purification), Multivariate Analysis, Odds Ratio, Republic of Korea (epidemiology), Risk Factors.
MESH :
- epidemiology : Coronavirus Infections, Cross Infection, Republic of Korea.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- microbiology : Coronavirus Infections.
- pathology : Coronavirus Infections.
- transmission : Coronavirus Infections.
- virology : Lung.
- Adult, Aged, Body Temperature, Disease Outbreaks, Female, Humans, Length of Stay, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Risk Factors.

Abstract

Nosocomial transmission is an important characteristic of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection. Risk factors for transmission of MERS-CoV in healthcare settings are not well defined. During the Korean outbreak in 2015, 186 patients had laboratory-confirmed MERS-CoV infection. Those suspected as a source of viral transmission were categorized into the spreader groups (super-spreader [n = 5] and usual-spreader [n = 10]) and compared to the non-spreader group (n = 171). Body temperature of ≥ 38.5°C (adjusted odds ratio [aOR], 5.54; 95% confidence interval [CI], 1.38-22.30; P = 0.016), pulmonary infiltration of ≥ 3 lung zones (aOR, 7.33; 95% CI, 1.93-27.79; P = 0.003), and a more nonisolated in-hospital days (aOR, 1.32 per 1 day; 95% CI, 1.09-1.60; P = 0.004) were significant risk factors in the spreader group. There was no different clinical factor between super-spreaders and usual-spreaders. Nonisolated in-hospital days was the only factor which tended to be higher in super-spreaders than usual-spreaders (Mean, 6.6 vs. 2.9 days; P = 0.061). Early active quarantine might help reducing the size of an outbreak.

DOI: 10.3346/jkms.2017.32.5.744
PubMed: 28378546

Affiliations:

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<front><div type="abstract" xml:lang="en">Nosocomial transmission is an important characteristic of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection. Risk factors for transmission of MERS-CoV in healthcare settings are not well defined. During the Korean outbreak in 2015, 186 patients had laboratory-confirmed MERS-CoV infection. Those suspected as a source of viral transmission were categorized into the spreader groups (super-spreader [n = 5] and usual-spreader [n = 10]) and compared to the non-spreader group (n = 171). Body temperature of ≥ 38.5°C (adjusted odds ratio [aOR], 5.54; 95% confidence interval [CI], 1.38-22.30; P = 0.016), pulmonary infiltration of ≥ 3 lung zones (aOR, 7.33; 95% CI, 1.93-27.79; P = 0.003), and a more nonisolated in-hospital days (aOR, 1.32 per 1 day; 95% CI, 1.09-1.60; P = 0.004) were significant risk factors in the spreader group. There was no different clinical factor between super-spreaders and usual-spreaders. Nonisolated in-hospital days was the only factor which tended to be higher in super-spreaders than usual-spreaders (Mean, 6.6 vs. 2.9 days; P = 0.061). Early active quarantine might help reducing the size of an outbreak.</div>
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<Month>11</Month>
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</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1598-6357</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>32</Volume>
<Issue>5</Issue>
<PubDate><Year>2017</Year>
<Month>May</Month>
</PubDate>
</JournalIssue>
<Title>Journal of Korean medical science</Title>
<ISOAbbreviation>J. Korean Med. Sci.</ISOAbbreviation>
</Journal>
<ArticleTitle>Clinical and Epidemiologic Characteristics of Spreaders of Middle East Respiratory Syndrome Coronavirus during the 2015 Outbreak in Korea.</ArticleTitle>
<Pagination><MedlinePgn>744-749</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.3346/jkms.2017.32.5.744</ELocationID>
<Abstract><AbstractText>Nosocomial transmission is an important characteristic of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection. Risk factors for transmission of MERS-CoV in healthcare settings are not well defined. During the Korean outbreak in 2015, 186 patients had laboratory-confirmed MERS-CoV infection. Those suspected as a source of viral transmission were categorized into the spreader groups (super-spreader [n = 5] and usual-spreader [n = 10]) and compared to the non-spreader group (n = 171). Body temperature of ≥ 38.5°C (adjusted odds ratio [aOR], 5.54; 95% confidence interval [CI], 1.38-22.30; P = 0.016), pulmonary infiltration of ≥ 3 lung zones (aOR, 7.33; 95% CI, 1.93-27.79; P = 0.003), and a more nonisolated in-hospital days (aOR, 1.32 per 1 day; 95% CI, 1.09-1.60; P = 0.004) were significant risk factors in the spreader group. There was no different clinical factor between super-spreaders and usual-spreaders. Nonisolated in-hospital days was the only factor which tended to be higher in super-spreaders than usual-spreaders (Mean, 6.6 vs. 2.9 days; P = 0.061). Early active quarantine might help reducing the size of an outbreak.</AbstractText>
<CopyrightInformation>© 2017 The Korean Academy of Medical Sciences.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kang</LastName>
<ForeName>Chang Kyung</ForeName>
<Initials>CK</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0003-1952-072X</Identifier>
<AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Song</LastName>
<ForeName>Kyoung Ho</ForeName>
<Initials>KH</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-4517-3840</Identifier>
<AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Choe</LastName>
<ForeName>Pyoeng Gyun</ForeName>
<Initials>PG</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0001-6794-7918</Identifier>
<AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Park</LastName>
<ForeName>Wan Beom</ForeName>
<Initials>WB</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0003-0022-9625</Identifier>
<AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bang</LastName>
<ForeName>Ji Hwan</ForeName>
<Initials>JH</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-7628-1182</Identifier>
<AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kim</LastName>
<ForeName>Eu Suk</ForeName>
<Initials>ES</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0001-7132-0157</Identifier>
<AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Park</LastName>
<ForeName>Sang Won</ForeName>
<Initials>SW</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-0550-1897</Identifier>
<AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kim</LastName>
<ForeName>Hong Bin</ForeName>
<Initials>HB</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0001-6262-372X</Identifier>
<AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kim</LastName>
<ForeName>Nam Joong</ForeName>
<Initials>NJ</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0001-6793-9467</Identifier>
<AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cho</LastName>
<ForeName>Sung Il</ForeName>
<Initials>SI</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0003-4085-1494</Identifier>
<AffiliationInfo><Affiliation>JW Lee Center for Global Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Graduate School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lee</LastName>
<ForeName>Jong Koo</ForeName>
<Initials>JK</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0003-4833-1178</Identifier>
<AffiliationInfo><Affiliation>JW Lee Center for Global Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Graduate School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Oh</LastName>
<ForeName>Myoung Don</ForeName>
<Initials>MD</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-2344-7695</Identifier>
<AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>JW Lee Center for Global Medicine, Seoul National University College of Medicine, Seoul, Korea. mdohmd@snu.ac.kr.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>Korea (South)</Country>
<MedlineTA>J Korean Med Sci</MedlineTA>
<NlmUniqueID>8703518</NlmUniqueID>
<ISSNLinking>1011-8934</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001831" MajorTopicYN="N">Body Temperature</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
<QualifierName UI="Q000635" MajorTopicYN="N">transmission</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003428" MajorTopicYN="N">Cross Infection</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004196" MajorTopicYN="N">Disease Outbreaks</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007902" MajorTopicYN="N">Length of Stay</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D065207" MajorTopicYN="N">Middle East Respiratory Syndrome Coronavirus</DescriptorName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015999" MajorTopicYN="N">Multivariate Analysis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016017" MajorTopicYN="N">Odds Ratio</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D056910" MajorTopicYN="N">Republic of Korea</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Hospital Infection</Keyword>
<Keyword MajorTopicYN="N">Infection Transmission</Keyword>
<Keyword MajorTopicYN="N">Korea</Keyword>
<Keyword MajorTopicYN="N">MERS-CoV</Keyword>
<Keyword MajorTopicYN="N">Outbreak</Keyword>
</KeywordList>
<CoiStatement>The authors have no potential conflicts of interest to disclose.</CoiStatement>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year>
<Month>12</Month>
<Day>27</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2017</Year>
<Month>01</Month>
<Day>30</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2017</Year>
<Month>4</Month>
<Day>6</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="pubmed"><Year>2017</Year>
<Month>4</Month>
<Day>6</Day>
<Hour>6</Hour>
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</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2017</Year>
<Month>9</Month>
<Day>9</Day>
<Hour>6</Hour>
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</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">28378546</ArticleId>
<ArticleId IdType="pii">32.744</ArticleId>
<ArticleId IdType="doi">10.3346/jkms.2017.32.5.744</ArticleId>
<ArticleId IdType="pmc">PMC5383605</ArticleId>
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</pubmed>
<affiliations><list><country><li>Corée du Sud</li>
</country>
<region><li>Région capitale de Séoul</li>
</region>
<settlement><li>Séoul</li>
</settlement>
</list>
<tree><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Kang, Chang Kyung" sort="Kang, Chang Kyung" uniqKey="Kang C" first="Chang Kyung" last="Kang">Chang Kyung Kang</name>
</region>
<name sortKey="Bang, Ji Hwan" sort="Bang, Ji Hwan" uniqKey="Bang J" first="Ji Hwan" last="Bang">Ji Hwan Bang</name>
<name sortKey="Cho, Sung Il" sort="Cho, Sung Il" uniqKey="Cho S" first="Sung Il" last="Cho">Sung Il Cho</name>
<name sortKey="Choe, Pyoeng Gyun" sort="Choe, Pyoeng Gyun" uniqKey="Choe P" first="Pyoeng Gyun" last="Choe">Pyoeng Gyun Choe</name>
<name sortKey="Kim, Eu Suk" sort="Kim, Eu Suk" uniqKey="Kim E" first="Eu Suk" last="Kim">Eu Suk Kim</name>
<name sortKey="Kim, Hong Bin" sort="Kim, Hong Bin" uniqKey="Kim H" first="Hong Bin" last="Kim">Hong Bin Kim</name>
<name sortKey="Kim, Nam Joong" sort="Kim, Nam Joong" uniqKey="Kim N" first="Nam Joong" last="Kim">Nam Joong Kim</name>
<name sortKey="Lee, Jong Koo" sort="Lee, Jong Koo" uniqKey="Lee J" first="Jong Koo" last="Lee">Jong Koo Lee</name>
<name sortKey="Oh, Myoung Don" sort="Oh, Myoung Don" uniqKey="Oh M" first="Myoung Don" last="Oh">Myoung Don Oh</name>
<name sortKey="Park, Sang Won" sort="Park, Sang Won" uniqKey="Park S" first="Sang Won" last="Park">Sang Won Park</name>
<name sortKey="Park, Wan Beom" sort="Park, Wan Beom" uniqKey="Park W" first="Wan Beom" last="Park">Wan Beom Park</name>
<name sortKey="Song, Kyoung Ho" sort="Song, Kyoung Ho" uniqKey="Song K" first="Kyoung Ho" last="Song">Kyoung Ho Song</name>
</country>
</tree>
</affiliations>
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Clinical and Epidemiologic Characteristics of Spreaders of Middle East Respiratory Syndrome Coronavirus during the 2015 Outbreak in Korea.

Clinical and Epidemiologic Characteristics of Spreaders of Middle East Respiratory Syndrome Coronavirus during the 2015 Outbreak in Korea.

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