[In vitro anti-HIV activity of phosphorothioate alpha-anomeric oligodeoxynucleotides].
Identifieur interne : 004A89 ( Main/Curation ); précédent : 004A88; suivant : 004A90[In vitro anti-HIV activity of phosphorothioate alpha-anomeric oligodeoxynucleotides].
Auteurs : B. Rayner ; M. Matsukura ; F. Morvan ; J S Cohen ; J L ImbachSource :
- Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie [ 0764-4469 ] ; 1989.
Descripteurs français
- KwdFr :
- MESH :
- immunologie : Lymphocytes T.
- microbiologie : Lymphocytes T.
- pharmacologie : Oligonucléotides, Thionucléotides.
- Dépression chimique, Humains, Oligonucléotides antisens, Séquence nucléotidique, Techniques in vitro, VIH (Virus de l'Immunodéficience Humaine).
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Oligonucleotides, Thionucleotides.
- drug effects : HIV.
- immunology : T-Lymphocytes.
- microbiology : T-Lymphocytes.
- Base Sequence, Depression, Chemical, Humans, In Vitro Techniques, Oligonucleotides, Antisense.
Abstract
Oligonucleotide analogs consisting exclusively of alpha-anomeric deoxynucleoside units bridged with phosphorothioate linkages have been synthesized and tested in vitro as antiviral agents against human immunodeficiency virus (HIV) in human T cells. Two 28-mers, an homopolymer alpha-S-dC28 and an oligomer alpha-S-anti-rev complementary to the initiation site of the regulatory viral gene rev exhibited antiviral activities comparable to those reported for the corresponding beta-anomeric phosphorothioate analogs. In contrast, a nuclease-resistant homopolymer, alpha-dC28 was inactive. Their preliminary results would indicate that the origin of oligonucleotide phosphorothioate anti-HIV activity is not exclusively correlated with their higher nuclease resistance.
PubMed: 2516764
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B. Rayner<affiliation><nlm:affiliation>Laboratoire de Chimie bio-organique, U.A. n 488, C.N.R.S., Université de Montpellier-II.</nlm:affiliation>
<wicri:noCountry code="subField">Université de Montpellier-II</wicri:noCountry>
</affiliation>
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<term>Oligonucleotides, Antisense</term>
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<term>Oligonucléotides (pharmacologie)</term>
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<term>Séquence nucléotidique</term>
<term>Techniques in vitro</term>
<term>Thionucléotides (pharmacologie)</term>
<term>VIH (Virus de l'Immunodéficience Humaine) ()</term>
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<term>Techniques in vitro</term>
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<front><div type="abstract" xml:lang="en">Oligonucleotide analogs consisting exclusively of alpha-anomeric deoxynucleoside units bridged with phosphorothioate linkages have been synthesized and tested in vitro as antiviral agents against human immunodeficiency virus (HIV) in human T cells. Two 28-mers, an homopolymer alpha-S-dC28 and an oligomer alpha-S-anti-rev complementary to the initiation site of the regulatory viral gene rev exhibited antiviral activities comparable to those reported for the corresponding beta-anomeric phosphorothioate analogs. In contrast, a nuclease-resistant homopolymer, alpha-dC28 was inactive. Their preliminary results would indicate that the origin of oligonucleotide phosphorothioate anti-HIV activity is not exclusively correlated with their higher nuclease resistance.</div>
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