[In vitro anti-HIV activity of phosphorothioate alpha-anomeric oligodeoxynucleotides].
Identifieur interne : 004A89 ( Main/Exploration ); précédent : 004A88; suivant : 004A90[In vitro anti-HIV activity of phosphorothioate alpha-anomeric oligodeoxynucleotides].
Auteurs : B. Rayner ; M. Matsukura ; F. Morvan ; J S Cohen ; J L ImbachSource :
- Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie [ 0764-4469 ] ; 1989.
Descripteurs français
- KwdFr :
- MESH :
- immunologie : Lymphocytes T.
- microbiologie : Lymphocytes T.
- pharmacologie : Oligonucléotides, Thionucléotides.
- Dépression chimique, Humains, Oligonucléotides antisens, Séquence nucléotidique, Techniques in vitro, VIH (Virus de l'Immunodéficience Humaine).
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Oligonucleotides, Thionucleotides.
- drug effects : HIV.
- immunology : T-Lymphocytes.
- microbiology : T-Lymphocytes.
- Base Sequence, Depression, Chemical, Humans, In Vitro Techniques, Oligonucleotides, Antisense.
Abstract
Oligonucleotide analogs consisting exclusively of alpha-anomeric deoxynucleoside units bridged with phosphorothioate linkages have been synthesized and tested in vitro as antiviral agents against human immunodeficiency virus (HIV) in human T cells. Two 28-mers, an homopolymer alpha-S-dC28 and an oligomer alpha-S-anti-rev complementary to the initiation site of the regulatory viral gene rev exhibited antiviral activities comparable to those reported for the corresponding beta-anomeric phosphorothioate analogs. In contrast, a nuclease-resistant homopolymer, alpha-dC28 was inactive. Their preliminary results would indicate that the origin of oligonucleotide phosphorothioate anti-HIV activity is not exclusively correlated with their higher nuclease resistance.
PubMed: 2516764
Affiliations:
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Le document en format XML
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Morvan</name></author><author><name sortKey="Cohen, J S" sort="Cohen, J S" uniqKey="Cohen J" first="J S" last="Cohen">J S Cohen</name></author><author><name sortKey="Imbach, J L" sort="Imbach, J L" uniqKey="Imbach J" first="J L" last="Imbach">J L Imbach</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1989">1989</date><idno type="RBID">pubmed:2516764</idno><idno type="pmid">2516764</idno><idno type="wicri:Area/PubMed/Corpus">002A48</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002A48</idno><idno type="wicri:Area/PubMed/Curation">002A48</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002A48</idno><idno type="wicri:Area/PubMed/Checkpoint">002875</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002875</idno><idno type="wicri:Area/Ncbi/Merge">000E84</idno><idno type="wicri:Area/Ncbi/Curation">000E84</idno><idno type="wicri:Area/Ncbi/Checkpoint">000E84</idno><idno type="wicri:doubleKey">0764-4469:1989:Rayner B:in:vitro:anti</idno><idno type="wicri:Area/Main/Merge">004B67</idno><idno type="wicri:Area/Main/Curation">004A89</idno><idno type="wicri:Area/Main/Exploration">004A89</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[In vitro anti-HIV activity of phosphorothioate alpha-anomeric oligodeoxynucleotides].</title><author><name sortKey="Rayner, B" sort="Rayner, B" uniqKey="Rayner B" first="B" last="Rayner">B. Rayner</name><affiliation><nlm:affiliation>Laboratoire de Chimie bio-organique, U.A. n 488, C.N.R.S., Université de Montpellier-II.</nlm:affiliation><wicri:noCountry code="subField">Université de Montpellier-II</wicri:noCountry></affiliation></author><author><name sortKey="Matsukura, M" sort="Matsukura, M" uniqKey="Matsukura M" first="M" last="Matsukura">M. Matsukura</name></author><author><name sortKey="Morvan, F" sort="Morvan, F" uniqKey="Morvan F" first="F" last="Morvan">F. Morvan</name></author><author><name sortKey="Cohen, J S" sort="Cohen, J S" uniqKey="Cohen J" first="J S" last="Cohen">J S Cohen</name></author><author><name sortKey="Imbach, J L" sort="Imbach, J L" uniqKey="Imbach J" first="J L" last="Imbach">J L Imbach</name></author></analytic><series><title level="j">Comptes rendus de l'Academie des sciences. 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Two 28-mers, an homopolymer alpha-S-dC28 and an oligomer alpha-S-anti-rev complementary to the initiation site of the regulatory viral gene rev exhibited antiviral activities comparable to those reported for the corresponding beta-anomeric phosphorothioate analogs. In contrast, a nuclease-resistant homopolymer, alpha-dC28 was inactive. Their preliminary results would indicate that the origin of oligonucleotide phosphorothioate anti-HIV activity is not exclusively correlated with their higher nuclease resistance.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Cohen, J S" sort="Cohen, J S" uniqKey="Cohen J" first="J S" last="Cohen">J S Cohen</name><name sortKey="Imbach, J L" sort="Imbach, J L" uniqKey="Imbach J" first="J L" last="Imbach">J L Imbach</name><name sortKey="Matsukura, M" sort="Matsukura, M" uniqKey="Matsukura M" first="M" last="Matsukura">M. Matsukura</name><name sortKey="Morvan, F" sort="Morvan, F" uniqKey="Morvan F" first="F" last="Morvan">F. Morvan</name><name sortKey="Rayner, B" sort="Rayner, B" uniqKey="Rayner B" first="B" last="Rayner">B. Rayner</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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