[In vitro anti-HIV activity of phosphorothioate alpha-anomeric oligodeoxynucleotides].
Identifieur interne : 002A48 ( PubMed/Corpus ); précédent : 002A47; suivant : 002A49[In vitro anti-HIV activity of phosphorothioate alpha-anomeric oligodeoxynucleotides].
Auteurs : B. Rayner ; M. Matsukura ; F. Morvan ; J S Cohen ; J L ImbachSource :
- Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie [ 0764-4469 ] ; 1989.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Oligonucleotides, Thionucleotides.
- drug effects : HIV.
- immunology : T-Lymphocytes.
- microbiology : T-Lymphocytes.
- Base Sequence, Depression, Chemical, Humans, In Vitro Techniques, Oligonucleotides, Antisense.
Abstract
Oligonucleotide analogs consisting exclusively of alpha-anomeric deoxynucleoside units bridged with phosphorothioate linkages have been synthesized and tested in vitro as antiviral agents against human immunodeficiency virus (HIV) in human T cells. Two 28-mers, an homopolymer alpha-S-dC28 and an oligomer alpha-S-anti-rev complementary to the initiation site of the regulatory viral gene rev exhibited antiviral activities comparable to those reported for the corresponding beta-anomeric phosphorothioate analogs. In contrast, a nuclease-resistant homopolymer, alpha-dC28 was inactive. Their preliminary results would indicate that the origin of oligonucleotide phosphorothioate anti-HIV activity is not exclusively correlated with their higher nuclease resistance.
PubMed: 2516764
Links to Exploration step
pubmed:2516764Le document en format XML
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<author><name sortKey="Matsukura, M" sort="Matsukura, M" uniqKey="Matsukura M" first="M" last="Matsukura">M. Matsukura</name>
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<author><name sortKey="Morvan, F" sort="Morvan, F" uniqKey="Morvan F" first="F" last="Morvan">F. Morvan</name>
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<author><name sortKey="Cohen, J S" sort="Cohen, J S" uniqKey="Cohen J" first="J S" last="Cohen">J S Cohen</name>
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<author><name sortKey="Imbach, J L" sort="Imbach, J L" uniqKey="Imbach J" first="J L" last="Imbach">J L Imbach</name>
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<term>Depression, Chemical</term>
<term>HIV (drug effects)</term>
<term>Humans</term>
<term>In Vitro Techniques</term>
<term>Oligonucleotides (pharmacology)</term>
<term>Oligonucleotides, Antisense</term>
<term>T-Lymphocytes (immunology)</term>
<term>T-Lymphocytes (microbiology)</term>
<term>Thionucleotides (pharmacology)</term>
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<front><div type="abstract" xml:lang="en">Oligonucleotide analogs consisting exclusively of alpha-anomeric deoxynucleoside units bridged with phosphorothioate linkages have been synthesized and tested in vitro as antiviral agents against human immunodeficiency virus (HIV) in human T cells. Two 28-mers, an homopolymer alpha-S-dC28 and an oligomer alpha-S-anti-rev complementary to the initiation site of the regulatory viral gene rev exhibited antiviral activities comparable to those reported for the corresponding beta-anomeric phosphorothioate analogs. In contrast, a nuclease-resistant homopolymer, alpha-dC28 was inactive. Their preliminary results would indicate that the origin of oligonucleotide phosphorothioate anti-HIV activity is not exclusively correlated with their higher nuclease resistance.</div>
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<Abstract><AbstractText>Oligonucleotide analogs consisting exclusively of alpha-anomeric deoxynucleoside units bridged with phosphorothioate linkages have been synthesized and tested in vitro as antiviral agents against human immunodeficiency virus (HIV) in human T cells. Two 28-mers, an homopolymer alpha-S-dC28 and an oligomer alpha-S-anti-rev complementary to the initiation site of the regulatory viral gene rev exhibited antiviral activities comparable to those reported for the corresponding beta-anomeric phosphorothioate analogs. In contrast, a nuclease-resistant homopolymer, alpha-dC28 was inactive. Their preliminary results would indicate that the origin of oligonucleotide phosphorothioate anti-HIV activity is not exclusively correlated with their higher nuclease resistance.</AbstractText>
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